UBAP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBAP2_MOUSE
• UniProt AC: Q91VX2
• Protein Name: Ubiquitin-associated protein 2
• Gene Name: Ubap2 {ECO:0000312|MGI:MGI:1916176}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1132
• Protein Sequence: MMTSVSNDRCRGAREKPQMPTAHAAQSQKQVVQATAEQMRLAQVIFDKNDSDFEAKVKQLMEVTGKNQDECIVALHDCNGDVNKAINILLEGNSDTTSWETVGGKKKNFGRESSENKENREKRTEREASRGRGTNNRKGRGGNRVREFKGEENGIDCSQGDKPAERGKRARGRGFGRGRGRGTGRFSAQSMGTFNPADYSESMSTDGCGTKLAVWEAAQNGTDEGPEGLAKSHSMSQEPPSKSSYGLKGAWKNSVEEWTTEDWTEDLSETKVFTASSAPAENHVTPGHSIDLVALLHKPAPPTQATEVNSFETSQQQGFGQALVFTNSQHNNQMAPGTANSTSASSYSPQSLSSVLGSGFGELPQSNMVNISNSQILDKLKPPGLSPFPAASSAQQNDTASPPATTAAWDLKPSAPQPSVLSRLDFKSQPEPSPVLSQLSQRQQHQTQAVSVPPPGLESFSSLAKPRESTAGDGPSTVSRLLQLPNMTVENIVSAHQPQPKHIKLPKRRVPPASKVPVSAVEMPGSSDVTGLNVQFGALEFGSEPSLSEFGSAASASENSNQIPISLYPKSLSEPLNASFPMTSAVQSSTYTTSVVTSSTLTSSALSSTSPVTTSSSYDQSSVHTRIAYQSSASPPDSAPGSVANGHGGGRSQHTVDTTSSVPAPKKTDPSALPSVSTLPGPASCTALLPSSAQHTATLPSLTPAAAELSSSPLSQLSSSLSGHQNSMTSAHATRSTSTPHTHASVESTASSAAFSAAATSAPSAPSSGVVLPGSMSTVSSLCLGGTTVSVPSSSTRATALVTSGKAPPNLPQGVPPLLHNQYLVGPGGLLPAYPIYGYDELQMLQSRLPMDYYGIPFAAPTALASRDGNLANNPYSGDVTKFGRGDSASPAPPTTPAQAQQSQSQTHHTAQQPFLNPGLPPGYSYTGLPYYTGVPSAFQYGPTMFVPPTSAKQHGVALSTPPTPFQQASGYGQHAYSTGYDDLTQGTAAGDYTKGGYGGSSQAPNKSTGSGPGKGVSVSSGTGLPDMTGSVYNKTQTFDKQGFHAGTPPPFSLPSALGSTGPLAPAAAPGYAPAPFLHIMPAHQQPHSQLLHHHLQQDAPSGSGQRSQPSSLQPKSQASKPTYGSAPYWTN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Acetylation	LAQVIFDKNDSDFEA HHHHHHCCCCCHHHH	52.48	23806337
101	Phosphorylation	SDTTSWETVGGKKKN CCCCCCEECCCCCCC	20.42	27600695
113	Phosphorylation	KKNFGRESSENKENR CCCCCCCCCCCHHHH	41.41	26745281
114	Phosphorylation	KNFGRESSENKENRE CCCCCCCCCCHHHHH	40.20	26745281
166	Methylation	QGDKPAERGKRARGR CCCCHHHHCCCCCCC	59.02	18958527
232	Phosphorylation	GPEGLAKSHSMSQEP CHHHHHHCCCCCCCC	18.39	29550500
234	Phosphorylation	EGLAKSHSMSQEPPS HHHHHCCCCCCCCCC	27.50	27149854
236	Phosphorylation	LAKSHSMSQEPPSKS HHHCCCCCCCCCCCC	34.11	29550500
254	Phosphorylation	LKGAWKNSVEEWTTE CCCHHHCCHHCCCCC	27.46	25266776
259	Phosphorylation	KNSVEEWTTEDWTED HCCHHCCCCCCCCCC	24.48	26643407
260	Phosphorylation	NSVEEWTTEDWTEDL CCHHCCCCCCCCCCC	32.78	26643407
386	Phosphorylation	KLKPPGLSPFPAASS HCCCCCCCCCCCCCC	30.34	26643407
392	Phosphorylation	LSPFPAASSAQQNDT CCCCCCCCCHHCCCC	28.45	26643407
393	Phosphorylation	SPFPAASSAQQNDTA CCCCCCCCHHCCCCC	25.93	26643407
399	Phosphorylation	SSAQQNDTASPPATT CCHHCCCCCCCCCCC	36.26	26160508
401	Phosphorylation	AQQNDTASPPATTAA HHCCCCCCCCCCCCC	33.24	26824392
401	O-linked_Glycosylation	AQQNDTASPPATTAA HHCCCCCCCCCCCCC	33.24	30059200
405	Phosphorylation	DTASPPATTAAWDLK CCCCCCCCCCCCCCC	23.81	25266776
406	Phosphorylation	TASPPATTAAWDLKP CCCCCCCCCCCCCCC	19.24	26160508
414	Phosphorylation	AAWDLKPSAPQPSVL CCCCCCCCCCCCCHH	51.50	26160508
