FYCO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FYCO1_MOUSE
• UniProt AC: Q8VDC1
• Protein Name: FYVE and coiled-coil domain-containing protein 1
• Gene Name: Fyco1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1437
• Subcellular Localization: Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes..
• Protein Description: May mediate microtubule plus end-directed vesicle transport..
• Protein Sequence: MASSSTETQLQRIIRDLQDAATELSHEFKEGGEPITDDSTSLHKFSYKLEYLLQFDQKEKASLLGSKKDYWDYFCACLAKVKGANDGIRFVRSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLKPKLSSDIVGQLYELTEVQFDLAPRGYDLDAAWPTFARRTLATSTSAYMWKPPSRSSSMSSLVSNYLQTQEMASSLDLNCSLNNEALESFDEMRLELDQLEVREKQLQERVQQLDRENQALRMLVSRQGGQLQVEKEMGYLAVEDSIGLVSLVAELQKQGDVSQATVKKLQSCLQALELNVDKKEYSPSALQLENMAKELDTVRGSLGRENQLLASLSERLARAEKGEKTPPDTELHQEPVPADLVLKFQELKGKLQALEGENTEAQELNRQQSIKLEQLAKELQLKEEARASLAHLVKDVVPLQEELSGKKQESAQLRRQLQESLAHLSSVEEELAEARQQEKQHREEKQLLEQEATSLTWQLQLLETQLGQVSQLVSDLEEQKKQLMQERDHLSQRVGTLEQLAEVHGPPQSAEMPEKRQQCLREEQVNNSTVSEAEQEELQKELQNMVDRNQLLEGKLQALQTDYKALQQREAAIQGSLASLEAEQASIRHLGNQMEASLLAVKKAKETMKAQVAEKEAALQSKESECQRLQEEADQCRLQAEAQAQELRALENQCQQQIQLIEVLSAEKGQQGLSLPQVNTDQLALSQAQLEIHQGEAQRLQNEVVDLQAKLQVALGDRDKLQSQLGVAETVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGILQEESIYKAQKQEQELRALQAELSQVRCSSEGAHLEHAELQDQLHRANTDTAELGIQVCALTAEKDRMEEALASLAQELQDSKEAALQERKGLELQVMQLQQEKEKLQEKVKAAEEAASSFSGLQAQLAQAEQLAQSLQETAHQEQDALKFQLSAEIMDHQNRLKTANEECGHLRAQLEEQGQQLQMTKEAVQELEITKAAMEEKLNCTSSHLAECQATLLRKDEESTMLQTSLERTQKELEKATSKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEEKCLGDMEVNHCHDCKREFSWIVRRHHCRICGRIFCYYCCNNYVVTKPSGKKERCCRACFQKFGEGSGSNDSSGSGTSQGEPSPMVSPAEASPQSIGSQGINSVCRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSMDPNTAEQDTTSNSLTPEDTEDVPMGQDAEICLLKSGELMIKLPLTVEEVASFGEGSRELFVRSSTYSLITITVAEPGLTISWVFSSDPKSISFSVVFQETEDTPLDQCKVLIPTTRCNSHKENIRGQLKVRIPGIYLLIFDNTFSRFISKKVLYHLTVDRPVIYDGSDFP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASSSTETQ ------CCCCCHHHH	29.44	-
8	Phosphorylation	MASSSTETQLQRIIR CCCCCHHHHHHHHHH	34.37	28576409
139	Phosphorylation	SDWYYARSPFLKPKL CCCEEECCCCCCCCC	16.31	24719451
187	Phosphorylation	RRTLATSTSAYMWKP HHHHCCCCCCEECCC	17.02	24719451
190	Phosphorylation	LATSTSAYMWKPPSR HCCCCCCEECCCCCC	11.86	22817900
196	Phosphorylation	AYMWKPPSRSSSMSS CEECCCCCCCCHHHH	54.01	27742792
200	Phosphorylation	KPPSRSSSMSSLVSN CCCCCCCHHHHHHHH	24.75	23649490
217	Phosphorylation	QTQEMASSLDLNCSL HHHHHHHHCCCCCCC	19.16	23649490
308	Phosphorylation	QGDVSQATVKKLQSC CCCCCHHHHHHHHHH	25.81	28059163
328	Phosphorylation	LNVDKKEYSPSALQL CCCCCCCCCCCHHHH	34.46	28066266
329	Phosphorylation	NVDKKEYSPSALQLE CCCCCCCCCCHHHHH	17.30	24899341
331	Phosphorylation	DKKEYSPSALQLENM CCCCCCCCHHHHHHH	35.35	24899341
372	Phosphorylation	RAEKGEKTPPDTELH HHHCCCCCCCCCCCC	35.43	25521595
376	Phosphorylation	GEKTPPDTELHQEPV CCCCCCCCCCCCCCC	46.34	27742792
406	Phosphorylation	QALEGENTEAQELNR HHHCCCCHHHHHHHH	28.53	22324799
416	Phosphorylation	QELNRQQSIKLEQLA HHHHHHHHHHHHHHH	17.22	29514104
556	Phosphorylation	EVHGPPQSAEMPEKR HHHCCCCCCCCHHHH	31.78	29514104
578	Phosphorylation	QVNNSTVSEAEQEEL HCCCCCCCHHHHHHH	31.04	25521595
837	Phosphorylation	RALQAELSQVRCSSE HHHHHHHHHCHHCCC	20.38	30352176
843	Phosphorylation	LSQVRCSSEGAHLEH HHHCHHCCCCCCCCH	43.61	-
862	Phosphorylation	DQLHRANTDTAELGI HHHHHCCCCHHHHHH	33.47	-
1301	Sumoylation	DAEICLLKSGELMIK CCEEEEEECCCEEEE	43.39	28289178
1302	Phosphorylation	AEICLLKSGELMIKL CEEEEEECCCEEEEC	37.15	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FYCO1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FYCO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FYCO1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FYCO1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-372, AND MASSSPECTROMETRY.
PubMed: 19367708