dbPTM

UBP2L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBP2L_MOUSE
UniProt AC	Q80X50
Protein Name	Ubiquitin-associated protein 2-like
Gene Name	Ubap2l
Organism	Mus musculus (Mouse).
Sequence Length	1107
Subcellular Localization
Protein Description	Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs). [PubMed: 25185265]
Protein Sequence	MMTSVGTNRARGNWEQPQNQNQTQHKQRPQATAEQIRLAQMISDHNDADFEEKVKQLIDITGKNQDECVIALHDCNGDVNRAINVLLEGNPDTHSWEMVGKKKGVSGQKDGGQTESNEEGKENRDRDRDYSRRRGGPPRRGRGASRGREFRGQENGLDGTKSGGPSGRGTDRGRRGRGRGRGSSGRRGGRFSAQGMGTFNPADYAEPANTDDNYGNSSGNTWNNTGHFEPDDGTRLDFIGVEGSNYPRKFETAPGAWRTATEEWGTEDWNEDLSETKIFTASNVSSVPLPAENVTITAGQRIDLAVLLGKTPSSMENDSSNLDPSQAPSLAQPLVFSNSKQNAISQPASGSTFSHHSMVSMLGKGFGDVGEAKGGSTTGSQFLEQFKTAQALAQLAAQHSQSGSTTTSSWDMGSTTQSPSLVQYDLKSANDSTVHSPFTKRQAFTPSSTMMEVFLQEKPPAVATSTAAPPPPSSPLPSKSTSAPQMSPGSSDNQSSSPQPAQQKLKQQKKKTSLTSKIPALAVEMPGSADISGLNLQFGALQFGSEPVLSDYESTPTTSASSSQAPSSLYTSTASESSSTVSSNQSQESGYQSGPIQSTTYTSQNNAQGPLYEQRSTQTRRYPSSISSSPQKDLTQAKNGFSSVQATQLQTTQSVEGATGSAVKSESPSTSSIPSLNETVPAASLLTTANQHSSSLSGLSHTEEIPNTTTTQHSSALSTQQNTLSSSTSSGRTSTSTLLHTSVESEANLHSSSSTFSTTSSTVSAPPPVVSVSSSLNSGSSLGLSLGSNSTVTASTRSSVATTSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYDDLQMLQTRFPLDYYSIPFPTPTTPLTGRDGSLASNPYSGDLTKFGRGDASSPAPATTLAQPQQNQTQTHHTTQQTFLNPALPPGYSYTSLPYYTGVPGLPSTFQYGPAVFPVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPDISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQTGSGQRSQTSSIPQKPQTNKSAYNSYSWGAN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMTSVGTN -------CCCCCCCC	31.30	-
32	Phosphorylation	HKQRPQATAEQIRLA CCCCHHHHHHHHHHH	26.02	22802335
43	Phosphorylation	IRLAQMISDHNDADF HHHHHHHHHCCCCCH	27.72	30635358
95	Phosphorylation	EGNPDTHSWEMVGKK CCCCCCCCEEECCEE	27.16	25338131
114	Phosphorylation	GQKDGGQTESNEEGK CCCCCCCCCCCCCCC	44.66	27087446
116	Phosphorylation	KDGGQTESNEEGKEN CCCCCCCCCCCCCCC	53.59	27087446
130	Phosphorylation	NRDRDRDYSRRRGGP CHHHHHHHHHHCCCC	12.64	29899451
131	Phosphorylation	RDRDRDYSRRRGGPP HHHHHHHHHHCCCCC	24.49	29899451
187	Asymmetric dimethylarginine	GRGSSGRRGGRFSAQ CCCCCCCCCCCCCCC	56.28	-
187	Methylation	GRGSSGRRGGRFSAQ CCCCCCCCCCCCCCC	56.28	-
190	Asymmetric dimethylarginine	SSGRRGGRFSAQGMG CCCCCCCCCCCCCCC	25.77	-
190	Methylation	SSGRRGGRFSAQGMG CCCCCCCCCCCCCCC	25.77	-
198	Phosphorylation	FSAQGMGTFNPADYA CCCCCCCCCCHHHCC	16.02	25521595
210	Phosphorylation	DYAEPANTDDNYGNS HCCCCCCCCCCCCCC	47.00	25521595
221	Phosphorylation	YGNSSGNTWNNTGHF CCCCCCCCCCCCCCC	32.85	25521595
