dbPTM

MDC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MDC1_MOUSE
UniProt AC	Q5PSV9
Protein Name	Mediator of DNA damage checkpoint protein 1
Gene Name	Mdc1
Organism	Mus musculus (Mouse).
Sequence Length	1707
Subcellular Localization	Nucleus. Chromosome. Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires phosphorylation of H2AFX. Colocalizes with APTX at sites of DNA double-strand breaks (By similarity)..
Protein Description	Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (By similarity)..
Protein Sequence	MESTQVIDWDAEEEEETELSSGSLGYSVEPIGQLRLFSGTHGPERDFPLYLGKNVVGRSPDCSVALPFPSISKQHAVIEISAWNKAPILQDCGSLNGTQIVKPPRVLPPGVSHRLRDQELILFADFPCQYHRLDVPPPLVPRSLLTIEKTPRIRIESQNSRVLLAADSEEEGDFPSGRCVANGQRNTASPSATVVPESDEEVSSPAPSVPGPSSPFGLGSDTDEEQGQQPGVEESSLADSSGAAGEAEQPEANGTTAGIQAQPTEHKLKDTKVKKEAGRAGVSDGSVLERSPTLGEDSDTEVDEDHKPGFADSETDVEEERIPVTPPVAPVKKNQVLLAVGIGDPEAPGVAHLQDCLAGSGTDVEDKTALDVPLERNHTPMVINSDTDEEEEEEEEVSAALTLAHLKERGIGLWSRDPGAEEVKSQPQVLVEQSQSASGRDSDTDVEEESSGRKREIIPDSPMDVDEALTVTQPESQPPRRPNDADEYMDMSSPGSHLVVNQASFAVVGKTRAQVEEEVPGPSVILGEKHQVPLEGAQPPEEAWETAVQEGSSSPEAAASVRPSQQPVAEDAGTECATAVSEQESTLEVRSQSGSPAAPVEQVVIHTDTSGDPTLPQREGAQTPTGREREAHVGRTKSAKECCDAEPEDLCLPATQCFVEGESQHPEAVQSLENEPTQLFPCTLPQEPGPSHLSLQTPGADTLDVPWEVLATQPFCLREQSETSELHEAHGSQPSLPREPPGHQHLVHTSPVHTELLRIEGREIQTVEKAMGIPKEMADRMTPEREPLEREIRGRTENSERDVIGEELIQGTKDREPKKVLARDSQRKEADKDLEGNRESLEVEIEMSKDSQKRERKVEKPEPKREWEPADLEVTPDRGVTEEGSHDQKGQIASLTLKPGVGVKDLEGLASAPIITGSQADGGKGDPLSPGRQQRGRLSCQTTPAGKASRGDPEPPDHCLFSSVPEASTQSLLTSQSQKQSTPQPLFSTSSSEIPLPESLHTKPNVRPRRSSRMTPSPHSSAALKPNTTCPTNQPAASRPTSRPTRGRANRSSTRTPELIVPVDPELQPSTSTEQPVIPKLTSQVTEGRVQMPEPLLTGPEIQSPTSTEQSVTPDRKPRATRGRPSKSPNKTPEPLISTGPELQPPTSIEQPVIPKPTSRVTRGRPRKSSVRTPESVVSTGPELQPLTSIEQPVIPEPRATRGRPSKSSIKTPESVVPTGPELQPLTSAKQPVTPNLTSRASRGRSSKSIRTPEPVVQTGPEFHPSTSTEQPDTREPSSQARTRRSAVKTPEASVPTTPELQPFTSKKQPAPKPTALVTQGRTYKPSTEDCESVGPVAPDFEPSTSTDHLVTPKVTDQSLTLQSSPLSASPVSSTPDLKPPVPIAQPVTPEPIPQANHQRKRRAAGKQGSRTVPLGHKSYSALSEPEPQSSASQSSGASEADSPRQKRPRRQASQKTVVIKEEPVETEVKEEPQETAIPTPEKRKRDHAEEVTQGKPTRSRRTKPNQETAPKVLFTGVMDSRGERAVLALGGSLASSVNEASHLVTDRIRRTVKFLCALGKGIPILSLNWLYQSRKAGCFLPPDDYLVTDPEQEKNFSFSLRDSLCRARERRLLEDYEIHVTPGVQPPPPQMGEIISCCGGTFLPSMPHSYKLHRVIITCTEDLPRCAIPSRLGLPLLSPEFLLTGVLKQEATPEAFVLSNLEMSST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MESTQVIDWDA ----CCCCEEECCCC	30.10	-
59	Phosphorylation	GKNVVGRSPDCSVAL CCCCCCCCCCCEEEE	21.11	25293948
146	Phosphorylation	LVPRSLLTIEKTPRI CCCHHHEEECCCCCE	32.17	26643407
149	Acetylation	RSLLTIEKTPRIRIE HHHEEECCCCCEEEE	61.04	23806337
