TGO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TGO1_MOUSE
• UniProt AC: Q8BI84
• Protein Name: Transport and Golgi organization protein 1 homolog {ECO:0000305}
• Gene Name: Mia3 {ECO:0000312|MGI:MGI:2443183}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1930
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein . Localizes at endoplasmic reticulum exit sites. After loading of COL7A1 into transport carriers, it is not incorporated into COPII carriers and remains in the endoplasmic reticulum membra
• Protein Description: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum..
• Protein Sequence: MAAAPGLLFWLFVLGALWWVPGQSDLSHGRRFSDLKVCGDEECSMLMYRGKALEDFTGPDCRFVNFKKGDDVYVYYKLAGGSLELWAGSVEHSFGYFPKDLIKVLHKYTEEELHIPADETDFVCFEGGRDDFNSYNVEELLGSLELEDSVPEESKKAEEVSQHREKSPEESRGRELDPVPEPEAFRADSEDGEGAFSESTEGLQGQPSAQESHPHTSGPAANAQGVQSSLDTFEEILHDKLKVPGSESRTGNSSPASVEREKTDAYKVLKTEMSLDLKTKFGSTADALVSDDEATRLVTSLEDGFDEALDAEYYPMEEEEEVEEDADSSDELPLLTFSDKDEKVPGKPMIEKYLTDKDPNLSEEDKVEPPTWGDAFFSIVTGGEGKPGVVDLERSIEEEEDVSVSSSHQRKPQPAAGYTDSEDEGDDLFVEEPKTNDVKDSETDPELVITGEEKDIQESRKGLVQPESQSEDAKSETASAYRLQGSKLNPLSAAEKGRDFTLKAVFEKKENGLKESVIHISKETLHEDKTREIQRDSLESELVHRALGSSVTENNKPKSLGVAPLLGNNKPDASKDSTEVPDGSVSGPKAGQQEGFLEPGLKTQHQPRFSPPEETGPSRELGGKVPISGRNLSWQQEQDVAAVVGKHANEKTGFPEEESREDGTDAEQARAIRRPQEAESPEVLSVQPGRPDEEEEEEEGDNYPPEGLMEDENAVSAQQSRENSPSARDGRSDMNSQVFEKVILGTLNLNTEKTKQPANMILETGQESETTSEEAGDVGKESGHSVVVDSEESHLADMRAQRPSQVHGLRDETAAQTPGSGEAVLSKNPNDLQKDNPEEELVNTLGLEDPGVGEISEGEPEDTKEFGVSESQGTDAEDLRDDPSRQATPEIPDIVLKSIREDLPIINSFFKDDQQSLHRFLKYFDVRELEGLLEDMSIRLRSAHQNSLPYNMEKVLDKVFRASESRILSMAEKMLDTGVAKNRDLGSKESSPLEEAEVLDDIQDLIYFVRYQYSGVETAPLVTPPPPEEGWARPGEERQPPQQDSLPQENTGDLSVQPPEEPELSDQPVTSVQPPEEPELSDQPVTSVQPPEEPELSDQPVTSVQPPEEPELSDQPVTGYTSTSEVSQKPDTKKDIDLGPVMEGGPVGAGDVQKQLETIAEEPAAVPPLESAFGSLYAFILYLSKMLLATLPDNVQPGPDFYGLPWQPVIITAVLGIVSFAIFSWRTILVVKSRVYQVTEKQISEKLENIKKENAELMQKLSSYEQKIKESKKYVQETKKQNMILSDEAVKYKDKIKILEETNVSLGDKAKSLRLQLESEREQNVKNQDLILENKKSIEKLKDVISMNASELSEVQVALNEAKLSEENVKSECHRVQEENARLKKKKEQLQQQVEEWSKSHAELTGQIKSFEKSQEDLEIALTHKDDNISALTNCITQLNRLECELESEDPDKGGNESDDLANGETGGDRSEKIRNRIKQMMDVSRTQTAVSIVEEDLKLLQLKLRASMSTKCNLEDQIKKLEDDRSSLQTAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQDREQRLTAADEKVVLAAEEVKTYKRRIEEMEEELQKTERSFKNQIAAHEKKAHDNWLKARAAERAMAEEKREAANLRHKLLEMTQKMAMRQDEPVIVKPMPGRPNTQNPPRRGLLSQNGSFGPSPVSGGECSPPLPAEPPGRPLSATLSRRDTPRSEFGSLDRHLPRPRWPSEASGKHSASDPGPAPVVNSSSRSSSPAKAVDEGKVNMAPKGPPPFPGVPLMGGPVPPPIRYGPPPQLCGGPFGPRPLPPPFVPGMHPPLGVREYAPGVLPGKRDLPLDPREFLPGHTPFRPPGSLGPREFFIPGTRLPPPTHGPQEYPPPPPAVRDSLPSGPREEAKPASPSSVQDRSQASKPTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
229	Phosphorylation	NAQGVQSSLDTFEEI CCHHHHHHHHHHHHH		-
246	Phosphorylation	DKLKVPGSESRTGNS HHCCCCCCCCCCCCC		-
248	Phosphorylation	LKVPGSESRTGNSSP CCCCCCCCCCCCCCC		-
250	Phosphorylation	VPGSESRTGNSSPAS CCCCCCCCCCCCCCC		-
250	O-linked_Glycosylation	VPGSESRTGNSSPAS CCCCCCCCCCCCCCC		30059200
253	O-linked_Glycosylation	SESRTGNSSPASVER CCCCCCCCCCCCHHH		30059200
254	Phosphorylation	ESRTGNSSPASVERE CCCCCCCCCCCHHHH		27841257
257	Phosphorylation	TGNSSPASVEREKTD CCCCCCCCHHHHHCC		27841257
274	Phosphorylation	KVLKTEMSLDLKTKF HHHHHHCCCCCHHHC		27742792
290	Phosphorylation	STADALVSDDEATRL CHHHHCCCHHHHHHH		28066266
295	Phosphorylation	LVSDDEATRLVTSLE CCCHHHHHHHHHHHH		28066266
355	Phosphorylation	PMIEKYLTDKDPNLS CCHHHHCCCCCCCCC		23984901
360	N-linked_Glycosylation	YLTDKDPNLSEEDKV HCCCCCCCCCHHHCC		-
362	Phosphorylation	TDKDPNLSEEDKVEP CCCCCCCCHHHCCCC		28542873
371	Phosphorylation	EDKVEPPTWGDAFFS HHCCCCCCCHHCEEE		17203969
395	Phosphorylation	GVVDLERSIEEEEDV CEEEHHHCCCCCCCC		25619855
403	Phosphorylation	IEEEEDVSVSSSHQR CCCCCCCCCCCCCCC		27841257
418	Phosphorylation	KPQPAAGYTDSEDEG CCCCCCCCCCCCCCC		23984901
419	Phosphorylation	PQPAAGYTDSEDEGD CCCCCCCCCCCCCCC		26525534
421	Phosphorylation	PAAGYTDSEDEGDDL CCCCCCCCCCCCCCC		27180971
521	Phosphorylation	KESVIHISKETLHED HHEEEEECHHHHCCC		29472430
537	Phosphorylation	TREIQRDSLESELVH CHHHHHHCHHHHHHH		26824392
540	Phosphorylation	IQRDSLESELVHRAL HHHHCHHHHHHHHHH		22942356
574	Phosphorylation	GNNKPDASKDSTEVP CCCCCCCCCCCCCCC		23984901
577	Phosphorylation	KPDASKDSTEVPDGS CCCCCCCCCCCCCCC		30352176
578	Phosphorylation	PDASKDSTEVPDGSV CCCCCCCCCCCCCCC		23984901
584	Phosphorylation	STEVPDGSVSGPKAG CCCCCCCCCCCCCCC		23140645
586	Phosphorylation	EVPDGSVSGPKAGQQ CCCCCCCCCCCCCCC		29472430
631	N-linked_Glycosylation	KVPISGRNLSWQQEQ CCCCCCCCCCCCCHH		-
652	Phosphorylation	GKHANEKTGFPEEES HCCCCCCCCCCHHHH		23984901
659	Phosphorylation	TGFPEEESREDGTDA CCCCHHHHCCCCCCH		27087446