244	Phosphorylation	DFIGVEGSNYPRKFE EEEEECCCCCCCCCC	21.49	25159016
246	Phosphorylation	IGVEGSNYPRKFETA EEECCCCCCCCCCCC	13.20	25159016
246 (in isoform 5)	Phosphorylation	-	13.20	29514104
249	Acetylation	EGSNYPRKFETAPGA CCCCCCCCCCCCCCC	42.94	23806337
249	Succinylation	EGSNYPRKFETAPGA CCCCCCCCCCCCCCC	42.94	23806337
249	Ubiquitination	EGSNYPRKFETAPGA CCCCCCCCCCCCCCC	42.94	-
274	Phosphorylation	EDWNEDLSETKIFTA CCCCCCCCCCEEEEE	56.39	26745281
276	Phosphorylation	WNEDLSETKIFTASN CCCCCCCCEEEEECC	26.51	26745281
285	Phosphorylation	IFTASNVSSVPLPAE EEEECCCCCCCCCCC	29.84	29514104
297	O-linked_Glycosylation	PAENVTITAGQRIDL CCCCCEEECCCEEEE	18.50	55412927
311	Phosphorylation	LAVLLGKTPSSMEND EEHHHCCCCCCCCCC	26.97	26643407
313	Phosphorylation	VLLGKTPSSMENDSS HHHCCCCCCCCCCCC	47.77	26643407
314	Phosphorylation	LLGKTPSSMENDSSN HHCCCCCCCCCCCCC	31.17	26643407
319	Phosphorylation	PSSMENDSSNLDPSQ CCCCCCCCCCCCHHH	32.48	25521595
320	Phosphorylation	SSMENDSSNLDPSQA CCCCCCCCCCCHHHC	44.25	26643407
325	Phosphorylation	DSSNLDPSQAPSLAQ CCCCCCHHHCCCHHH	38.34	26643407
337	Phosphorylation	LAQPLVFSNSKQNAI HHHCEEECCCCCCCC	32.49	25338131
345	O-linked_Glycosylation	NSKQNAISQPASGST CCCCCCCCCCCCCCC	27.92	30059200
364	Ubiquitination	SMVSMLGKGFGDVGE HHHHHHCCCCCCCCC	47.29	22790023
373	Ubiquitination	FGDVGEAKGGSTTGS CCCCCCCCCCCCCHH	60.55	22790023
376	Phosphorylation	VGEAKGGSTTGSQFL CCCCCCCCCCHHHHH	31.31	24899341
377	Phosphorylation	GEAKGGSTTGSQFLE CCCCCCCCCHHHHHH	38.15	26745281
378	Phosphorylation	EAKGGSTTGSQFLEQ CCCCCCCCHHHHHHH	36.21	26745281
380	Phosphorylation	KGGSTTGSQFLEQFK CCCCCCHHHHHHHHH	18.70	29233185
388	Phosphorylation	QFLEQFKTAQALAQL HHHHHHHHHHHHHHH	25.87	26643407
400	Phosphorylation	AQLAAQHSQSGSTTT HHHHHHHCCCCCCCC	17.60	26643407
402	Phosphorylation	LAAQHSQSGSTTTSS HHHHHCCCCCCCCCC	37.41	26643407
404	Phosphorylation	AQHSQSGSTTTSSWD HHHCCCCCCCCCCCC	28.03	26643407
405	Phosphorylation	QHSQSGSTTTSSWDM HHCCCCCCCCCCCCC	37.30	26643407
406	Phosphorylation	HSQSGSTTTSSWDMG HCCCCCCCCCCCCCC	26.78	26643407
407	Phosphorylation	SQSGSTTTSSWDMGS CCCCCCCCCCCCCCC	22.35	26643407
408	Phosphorylation	QSGSTTTSSWDMGST CCCCCCCCCCCCCCC	27.60	26643407
409	Phosphorylation	SGSTTTSSWDMGSTT CCCCCCCCCCCCCCC	25.63	26643407
414	Phosphorylation	TSSWDMGSTTQSPSL CCCCCCCCCCCCCCE	22.95	26643407
415	Phosphorylation	SSWDMGSTTQSPSLV CCCCCCCCCCCCCEE	24.11	26643407
416	Phosphorylation	SWDMGSTTQSPSLVQ CCCCCCCCCCCCEEE	28.84	26643407