150	Phosphorylation	SLLTIEKTPRIRIES HHEEECCCCCEEEEE	12.66	26239621
157	Phosphorylation	TPRIRIESQNSRVLL CCCEEEEECCCEEEE	32.08	26824392
160	Phosphorylation	IRIESQNSRVLLAAD EEEEECCCEEEEECC	19.01	27566939
168	Phosphorylation	RVLLAADSEEEGDFP EEEEECCCCCCCCCC	42.03	27087446
176	Phosphorylation	EEEGDFPSGRCVANG CCCCCCCCCCEEECC	38.57	27149854
283	Phosphorylation	EAGRAGVSDGSVLER HHHCCCCCCCCEECC	35.02	23737553
286	Phosphorylation	RAGVSDGSVLERSPT CCCCCCCCEECCCCC	28.64	23737553
291	Phosphorylation	DGSVLERSPTLGEDS CCCEECCCCCCCCCC	16.92	21149613
293	Phosphorylation	SVLERSPTLGEDSDT CEECCCCCCCCCCCC	48.95	25293948
298	Phosphorylation	SPTLGEDSDTEVDED CCCCCCCCCCCCCCC	41.97	21149613
300	Phosphorylation	TLGEDSDTEVDEDHK CCCCCCCCCCCCCCC	41.69	21149613
313	Phosphorylation	HKPGFADSETDVEEE CCCCCCCCCCCCCHH	38.68	21149613
315	Phosphorylation	PGFADSETDVEEERI CCCCCCCCCCCHHCC	49.66	21149613
325	Phosphorylation	EEERIPVTPPVAPVK CHHCCCCCCCCCCCC	19.27	22942356
360	Phosphorylation	LQDCLAGSGTDVEDK HHHHHCCCCCCCCCC	32.67	25293948
362	Phosphorylation	DCLAGSGTDVEDKTA HHHCCCCCCCCCCCC	38.27	25293948
368	Phosphorylation	GTDVEDKTALDVPLE CCCCCCCCCCCCCCC	44.78	25293948
379	Phosphorylation	VPLERNHTPMVINSD CCCCCCCCCCEECCC	19.34	22817900
385	Phosphorylation	HTPMVINSDTDEEEE CCCCEECCCCCHHHH	30.66	21659605
387	Phosphorylation	PMVINSDTDEEEEEE CCEECCCCCHHHHHH	45.17	21659605
398	Phosphorylation	EEEEEEVSAALTLAH HHHHHHHHHHHHHHH	15.88	-
402	Phosphorylation	EEVSAALTLAHLKER HHHHHHHHHHHHHHC	19.71	21183079
415	Phosphorylation	ERGIGLWSRDPGAEE HCCCCCCCCCCCCHH	31.67	-
425	Phosphorylation	PGAEEVKSQPQVLVE CCCHHHHCCCEEEEE	52.87	25619855
434	Phosphorylation	PQVLVEQSQSASGRD CEEEEECCCCCCCCC	16.76	21082442
436	Phosphorylation	VLVEQSQSASGRDSD EEEECCCCCCCCCCC	29.64	25619855
438	Phosphorylation	VEQSQSASGRDSDTD EECCCCCCCCCCCCC	39.34	21082442
442	Phosphorylation	QSASGRDSDTDVEEE CCCCCCCCCCCHHHH	40.84	27087446
444	Phosphorylation	ASGRDSDTDVEEESS CCCCCCCCCHHHHHC	45.99	25521595
450	Phosphorylation	DTDVEEESSGRKREI CCCHHHHHCCCCCCC	41.18	25619855
451	Phosphorylation	TDVEEESSGRKREII CCHHHHHCCCCCCCC	45.99	25619855
461	Phosphorylation	KREIIPDSPMDVDEA CCCCCCCCCCCHHHC	19.44	26824392
470	Phosphorylation	MDVDEALTVTQPESQ CCHHHCCCCCCCCCC	28.67	25619855
472	Phosphorylation	VDEALTVTQPESQPP HHHCCCCCCCCCCCC	32.92	25619855
476	Phosphorylation	LTVTQPESQPPRRPN CCCCCCCCCCCCCCC	55.45	25619855
488	Phosphorylation	RPNDADEYMDMSSPG CCCCHHHHCCCCCCC	10.04	25293948
492	Phosphorylation	ADEYMDMSSPGSHLV HHHHCCCCCCCCEEE	29.17	22817900
