LIPA3_MOUSE - dbPTM
LIPA3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LIPA3_MOUSE
UniProt AC P60469
Protein Name Liprin-alpha-3
Gene Name Ppfia3
Organism Mus musculus (Mouse).
Sequence Length 1194
Subcellular Localization Cytoplasm . Cytoplasmic vesicle, secretory vesicle, acrosome . Also detected in epididymosome.
Protein Description May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates..
Protein Sequence MMCEVMPTISEDGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQEALNLRDQLSRRRSGLEEPGKDGDGQTLANGLGPVGESNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAPLDPYGAGSGRAGKRGRWSGAKDESSKDWDRSAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVSSSGLDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSPAREGTDKTNHVSKEEAGVPRGEGPAVPGDTPPPTPRSARLERMAQALALQAGSPEDGAPPRGSESTPDSLHKAPKRKSIKSSIGRLFGKKEKGRMGPPGRESVSLAGTPSDETLATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTPTGNVWMTHEEMESLTAATKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLRGVTPDSAEMLPPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMMCEVMPTISEDGRR
CCCCCCCCCCCCCCC
21.0224759943
10PhosphorylationCEVMPTISEDGRRGS
CCCCCCCCCCCCCCC
31.9225777480
17PhosphorylationSEDGRRGSALGPDEA
CCCCCCCCCCCCCCC
20.6425521595
69PhosphorylationELGHEKDSLQRQLSI
HHCCCHHHHHHHHHH
37.1522324799
75PhosphorylationDSLQRQLSIALPQEF
HHHHHHHHHHCHHHH
9.4729899451
134PhosphorylationHERSLRMTVVKRQAQ
CHHHHHEEEEEHHCC
18.73-
142PhosphorylationVVKRQAQSPGGVSSE
EEEHHCCCCCCCCHH
28.6425521595
207PhosphorylationDQLSRRRSGLEEPGK
HHHHHHHHCCCCCCC
55.7624899341
264PhosphorylationAVLCRQMSQLEEELG
HHHHHHHHHHHHHHH
44.3425521595
357PhosphorylationLAEWLDDAKQKLQQT
HHHHHHHHHHHHHHH
32.7325521595
361PhosphorylationLDDAKQKLQQTLQKA
HHHHHHHHHHHHHHH
27.9521183079
368PhosphorylationLQQTLQKAETLPEIE
HHHHHHHHHCHHHHH
17.27-
431PhosphorylationDDHNKRLSETVDKLL
HHHHHHHHHHHHHHH
23.17-
450UbiquitinationERLQLHLKERMGALE
HHHHHHHHHHHHHHH
20.29-
489PhosphorylationQLLAEMERMQMEIDQ
HHHHHHHHHHHHHHH
26.1021183079
494PhosphorylationMERMQMEIDQLRGRP
HHHHHHHHHHHCCCC
37.4525521595
503PhosphorylationQLRGRPPSSYSRSLP
HHCCCCCCCCCCCCC
45.9526824392
504PhosphorylationLRGRPPSSYSRSLPG
HCCCCCCCCCCCCCC
9.4326824392
505PhosphorylationRGRPPSSYSRSLPGS
CCCCCCCCCCCCCCC
10.5126824392
507PhosphorylationRPPSSYSRSLPGSAL
CCCCCCCCCCCCCCE
36.0921183079
508PhosphorylationPPSSYSRSLPGSALE
CCCCCCCCCCCCCEE
8.1525521595
509PhosphorylationPSSYSRSLPGSALEL
CCCCCCCCCCCCEEE
24.0421183079
510PhosphorylationSSYSRSLPGSALELR
CCCCCCCCCCCEEEE
25.6322807455
511PhosphorylationSYSRSLPGSALELRY
CCCCCCCCCCEEEEC
19.05-
512PhosphorylationYSRSLPGSALELRYS
CCCCCCCCCEEEECC
25.0125521595
515PhosphorylationSLPGSALELRYSQAP
CCCCCCEEEECCCCC
29.0821183079
517PhosphorylationPGSALELRYSQAPTL
CCCCEEEECCCCCCC
47.1221183079
519PhosphorylationSALELRYSQAPTLPS
CCEEEECCCCCCCCC
45.52-
519O-linked_GlycosylationSALELRYSQAPTLPS
CCEEEECCCCCCCCC
45.5255413435
520PhosphorylationALELRYSQAPTLPSG
CEEEECCCCCCCCCC
52.9521183079
521PhosphorylationLELRYSQAPTLPSGA
EEEECCCCCCCCCCC
46.4222807455
524PhosphorylationRYSQAPTLPSGAPLD
ECCCCCCCCCCCCCC
43.5621183079
525PhosphorylationYSQAPTLPSGAPLDP
CCCCCCCCCCCCCCC
13.5219060867
532PhosphorylationPSGAPLDPYGAGSGR
CCCCCCCCCCCCCCC
30.0825521595
533PhosphorylationSGAPLDPYGAGSGRA
CCCCCCCCCCCCCCC
40.9029899451
537PhosphorylationLDPYGAGSGRAGKRG
CCCCCCCCCCCCCCC
33.3929899451
539MethylationPYGAGSGRAGKRGRW
CCCCCCCCCCCCCCC
67.6458859081
