PYR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PYR1_MOUSE
• UniProt AC: B2RQC6
• Protein Name: CAD protein
• Gene Name: Cad
• Organism: Mus musculus (Mouse).
• Sequence Length: 2225
• Subcellular Localization: Cytoplasm. Nucleus. Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth..
• Protein Description: This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)..
• Protein Sequence: MAALVLEDGSVLQGRPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYGIPSDEEDEFGLSKWFESSEIHVAGLVVGECCPTPSHWSANCTLHEWLQQRGIPGLQGVDTRELTKKLREQGSLLGKLVQKGTEPSALPFVDPNARPLAPEVSIKTPRVFNAGGAPRICALDCGLKYNQIRCLCQLGAEVTVVPWDHELDSQKYDGLFLSNGPGDPASYPGVVSTLSRVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGTGRCFLTSQNHGFAVDADSLPAGWAPLFTNANDCSNEGIVHDSLPFFSVQFHPEHRAGPSDMELLFDVFLETVREAAAGNIGGQTVRERLAQRLCPPELPIPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFLPITLHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASTKEELSALVAPAFAHTSQVLIDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRRTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAAFEPSLDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVERLYELTRIDCWFLHRMKRIVTHAQLLEQHRGQALPQDLLHQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGNTHDLDFRAPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCHTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVACDGIVSAIAISEHVENAGVHSGDATLVTPPQDITPKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRIIMGEKVEPVGLMTGSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPEKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILDQLAENHFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGVTMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFTLFLGASSENAGTLGAVAGSAAGLKLYLNETFSELRLDSVAQWMEHFETWPAHLPIVAHAERQSVAAVLMVAQLTQRPVHICHVARKEEILLIKTAKAQGLPVTCEVAPHHLFLNREDLERLGPGKGEVRPELGSREDMEALWENMAVIDCFASDHAPHTLEEKCGPKPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPLQEDTYVEVDLEHEWTVPSHMPFSKARWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGVVPQPPPSTPATTEITTTPERPRRVIPGLPDGRFHLPPRIHRASDPGLPAEEPKEKPPRKVVEPELMGTPDGPCYPAPPVPRQASPQNLGSSGLLHPQMSPLLHSLVGQHILSVKQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVIVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSLRYVAPPSLRMPPSVRDFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSVQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLGRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAALVLEDG ------CCEEEECCC		-
64	Phosphorylation	IGNYGIPSDEEDEFG CCCCCCCCCCCCCCC		26745281
73	Phosphorylation	EEDEFGLSKWFESSE CCCCCCHHHHHCCCC		26745281
133	Phosphorylation	KKLREQGSLLGKLVQ HHHHHHCCHHHHHHH		29176673
163	Phosphorylation	RPLAPEVSIKTPRVF CCCCCCCCCCCCCCC		29176673
186	Acetylation	CALDCGLKYNQIRCL EEECCCCCHHHHHHH		22826441
344	Phosphorylation	PEHRAGPSDMELLFD HHHCCCCCHHHHHHH		22345495
356	Phosphorylation	LFDVFLETVREAAAG HHHHHHHHHHHHHCC		22345495
369	Phosphorylation	AGNIGGQTVRERLAQ CCCCCCHHHHHHHHH		22345495
414	Phosphorylation	GQAGEFDYSGSQAIK CCCCCCCCCHHHHHH		23140645
415	Phosphorylation	QAGEFDYSGSQAIKA CCCCCCCCHHHHHHH		23140645
417	Phosphorylation	GEFDYSGSQAIKALK CCCCCCHHHHHHHHH		23140645
456	Phosphorylation	KVYFLPITLHYVTQV EEEEEEHHHHHHHHH		-
688	Phosphorylation	IEVNARLSRSSALAS EEEECEECCHHHHHH		23984901
690	Phosphorylation	VNARLSRSSALASKA EECEECCHHHHHHHC		23984901
691	Phosphorylation	NARLSRSSALASKAT ECEECCHHHHHHHCC		23984901
695	Phosphorylation	SRSSALASKATGYPL CCHHHHHHHCCCCCH		23984901
696	Acetylation	RSSALASKATGYPLA CHHHHHHHCCCCCHH		-
696	Ubiquitination	RSSALASKATGYPLA CHHHHHHHCCCCCHH		22790023
698	Phosphorylation	SALASKATGYPLAYV HHHHHHCCCCCHHHH		-
