SPT13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPT13_MOUSE
• UniProt AC: Q5DU57
• Protein Name: Spermatogenesis-associated protein 13
• Gene Name: Spata13
• Organism: Mus musculus (Mouse).
• Sequence Length: 656
• Subcellular Localization: Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment..
• Protein Description: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression..
• Protein Sequence: MHPASVTTTSQDPCAPSGSCRGGRRRRPISVIGGVSFYGNTQVEDVENLLVQPAARPPVPAHQVPPYKAVSARLRPFTFSQSTPIGLDRVGRRRQMKTSNVSSDGGAESSALVDDNGSEEDFSYEELCQANPRYLQPGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRNEDKEAWFPASFVRLRVNQEELPENCSSSHGEEQDEDTSKARHKHPESQQQMRTNVIQEIMNTERVYIKHLKDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLEHQEGFAIYSEYCNNHPGACVELSNLMKHSKYRHFFEACRLLQQMIDIALDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYNNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITRQGKSQQRIFFLFDHQLVSCKKDLLRRDMLYYKGRMDMDEVELVDVEDGRDKDWSLSLRNAFKLVSKATDEVHLFCARKQEDKARWLQAYADERRRVQEDQQMGMEIPENQKKLAMLNAQKAGHGKSKGYNSCPVAPPHQSLPPLHQRHITVPTSIPQQQVFALAEPKRKPSIFWHTFHKLTPFRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MHPASVTTTSQD ---CCCCCCEECCCC	25.17	29472430
7	Phosphorylation	-MHPASVTTTSQDPC -CCCCCCEECCCCCC	23.12	29472430
8	Phosphorylation	MHPASVTTTSQDPCA CCCCCCEECCCCCCC	23.46	29472430
9	Phosphorylation	HPASVTTTSQDPCAP CCCCCEECCCCCCCC	18.28	29472430
10	Phosphorylation	PASVTTTSQDPCAPS CCCCEECCCCCCCCC	30.41	29472430
17	Phosphorylation	SQDPCAPSGSCRGGR CCCCCCCCCCCCCCC	25.47	29472430
19	Phosphorylation	DPCAPSGSCRGGRRR CCCCCCCCCCCCCCC	12.65	29472430
21	Methylation	CAPSGSCRGGRRRRP CCCCCCCCCCCCCCC	52.91	67195647
24	Methylation	SGSCRGGRRRRPISV CCCCCCCCCCCCEEE	31.58	67195615
78	Phosphorylation	SARLRPFTFSQSTPI HEECCCCCCCCCCCC	25.67	26239621
80	Phosphorylation	RLRPFTFSQSTPIGL ECCCCCCCCCCCCCC	21.84	26239621
82	Phosphorylation	RPFTFSQSTPIGLDR CCCCCCCCCCCCCCC	34.65	25521595
83	Phosphorylation	PFTFSQSTPIGLDRV CCCCCCCCCCCCCCC	15.99	26239621
118	Phosphorylation	ALVDDNGSEEDFSYE EEECCCCCCCCCCHH	44.03	16141072
602	Phosphorylation	GKSKGYNSCPVAPPH CCCCCCCCCCCCCCC	16.00	-
618	Methylation	SLPPLHQRHITVPTS CCCCCCCCCCCCCCC	16.66	67195683
618	Dimethylation	SLPPLHQRHITVPTS CCCCCCCCCCCCCCC	16.66	-
642	Phosphorylation	AEPKRKPSIFWHTFH CCCCCCCCCCCEECC	33.19	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPT13_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPT13_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPT13_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SPT13_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.