419	Phosphorylation	KPSAPQPSVLSRLDF CCCCCCCCHHHCCCC	30.37	25777480
422	Phosphorylation	APQPSVLSRLDFKSQ CCCCCHHHCCCCCCC	28.74	25777480
428	Phosphorylation	LSRLDFKSQPEPSPV HHCCCCCCCCCCCHH	51.46	28066266
433	Phosphorylation	FKSQPEPSPVLSQLS CCCCCCCCHHHHHHH	26.44	26643407
437	Phosphorylation	PEPSPVLSQLSQRQQ CCCCHHHHHHHHHHH	29.34	28066266
440	Phosphorylation	SPVLSQLSQRQQHQT CHHHHHHHHHHHHCC	18.71	25266776
519	Phosphorylation	PASKVPVSAVEMPGS CCHHCCCEEEECCCC	22.11	22802335
526	Phosphorylation	SAVEMPGSSDVTGLN EEEECCCCCCCCCCC	19.93	22802335
527	Phosphorylation	AVEMPGSSDVTGLNV EEECCCCCCCCCCCE	41.85	22802335
530	Phosphorylation	MPGSSDVTGLNVQFG CCCCCCCCCCCEEEE	40.73	22802335
560	Phosphorylation	AASASENSNQIPISL CCCCCCCCCCCCCEE	26.51	22802335
566	Phosphorylation	NSNQIPISLYPKSLS CCCCCCCEECCCCCC	19.25	22802335
568	Phosphorylation	NQIPISLYPKSLSEP CCCCCEECCCCCCCC	11.21	22802335
629	Phosphorylation	SVHTRIAYQSSASPP CCEEEEEEECCCCCC	13.42	25619855
631	Phosphorylation	HTRIAYQSSASPPDS EEEEEEECCCCCCCC	18.39	27087446
632	Phosphorylation	TRIAYQSSASPPDSA EEEEEECCCCCCCCC	19.76	22942356
634	Phosphorylation	IAYQSSASPPDSAPG EEEECCCCCCCCCCC	38.62	27087446
638	Phosphorylation	SSASPPDSAPGSVAN CCCCCCCCCCCCCCC	41.98	22942356
642	Phosphorylation	PPDSAPGSVANGHGG CCCCCCCCCCCCCCC	19.59	25619855
853	Phosphorylation	QSRLPMDYYGIPFAA HHCCCCCCCCCCCCC	9.42	22817900
854	Phosphorylation	SRLPMDYYGIPFAAP HCCCCCCCCCCCCCC	12.33	22817900
876	Phosphorylation	GNLANNPYSGDVTKF CCCCCCCCCCCCCCC	27.66	22817900
877	Phosphorylation	NLANNPYSGDVTKFG CCCCCCCCCCCCCCC	29.76	25367039
882	Ubiquitination	PYSGDVTKFGRGDSA CCCCCCCCCCCCCCC	45.74	-
964	Phosphorylation	VALSTPPTPFQQASG CCCCCCCCCHHHCCC	37.63	22028470
1018	Phosphorylation	SGPGKGVSVSSGTGL CCCCCCCCCCCCCCC	25.58	25266776
1018	O-linked_Glycosylation	SGPGKGVSVSSGTGL CCCCCCCCCCCCCCC	25.58	30059200
1020	O-linked_Glycosylation	PGKGVSVSSGTGLPD CCCCCCCCCCCCCCC	18.62	30059200
1020	Phosphorylation	PGKGVSVSSGTGLPD CCCCCCCCCCCCCCC	18.62	18846507
1021	Phosphorylation	GKGVSVSSGTGLPDM CCCCCCCCCCCCCCC	37.91	18846507
1116	Ubiquitination	QPSSLQPKSQASKPT CCCCCCCCCCCCCCC	42.09	-
1117	Phosphorylation	PSSLQPKSQASKPTY CCCCCCCCCCCCCCC	37.35	26643407
1120	Phosphorylation	LQPKSQASKPTYGSA CCCCCCCCCCCCCCC	31.37	26643407
1123	Phosphorylation	KSQASKPTYGSAPYW CCCCCCCCCCCCCCC	44.22	26643407
1124	Phosphorylation	SQASKPTYGSAPYWT CCCCCCCCCCCCCCC	20.01	15879432
1126	Phosphorylation	ASKPTYGSAPYWTN- CCCCCCCCCCCCCC-	18.69	26643407
1129	Phosphorylation	PTYGSAPYWTN---- CCCCCCCCCCC----	25.28	25367039
1131	Phosphorylation	YGSAPYWTN------ CCCCCCCCC------	25.80	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
964	T	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBAP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBAP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UBAP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.