dbPTM

LIPA3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LIPA3_MOUSE
UniProt AC	P60469
Protein Name	Liprin-alpha-3
Gene Name	Ppfia3
Organism	Mus musculus (Mouse).
Sequence Length	1194
Subcellular Localization	Cytoplasm . Cytoplasmic vesicle, secretory vesicle, acrosome . Also detected in epididymosome.
Protein Description	May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates..
Protein Sequence	MMCEVMPTISEDGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQEALNLRDQLSRRRSGLEEPGKDGDGQTLANGLGPVGESNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAPLDPYGAGSGRAGKRGRWSGAKDESSKDWDRSAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVSSSGLDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSPAREGTDKTNHVSKEEAGVPRGEGPAVPGDTPPPTPRSARLERMAQALALQAGSPEDGAPPRGSESTPDSLHKAPKRKSIKSSIGRLFGKKEKGRMGPPGRESVSLAGTPSDETLATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTPTGNVWMTHEEMESLTAATKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLRGVTPDSAEMLPPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MMCEVMPTISEDGRR CCCCCCCCCCCCCCC	21.02	24759943
10	Phosphorylation	CEVMPTISEDGRRGS CCCCCCCCCCCCCCC	31.92	25777480
17	Phosphorylation	SEDGRRGSALGPDEA CCCCCCCCCCCCCCC	20.64	25521595
69	Phosphorylation	ELGHEKDSLQRQLSI HHCCCHHHHHHHHHH	37.15	22324799
75	Phosphorylation	DSLQRQLSIALPQEF HHHHHHHHHHCHHHH	9.47	29899451
134	Phosphorylation	HERSLRMTVVKRQAQ CHHHHHEEEEEHHCC	18.73	-
142	Phosphorylation	VVKRQAQSPGGVSSE EEEHHCCCCCCCCHH	28.64	25521595
207	Phosphorylation	DQLSRRRSGLEEPGK HHHHHHHHCCCCCCC	55.76	24899341
264	Phosphorylation	AVLCRQMSQLEEELG HHHHHHHHHHHHHHH	44.34	25521595
357	Phosphorylation	LAEWLDDAKQKLQQT HHHHHHHHHHHHHHH	32.73	25521595
361	Phosphorylation	LDDAKQKLQQTLQKA HHHHHHHHHHHHHHH	27.95	21183079
368	Phosphorylation	LQQTLQKAETLPEIE HHHHHHHHHCHHHHH	17.27	-
431	Phosphorylation	DDHNKRLSETVDKLL HHHHHHHHHHHHHHH	23.17	-
450	Ubiquitination	ERLQLHLKERMGALE HHHHHHHHHHHHHHH	20.29	-
489	Phosphorylation	QLLAEMERMQMEIDQ HHHHHHHHHHHHHHH	26.10	21183079
494	Phosphorylation	MERMQMEIDQLRGRP HHHHHHHHHHHCCCC	37.45	25521595
503	Phosphorylation	QLRGRPPSSYSRSLP HHCCCCCCCCCCCCC	45.95	26824392
504	Phosphorylation	LRGRPPSSYSRSLPG HCCCCCCCCCCCCCC	9.43	26824392
505	Phosphorylation	RGRPPSSYSRSLPGS CCCCCCCCCCCCCCC	10.51	26824392
507	Phosphorylation	RPPSSYSRSLPGSAL CCCCCCCCCCCCCCE	36.09	21183079
508	Phosphorylation	PPSSYSRSLPGSALE CCCCCCCCCCCCCEE	8.15	25521595
509	Phosphorylation	PSSYSRSLPGSALEL CCCCCCCCCCCCEEE	24.04	21183079
510	Phosphorylation	SSYSRSLPGSALELR CCCCCCCCCCCEEEE	25.63	22807455
511	Phosphorylation	SYSRSLPGSALELRY CCCCCCCCCCEEEEC	19.05	-
512	Phosphorylation	YSRSLPGSALELRYS CCCCCCCCCEEEECC	25.01	25521595
515	Phosphorylation	SLPGSALELRYSQAP CCCCCCEEEECCCCC	29.08	21183079
517	Phosphorylation	PGSALELRYSQAPTL CCCCEEEECCCCCCC	47.12	21183079
519	Phosphorylation	SALELRYSQAPTLPS CCEEEECCCCCCCCC	45.52	-
519	O-linked_Glycosylation	SALELRYSQAPTLPS CCEEEECCCCCCCCC	45.52	55413435
520	Phosphorylation	ALELRYSQAPTLPSG CEEEECCCCCCCCCC	52.95	21183079
521	Phosphorylation	LELRYSQAPTLPSGA EEEECCCCCCCCCCC	46.42	22807455
524	Phosphorylation	RYSQAPTLPSGAPLD ECCCCCCCCCCCCCC	43.56	21183079
525	Phosphorylation	YSQAPTLPSGAPLDP CCCCCCCCCCCCCCC	13.52	19060867
532	Phosphorylation	PSGAPLDPYGAGSGR CCCCCCCCCCCCCCC	30.08	25521595
533	Phosphorylation	SGAPLDPYGAGSGRA CCCCCCCCCCCCCCC	40.90	29899451
537	Phosphorylation	LDPYGAGSGRAGKRG CCCCCCCCCCCCCCC	33.39	29899451
539	Methylation	PYGAGSGRAGKRGRW CCCCCCCCCCCCCCC	67.64	58859081