493	Phosphorylation	DEYMDMSSPGSHLVV HHHCCCCCCCCEEEE	27.00	22817900
496	Phosphorylation	MDMSSPGSHLVVNQA CCCCCCCCEEEECCC	19.61	22817900
504	Phosphorylation	HLVVNQASFAVVGKT EEEECCCEEEEECCC	12.18	25293948
552	Phosphorylation	ETAVQEGSSSPEAAA HHHHHHCCCCHHHHH	27.22	25293948
553	Phosphorylation	TAVQEGSSSPEAAAS HHHHHCCCCHHHHHH	61.85	25293948
554	Phosphorylation	AVQEGSSSPEAAASV HHHHCCCCHHHHHHC	28.58	21149613
591	Phosphorylation	ESTLEVRSQSGSPAA CCCEEEECCCCCCCC	33.60	25521595
593	Phosphorylation	TLEVRSQSGSPAAPV CEEEECCCCCCCCCC	42.35	25521595
595	Phosphorylation	EVRSQSGSPAAPVEQ EEECCCCCCCCCCEE	19.33	23527152
607	Phosphorylation	VEQVVIHTDTSGDPT CEEEEEEECCCCCCC	29.83	28833060
609	Phosphorylation	QVVIHTDTSGDPTLP EEEEEECCCCCCCCC	35.45	28833060
610	Phosphorylation	VVIHTDTSGDPTLPQ EEEEECCCCCCCCCC	43.97	28833060
614	Phosphorylation	TDTSGDPTLPQREGA ECCCCCCCCCCCCCC	56.67	28833060
623	Phosphorylation	PQREGAQTPTGRERE CCCCCCCCCCCCCCH	23.45	27087446
625	Phosphorylation	REGAQTPTGREREAH CCCCCCCCCCCCHHH	52.86	24453211
721	Phosphorylation	PFCLREQSETSELHE CEEECCCCHHHHHHH	37.78	25619855
723	Phosphorylation	CLREQSETSELHEAH EECCCCHHHHHHHHH	32.52	25619855
724	Phosphorylation	LREQSETSELHEAHG ECCCCHHHHHHHHHC	33.82	25619855
732	Phosphorylation	ELHEAHGSQPSLPRE HHHHHHCCCCCCCCC	29.11	17525332
735	Phosphorylation	EAHGSQPSLPREPPG HHHCCCCCCCCCCCC	43.28	25619855
749	Phosphorylation	GHQHLVHTSPVHTEL CCCCCEECCCCCHHH	27.52	25159016
750	Phosphorylation	HQHLVHTSPVHTELL CCCCEECCCCCHHHE	15.28	26824392
751	Phosphorylation	QHLVHTSPVHTELLR CCCEECCCCCHHHEE	24.06	24719451
769	Acetylation	REIQTVEKAMGIPKE EEEHHHHHHHCCCHH	39.06	22826441
782	Phosphorylation	KEMADRMTPEREPLE HHHHHHCCCCCCHHH	23.92	26824392
783	Phosphorylation	EMADRMTPEREPLER HHHHHCCCCCCHHHH	29.33	24719451
796	Phosphorylation	EREIRGRTENSERDV HHHHCCCCCCCCCCH	42.20	25159016
799	Phosphorylation	IRGRTENSERDVIGE HCCCCCCCCCCHHCH	27.98	25159016
825	Phosphorylation	KKVLARDSQRKEADK HHHCCCHHHHHHHHH	26.74	29514104
875	Phosphorylation	EPADLEVTPDRGVTE CCCCCEECCCCCCCC	15.31	21149613
881	Phosphorylation	VTPDRGVTEEGSHDQ ECCCCCCCCCCCCCC	31.01	29550500
885	Phosphorylation	RGVTEEGSHDQKGQI CCCCCCCCCCCCCCE	27.46	27841257
894	Phosphorylation	DQKGQIASLTLKPGV CCCCCEEEEEECCCC	24.42	27841257
911	Phosphorylation	KDLEGLASAPIITGS CCCCCHHCCCEEECC	39.35	25619855
916	Phosphorylation	LASAPIITGSQADGG HHCCCEEECCCCCCC	31.34	25619855
918	Phosphorylation	SAPIITGSQADGGKG CCCEEECCCCCCCCC	17.34	26824392
929	Phosphorylation	GGKGDPLSPGRQQRG CCCCCCCCCCCCCCC	30.60	26824392
939	Phosphorylation	RQQRGRLSCQTTPAG CCCCCCCEEECCCCC	11.65	25159016
