dbPTM

FXR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FXR1_MOUSE
UniProt AC	Q61584
Protein Name	Fragile X mental retardation syndrome-related protein 1
Gene Name	Fxr1
Organism	Mus musculus (Mouse).
Sequence Length	677
Subcellular Localization	Cytoplasm.
Protein Description	RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs..
Protein Sequence	MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESAEAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGMGFRPSSTRGPEREKGYATDESTVSSVQGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRETRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGLTESDTASVNENGLDDSEKKPQRRNRSRRRRFRGQAEDRQPVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDEIPKLPRTLGEEKTKTLKEDSTQEAAVLNGVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAELTVEVR ------CCEEEEEEE	22.10	-
11	Phosphorylation	LTVEVRGSNGAFYKG EEEEEECCCCCEEEC	22.86	24899341
68	Phosphorylation	EGDEVEVYSRANDQE CCCEEEEEECCCCCC	4.48	22817900
69	Phosphorylation	GDEVEVYSRANDQEP CCEEEEEECCCCCCC	30.05	30635358
92	Phosphorylation	RMMKGEFYVIEYAAC HHHCCCEEEEEEEEE	9.01	-
96	Phosphorylation	GEFYVIEYAACDATY CCEEEEEEEEECCCC	6.59	-
103	Phosphorylation	YAACDATYNEIVTFE EEEECCCCCEEEEEE	16.72	-
125	Phosphorylation	NKTVKKNTFFKCTVD CCCCCCCCEEEEEEE	39.05	22817900
246	Ubiquitination	SNIQQARKVPGVTAI CCHHHHHCCCCEEEE	56.66	-
295	Acetylation	VPRNLVGKVIGKNGK CCHHHHHHHHCCCCC	24.17	19857311
295	Malonylation	VPRNLVGKVIGKNGK CCHHHHHHHHCCCCC	24.17	32601280
302	Ubiquitination	KVIGKNGKVIQEIVD HHHCCCCCEEEEEEC	45.63	-
325	Ubiquitination	IEGDNENKLPREDGM EECCCCCCCCCCCCC	54.40	-
394	Ubiquitination	TRGPEREKGYATDES CCCCCCCCCCCCCCC	64.54	-
396	Phosphorylation	GPEREKGYATDESTV CCCCCCCCCCCCCCC	19.86	25619855
398	Phosphorylation	EREKGYATDESTVSS CCCCCCCCCCCCCCC	31.64	27742792
401	Phosphorylation	KGYATDESTVSSVQG CCCCCCCCCCCCCCC	36.60	27742792
402	Phosphorylation	GYATDESTVSSVQGS CCCCCCCCCCCCCCC	23.51	25619855
404	Phosphorylation	ATDESTVSSVQGSRS CCCCCCCCCCCCCCC	25.53	25619855
405	Phosphorylation	TDESTVSSVQGSRSY CCCCCCCCCCCCCCC	17.70	27742792
409	Phosphorylation	TVSSVQGSRSYSGRG CCCCCCCCCCCCCCC	10.85	25619855
413	Phosphorylation	VQGSRSYSGRGRGRR CCCCCCCCCCCCCCC	24.22	-
424	Phosphorylation	RGRRGPNYTSGYGTN CCCCCCCCCCCCCCC	12.86	25619855
425	Phosphorylation	GRRGPNYTSGYGTNS CCCCCCCCCCCCCCC	23.47	25619855
426	Phosphorylation	RRGPNYTSGYGTNSE CCCCCCCCCCCCCCC	21.47	25619855
428	Phosphorylation	GPNYTSGYGTNSELS CCCCCCCCCCCCCCC	22.12	25619855
430	Phosphorylation	NYTSGYGTNSELSNP CCCCCCCCCCCCCCC	27.39	25619855
432	Phosphorylation	TSGYGTNSELSNPSE CCCCCCCCCCCCCCC	39.49	25619855
435	Phosphorylation	YGTNSELSNPSETES CCCCCCCCCCCCCHH	42.52	27087446
438	Phosphorylation	NSELSNPSETESERK CCCCCCCCCCHHHHH	62.49	27087446
440	Phosphorylation	ELSNPSETESERKDE CCCCCCCCHHHHHHH	49.50	27742792
