UniProt ID | LIPA3_MOUSE | |
---|---|---|
UniProt AC | P60469 | |
Protein Name | Liprin-alpha-3 | |
Gene Name | Ppfia3 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 1194 | |
Subcellular Localization | Cytoplasm . Cytoplasmic vesicle, secretory vesicle, acrosome . Also detected in epididymosome. | |
Protein Description | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.. | |
Protein Sequence | MMCEVMPTISEDGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQEALNLRDQLSRRRSGLEEPGKDGDGQTLANGLGPVGESNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAPLDPYGAGSGRAGKRGRWSGAKDESSKDWDRSAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVSSSGLDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSPAREGTDKTNHVSKEEAGVPRGEGPAVPGDTPPPTPRSARLERMAQALALQAGSPEDGAPPRGSESTPDSLHKAPKRKSIKSSIGRLFGKKEKGRMGPPGRESVSLAGTPSDETLATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTPTGNVWMTHEEMESLTAATKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLRGVTPDSAEMLPPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
8 | Phosphorylation | MMCEVMPTISEDGRR CCCCCCCCCCCCCCC | 21.02 | 24759943 | |
10 | Phosphorylation | CEVMPTISEDGRRGS CCCCCCCCCCCCCCC | 31.92 | 25777480 | |
17 | Phosphorylation | SEDGRRGSALGPDEA CCCCCCCCCCCCCCC | 20.64 | 25521595 | |
69 | Phosphorylation | ELGHEKDSLQRQLSI HHCCCHHHHHHHHHH | 37.15 | 22324799 | |
75 | Phosphorylation | DSLQRQLSIALPQEF HHHHHHHHHHCHHHH | 9.47 | 29899451 | |
134 | Phosphorylation | HERSLRMTVVKRQAQ CHHHHHEEEEEHHCC | 18.73 | - | |
142 | Phosphorylation | VVKRQAQSPGGVSSE EEEHHCCCCCCCCHH | 28.64 | 25521595 | |
207 | Phosphorylation | DQLSRRRSGLEEPGK HHHHHHHHCCCCCCC | 55.76 | 24899341 | |
264 | Phosphorylation | AVLCRQMSQLEEELG HHHHHHHHHHHHHHH | 44.34 | 25521595 | |
357 | Phosphorylation | LAEWLDDAKQKLQQT HHHHHHHHHHHHHHH | 32.73 | 25521595 | |
361 | Phosphorylation | LDDAKQKLQQTLQKA HHHHHHHHHHHHHHH | 27.95 | 21183079 | |
368 | Phosphorylation | LQQTLQKAETLPEIE HHHHHHHHHCHHHHH | 17.27 | - | |
431 | Phosphorylation | DDHNKRLSETVDKLL HHHHHHHHHHHHHHH | 23.17 | - | |
450 | Ubiquitination | ERLQLHLKERMGALE HHHHHHHHHHHHHHH | 20.29 | - | |
489 | Phosphorylation | QLLAEMERMQMEIDQ HHHHHHHHHHHHHHH | 26.10 | 21183079 | |
494 | Phosphorylation | MERMQMEIDQLRGRP HHHHHHHHHHHCCCC | 37.45 | 25521595 | |
503 | Phosphorylation | QLRGRPPSSYSRSLP HHCCCCCCCCCCCCC | 45.95 | 26824392 | |
504 | Phosphorylation | LRGRPPSSYSRSLPG HCCCCCCCCCCCCCC | 9.43 | 26824392 | |
505 | Phosphorylation | RGRPPSSYSRSLPGS CCCCCCCCCCCCCCC | 10.51 | 26824392 | |
507 | Phosphorylation | RPPSSYSRSLPGSAL CCCCCCCCCCCCCCE | 36.09 | 21183079 | |
508 | Phosphorylation | PPSSYSRSLPGSALE CCCCCCCCCCCCCEE | 8.15 | 25521595 | |