942	Phosphorylation	RGRLSCQTTPAGKAS CCCCEEECCCCCCCC	38.79	25159016
943	Phosphorylation	GRLSCQTTPAGKASR CCCEEECCCCCCCCC	5.81	25159016
962	Phosphorylation	PPDHCLFSSVPEAST CCCCCCCCCCCCHHH	19.92	-
963	Phosphorylation	PDHCLFSSVPEASTQ CCCCCCCCCCCHHHH	34.06	-
977	Phosphorylation	QSLLTSQSQKQSTPQ HHHHHCCHHCCCCCC	38.83	25159016
991	Phosphorylation	QPLFSTSSSEIPLPE CCCCCCCCCCCCCCH	31.88	-
1015	Phosphorylation	PRRSSRMTPSPHSSA CCCCCCCCCCCCCCC	21.36	25293948
1017	Phosphorylation	RSSRMTPSPHSSAAL CCCCCCCCCCCCCCC	26.53	25293948
1020	Phosphorylation	RMTPSPHSSAALKPN CCCCCCCCCCCCCCC	25.67	25293948
1021	Phosphorylation	MTPSPHSSAALKPNT CCCCCCCCCCCCCCC	17.96	25293948
1052	Phosphorylation	TRGRANRSSTRTPEL CCCCCCCCCCCCCCE	35.55	25619855
1053	Phosphorylation	RGRANRSSTRTPELI CCCCCCCCCCCCCEE	20.76	25619855
1054	Phosphorylation	GRANRSSTRTPELIV CCCCCCCCCCCCEEE	39.55	25619855
1056	Phosphorylation	ANRSSTRTPELIVPV CCCCCCCCCCEEEEC	22.62	22942356
1070	Phosphorylation	VDPELQPSTSTEQPV CCCCCCCCCCCCCCC	23.25	25619855
1071	Phosphorylation	DPELQPSTSTEQPVI CCCCCCCCCCCCCCH	46.48	25619855
1072	Phosphorylation	PELQPSTSTEQPVIP CCCCCCCCCCCCCHH	33.99	25619855
1073	Phosphorylation	ELQPSTSTEQPVIPK CCCCCCCCCCCCHHH	38.43	25619855
1098	Phosphorylation	QMPEPLLTGPEIQSP CCCCCCCCCCCCCCC	59.37	25619855
1104	Phosphorylation	LTGPEIQSPTSTEQS CCCCCCCCCCCCCCC	35.49	25619855
1106	Phosphorylation	GPEIQSPTSTEQSVT CCCCCCCCCCCCCCC	54.23	25619855
1107	Phosphorylation	PEIQSPTSTEQSVTP CCCCCCCCCCCCCCC	33.07	25619855
1108	Phosphorylation	EIQSPTSTEQSVTPD CCCCCCCCCCCCCCC	40.29	25619855
1111	Phosphorylation	SPTSTEQSVTPDRKP CCCCCCCCCCCCCCC	23.02	25619855
1113	Phosphorylation	TSTEQSVTPDRKPRA CCCCCCCCCCCCCCC	25.39	22942356
1126	Phosphorylation	RATRGRPSKSPNKTP CCCCCCCCCCCCCCC	44.39	25159016
1128	Phosphorylation	TRGRPSKSPNKTPEP CCCCCCCCCCCCCCC	37.73	26824392
1132	Phosphorylation	PSKSPNKTPEPLIST CCCCCCCCCCCCCCC	39.25	25159016
1138	Phosphorylation	KTPEPLISTGPELQP CCCCCCCCCCCCCCC	34.69	25293948
1139	Phosphorylation	TPEPLISTGPELQPP CCCCCCCCCCCCCCC	50.16	25293948
1147	Phosphorylation	GPELQPPTSIEQPVI CCCCCCCCCCCCCCC	49.36	25159016
1148	Phosphorylation	PELQPPTSIEQPVIP CCCCCCCCCCCCCCC	29.87	25159016
1158	Phosphorylation	QPVIPKPTSRVTRGR CCCCCCCCCCCCCCC	34.98	25777480
1159	Phosphorylation	PVIPKPTSRVTRGRP CCCCCCCCCCCCCCC	33.03	25777480
1169	Phosphorylation	TRGRPRKSSVRTPES CCCCCCCCCCCCCHH	35.03	21659605
1170	Phosphorylation	RGRPRKSSVRTPESV CCCCCCCCCCCCHHH	20.75	21659605
1173	Phosphorylation	PRKSSVRTPESVVST CCCCCCCCCHHHHCC	29.29	21082442