418	Phosphorylation	DMGSTTQSPSLVQYD CCCCCCCCCCEEEEE	17.86	26643407
420	Phosphorylation	GSTTQSPSLVQYDLK CCCCCCCCEEEEECC	46.55	26643407
424	Phosphorylation	QSPSLVQYDLKSAND CCCCEEEEECCCCCC	18.76	26643407
428	Phosphorylation	LVQYDLKSANDSTVH EEEEECCCCCCCCCC	39.33	30352176
432	Phosphorylation	DLKSANDSTVHSPFT ECCCCCCCCCCCCCC	31.94	25619855
433	Phosphorylation	LKSANDSTVHSPFTK CCCCCCCCCCCCCCC	25.71	23984901
436	Phosphorylation	ANDSTVHSPFTKRQA CCCCCCCCCCCCCCC	19.85	27087446
439	Phosphorylation	STVHSPFTKRQAFTP CCCCCCCCCCCCCCC	28.80	25619855
445	Phosphorylation	FTKRQAFTPSSTMME CCCCCCCCCCCCHHH	25.85	25159016
447	Phosphorylation	KRQAFTPSSTMMEVF CCCCCCCCCCHHHHH	35.07	25159016
448	Phosphorylation	RQAFTPSSTMMEVFL CCCCCCCCCHHHHHH	22.86	25159016
449	Phosphorylation	QAFTPSSTMMEVFLQ CCCCCCCCHHHHHHC	25.52	25159016
464	Phosphorylation	EKPPAVATSTAAPPP CCCCCEEECCCCCCC	21.73	25159016
465	Phosphorylation	KPPAVATSTAAPPPP CCCCEEECCCCCCCC	13.30	25159016
466	Phosphorylation	PPAVATSTAAPPPPS CCCEEECCCCCCCCC	23.60	25159016
473	Phosphorylation	TAAPPPPSSPLPSKS CCCCCCCCCCCCCCC	50.81	25293948
474	Phosphorylation	AAPPPPSSPLPSKST CCCCCCCCCCCCCCC	35.91	25521595
478	Phosphorylation	PPSSPLPSKSTSAPQ CCCCCCCCCCCCCCC	47.09	25159016
480	Phosphorylation	SSPLPSKSTSAPQMS CCCCCCCCCCCCCCC	31.75	27087446
481	Phosphorylation	SPLPSKSTSAPQMSP CCCCCCCCCCCCCCC	32.42	27742792
482	Phosphorylation	PLPSKSTSAPQMSPG CCCCCCCCCCCCCCC	45.07	25521595
487	Phosphorylation	STSAPQMSPGSSDNQ CCCCCCCCCCCCCCC	22.36	27087446
490	Phosphorylation	APQMSPGSSDNQSSS CCCCCCCCCCCCCCC	37.59	25521595
491	Phosphorylation	PQMSPGSSDNQSSSP CCCCCCCCCCCCCCC	46.63	25521595
495	Phosphorylation	PGSSDNQSSSPQPAQ CCCCCCCCCCCHHHH	38.75	25521595
496	Phosphorylation	GSSDNQSSSPQPAQQ CCCCCCCCCCHHHHH	35.95	25521595
497	Phosphorylation	SSDNQSSSPQPAQQK CCCCCCCCCHHHHHH	32.57	25521595
512	Phosphorylation	LKQQKKKTSLTSKIP HHHHHHHHCCCCCCC	37.54	25266776
513	Phosphorylation	KQQKKKTSLTSKIPA HHHHHHHCCCCCCCE	38.23	26824392
515	Phosphorylation	QKKKTSLTSKIPALA HHHHHCCCCCCCEEE	27.95	25266776
516	Phosphorylation	KKKTSLTSKIPALAV HHHHCCCCCCCEEEE	33.60	25266776
612	Phosphorylation	NNAQGPLYEQRSTQT CCCCCCCEECCCCCC	17.10	18563927
622	Phosphorylation	RSTQTRRYPSSISSS CCCCCCCCCCCCCCC	12.27	27742792
624	Phosphorylation	TQTRRYPSSISSSPQ CCCCCCCCCCCCCCC	31.22	25521595
625	O-linked_Glycosylation	QTRRYPSSISSSPQK CCCCCCCCCCCCCCH	23.22	56251
625	Phosphorylation	QTRRYPSSISSSPQK CCCCCCCCCCCCCCH	23.22	25521595
627	Phosphorylation	RRYPSSISSSPQKDL CCCCCCCCCCCCHHH	27.06	27087446
