dbPTM

PRC2B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRC2B_MOUSE
UniProt AC	Q7TPM1
Protein Name	Protein PRRC2B
Gene Name	Prrc2b
Organism	Mus musculus (Mouse).
Sequence Length	1486
Subcellular Localization
Protein Description
Protein Sequence	MSDRLGQITQGKDGKSKYSTLSLFDKYKGRSVGAVRSSVIPRHGLQSLGKVATARRMPPPANLPSLKSENKGNDPNIVIVPKDGTGWANKQDQQDPKSSSVTASQPPESQPQPGLQKSVSNLQKPTQSISQENTNSVPGGPKSWAQLSGKPVGHEGGLRGSSRLLSFSPEEFPTLKAAGGQDKAGKEKGALDLSYGPGPSLRPQNVTSWREGGGRNIISAASLSASPTELGSRNASGADGAPSLACTSDSKEPSLRPAQPSRRGASQFMGHGYQPPTYHDMLPAFMCSPQSSENQTTVERSSFPLPQLRLEPRVPFRQFQMNDQDGKERPGVARPVRPLRQLVERAPRPTIINAENLKGLDDLDTDADDGWAGLHEEVDYSEKLKFSDDEDEEDVVKDGRSKWNNWDPRRQRALSLSSADSTDAKRTQEEGKDWSGTAGGSRVIRKVPEPQPPSRKLHSWASGPDYQKPTMGSMFRQHSAEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCRQAQKANETPKPVEKEVPRSPGIEKVSPPENGPVVRKGSPEFPVQEAPTMFLEETPATSPTVAQSNSSSSSSSSSSIEEEVRESGSPAQEFSKYQKSLPPRFQRQQQQQQQQQQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQMLGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLSGTGCRSEDQNCVPSLQERKVTALDPAPVWSPEGYMALQNKGYSLPHPKSADTLAMGMHVRSPDEALPGGLGSHSPYALERTTHASSDGPETPSKKSEREVSLPTQRASEQEEARKQFDLGYGNALIDNCASSPGEENEASSVVGEGFIEVLTKKQRRLLEEERRKKEQAAQVPVKGRGLSSRIPPRFAKKQNGLCLEQDVTVPGSSLGTEIWENSSQALPVQGAASDSWRTAVTAFSSTEPGTSEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEISGPGLAESKADSHKDQAQKQAEHKDSEQGSAQSKEHRPGPIGNERSLKNRKGSEGAERLPGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDSDFSLPPGSVSGPVGNPVAKLQDVLASNAGLTQSIPILRRDHHMQRAIGLSPMSFPTADLTLKMESARKAWENSPSLPEQSSPGGAGSGIQPPSSVGASNGVNYSSFGGVSMPPMPVASVAPSASIPGSHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAATAQQIPISLHTSLQAQAQLGLRGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGIQPLEMVKPQSGSPYQPMSGNQALVYEGQLGQAAGLGTSQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQLPPGQSLSVGAPRRVPPPGSQPPVLNTSRESAPMELKGFHFADSKQNVPTGGSAPSPQAYRQSEWMKNPAWEP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	SDRLGQITQGKDGKS CCCCCCCCCCCCCCC	24.31	-
47	Phosphorylation	IPRHGLQSLGKVATA CCCCHHHHHCCHHHH	44.10	22817900
50	Acetylation	HGLQSLGKVATARRM CHHHHHCCHHHHCCC	33.71	22902405
68	Phosphorylation	ANLPSLKSENKGNDP CCCCCCCCCCCCCCC	52.25	25177544
118	Phosphorylation	PQPGLQKSVSNLQKP CCCCHHHHHHHCCCC	20.16	29899451
120	Phosphorylation	PGLQKSVSNLQKPTQ CCHHHHHHHCCCCCC	38.62	27841257
126	Phosphorylation	VSNLQKPTQSISQEN HHHCCCCCCCCCCCC	41.82	26060331
128	Phosphorylation	NLQKPTQSISQENTN HCCCCCCCCCCCCCC	27.04	26060331
130	Phosphorylation	QKPTQSISQENTNSV CCCCCCCCCCCCCCC	36.37	26060331
134	Phosphorylation	QSISQENTNSVPGGP CCCCCCCCCCCCCCC	28.28	26060331
136	Phosphorylation	ISQENTNSVPGGPKS CCCCCCCCCCCCCCC	27.87	26060331
150	Acetylation	SWAQLSGKPVGHEGG CHHHHCCCCCCCCCC	32.90	22902405
166	Phosphorylation	RGSSRLLSFSPEEFP CCCCCCCCCCHHHCC	28.41	26824392
168	Phosphorylation	SSRLLSFSPEEFPTL CCCCCCCCHHHCCCH	28.20	26824392
174	Phosphorylation	FSPEEFPTLKAAGGQ CCHHHCCCHHHCCCC	46.33	25777480