563PhosphorylationDWDRSAPAGSIPPPF
CCCCCCCCCCCCCCC
43.5425521595
567PhosphorylationSAPAGSIPPPFPGEL
CCCCCCCCCCCCCCC
36.7921183079
586PhosphorylationEEEAEGMFGAELLSP
HHHHCCCCCCCCCCC
28.2919060867
615PhosphorylationEQLEAINKEIKLIQE
HHHHHHHHHHHHHHH
24.86-
639PhosphorylationEELESRVSSSGLDSL
HHHHHHHHHCCCHHH
16.5929899451
640PhosphorylationELESRVSSSGLDSLG
HHHHHHHHCCCHHHH
43.3721183079
641PhosphorylationLESRVSSSGLDSLGR
HHHHHHHCCCHHHHC
17.6329899451
645PhosphorylationVSSSGLDSLGRYRSS
HHHCCCHHHHCCCCC
50.4925521595
658PhosphorylationSSCSLPPSLTTSTLA
CCCCCCCCCCCCCCC
40.3921183079
660PhosphorylationCSLPPSLTTSTLASP
CCCCCCCCCCCCCCC
42.4421183079
661PhosphorylationSLPPSLTTSTLASPS
CCCCCCCCCCCCCCC
56.8122807455
662PhosphorylationLPPSLTTSTLASPSP
CCCCCCCCCCCCCCC
53.4621183079
666PhosphorylationLTTSTLASPSPPSSG
CCCCCCCCCCCCCCC
64.2521183079
668PhosphorylationTSTLASPSPPSSGHS
CCCCCCCCCCCCCCC
62.1021183079
671PhosphorylationLASPSPPSSGHSTPR
CCCCCCCCCCCCCCC
34.6621183079
672PhosphorylationASPSPPSSGHSTPRL
CCCCCCCCCCCCCCC
59.0719060867
675PhosphorylationSPPSSGHSTPRLAPP
CCCCCCCCCCCCCCC
57.0621183079
676PhosphorylationPPSSGHSTPRLAPPS
CCCCCCCCCCCCCCC
53.7019060867
683PhosphorylationTPRLAPPSPAREGTD
CCCCCCCCCCCCCCC
24.5323527152
714PhosphorylationGPAVPGDTPPPTPRS
CCCCCCCCCCCCCCH
5.2225521595
718PhosphorylationPGDTPPPTPRSARLE
CCCCCCCCCCHHHHH
8.7625521595
737PhosphorylationALALQAGSPEDGAPP
HHHHHCCCCCCCCCC
23.8225521595
766PhosphorylationKRKSIKSSIGRLFGK
CHHHHHHHHHHHHCC
40.55-
786PhosphorylationMGPPGRESVSLAGTP
CCCCCCCCCCCCCCC
74.2529899451
788PhosphorylationPPGRESVSLAGTPSD
CCCCCCCCCCCCCCC
51.9229899451
792PhosphorylationESVSLAGTPSDETLA
CCCCCCCCCCCCCCC
13.7429899451
794PhosphorylationVSLAGTPSDETLATD
CCCCCCCCCCCCCCC
29.7229899451
797PhosphorylationAGTPSDETLATDPLG
CCCCCCCCCCCCCCC
14.1129899451
800PhosphorylationPSDETLATDPLGLAK
CCCCCCCCCCCCCHH
23.2629899451
906PhosphorylationQEMVSLTSPSAPASS
HHHHHCCCCCCCCCC
45.6229899451
954PhosphorylationLAYGDMNHEWVGNDW
HHHCCCCCCCCCCCC
31.64-
961PhosphorylationHEWVGNDWLPSLGLP
CCCCCCCCHHHCCCH
31.46-
976PhosphorylationQYRSYFMESLVDARM
HHHHHHHHHHHHHHH
23.30-
978PhosphorylationRSYFMESLVDARMLD
HHHHHHHHHHHHHHH
40.54-
1013PhosphorylationSLHYGIMCLKRLNYD
HHHHHHHHHHHCCCC
19.3523527152
1105PhosphorylationQLLEKEFSNLISLGT
HHHHHHHHHHHHHCC
-
1112PhosphorylationSNLISLGTDRRLDED
HHHHHHCCCCCCCHH
-
1123PhosphorylationLDEDSAKSFSRSPSW
CCHHHHHHHCCCHHH
-
1125PhosphorylationEDSAKSFSRSPSWRK
HHHHHHHCCCHHHHH
23375375
1127PhosphorylationSAKSFSRSPSWRKMF
HHHHHCCCHHHHHHH
22324799
1129PhosphorylationKSFSRSPSWRKMFRE
HHHCCCHHHHHHHHH
23375375
1156PhosphorylationMLPPNFRSAAAGALG
HCCCCHHHHHCHHHC
23527152
1164PhosphorylationAAAGALGSPGLPLRK
HHCHHHCCCCCCCCC
23527152
1178PhosphorylationKLQPEGQTSGSSRAD
CCCCCCCCCCCCCCC
29899451
1179PhosphorylationLQPEGQTSGSSRADG
CCCCCCCCCCCCCCC
29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LIPA3_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LIPA3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LIPA3_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LIPA3_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LIPA3_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND MASSSPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-357; SER-494 ANDTHR-563, AND MASS SPECTROMETRY.
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494 AND SER-532, ANDMASS SPECTROMETRY.

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