F120A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F120A_MOUSE
• UniProt AC: Q6A0A9
• Protein Name: Constitutive coactivator of PPAR-gamma-like protein 1
• Gene Name: FAM120A
• Organism: Mus musculus (Mouse).
• Sequence Length: 1112
• Subcellular Localization: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Translocates to plasma membrane upon ultraviolet exposure..
• Protein Description: Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II (By similarity). May participate in mRNA transport in the cytoplasm..
• Protein Sequence: MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNIELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVADYVRNIHDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAVGYYSATSKPMPFHPPHYLARPNPFGMPGMVPPYVPPQMLNIPQTSLQAKPAVPQVPSPGGTPGQAPYPYSLSEPALTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINLAQSGSPNHVDSAYFPGSSTSSSSDNDEGGGGATNHISGNKIGWEKTGSHAEPLARGDPGDQVKVEGSSTASSGSQLAEGKGSHMGTVQPIPCLLSMPTRNHMDITTPPLPPVAPEVLRVAEHRHKKGLMYPYIFHILTKGEIKIAVSIEDEANKDLPPAALLYRPVRQYVYGVLFSLAESRKKTERLAFRKNRLPPEFSPLIIKEWAAYKGKSPQTPELVEALAFREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLRYMVQWPGARILRRQELDAFLAQALSPKLYEPDQLQELKIDNLDPRGIQLSALFMSGVDMALFANDACGQPIPWEHCCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQAEQAAKVEKMRQSILEGLSFSRQNHPLPFPPPPALPFYPASVYPRHFGPVPPSQGRGRGFAGVCGFGGHYGETVATGPYRAFRVTAASGHCGAFSGSDSSRTSKSQGGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKSQGAIQGRPPYAASAEEVAKELKSKSGESKSSAVSLAENGVMAEEKPVPQLNGSTGDPRVPSHSESALNNDSKPCNTNPHLNALSTDSACRREAALEAAVLNKEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	GFQDYIEKHCPSAVV HHHHHHHHHCCCCEE	40.73	22790023
25	Ubiquitination	VVPVELQKLARGSLV EEEHHHHHHHCCCCC	57.65	22790023
30	Phosphorylation	LQKLARGSLVGGGRQ HHHHHCCCCCCCCCC	17.83	29176673
129	Ubiquitination	IVSHVQNKGTPPPKV HHHHHHHCCCCCCCC	47.25	27667366
304	Ubiquitination	SDLDAIAKDVFQHSQ CCHHHHHHHHHHHHC	48.59	22790023
382	Phosphorylation	PAVPQVPSPGGTPGQ CCCCCCCCCCCCCCC	37.00	26824392
386	Phosphorylation	QVPSPGGTPGQAPYP CCCCCCCCCCCCCCC	30.11	25168779
392	Phosphorylation	GTPGQAPYPYSLSEP CCCCCCCCCCCCCCC	20.16	26745281
394	Phosphorylation	PGQAPYPYSLSEPAL CCCCCCCCCCCCCEE	19.19	26745281
395	Phosphorylation	GQAPYPYSLSEPALT CCCCCCCCCCCCEEE	22.40	26745281
397	Phosphorylation	APYPYSLSEPALTLD CCCCCCCCCCEEEEC	35.28	23984901
402	Phosphorylation	SLSEPALTLDTSGKN CCCCCEEEECCCCCC	25.37	25293948
405	Phosphorylation	EPALTLDTSGKNLTE CCEEEECCCCCCCCC	42.35	25777480
406	Phosphorylation	PALTLDTSGKNLTEQ CEEEECCCCCCCCCC	47.65	25777480