442	Phosphorylation	SNPSETESERKDELS CCCCCCHHHHHHHHH	50.55	27742792
449	Phosphorylation	SERKDELSDWSLAGE HHHHHHHHHHHHCCC	34.68	27087446
452	Phosphorylation	KDELSDWSLAGEDDR HHHHHHHHHCCCCHH	17.21	27087446
461	Phosphorylation	AGEDDRETRHQRDSR CCCCHHHHHHHHHCC	34.05	18846507
474	Methylation	SRRRPGGRGRSVSGG CCCCCCCCCCCCCCC	43.18	-
476	Methylation	RRPGGRGRSVSGGRG CCCCCCCCCCCCCCC	32.31	-
477	Phosphorylation	RPGGRGRSVSGGRGR CCCCCCCCCCCCCCC	24.37	23737553
479	Phosphorylation	GGRGRSVSGGRGRGG CCCCCCCCCCCCCCC	36.46	23737553
482	Methylation	GRSVSGGRGRGGPRG CCCCCCCCCCCCCCC	34.85	-
484	Methylation	SVSGGRGRGGPRGGK CCCCCCCCCCCCCCC	45.60	-
492	Phosphorylation	GGPRGGKSSISSVLK CCCCCCCCCHHHHHC	35.86	23984901
493	Phosphorylation	GPRGGKSSISSVLKD CCCCCCCCHHHHHCC	29.94	23984901
495	Phosphorylation	RGGKSSISSVLKDPD CCCCCCHHHHHCCCC	19.15	23984901
496	Phosphorylation	GGKSSISSVLKDPDS CCCCCHHHHHCCCCC	29.78	23984901
503	Phosphorylation	SVLKDPDSNPYSLLD HHHCCCCCCCCCCCC	45.13	23984901
506	Phosphorylation	KDPDSNPYSLLDNTE CCCCCCCCCCCCCCC	19.05	27742792
507	Phosphorylation	DPDSNPYSLLDNTES CCCCCCCCCCCCCCC	24.58	27087446
511 (in isoform 2)	Phosphorylation	-	45.79	30635358
512	Phosphorylation	PYSLLDNTESDQTAD CCCCCCCCCCCCCCC	36.21	27087446
514	Phosphorylation	SLLDNTESDQTADTD CCCCCCCCCCCCCCC	32.74	27087446
517	Phosphorylation	DNTESDQTADTDASE CCCCCCCCCCCCHHH	31.34	21659605
520	Phosphorylation	ESDQTADTDASESHH CCCCCCCCCHHHCHH	30.88	21149613
522 (in isoform 2)	Phosphorylation	-	19.79	30635358
523	Phosphorylation	QTADTDASESHHSTN CCCCCCHHHCHHHHH	42.30	21149613
524 (in isoform 2)	Phosphorylation	-	56.67	30635358
525	Phosphorylation	ADTDASESHHSTNRR CCCCHHHCHHHHHHH	24.81	21149613
526 (in isoform 2)	Phosphorylation	-	18.18	30635358
528 (in isoform 2)	Phosphorylation	-	23.19	30635358
528	Phosphorylation	DASESHHSTNRRRRS CHHHCHHHHHHHHHH	23.19	21149613
529	Phosphorylation	ASESHHSTNRRRRSR HHHCHHHHHHHHHHH	28.52	21149613
540 (in isoform 3)	Phosphorylation	-	41.76	30635358
540	Phosphorylation	RRSRRRRTDEDAVLM HHHHHCCCCCCCEEC	41.76	23737553
551	Phosphorylation	AVLMDGLTESDTASV CEECCCCCHHHCCCC	38.68	24899341
551 (in isoform 3)	Phosphorylation	-	38.68	30635358
553	Phosphorylation	LMDGLTESDTASVNE ECCCCCHHHCCCCCC	34.72	24899341
553 (in isoform 3)	Phosphorylation	-	34.72	30635358
555 (in isoform 3)	Phosphorylation	-	30.06	30635358
555	Phosphorylation	DGLTESDTASVNENG CCCCHHHCCCCCCCC	30.06	24899341
557 (in isoform 3)	Phosphorylation	-	27.80	30635358
557	Phosphorylation	LTESDTASVNENGLD CCHHHCCCCCCCCCC	27.80	23737553
566	Phosphorylation	NENGLDDSEKKPQRR CCCCCCCCCCCCCHH	51.48	25293948
598	Phosphorylation	VTVADYISRAESQSR CCHHHHHHHHHHHHH	21.14	25338131
602	Phosphorylation	DYISRAESQSRQRNL HHHHHHHHHHHHHCC	32.25	25338131
604	Phosphorylation	ISRAESQSRQRNLPR HHHHHHHHHHHCCCH	39.39	23684622
613	Phosphorylation	QRNLPRETLAKNKKE HHCCCHHHHHHCHHH	33.04	22817900
