dbPTM

LMTK3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LMTK3_MOUSE
UniProt AC	Q5XJV6
Protein Name	Serine/threonine-protein kinase LMTK3
Gene Name	Lmtk3
Organism	Mus musculus (Mouse).
Sequence Length	1424
Subcellular Localization	Membrane Single-pass membrane protein . Cell projection, axon . Cell projection, dendrite . Golgi apparatus membrane . Punctate pattern in cell projections.
Protein Description	Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons. [PubMed: 24760852]
Protein Sequence	MPAPGALILLAAVSASGCLASPAHPDGFALSRAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVRFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPPHSDISTPLGLSRQHLSYLQEIGSGWFGKVILGEVFSDYSPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGVCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGMSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWVPLRWAAPELLGELHGSFVLVDQSRESNVWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPSHSAPRPGTLSSQFPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPPWQPASAPPAPHTNPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPGPQAPQTPSEVPQLVSETWASPLFPAPRPFPAQSSGSGGFLLSGWDPEGRGAGETLAGDPAEVLGEQGTAPWAEEEEEESSPGEDSSSLGGGPSRRGPLPCPLCSREGPCSCLPLERGDAVAGWGDHPALGCPHPPEDDSSLRAERGSLADLPLVPPTSAPLEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPRASAEPAASPDPPSALASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAKEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGSQEKPTFVVQVSTEQLLMSLREDVTKNLLGDKGSTPGETGPRKAGRSPANREKGPGPNRDLTSLVSRKKVPSRSLPVNGVTVLENGKPGVPDMKEKVAENGLESPEKEERALVNGEPMSPEAGEKVLANGVLMSPKSEEKVAENGVLRLPRNTERPPEIGPRRVPGPWEKTPETGGLAPETLLDRAPAPCEAALPQNGLEMAPGQLGPAPKSGNPDPGTEWRVHESGGAPRAPGAGKLDLGSGGRALGGVGTAPAGGPASAVDAKAGWVDNSRPLPPPPQPLGAQQRRPEPVPLKARPEVAQEEEPGVPDNRLGGDMAPSVDEDPLKPERKGPEMPRLFLDLGPPQGNSEQIKAKLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEDEEAAGSRDPGRTREAPVPVVVSSADGDTVRPLRGLLKSPRAADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQGTPEGDTEPSTPPAPPTPPHPTTPGDGFPNSDSGFGGSFEWAEDFPLLPPPGPPLCFSRFSVSPALETPGPPARAPDARPAGPVEN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
232	Phosphorylation	QRPPEGMSPELPPRD CCCCCCCCCCCCHHH	26.53	25521595
290	Phosphorylation	GDYGLAHSNYKEDYY CCCCCCCCCCCCCCC	35.93	-
486	Methylation	CLWEKARRGAGRGGG HHHHHHHHCCCCCCC	44.14	58858365
490	Methylation	KARRGAGRGGGAPPW HHHHCCCCCCCCCCC	39.80	24129315
531	Phosphorylation	LPVISARSPSVSSEY CCEEECCCCCCCCEE	22.65	25521595
533	Phosphorylation	VISARSPSVSSEYYI EEECCCCCCCCEEEE	35.56	30372032
535	Phosphorylation	SARSPSVSSEYYIRL ECCCCCCCCEEEEEH	23.07	19060867
645	Phosphorylation	AEEEEEESSPGEDSS HHHHHHHCCCCCCCC	45.15	29899451
646	Phosphorylation	EEEEEESSPGEDSSS HHHHHHCCCCCCCCC	39.96	29899451
705	Phosphorylation	PHPPEDDSSLRAERG CCCCCCCCCHHHHCC	43.52	29899451
706	Phosphorylation	HPPEDDSSLRAERGS CCCCCCCCHHHHCCC	28.95	29899451
877	Phosphorylation	NLLGDKGSTPGETGP HHHCCCCCCCCCCCC	36.85	23737553
878	Phosphorylation	LLGDKGSTPGETGPR HHCCCCCCCCCCCCC	43.94	23737553
882	Phosphorylation	KGSTPGETGPRKAGR CCCCCCCCCCCCCCC	59.40	23737553
947	Phosphorylation	VAENGLESPEKEERA HHHCCCCCHHHHHHH	43.32	25521595
962	Phosphorylation	LVNGEPMSPEAGEKV HHCCCCCCHHHHHHH	30.24	25521595
977	Phosphorylation	LANGVLMSPKSEEKV HHCCEECCCCCHHHH	25.64	25521595
1280	O-linked_Glycosylation	APVPVVVSSADGDTV CCCCEEEECCCCCCC	14.27	55412471
1296	Phosphorylation	PLRGLLKSPRAADEP CCHHHHCCCCCCCCC	21.42	29472430

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LMTK3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LMTK3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LMTK3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LMTK3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LMTK3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-962 AND SER-977, ANDMASS SPECTROMETRY.	17114649 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-947, AND MASSSPECTROMETRY.	16452087 [Abstract]