AINX_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AINX_MOUSE
• UniProt AC: P46660
• Protein Name: Alpha-internexin
• Gene Name: Ina
• Organism: Mus musculus (Mouse).
• Sequence Length: 501
• Protein Description: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges (By similarity)..
• Protein Sequence: MSFGSEHYLCSASSYRKVFGDSSRLSARLSGPGGSGSFRSQSLSRSNVASTAACSSASSLGLGLAYRRLPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRELRAQLEEASSARAQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVAVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLESDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTGGLSISGLNPLPNPSYLLPPRILSSTASKVSSAGLSLKKEEEEEEEEASKEVSKKTSKVGEGFEETLGEAVISTKKTGKSATEESTSSSQKM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFGSEHYL ------CCCCCCEEE	38.01	20415495
5	Phosphorylation	---MSFGSEHYLCSA ---CCCCCCEEEECH	21.13	20415495
13	Phosphorylation	EHYLCSASSYRKVFG CEEEECHHHHHHHHC	16.17	22817900
14	Phosphorylation	HYLCSASSYRKVFGD EEEECHHHHHHHHCC	28.77	20415495
17	Ubiquitination	CSASSYRKVFGDSSR ECHHHHHHHHCCCCC	33.41	27667366
22	Phosphorylation	YRKVFGDSSRLSARL HHHHHCCCCCEEHHH	20.10	22324799
23	Phosphorylation	RKVFGDSSRLSARLS HHHHCCCCCEEHHHC	41.82	22324799
26	Phosphorylation	FGDSSRLSARLSGPG HCCCCCEEHHHCCCC	15.38	29899451
30	Phosphorylation	SRLSARLSGPGGSGS CCEEHHHCCCCCCCC	37.07	22324799
35	Phosphorylation	RLSGPGGSGSFRSQS HHCCCCCCCCCCCCC	36.86	22324799
37	Phosphorylation	SGPGGSGSFRSQSLS CCCCCCCCCCCCCCC	21.13	25521595
42	Phosphorylation	SGSFRSQSLSRSNVA CCCCCCCCCCCCCCC	29.56	29899451
54	S-nitrosocysteine	NVASTAACSSASSLG CCCCHHHHHHHHHCC	2.83	-
54	S-nitrosylation	NVASTAACSSASSLG CCCCHHHHHHHHHCC	2.83	22178444
55	O-linked_Glycosylation	VASTAACSSASSLGL CCCHHHHHHHHHCCC	24.98	22645316
56	Phosphorylation	ASTAACSSASSLGLG CCHHHHHHHHHCCCC	31.86	29899451
58	Phosphorylation	TAACSSASSLGLGLA HHHHHHHHHCCCCHH	28.22	29899451
59	Phosphorylation	AACSSASSLGLGLAY HHHHHHHHCCCCHHH	26.60	29899451
72	Phosphorylation	AYRRLPASDGLDLSQ HHCCCCCCCCCCHHH	30.21	22817900
72	O-linked_Glycosylation	AYRRLPASDGLDLSQ HHCCCCCCCCCCHHH	30.21	161385
78	Phosphorylation	ASDGLDLSQAAARTN CCCCCCHHHHHHHCC	19.89	22817900
88	Ubiquitination	AARTNEYKIIRTNEK HHHCCCCEEEECCHH	26.02	27667366
95	Ubiquitination	KIIRTNEKEQLQGLN EEEECCHHHHHCCCH	53.48	22790023
117	Phosphorylation	EKVHQLETQNRALEA HHHHHHHHHHHHHHH	39.47	25521595
158	Phosphorylation	RAQLEEASSARAQAL HHHHHHHHHHHHHHH	28.01	29899451
159	Phosphorylation	AQLEEASSARAQALL HHHHHHHHHHHHHHH	28.90	29899451
186	Phosphorylation	RARCEEESRGREGAE HHHHHHHHHHHHHHH	43.23	29899451
216	Ubiquitination	ARLDLEKKVESLLDE HHHCHHHHHHHHHHH	41.69	22790023
219	Phosphorylation	DLEKKVESLLDELAF CHHHHHHHHHHHHHH	36.90	22817900
274	Phosphorylation	EIRAQYESLAAKNLQ HHHHHHHHHHHHHCC	20.55	29899451