509 | Phosphorylation | PSSYSRSLPGSALEL CCCCCCCCCCCCEEE | 24.04 | 21183079 | |
510 | Phosphorylation | SSYSRSLPGSALELR CCCCCCCCCCCEEEE | 25.63 | 22807455 | |
511 | Phosphorylation | SYSRSLPGSALELRY CCCCCCCCCCEEEEC | 19.05 | - | |
512 | Phosphorylation | YSRSLPGSALELRYS CCCCCCCCCEEEECC | 25.01 | 25521595 | |
515 | Phosphorylation | SLPGSALELRYSQAP CCCCCCEEEECCCCC | 29.08 | 21183079 | |
517 | Phosphorylation | PGSALELRYSQAPTL CCCCEEEECCCCCCC | 47.12 | 21183079 | |
519 | Phosphorylation | SALELRYSQAPTLPS CCEEEECCCCCCCCC | 45.52 | - | |
519 | O-linked_Glycosylation | SALELRYSQAPTLPS CCEEEECCCCCCCCC | 45.52 | 55413435 | |
520 | Phosphorylation | ALELRYSQAPTLPSG CEEEECCCCCCCCCC | 52.95 | 21183079 | |
521 | Phosphorylation | LELRYSQAPTLPSGA EEEECCCCCCCCCCC | 46.42 | 22807455 | |
524 | Phosphorylation | RYSQAPTLPSGAPLD ECCCCCCCCCCCCCC | 43.56 | 21183079 | |
525 | Phosphorylation | YSQAPTLPSGAPLDP CCCCCCCCCCCCCCC | 13.52 | 19060867 | |
532 | Phosphorylation | PSGAPLDPYGAGSGR CCCCCCCCCCCCCCC | 30.08 | 25521595 | |
533 | Phosphorylation | SGAPLDPYGAGSGRA CCCCCCCCCCCCCCC | 40.90 | 29899451 | |
537 | Phosphorylation | LDPYGAGSGRAGKRG CCCCCCCCCCCCCCC | 33.39 | 29899451 | |
539 | Methylation | PYGAGSGRAGKRGRW CCCCCCCCCCCCCCC | 67.64 | 58859081 | |
563 | Phosphorylation | DWDRSAPAGSIPPPF CCCCCCCCCCCCCCC | 43.54 | 25521595 | |
567 | Phosphorylation | SAPAGSIPPPFPGEL CCCCCCCCCCCCCCC | 36.79 | 21183079 | |
586 | Phosphorylation | EEEAEGMFGAELLSP HHHHCCCCCCCCCCC | 28.29 | 19060867 | |
615 | Phosphorylation | EQLEAINKEIKLIQE HHHHHHHHHHHHHHH | 24.86 | - | |
639 | Phosphorylation | EELESRVSSSGLDSL HHHHHHHHHCCCHHH | 16.59 | 29899451 | |
640 | Phosphorylation | ELESRVSSSGLDSLG HHHHHHHHCCCHHHH | 43.37 | 21183079 | |
641 | Phosphorylation | LESRVSSSGLDSLGR HHHHHHHCCCHHHHC | 17.63 | 29899451 | |
645 | Phosphorylation | VSSSGLDSLGRYRSS HHHCCCHHHHCCCCC | 50.49 | 25521595 | |
658 | Phosphorylation | SSCSLPPSLTTSTLA CCCCCCCCCCCCCCC | 40.39 | 21183079 | |
660 | Phosphorylation | CSLPPSLTTSTLASP CCCCCCCCCCCCCCC | 42.44 | 21183079 | |
661 | Phosphorylation | SLPPSLTTSTLASPS CCCCCCCCCCCCCCC | 56.81 | 22807455 | |
662 | Phosphorylation | LPPSLTTSTLASPSP CCCCCCCCCCCCCCC | 53.46 | 21183079 | |
666 | Phosphorylation | LTTSTLASPSPPSSG CCCCCCCCCCCCCCC | 64.25 | 21183079 | |
668 | Phosphorylation | TSTLASPSPPSSGHS CCCCCCCCCCCCCCC | 62.10 | 21183079 | |
671 | Phosphorylation | LASPSPPSSGHSTPR CCCCCCCCCCCCCCC | 34.66 | 21183079 | |
672 | Phosphorylation | ASPSPPSSGHSTPRL CCCCCCCCCCCCCCC | 59.07 | 19060867 | |
675 | Phosphorylation | SPPSSGHSTPRLAPP CCCCCCCCCCCCCCC | 57.06 | 21183079 | |