640	Phosphorylation	EKAINGPTSASGDEI HHHCCCCCCCCCCCC	38.02	27742792
641	Phosphorylation	KAINGPTSASGDEIP HHCCCCCCCCCCCCC	24.46	27087446
643	Phosphorylation	INGPTSASGDEIPKL CCCCCCCCCCCCCCC	46.69	25521595
666	Phosphorylation	TKTLKEDSTQEAAVL CCCCCCCCHHHHHHH	32.84	28464351
667	Phosphorylation	KTLKEDSTQEAAVLN CCCCCCCHHHHHHHC	42.63	-
677	Phosphorylation	AAVLNGVS------- HHHHCCCC-------	35.58	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FXR1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FXR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FXR1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANFY1_MOUSE	Ankfy1	physical	28671696
AP2A1_MOUSE	Ap2a1	physical	28671696
AP2A2_MOUSE	Ap2a2	physical	28671696
ARHG7_MOUSE	Arhgef7	physical	28671696
BAIP2_MOUSE	Baiap2	physical	28671696
KCC2A_MOUSE	Camk2a	physical	28671696
KCC2B_MOUSE	Camk2b	physical	28671696
CAPR1_MOUSE	Caprin1	physical	28671696
CADH2_MOUSE	Cdh2	physical	28671696
CTNB1_MOUSE	Ctnnb1	physical	28671696
AGO1_MOUSE	Ago1	physical	28671696
AGO2_MOUSE	Ago2	physical	28671696
ELAV1_MOUSE	Elavl1	physical	28671696
ELAV2_MOUSE	Elavl2	physical	28671696
ELAV4_MOUSE	Elavl4	physical	28671696
E41L3_MOUSE	Epb4.1l3	physical	28671696
EXOG_MOUSE	Exog	physical	28671696
F120A_MOUSE	Fam120a	physical	28671696
SYFA_MOUSE	Farsa	physical	28671696
SYFB_MOUSE	Farsb	physical	28671696
GIT1_MOUSE	Git1	physical	28671696
HNRPK_MOUSE	Hnrnpk	physical	28671696
HNRPM_MOUSE	Hnrnpm	physical	28671696
HNRPU_MOUSE	Hnrnpu	physical	28671696
HNRL2_MOUSE	Hnrnpul2	physical	28671696
GRP75_MOUSE	Hspa9	physical	28671696
AINX_MOUSE	Ina	physical	28671696
PABP1_MOUSE	Pabpc1	physical	28671696
PAK2_MOUSE	Pak2	physical	28671696
PAK3_MOUSE	Pak3	physical	28671696
LIPA3_MOUSE	Ppfia3	physical	28671696
PPM1H_MOUSE	Ppm1h	physical	28671696
PURA_MOUSE	Pura	physical	28671696
RL12_MOUSE	Rpl12	physical	28671696
SPKAP_MOUSE	Sphkap	physical	28671696
TDRD3_MOUSE	Tdrd3	physical	28671696
TENR_MOUSE	Tnr	physical	28671696
TP53B_MOUSE	Trp53bp1	physical	28671696
RENT1_MOUSE	Upf1	physical	28671696
AAK1_MOUSE	Aak1	physical	28671696
AKAP8_MOUSE	Akap8	physical	28671696
AKAP9_MOUSE	Akap9	physical	28671696
THOC4_MOUSE	Alyref	physical	28671696
AP2B1_MOUSE	Ap2b1	physical	28671696
ARHG2_MOUSE	Arhgef2	physical	28671696
BCLF1_MOUSE	Bclaf1	physical	28671696
BCOR_MOUSE	Bcor	physical	28671696
BUB3_MOUSE	Bub3	physical	28671696
PYR1_MOUSE	Cad	physical	28671696
CCAR1_MOUSE	Ccar1	physical	28671696
CCAR2_MOUSE	Ccar2	physical	28671696
GRDN_MOUSE	Ccdc88a	physical	28671696
CDC5L_MOUSE	Cdc5l	physical	28671696
CE170_MOUSE	Cep170	physical	28671696
C170B_MOUSE	Cep170b	physical	28671696
CLIP1_MOUSE	Clip1	physical	28671696
CNOT1_MOUSE	Cnot1	physical	28671696
CTCF_MOUSE	Ctcf	physical	28671696
CTNA1_MOUSE	Ctnna1	physical	28671696
DIDO1_MOUSE	Dido1	physical	28671696
DNJA1_MOUSE	Dnaja1	physical	28671696