219	Phosphorylation	GGGRNIISAASLSAS CCCCCEEEEEEECCC	17.62	25619855
222	Phosphorylation	RNIISAASLSASPTE CCEEEEEEECCCCCH	23.67	21082442
224	Phosphorylation	IISAASLSASPTELG EEEEEEECCCCCHHH	24.97	27566939
226	Phosphorylation	SAASLSASPTELGSR EEEEECCCCCHHHCC	29.04	25521595
228	Phosphorylation	ASLSASPTELGSRNA EEECCCCCHHHCCCC	41.15	22942356
232	Phosphorylation	ASPTELGSRNASGAD CCCCHHHCCCCCCCC	34.68	25619855
387	Phosphorylation	YSEKLKFSDDEDEED HHHCCCCCCCCCHHH	42.43	24925903
415	Phosphorylation	PRRQRALSLSSADST HHHHHHHHHHCCCCC	25.81	27087446
417	Phosphorylation	RQRALSLSSADSTDA HHHHHHHHCCCCCCH	21.80	27742792
418	Phosphorylation	QRALSLSSADSTDAK HHHHHHHCCCCCCHH	41.19	27149854
421	Phosphorylation	LSLSSADSTDAKRTQ HHHHCCCCCCHHHHH	28.09	27149854
422	Phosphorylation	SLSSADSTDAKRTQE HHHCCCCCCHHHHHH	40.29	25619855
462	Phosphorylation	RKLHSWASGPDYQKP CCCCCCCCCCCCCCC	44.60	18846507
466	Phosphorylation	SWASGPDYQKPTMGS CCCCCCCCCCCCHHH	22.90	-
473	Phosphorylation	YQKPTMGSMFRQHSA CCCCCHHHHHHHCCC	12.15	23375375
479	Phosphorylation	GSMFRQHSAEDKEDK HHHHHHCCCCCCCCC	25.64	27087446
555	Phosphorylation	VEKEVPRSPGIEKVS CCCCCCCCCCCCCCC	22.77	25521595
562	Phosphorylation	SPGIEKVSPPENGPV CCCCCCCCCCCCCCC	45.89	26824392
574	Phosphorylation	GPVVRKGSPEFPVQE CCCCCCCCCCCCCCC	25.04	25338131
619	Phosphorylation	IEEEVRESGSPAQEF HHHHHHHCCCCHHHH	33.72	27742792
621	Phosphorylation	EEVRESGSPAQEFSK HHHHHCCCCHHHHHH	26.75	25521595
627	Phosphorylation	GSPAQEFSKYQKSLP CCCHHHHHHHHHHCC	29.69	23737553
658	Phosphorylation	QQQQEQLYKMQHWQP HHHHHHHHHHHCCCC	12.24	-
697 (in isoform 2)	Phosphorylation	-	10.32	23684622
700 (in isoform 2)	Phosphorylation	-	17.03	29514104
703	Phosphorylation	SYMDPRITPTRTPVD CCCCCCCCCCCCCCC	21.64	26643407
703 (in isoform 2)	Phosphorylation	-	21.64	29514104
705	Phosphorylation	MDPRITPTRTPVDFY CCCCCCCCCCCCCCC	38.23	26643407
707	Phosphorylation	PRITPTRTPVDFYPS CCCCCCCCCCCCCCC	30.09	26643407
707 (in isoform 2)	Phosphorylation	-	30.09	23684622
710 (in isoform 2)	Phosphorylation	-	38.27	25338131
711 (in isoform 2)	Phosphorylation	-	11.14	25338131
713 (in isoform 2)	Phosphorylation	-	17.08	25338131
753	Phosphorylation	SLQERKVTALDPAPV CHHCCCCCCCCCCCC	25.25	-
762	Phosphorylation	LDPAPVWSPEGYMAL CCCCCCCCHHHHHHH	17.20	25266776
766	Phosphorylation	PVWSPEGYMALQNKG CCCCHHHHHHHHCCC	4.23	28066266
781	Phosphorylation	YSLPHPKSADTLAMG CCCCCCCCCCCCCCC	35.51	25521595
784	Phosphorylation	PHPKSADTLAMGMHV CCCCCCCCCCCCCEE	19.01	29472430
793	Phosphorylation	AMGMHVRSPDEALPG CCCCEECCCCCCCCC	35.30	22942356
804	Phosphorylation	ALPGGLGSHSPYALE CCCCCCCCCCCCHHH	26.32	26239621
806	Phosphorylation	PGGLGSHSPYALERT CCCCCCCCCCHHHHC	22.70	27149854
808	Phosphorylation	GLGSHSPYALERTTH CCCCCCCCHHHHCCC	27.17	21659605
817	Phosphorylation	LERTTHASSDGPETP HHHCCCCCCCCCCCC	22.74	29895711
818	Phosphorylation	ERTTHASSDGPETPS HHCCCCCCCCCCCCC	47.58	23984901
823	Phosphorylation	ASSDGPETPSKKSER CCCCCCCCCCCHHHC	35.68	25263469