676 | Phosphorylation | PPSSGHSTPRLAPPS CCCCCCCCCCCCCCC | 53.70 | 19060867 | |
683 | Phosphorylation | TPRLAPPSPAREGTD CCCCCCCCCCCCCCC | 24.53 | 23527152 | |
714 | Phosphorylation | GPAVPGDTPPPTPRS CCCCCCCCCCCCCCH | 5.22 | 25521595 | |
718 | Phosphorylation | PGDTPPPTPRSARLE CCCCCCCCCCHHHHH | 8.76 | 25521595 | |
737 | Phosphorylation | ALALQAGSPEDGAPP HHHHHCCCCCCCCCC | 23.82 | 25521595 | |
766 | Phosphorylation | KRKSIKSSIGRLFGK CHHHHHHHHHHHHCC | 40.55 | - | |
786 | Phosphorylation | MGPPGRESVSLAGTP CCCCCCCCCCCCCCC | 74.25 | 29899451 | |
788 | Phosphorylation | PPGRESVSLAGTPSD CCCCCCCCCCCCCCC | 51.92 | 29899451 | |
792 | Phosphorylation | ESVSLAGTPSDETLA CCCCCCCCCCCCCCC | 13.74 | 29899451 | |
794 | Phosphorylation | VSLAGTPSDETLATD CCCCCCCCCCCCCCC | 29.72 | 29899451 | |
797 | Phosphorylation | AGTPSDETLATDPLG CCCCCCCCCCCCCCC | 14.11 | 29899451 | |
800 | Phosphorylation | PSDETLATDPLGLAK CCCCCCCCCCCCCHH | 23.26 | 29899451 | |
906 | Phosphorylation | QEMVSLTSPSAPASS HHHHHCCCCCCCCCC | 45.62 | 29899451 | |
954 | Phosphorylation | LAYGDMNHEWVGNDW HHHCCCCCCCCCCCC | 31.64 | - | |
961 | Phosphorylation | HEWVGNDWLPSLGLP CCCCCCCCHHHCCCH | 31.46 | - | |
976 | Phosphorylation | QYRSYFMESLVDARM HHHHHHHHHHHHHHH | 23.30 | - | |
978 | Phosphorylation | RSYFMESLVDARMLD HHHHHHHHHHHHHHH | 40.54 | - | |
1013 | Phosphorylation | SLHYGIMCLKRLNYD HHHHHHHHHHHCCCC | 19.35 | 23527152 | |
1105 | Phosphorylation | QLLEKEFSNLISLGT HHHHHHHHHHHHHCC | - | ||
1112 | Phosphorylation | SNLISLGTDRRLDED HHHHHHCCCCCCCHH | - | ||
1123 | Phosphorylation | LDEDSAKSFSRSPSW CCHHHHHHHCCCHHH | - | ||
1125 | Phosphorylation | EDSAKSFSRSPSWRK HHHHHHHCCCHHHHH | 23375375 | ||
1127 | Phosphorylation | SAKSFSRSPSWRKMF HHHHHCCCHHHHHHH | 22324799 | ||
1129 | Phosphorylation | KSFSRSPSWRKMFRE HHHCCCHHHHHHHHH | 23375375 | ||
1156 | Phosphorylation | MLPPNFRSAAAGALG HCCCCHHHHHCHHHC | 23527152 | ||
1164 | Phosphorylation | AAAGALGSPGLPLRK HHCHHHCCCCCCCCC | 23527152 | ||
1178 | Phosphorylation | KLQPEGQTSGSSRAD CCCCCCCCCCCCCCC | 29899451 | ||
1179 | Phosphorylation | LQPEGQTSGSSRADG CCCCCCCCCCCCCCC | 29899451 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LIPA3_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LIPA3_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LIPA3_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of LIPA3_MOUSE !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND MASSSPECTROMETRY. | |
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-357; SER-494 ANDTHR-563, AND MASS SPECTROMETRY. | |
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494 AND SER-532, ANDMASS SPECTROMETRY. |