411	Phosphorylation	DTSGKNLTEQNSYSN CCCCCCCCCCCCCCC	44.94	25159016
415	Phosphorylation	KNLTEQNSYSNIPHE CCCCCCCCCCCCCCC	29.63	26824392
416	Phosphorylation	NLTEQNSYSNIPHEG CCCCCCCCCCCCCCC	17.18	25159016
417	Phosphorylation	LTEQNSYSNIPHEGK CCCCCCCCCCCCCCC	28.27	25159016
426	Phosphorylation	IPHEGKHTPLYERSS CCCCCCCCCCCCCCC	20.62	27742792
429	Phosphorylation	EGKHTPLYERSSPIN CCCCCCCCCCCCCCC	15.53	25159016
432	Phosphorylation	HTPLYERSSPINLAQ CCCCCCCCCCCCHHH	28.64	19060867
433	Phosphorylation	TPLYERSSPINLAQS CCCCCCCCCCCHHHC	35.70	19060867
440	Phosphorylation	SPINLAQSGSPNHVD CCCCHHHCCCCCCCC	35.31	19060867
442	Phosphorylation	INLAQSGSPNHVDSA CCHHHCCCCCCCCCC	27.98	19060867
448	Phosphorylation	GSPNHVDSAYFPGSS CCCCCCCCCCCCCCC	24.63	19060867
450	Phosphorylation	PNHVDSAYFPGSSTS CCCCCCCCCCCCCCC	17.79	23984901
454	Phosphorylation	DSAYFPGSSTSSSSD CCCCCCCCCCCCCCC	30.58	25367039
455	Phosphorylation	SAYFPGSSTSSSSDN CCCCCCCCCCCCCCC	37.92	29472430
456	Phosphorylation	AYFPGSSTSSSSDND CCCCCCCCCCCCCCC	34.03	29472430
457	Phosphorylation	YFPGSSTSSSSDNDE CCCCCCCCCCCCCCC	30.12	29472430
458	Phosphorylation	FPGSSTSSSSDNDEG CCCCCCCCCCCCCCC	33.67	29472430
459	Phosphorylation	PGSSTSSSSDNDEGG CCCCCCCCCCCCCCC	41.29	29472430
460	Phosphorylation	GSSTSSSSDNDEGGG CCCCCCCCCCCCCCC	42.24	29472430
470	Phosphorylation	DEGGGGATNHISGNK CCCCCCCCCCCCCCC	30.51	25168779
474	Phosphorylation	GGATNHISGNKIGWE CCCCCCCCCCCCCCE	28.85	25168779
482	Ubiquitination	GNKIGWEKTGSHAEP CCCCCCEECCCCCCC	52.24	-
482	Malonylation	GNKIGWEKTGSHAEP CCCCCCEECCCCCCC	52.24	26320211
483	Phosphorylation	NKIGWEKTGSHAEPL CCCCCEECCCCCCCC	32.19	29550500
485	Phosphorylation	IGWEKTGSHAEPLAR CCCEECCCCCCCCCC	25.42	24899341
504	Phosphorylation	DQVKVEGSSTASSGS CCEEEECCCCCCCCC	15.83	29550500
505	Phosphorylation	QVKVEGSSTASSGSQ CEEEECCCCCCCCCC	38.56	29550500
506	Phosphorylation	VKVEGSSTASSGSQL EEEECCCCCCCCCCC	32.05	29472430
508	Phosphorylation	VEGSSTASSGSQLAE EECCCCCCCCCCCCC	35.01	25521595
509	Phosphorylation	EGSSTASSGSQLAEG ECCCCCCCCCCCCCC	39.74	25521595
511	Phosphorylation	SSTASSGSQLAEGKG CCCCCCCCCCCCCCC	24.78	25521595
529	Glutathionylation	GTVQPIPCLLSMPTR CCCCCCCEEECCCCC	6.55	24333276
650	Phosphorylation	WAAYKGKSPQTPELV HHHHCCCCCCCHHHH	30.79	26745281
653	Phosphorylation	YKGKSPQTPELVEAL HCCCCCCCHHHHHHH	23.32	26824392
677	Ubiquitination	LKRLWLGKAVEDKNR CHHHHCCHHHHCHHH	47.27	22790023
756	Ubiquitination	PDQLQELKIDNLDPR HHHHHCCCCCCCCCC	47.46	22790023
808	Ubiquitination	DGKLFQSKLLKASRE CCHHHHHHHHHHHHC	47.24	22790023
816	Ubiquitination	LLKASREKTPLIDLC HHHHHHCCCCCHHCC	55.09	22790023