1176	Phosphorylation	SSVRTPESVVSTGPE CCCCCCHHHHCCCCC	29.08	24453211
1179	Phosphorylation	RTPESVVSTGPELQP CCCHHHHCCCCCCCC	26.03	25293948
1180	Phosphorylation	TPESVVSTGPELQPL CCHHHHCCCCCCCCC	45.18	25293948
1188	Phosphorylation	GPELQPLTSIEQPVI CCCCCCCCCCCCCCC	34.05	24759943
1189	Phosphorylation	PELQPLTSIEQPVIP CCCCCCCCCCCCCCC	31.63	26643407
1208	Phosphorylation	TRGRPSKSSIKTPES CCCCCCCCCCCCCCC	41.45	26745281
1209	Phosphorylation	RGRPSKSSIKTPESV CCCCCCCCCCCCCCC	31.66	26745281
1212	Phosphorylation	PSKSSIKTPESVVPT CCCCCCCCCCCCCCC	30.53	24453211
1215	Phosphorylation	SSIKTPESVVPTGPE CCCCCCCCCCCCCCC	29.62	26745281
1219	Phosphorylation	TPESVVPTGPELQPL CCCCCCCCCCCCCCC	54.48	30635358
1234	Phosphorylation	TSAKQPVTPNLTSRA CCCCCCCCCCCCCCC	17.09	28066266
1249	Phosphorylation	SRGRSSKSIRTPEPV CCCCCCCCCCCCCCC	21.17	21659605
1252	Phosphorylation	RSSKSIRTPEPVVQT CCCCCCCCCCCCEEC	30.27	21082442
1259	Phosphorylation	TPEPVVQTGPEFHPS CCCCCEECCCCCCCC	42.99	26643407
1278	Phosphorylation	QPDTREPSSQARTRR CCCCCCCCHHHHHHH	30.26	-
1286	Phosphorylation	SQARTRRSAVKTPEA HHHHHHHHCCCCCCC	33.84	25159016
1290	Phosphorylation	TRRSAVKTPEASVPT HHHHCCCCCCCCCCC	21.55	22942356
1294	Phosphorylation	AVKTPEASVPTTPEL CCCCCCCCCCCCCCC	27.28	22942356
1297	Phosphorylation	TPEASVPTTPELQPF CCCCCCCCCCCCCCC	53.48	21082442
1298	Phosphorylation	PEASVPTTPELQPFT CCCCCCCCCCCCCCC	14.54	22942356
1327	Phosphorylation	QGRTYKPSTEDCESV CCCCCCCCCHHCCCC	40.03	-
1352	Phosphorylation	TSTDHLVTPKVTDQS CCCCCCCCCCCCCCC	24.61	-
1356	Phosphorylation	HLVTPKVTDQSLTLQ CCCCCCCCCCCEEEE	34.15	25159016
1359	Phosphorylation	TPKVTDQSLTLQSSP CCCCCCCCEEEECCC	26.57	24453211
1361	Phosphorylation	KVTDQSLTLQSSPLS CCCCCCEEEECCCCC	28.18	25293948
1364	Phosphorylation	DQSLTLQSSPLSASP CCCEEEECCCCCCCC	36.72	21659605
1365	Phosphorylation	QSLTLQSSPLSASPV CCEEEECCCCCCCCC	19.52	21659605
1368	Phosphorylation	TLQSSPLSASPVSST EEECCCCCCCCCCCC	30.04	25159016
1370	Phosphorylation	QSSPLSASPVSSTPD ECCCCCCCCCCCCCC	23.58	21659605
1373	Phosphorylation	PLSASPVSSTPDLKP CCCCCCCCCCCCCCC	31.70	25159016
1374	Phosphorylation	LSASPVSSTPDLKPP CCCCCCCCCCCCCCC	44.16	25293948
1375	Phosphorylation	SASPVSSTPDLKPPV CCCCCCCCCCCCCCC	17.20	25159016
1389	Phosphorylation	VPIAQPVTPEPIPQA CCCCCCCCCCCCCCC	28.72	24453211
1419	Phosphorylation	TVPLGHKSYSALSEP EECCCCCCCCCCCCC	20.74	25619855
1420	Phosphorylation	VPLGHKSYSALSEPE ECCCCCCCCCCCCCC	11.63	25619855
1421	Phosphorylation	PLGHKSYSALSEPEP CCCCCCCCCCCCCCC	29.80	25619855
1424	Phosphorylation	HKSYSALSEPEPQSS CCCCCCCCCCCCCCC	51.31	25619855