DNJC9_MOUSE	Dnajc9	physical	28671696
DYL1_MOUSE	Dynll1	physical	28671696
COE3_MOUSE	Ebf3	physical	28671696
EDC4_MOUSE	Edc4	physical	28671696
EPS15_MOUSE	Eps15	physical	28671696
EP15R_MOUSE	Eps15l1	physical	28671696
FYCO1_MOUSE	Fyco1	physical	28671696
GIT2_MOUSE	Git2	physical	28671696
GOGA3_MOUSE	Golga3	physical	28671696
GASP1_MOUSE	Gprasp1	physical	28671696
GRIK3_MOUSE	Grik3	physical	28671696
GSK3B_MOUSE	Gsk3b	physical	28671696
NOG1_MOUSE	Gtpbp4	physical	28671696
ILF2_MOUSE	Ilf2	physical	28671696
ILF3_MOUSE	Ilf3	physical	28671696
ITSN1_MOUSE	Itsn1	physical	28671696
KEAP1_MOUSE	Keap1	physical	28671696
KI21A_MOUSE	Kif21a	physical	28671696
KIF2A_MOUSE	Kif2a	physical	28671696
IMB1_MOUSE	Kpnb1	physical	28671696
LMTK3_MOUSE	Lmtk3	physical	28671696
M4K4_MOUSE	Map4k4	physical	28671696
MK_MOUSE	Mdk	physical	28671696
TGO1_MOUSE	Mia3	physical	28671696
AFAD_MOUSE	Mllt4	physical	28671696
MYCB2_MOUSE	Mycbp2	physical	28671696
MYEF2_MOUSE	Myef2	physical	28671696
NACC1_MOUSE	Nacc1	physical	28671696
NAT10_MOUSE	Nat10	physical	28671696
NCOR2_MOUSE	Ncor2	physical	28671696
NEDD4_MOUSE	Nedd4	physical	28671696
NFL_MOUSE	Nefl	physical	28671696
NFM_MOUSE	Nefm	physical	28671696
NOP56_MOUSE	Nop56	physical	28671696
NPM_MOUSE	Npm1	physical	28671696
PCM1_MOUSE	Pcm1	physical	28671696
MYOME_MOUSE	Pde4dip	physical	28671696
PRC2A_MOUSE	Prrc2a	physical	28671696
PRC2B_MOUSE	Prrc2b	physical	28671696
PRC2C_MOUSE	Prrc2c	physical	28671696
RBP2_MOUSE	Ranbp2	physical	28671696
RAGP1_MOUSE	Rangap1	physical	28671696
RCOR2_MOUSE	Rcor2	physical	28671696
RADI_MOUSE	Rdx	physical	28671696
MTMR5_MOUSE	Sbf1	physical	28671696
SCRIB_MOUSE	Scrib	physical	28671696
SENP1_MOUSE	Senp1	physical	28671696
SMCA4_MOUSE	Smarca4	physical	28671696
SMRC2_MOUSE	Smarcc2	physical	28671696
SNW1_MOUSE	Snw1	physical	28671696
SPT13_MOUSE	Spata13	physical	28671696
SPAS2_MOUSE	Spats2	physical	28671696
SRPK2_MOUSE	Srpk2	physical	28671696
SRSF1_MOUSE	Srsf1	physical	28671696
STON2_MOUSE	Ston2	physical	28671696
STRAP_MOUSE	Strap	physical	28671696
STRN_MOUSE	Strn	physical	28671696
TBK1_MOUSE	Tbk1	physical	28671696
TCOF_MOUSE	Tcof1	physical	28671696
TR150_MOUSE	Thrap3	physical	28671696
TOP3B_MOUSE	Top3b	physical	28671696
TIF1B_MOUSE	Trim28	physical	28671696
UBAP2_MOUSE	Ubap2	physical	28671696
UBP2L_MOUSE	Ubap2l	physical	28671696
USP9X_MOUSE	Usp9x	physical	28671696
VIME_MOUSE	Vim	physical	28671696
WDR47_MOUSE	Wdr47	physical	28671696

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FXR1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641, AND MASSSPECTROMETRY.	19131326 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling."; Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.; J. Immunol. 179:5864-5876(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-68, AND MASSSPECTROMETRY.	17947660 [Abstract]