288	Ubiquitination	QSAEEWYKSKFANLN CCHHHHHHHHHCCHH	48.52	22790023
290	Ubiquitination	AEEWYKSKFANLNEQ HHHHHHHHHCCHHHH	44.32	22790023
290	Acetylation	AEEWYKSKFANLNEQ HHHHHHHHHCCHHHH	44.32	-
301	Phosphorylation	LNEQAARSTEAIRAS HHHHHHHHHHHHHHH	26.35	29899451
302	Phosphorylation	NEQAARSTEAIRASR HHHHHHHHHHHHHHH	24.71	29899451
308	Phosphorylation	STEAIRASREEIHEY HHHHHHHHHHHHHHH	30.31	29899451
315	Phosphorylation	SREEIHEYRRQLQAR HHHHHHHHHHHHHHH	9.27	29899451
335	Phosphorylation	GLRGANESLERQILE CCCCCCHHHHHHHHH	35.02	22324799
357	Phosphorylation	EVAGYQDSIGQLESD HHHCCHHHHHHHHHH	17.06	29899451
363	Phosphorylation	DSIGQLESDLRNTKS HHHHHHHHHHHHCHH	51.00	29899451
379	Phosphorylation	MARHLREYQDLLNVK HHHHHHHHHHHHCHH	10.82	25367039
398	Ubiquitination	IEIAAYRKLLEGEET HHHHHHHHHHCCCCC	44.76	-
433	O-linked_Glycosylation	LLPPRILSSTASKVS CCCHHHHHCCCHHHH	24.22	8510477
433	Phosphorylation	LLPPRILSSTASKVS CCCHHHHHCCCHHHH	24.22	25521595
434	Phosphorylation	LPPRILSSTASKVSS CCHHHHHCCCHHHHH	25.25	29899451
434	O-linked_Glycosylation	LPPRILSSTASKVSS CCHHHHHCCCHHHHH	25.25	8510483
435	Phosphorylation	PPRILSSTASKVSSA CHHHHHCCCHHHHHC	31.41	25521595
435	O-linked_Glycosylation	PPRILSSTASKVSSA CHHHHHCCCHHHHHC	31.41	8527399
437	Phosphorylation	RILSSTASKVSSAGL HHHHCCCHHHHHCCC	33.41	25521595
437	O-linked_Glycosylation	RILSSTASKVSSAGL HHHHCCCHHHHHCCC	33.41	31441509
438	Ubiquitination	ILSSTASKVSSAGLS HHHCCCHHHHHCCCC	43.61	22790023
440	Phosphorylation	SSTASKVSSAGLSLK HCCCHHHHHCCCCCC	20.43	22324799
441	Phosphorylation	STASKVSSAGLSLKK CCCHHHHHCCCCCCH	29.37	25521595
445	Phosphorylation	KVSSAGLSLKKEEEE HHHHCCCCCCHHHHH	36.91	29899451
447	Ubiquitination	SSAGLSLKKEEEEEE HHCCCCCCHHHHHHH	51.22	27667366
458	Phosphorylation	EEEEEEASKEVSKKT HHHHHHHHHHHHHHH	63.26	29899451
467	Ubiquitination	EVSKKTSKVGEGFEE HHHHHHHHCCCCHHH	50.99	-
482	Phosphorylation	TLGEAVISTKKTGKS HHHHHHHCCCCCCCC	11.35	29899451
484	Ubiquitination	GEAVISTKKTGKSAT HHHHHCCCCCCCCCC	5.80	27667366
485	Ubiquitination	EAVISTKKTGKSATE HHHHCCCCCCCCCCC	27.81	-
486	Phosphorylation	AVISTKKTGKSATEE HHHCCCCCCCCCCCC	25.99	29899451
489	Phosphorylation	STKKTGKSATEESTS CCCCCCCCCCCCCCC	51.93	29899451
496	Phosphorylation	SATEESTSSSQKM-- CCCCCCCCCCCCC--	55.77	29899451
497	Phosphorylation	ATEESTSSSQKM--- CCCCCCCCCCCC---	27.62	29899451
498	Phosphorylation	TEESTSSSQKM---- CCCCCCCCCCC----	35.59	29899451
500	Ubiquitination	ESTSSSQKM------ CCCCCCCCC------	36.56	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AINX_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AINX_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AINX_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AINX_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72 AND SER-335, AND MASSSPECTROMETRY.
PubMed: 16452087