832	Ubiquitination	GQAEQAAKVEKMRQS CCHHHHHHHHHHHHH	54.68	22790023
871	Methylation	YPASVYPRHFGPVPP CCCCCCCCCCCCCCC	21.78	24129315
882	Dimethylation	PVPPSQGRGRGFAGV CCCCCCCCCCCCCCC	24.81	-
882	Methylation	PVPPSQGRGRGFAGV CCCCCCCCCCCCCCC	24.81	24129315
884	Dimethylation	PPSQGRGRGFAGVCG CCCCCCCCCCCCCCC	35.38	-
884	Methylation	PPSQGRGRGFAGVCG CCCCCCCCCCCCCCC	35.38	24129315
896	Phosphorylation	VCGFGGHYGETVATG CCCCCCCCCCCCCCC	21.67	18563927
905	Phosphorylation	ETVATGPYRAFRVTA CCCCCCCCCEEEEEE	18.87	18563927
911	Phosphorylation	PYRAFRVTAASGHCG CCCEEEEEECCCCCC	16.55	-
914	Phosphorylation	AFRVTAASGHCGAFS EEEEEECCCCCCCCC	26.97	-
917	S-nitrosocysteine	VTAASGHCGAFSGSD EEECCCCCCCCCCCC	4.86	-
917	Glutathionylation	VTAASGHCGAFSGSD EEECCCCCCCCCCCC	4.86	24333276
917	S-palmitoylation	VTAASGHCGAFSGSD EEECCCCCCCCCCCC	4.86	26165157
917	S-nitrosylation	VTAASGHCGAFSGSD EEECCCCCCCCCCCC	4.86	21278135
921	Phosphorylation	SGHCGAFSGSDSSRT CCCCCCCCCCCCCCC	36.53	26643407
923	Phosphorylation	HCGAFSGSDSSRTSK CCCCCCCCCCCCCCC	32.87	30352176
925	Phosphorylation	GAFSGSDSSRTSKSQ CCCCCCCCCCCCCCC	24.34	26643407
926	Phosphorylation	AFSGSDSSRTSKSQG CCCCCCCCCCCCCCC	44.56	26643407
930	Ubiquitination	SDSSRTSKSQGGVQP CCCCCCCCCCCCCCC	46.30	22790023
930	Acetylation	SDSSRTSKSQGGVQP CCCCCCCCCCCCCCC	46.30	23806337
931	Phosphorylation	DSSRTSKSQGGVQPI CCCCCCCCCCCCCCC	33.55	29472430
940	Phosphorylation	GGVQPIPSQGGKLEI CCCCCCCCCCCEEEE	42.02	30352176
958	Phosphorylation	VVGHWAGSRRGRGGR EEECCCCCCCCCCCC	15.85	-
980	Methylation	VSVGGPARGRPRGVI EEECCCCCCCCCCCC	44.80	24129315
984	Methylation	GPARGRPRGVISTPV CCCCCCCCCCCCCHH	51.12	-
988	Phosphorylation	GRPRGVISTPVIRTF CCCCCCCCCHHEECC	25.01	26745281
989	Phosphorylation	RPRGVISTPVIRTFG CCCCCCCCHHEECCC	15.51	26745281
993	Methylation	VISTPVIRTFGRGGR CCCCHHEECCCCCCC	25.00	-
1008	Phosphorylation	YYGRGYKSQGAIQGR CCCCCCCCCCCCCCC	25.93	23684622
1018	Phosphorylation	AIQGRPPYAASAEEV CCCCCCCCCCCHHHH	19.92	23984901
1021	Phosphorylation	GRPPYAASAEEVAKE CCCCCCCCHHHHHHH	28.21	25521595
1042	Phosphorylation	ESKSSAVSLAENGVM CCHHHHHHHHHHCCC	22.90	-
1097	Glutathionylation	ALSTDSACRREAALE HCCCCHHHHHHHHHH	4.95	24333276

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F120A_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
980	R	Methylation	Arg-980 is dimethylated, probably to asymmetric dimethylarginine.	24129315

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F120A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of F120A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.