664	Phosphorylation	EESREDGTDAEQARA HHHCCCCCCHHHHHH		29472430
726	Phosphorylation	QSRENSPSARDGRSD HHHHCCCCCCCCCCC		28059163
753	Ubiquitination	TLNLNTEKTKQPANM HCCCCCCCCCCCCCE		27667366
754	Phosphorylation	LNLNTEKTKQPANMI CCCCCCCCCCCCCEE		23140645
764	Phosphorylation	PANMILETGQESETT CCCEEECCCCCCCCC		23140645
768	Phosphorylation	ILETGQESETTSEEA EECCCCCCCCCCCCC		28609623
770	Phosphorylation	ETGQESETTSEEAGD CCCCCCCCCCCCCCC		28609623
771	Phosphorylation	TGQESETTSEEAGDV CCCCCCCCCCCCCCC		28609623
772	Phosphorylation	GQESETTSEEAGDVG CCCCCCCCCCCCCCC		25521595
782	Phosphorylation	AGDVGKESGHSVVVD CCCCCCCCCCEEEEC		30635358
785	Phosphorylation	VGKESGHSVVVDSEE CCCCCCCEEEECCCC		30635358
790	Phosphorylation	GHSVVVDSEESHLAD CCEEEECCCCHHHHH		24899341
793	Phosphorylation	VVVDSEESHLADMRA EEECCCCHHHHHHHC		30635358
817	Phosphorylation	RDETAAQTPGSGEAV CCCCCCCCCCCCCCH		25619855
820	Phosphorylation	TAAQTPGSGEAVLSK CCCCCCCCCCCHHCC		25521595
826	Phosphorylation	GSGEAVLSKNPNDLQ CCCCCHHCCCCCHHH		25619855
856	Phosphorylation	DPGVGEISEGEPEDT CCCCCCCCCCCCCCC		26525534
869	Phosphorylation	DTKEFGVSESQGTDA CCCCCCCCCCCCCCH		27841257
871	Phosphorylation	KEFGVSESQGTDAED CCCCCCCCCCCCHHH		30352176
987	Phosphorylation	AKNRDLGSKESSPLE CCCCCCCCCCCCCHH		26239621
990	Phosphorylation	RDLGSKESSPLEEAE CCCCCCCCCCHHHHH		26239621
991	Phosphorylation	DLGSKESSPLEEAEV CCCCCCCCCHHHHHH		26239621
1267	Ubiquitination	KLSSYEQKIKESKKY HHHHHHHHHHHHHHH		22790023
1309	Ubiquitination	TNVSLGDKAKSLRLQ CCCCHHHHHHHHHHH		22790023
1335	Acetylation	QDLILENKKSIEKLK HHHHHHCHHHHHHHH		7630991
1337	Phosphorylation	LILENKKSIEKLKDV HHHHCHHHHHHHHHH		25338131
1448	Phosphorylation	RLECELESEDPDKGG HCEEEECCCCCCCCC		25619855
1458	Phosphorylation	PDKGGNESDDLANGE CCCCCCCCHHHCCCC		25521595
1466	Phosphorylation	DDLANGETGGDRSEK HHHCCCCCCCCHHHH		23140645
1471	Phosphorylation	GETGGDRSEKIRNRI CCCCCCHHHHHHHHH		23140645
1504	Ubiquitination	DLKLLQLKLRASMST HHHHHHHHHHHHHCC		22790023
1566	Phosphorylation	MALQKKLSQEEYERQ HHHHHHHCHHHHHHH		25521595
1570	Phosphorylation	KKLSQEEYERQDREQ HHHCHHHHHHHHHHH		25159016
1615	Ubiquitination	QKTERSFKNQIAAHE HHHHHHHHHHHHHHH		27667366
1671	Ubiquitination	QDEPVIVKPMPGRPN CCCCEEEECCCCCCC		22790023
1689	Phosphorylation	PPRRGLLSQNGSFGP CCCCCCCCCCCCCCC		25619855
1693	Phosphorylation	GLLSQNGSFGPSPVS CCCCCCCCCCCCCCC		25619855