825	Phosphorylation	SDGPETPSKKSEREV CCCCCCCCCHHHCCC	61.20	23984901
983	Phosphorylation	SEQGFKSSQGDSGVD CCCCCCCCCCCCCCC	38.48	-
992	Phosphorylation	GDSGVDLSAESRESS CCCCCCCCHHHHCCC	26.06	25521595
995	Phosphorylation	GVDLSAESRESSATS CCCCCHHHHCCCCCC	40.85	25521595
998	Phosphorylation	LSAESRESSATSSQR CCHHHHCCCCCCCCC	24.94	29895711
999	Phosphorylation	SAESRESSATSSQRS CHHHHCCCCCCCCCC	30.71	26643407
1001	Phosphorylation	ESRESSATSSQRSSP HHHCCCCCCCCCCCC	30.75	26643407
1002	Phosphorylation	SRESSATSSQRSSPY HHCCCCCCCCCCCCC	24.96	26643407
1003	Phosphorylation	RESSATSSQRSSPYG HCCCCCCCCCCCCCC	25.84	25266776
1006	Phosphorylation	SATSSQRSSPYGTLK CCCCCCCCCCCCCCC	28.20	27742792
1007	Phosphorylation	ATSSQRSSPYGTLKP CCCCCCCCCCCCCCH	25.08	27742792
1009	Phosphorylation	SSQRSSPYGTLKPEE CCCCCCCCCCCCHHH	25.37	25619855
1011	Phosphorylation	QRSSPYGTLKPEEIS CCCCCCCCCCHHHCC	26.26	25619855
1018	Phosphorylation	TLKPEEISGPGLAES CCCHHHCCCCCCCCC	42.06	25195567
1025	Phosphorylation	SGPGLAESKADSHKD CCCCCCCCHHHHHHH	27.77	25619855
1070	Phosphorylation	SLKNRKGSEGAERLP HHCCCCCCCCHHCCC	35.57	27149854
1117	O-linked_Glycosylation	DFSLPPGSVSGPVGN CCCCCCCCCCCCCCC	20.91	30059200
1159	Phosphorylation	MQRAIGLSPMSFPTA HHHHHCCCCCCCCCC	17.22	26643407
1162	Phosphorylation	AIGLSPMSFPTADLT HHCCCCCCCCCCCEE	31.30	26643407
1312	Phosphorylation	SSLQPFRSQVYMHPS HHCCCCCCCCCCCCC	25.11	26643407
1315	Phosphorylation	QPFRSQVYMHPSLSP CCCCCCCCCCCCCCC	5.10	26643407
1319	Phosphorylation	SQVYMHPSLSPPSTM CCCCCCCCCCCCCEE	27.14	26643407
1321	Phosphorylation	VYMHPSLSPPSTMIL CCCCCCCCCCCEEEE	38.82	26643407
1324	Phosphorylation	HPSLSPPSTMILSGG CCCCCCCCEEEECCC	33.71	26643407
1325	Phosphorylation	PSLSPPSTMILSGGT CCCCCCCEEEECCCC	17.63	26643407
1329	Phosphorylation	PPSTMILSGGTALKP CCCEEEECCCCCCCC	25.01	26643407
1332	Phosphorylation	TMILSGGTALKPPYS EEEECCCCCCCCCCC	32.13	26643407
1440	Phosphorylation	SQPPVLNTSRESAPM CCCCCCCCCCCCCCC	25.63	27180971
1441	Phosphorylation	QPPVLNTSRESAPME CCCCCCCCCCCCCCE	32.74	27180971
1463	Phosphorylation	DSKQNVPTGGSAPSP CCCCCCCCCCCCCCH	50.30	25619855
1466	Phosphorylation	QNVPTGGSAPSPQAY CCCCCCCCCCCHHHH	38.05	25619855
1469	Phosphorylation	PTGGSAPSPQAYRQS CCCCCCCCHHHHHCC	29.39	25619855
1473	Phosphorylation	SAPSPQAYRQSEWMK CCCCHHHHHCCHHHC	12.16	25619855
1476	Phosphorylation	SPQAYRQSEWMKNPA CHHHHHCCHHHCCCC	24.99	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PRC2B_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRC2B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRC2B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PRC2B_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRC2B_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-621 AND SER-1007, ANDMASS SPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387, AND MASSSPECTROMETRY.	17203969 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387, AND MASSSPECTROMETRY.	16452087 [Abstract]