563	Phosphorylation	DWDRSAPAGSIPPPF CCCCCCCCCCCCCCC	43.54	25521595
567	Phosphorylation	SAPAGSIPPPFPGEL CCCCCCCCCCCCCCC	36.79	21183079
586	Phosphorylation	EEEAEGMFGAELLSP HHHHCCCCCCCCCCC	28.29	19060867
615	Phosphorylation	EQLEAINKEIKLIQE HHHHHHHHHHHHHHH	24.86	-
639	Phosphorylation	EELESRVSSSGLDSL HHHHHHHHHCCCHHH	16.59	29899451
640	Phosphorylation	ELESRVSSSGLDSLG HHHHHHHHCCCHHHH	43.37	21183079
641	Phosphorylation	LESRVSSSGLDSLGR HHHHHHHCCCHHHHC	17.63	29899451
645	Phosphorylation	VSSSGLDSLGRYRSS HHHCCCHHHHCCCCC	50.49	25521595
658	Phosphorylation	SSCSLPPSLTTSTLA CCCCCCCCCCCCCCC	40.39	21183079
660	Phosphorylation	CSLPPSLTTSTLASP CCCCCCCCCCCCCCC	42.44	21183079
661	Phosphorylation	SLPPSLTTSTLASPS CCCCCCCCCCCCCCC	56.81	22807455
662	Phosphorylation	LPPSLTTSTLASPSP CCCCCCCCCCCCCCC	53.46	21183079
666	Phosphorylation	LTTSTLASPSPPSSG CCCCCCCCCCCCCCC	64.25	21183079
668	Phosphorylation	TSTLASPSPPSSGHS CCCCCCCCCCCCCCC	62.10	21183079
671	Phosphorylation	LASPSPPSSGHSTPR CCCCCCCCCCCCCCC	34.66	21183079
672	Phosphorylation	ASPSPPSSGHSTPRL CCCCCCCCCCCCCCC	59.07	19060867
675	Phosphorylation	SPPSSGHSTPRLAPP CCCCCCCCCCCCCCC	57.06	21183079
676	Phosphorylation	PPSSGHSTPRLAPPS CCCCCCCCCCCCCCC	53.70	19060867
683	Phosphorylation	TPRLAPPSPAREGTD CCCCCCCCCCCCCCC	24.53	23527152
714	Phosphorylation	GPAVPGDTPPPTPRS CCCCCCCCCCCCCCH	5.22	25521595
718	Phosphorylation	PGDTPPPTPRSARLE CCCCCCCCCCHHHHH	8.76	25521595
737	Phosphorylation	ALALQAGSPEDGAPP HHHHHCCCCCCCCCC	23.82	25521595
766	Phosphorylation	KRKSIKSSIGRLFGK CHHHHHHHHHHHHCC	40.55	-
786	Phosphorylation	MGPPGRESVSLAGTP CCCCCCCCCCCCCCC	74.25	29899451
788	Phosphorylation	PPGRESVSLAGTPSD CCCCCCCCCCCCCCC	51.92	29899451
792	Phosphorylation	ESVSLAGTPSDETLA CCCCCCCCCCCCCCC	13.74	29899451
794	Phosphorylation	VSLAGTPSDETLATD CCCCCCCCCCCCCCC	29.72	29899451
797	Phosphorylation	AGTPSDETLATDPLG CCCCCCCCCCCCCCC	14.11	29899451
800	Phosphorylation	PSDETLATDPLGLAK CCCCCCCCCCCCCHH	23.26	29899451
906	Phosphorylation	QEMVSLTSPSAPASS HHHHHCCCCCCCCCC	45.62	29899451
954	Phosphorylation	LAYGDMNHEWVGNDW HHHCCCCCCCCCCCC	31.64	-
961	Phosphorylation	HEWVGNDWLPSLGLP CCCCCCCCHHHCCCH	31.46	-
976	Phosphorylation	QYRSYFMESLVDARM HHHHHHHHHHHHHHH	23.30	-
978	Phosphorylation	RSYFMESLVDARMLD HHHHHHHHHHHHHHH	40.54	-
1013	Phosphorylation	SLHYGIMCLKRLNYD HHHHHHHHHHHCCCC	19.35	23527152
1105	Phosphorylation	QLLEKEFSNLISLGT HHHHHHHHHHHHHCC		-
1112	Phosphorylation	SNLISLGTDRRLDED HHHHHHCCCCCCCHH		-
1123	Phosphorylation	LDEDSAKSFSRSPSW CCHHHHHHHCCCHHH		-
1125	Phosphorylation	EDSAKSFSRSPSWRK HHHHHHHCCCHHHHH		23375375
1127	Phosphorylation	SAKSFSRSPSWRKMF HHHHHCCCHHHHHHH		22324799
1129	Phosphorylation	KSFSRSPSWRKMFRE HHHCCCHHHHHHHHH		23375375
1156	Phosphorylation	MLPPNFRSAAAGALG HCCCCHHHHHCHHHC		23527152
1164	Phosphorylation	AAAGALGSPGLPLRK HHCHHHCCCCCCCCC		23527152
1178	Phosphorylation	KLQPEGQTSGSSRAD CCCCCCCCCCCCCCC		29899451
1179	Phosphorylation	LQPEGQTSGSSRADG CCCCCCCCCCCCCCC		29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LIPA3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LIPA3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LIPA3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LIPA3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LIPA3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-357; SER-494 ANDTHR-563, AND MASS SPECTROMETRY.	17114649 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494 AND SER-532, ANDMASS SPECTROMETRY.	16452087 [Abstract]