1430	Phosphorylation	LSEPEPQSSASQSSG CCCCCCCCCCCCCCC	38.29	25619855
1431	Phosphorylation	SEPEPQSSASQSSGA CCCCCCCCCCCCCCC	27.05	25619855
1433	Phosphorylation	PEPQSSASQSSGASE CCCCCCCCCCCCCCC	32.32	25619855
1435	Phosphorylation	PQSSASQSSGASEAD CCCCCCCCCCCCCCC	28.39	25619855
1436	Phosphorylation	QSSASQSSGASEADS CCCCCCCCCCCCCCC	30.64	25619855
1439	Phosphorylation	ASQSSGASEADSPRQ CCCCCCCCCCCCCCC	36.52	21082442
1443	Phosphorylation	SGASEADSPRQKRPR CCCCCCCCCCCCCCC	29.09	27087446
1467	Phosphorylation	IKEEPVETEVKEEPQ EECCCCCCCCCCCCC	46.44	25619855
1476	Phosphorylation	VKEEPQETAIPTPEK CCCCCCCCCCCCCCH	25.33	25619855
1480	Phosphorylation	PQETAIPTPEKRKRD CCCCCCCCCCHHHCC	37.66	26824392
1496	Acetylation	AEEVTQGKPTRSRRT HHHHHCCCCCCCCCC	33.14	23806337
1533	Phosphorylation	AVLALGGSLASSVNE EEHHHCCHHHHHHHH	20.97	30165576
1536	Phosphorylation	ALGGSLASSVNEASH HHCCHHHHHHHHHHH	39.86	30165576
1537	Phosphorylation	LGGSLASSVNEASHL HCCHHHHHHHHHHHH	24.29	30165576
1542	Phosphorylation	ASSVNEASHLVTDRI HHHHHHHHHHHHHHH	15.92	30165576
1546	Phosphorylation	NEASHLVTDRIRRTV HHHHHHHHHHHHHHH	26.39	30165576
1598	Phosphorylation	PEQEKNFSFSLRDSL HHHHCCCCCHHHHHH	24.26	22942356
1600	Phosphorylation	QEKNFSFSLRDSLCR HHCCCCCHHHHHHHH	22.69	22942356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MDC1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
4	T	Phosphorylation	-
Phosphorylation at Thr-4 by ATM stabilizes and enhances homodimerization via the FHA domain (By similarity).
1461	K	Sumoylation	-
Sumoylation at Lys-1461 by PIAS4 following DNA damage promotes ubiquitin-mediated degradation.
1461	K	ubiquitylation	-
Sumoylation at Lys-1461 by PIAS4 following DNA damage promotes ubiquitin-mediated degradation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MDC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NBN_MOUSE	Nbn	physical	18678890
BRCA1_MOUSE	Brca1	physical	18678890
TP53B_MOUSE	Trp53bp1	physical	18678890
RN168_MOUSE	Rnf168	physical	24324146
TP53B_MOUSE	Trp53bp1	physical	24324146

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MDC1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, AND MASSSPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168 AND SER-593, ANDMASS SPECTROMETRY.	19144319 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-732, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438; SER-442; THR-444AND SER-918, AND MASS SPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, AND MASSSPECTROMETRY.	17203969 [Abstract]

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