628	Phosphorylation	RYPSSISSSPQKDLT CCCCCCCCCCCHHHH	44.35	25521595
629	Phosphorylation	YPSSISSSPQKDLTQ CCCCCCCCCCHHHHH	25.26	27087446
635	Phosphorylation	SSPQKDLTQAKNGFS CCCCHHHHHHHHCCC	36.29	25619855
640 (in isoform 2)	Phosphorylation	-	24.09	19144319
642	Phosphorylation	TQAKNGFSSVQATQL HHHHHCCCHHEEEEE	30.88	22802335
643	Phosphorylation	QAKNGFSSVQATQLQ HHHHCCCHHEEEEEE	18.91	22802335
651	Phosphorylation	VQATQLQTTQSVEGA HEEEEEEEEECCCCC	35.08	25619855
652	Phosphorylation	QATQLQTTQSVEGAT EEEEEEEEECCCCCC	13.09	25619855
654	Phosphorylation	TQLQTTQSVEGATGS EEEEEEECCCCCCCC	21.75	25619855
659	Phosphorylation	TQSVEGATGSAVKSE EECCCCCCCCCEECC	42.39	25619855
802	Phosphorylation	STRSSVATTSGKAPP ECCCCCEECCCCCCC	21.24	22802335
803	Phosphorylation	TRSSVATTSGKAPPN CCCCCEECCCCCCCC	26.24	22802335
804	Phosphorylation	RSSVATTSGKAPPNL CCCCEECCCCCCCCC	33.66	22802335
823	Phosphorylation	PPLLPNPYIMAPGLL CCCCCCCCEECCCHH	15.23	22802335
854	Phosphorylation	QTRFPLDYYSIPFPT HHCCCCCEECCCCCC	13.54	18563927
855	Phosphorylation	TRFPLDYYSIPFPTP HCCCCCEECCCCCCC	10.37	25777480
856	Phosphorylation	RFPLDYYSIPFPTPT CCCCCEECCCCCCCC	19.98	25777480
861	Phosphorylation	YYSIPFPTPTTPLTG EECCCCCCCCCCCCC	33.38	26643407
863	Phosphorylation	SIPFPTPTTPLTGRD CCCCCCCCCCCCCCC	43.45	26643407
864	Phosphorylation	IPFPTPTTPLTGRDG CCCCCCCCCCCCCCC	19.94	30352176
867	Phosphorylation	PTPTTPLTGRDGSLA CCCCCCCCCCCCCCC	31.23	26643407
872	Phosphorylation	PLTGRDGSLASNPYS CCCCCCCCCCCCCCC	25.67	28833060
875	Phosphorylation	GRDGSLASNPYSGDL CCCCCCCCCCCCCCC	43.56	28833060
878	Phosphorylation	GSLASNPYSGDLTKF CCCCCCCCCCCCCCC	29.54	25521595
879	Phosphorylation	SLASNPYSGDLTKFG CCCCCCCCCCCCCCC	27.39	25521595
883	Phosphorylation	NPYSGDLTKFGRGDA CCCCCCCCCCCCCCC	29.12	28833060
884	Ubiquitination	PYSGDLTKFGRGDAS CCCCCCCCCCCCCCC	53.79	22790023
1012	Phosphorylation	VYSKTQQSFEKQGFH EEECCHHHHHHCCCC	26.09	27149854
1091	Acetylation	QTSSIPQKPQTNKSA CCCCCCCCCCCCCCC	33.47	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
864	T	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBP2L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBP2L_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of UBP2L_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBP2L_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-625 AND SER-629, ANDMASS SPECTROMETRY.	19131326 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, AND MASSSPECTROMETRY.	17114649 [Abstract]