1697	Phosphorylation	QNGSFGPSPVSGGEC CCCCCCCCCCCCCCC		27087446
1700	Phosphorylation	SFGPSPVSGGECSPP CCCCCCCCCCCCCCC		27087446
1705	Phosphorylation	PVSGGECSPPLPAEP CCCCCCCCCCCCCCC		25521595
1718	Phosphorylation	EPPGRPLSATLSRRD CCCCCCCEEEECCCC		25619855
1720	Phosphorylation	PGRPLSATLSRRDTP CCCCCEEEECCCCCC		25619855
1722	Phosphorylation	RPLSATLSRRDTPRS CCCEEEECCCCCCHH		25619855
1726	Phosphorylation	ATLSRRDTPRSEFGS EEECCCCCCHHHCCC		24899341
1729	Phosphorylation	SRRDTPRSEFGSLDR CCCCCCHHHCCCCCC		24899341
1733	Phosphorylation	TPRSEFGSLDRHLPR CCHHHCCCCCCCCCC		26824392
1745	Phosphorylation	LPRPRWPSEASGKHS CCCCCCCCCCCCCCC		28066266
1748	Phosphorylation	PRWPSEASGKHSASD CCCCCCCCCCCCCCC		29514104
1752	Phosphorylation	SEASGKHSASDPGPA CCCCCCCCCCCCCCC		23684622
1752	O-linked_Glycosylation	SEASGKHSASDPGPA CCCCCCCCCCCCCCC		30059200
1754	O-linked_Glycosylation	ASGKHSASDPGPAPV CCCCCCCCCCCCCCC		30059200
1754	Phosphorylation	ASGKHSASDPGPAPV CCCCCCCCCCCCCCC		25521595
1764	Phosphorylation	GPAPVVNSSSRSSSP CCCCCCCCCCCCCCC		25521595
1765	Phosphorylation	PAPVVNSSSRSSSPA CCCCCCCCCCCCCCC		25521595
1766	Phosphorylation	APVVNSSSRSSSPAK CCCCCCCCCCCCCCC		27087446
1768	Phosphorylation	VVNSSSRSSSPAKAV CCCCCCCCCCCCCCC		23684622
1769	Phosphorylation	VNSSSRSSSPAKAVD CCCCCCCCCCCCCCC		27087446
1770	Phosphorylation	NSSSRSSSPAKAVDE CCCCCCCCCCCCCCC		25521595
1773	Acetylation	SRSSSPAKAVDEGKV CCCCCCCCCCCCCCC		15620157
1779	Ubiquitination	AKAVDEGKVNMAPKG CCCCCCCCCCCCCCC		22790023
1805	Asymmetric dimethylarginine	GPVPPPIRYGPPPQL CCCCCCCCCCCCCCC		-
1805	Methylation	GPVPPPIRYGPPPQL CCCCCCCCCCCCCCC		24129315
1902	Phosphorylation	PPPAVRDSLPSGPRE CCCCHHHCCCCCCHH		25619855
1905	Phosphorylation	AVRDSLPSGPREEAK CHHHCCCCCCHHHCC		25619855
1915	Phosphorylation	REEAKPASPSSVQDR HHHCCCCCCCCCCCH		27087446
1917	Phosphorylation	EAKPASPSSVQDRSQ HCCCCCCCCCCCHHH		27742792
1918	Phosphorylation	AKPASPSSVQDRSQA CCCCCCCCCCCHHHC		25521595
1929	Phosphorylation	RSQASKPTP------ HHHCCCCCC------		19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TGO1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TGO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TGO1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TGO1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.