747	Acetylation	IPRWDLSKFLRVSTK ECCCCHHHHHHHHHH		-
752	Phosphorylation	LSKFLRVSTKIGSCM HHHHHHHHHHHHHHH		29176673
753	Phosphorylation	SKFLRVSTKIGSCMK HHHHHHHHHHHHHHH		29176673
760	Ubiquitination	TKIGSCMKSVGEVMG HHHHHHHHHHHHHHC		22790023
771	Phosphorylation	EVMGIGRSFEEAFQK HHHCCCCCHHHHHHH		27149854
778	Ubiquitination	SFEEAFQKALRMVDE CHHHHHHHHHHHHHH		22790023
867	Ubiquitination	QDLLHQAKCLGFSDK HHHHHHHHHCCCCHH		22790023
978	Phosphorylation	MVNYNPETVSTDYDM EECCCCCCCCCCHHH		-
980	Phosphorylation	NYNPETVSTDYDMCD CCCCCCCCCCHHHCC		-
981	Phosphorylation	YNPETVSTDYDMCDR CCCCCCCCCHHHCCC		-
983	Phosphorylation	PETVSTDYDMCDRLY CCCCCCCHHHCCCEE		-
1037	Phosphorylation	QQCRVLGTSPEAIDS HHHHHHCCCHHHHHH		30635358
1038	Phosphorylation	QCRVLGTSPEAIDSA HHHHHCCCHHHHHHH		26824392
1112	Phosphorylation	GDLERFLSSAAAVSK CCHHHHHHHHHHHCC		29176673
1113	Phosphorylation	DLERFLSSAAAVSKE CHHHHHHHHHHHCCC		29176673
1228	Ubiquitination	RSFPFVSKTLGVDLV CCCCCCCCCCCCCHH		-
1228	Acetylation	RSFPFVSKTLGVDLV CCCCCCCCCCCCCHH		23864654
1239	Phosphorylation	VDLVALATRIIMGEK CCHHHHHHHHHCCCC		-
1246	Acetylation	TRIIMGEKVEPVGLM HHHHCCCCCEEEEEE		23236377
1267	Phosphorylation	GVKVPQFSFSRLAGA EEECCCCCHHHHCCC		29176673
1269	Phosphorylation	KVPQFSFSRLAGADV ECCCCCHHHHCCCCE		29176673
1309	Succinylation	AMLSTGFKIPEKNIL HHHHCCCCCCCCCEE		23806337
1309	Acetylation	AMLSTGFKIPEKNIL HHHHCCCCCCCCCEE		23806337
1325	Acetylation	TIGSYKNKSELLPTV EEECCCCHHHHHHHH		23806337
1325	Succinylation	TIGSYKNKSELLPTV EEECCCCHHHHHHHH		23806337
1340	Phosphorylation	RLLESLGYSLYASLG HHHHHHCCHHHHCCC		21183079
1343	Phosphorylation	ESLGYSLYASLGTAD HHHCCHHHHCCCCCC		21183079
1348	Phosphorylation	SLYASLGTADFYTEH HHHHCCCCCCHHHHC		21183079
1406	Phosphorylation	GAGGRRLSSFVTKGY CCCCCCHHHHHCCCH		26824392
1407	Phosphorylation	AGGRRLSSFVTKGYR CCCCCHHHHHCCCHH		25168779
1410	Phosphorylation	RRLSSFVTKGYRTRR CCHHHHHCCCHHHCC		25777480
1411	Acetylation	RLSSFVTKGYRTRRL CHHHHHCCCHHHCCC		-
1411	Malonylation	RLSSFVTKGYRTRRL CHHHHHCCCHHHCCC		26320211
1556	Carboxylation	AGSAAGLKLYLNETF CCCHHHHHHHHCCCC		-
1556	N6-carboxylysine	AGSAAGLKLYLNETF CCCHHHHHHHHCCCC		-
1724	Phosphorylation	AVSEGRLSLDDLLQR HHHCCCCCHHHHHHH		-
1823	Phosphorylation	VVPQPPPSTPATTEI CCCCCCCCCCCCCEE		25159016
1824	Phosphorylation	VPQPPPSTPATTEIT CCCCCCCCCCCCEEE		21149613
1827	Phosphorylation	PPPSTPATTEITTTP CCCCCCCCCEEECCC		23684622
1828	Phosphorylation	PPSTPATTEITTTPE CCCCCCCCEEECCCC		21149613
1831	Phosphorylation	TPATTEITTTPERPR CCCCCEEECCCCCCC		25168779
1832	Phosphorylation	PATTEITTTPERPRR CCCCEEECCCCCCCC		25168779
1833	Phosphorylation	ATTEITTTPERPRRV CCCEEECCCCCCCCC		22942356
1859	Phosphorylation	PPRIHRASDPGLPAE CCCCCCCCCCCCCCC		27087446
1884	Phosphorylation	VEPELMGTPDGPCYP CCHHHCCCCCCCCCC		24453211
1900	Phosphorylation	PPVPRQASPQNLGSS CCCCCCCCCCCCCCC		26824392
1906	Phosphorylation	ASPQNLGSSGLLHPQ CCCCCCCCCCCCCCC		26745281
1907	Phosphorylation	SPQNLGSSGLLHPQM CCCCCCCCCCCCCCH		26745281
1915	Phosphorylation	GLLHPQMSPLLHSLV CCCCCCHHHHHHHHH		26745281
1920	Phosphorylation	QMSPLLHSLVGQHIL CHHHHHHHHHHHHHC		18846507
1928	Phosphorylation	LVGQHILSVKQFTKD HHHHHHCCEEECCHH		18846507
1938	Phosphorylation	QFTKDQMSHLFNVAH ECCHHHHHHHHHHHH		25521595
1956	Phosphorylation	MMVQKERSLDILKGK HHHHHHHHHHHHCCC		28973931
1973	Phosphorylation	ASMFYEVSTRTSSSF HHEEEECCCCCCHHH		23567750
2010	Phosphorylation	KGESLADSVQTMSCY CCCCHHHHHHHHHEE		28494245
2089	Phosphorylation	KHGRTVHSLACLLTQ CCCCCHHHHHHHHHC		-
2103	Phosphorylation	QYRVSLRYVAPPSLR CCCCEEEECCCCHHC		20139300
2108	Phosphorylation	LRYVAPPSLRMPPSV EEECCCCHHCCCCHH		20139300
2114	Phosphorylation	PSLRMPPSVRDFVAS CHHCCCCHHHHHHHC		20139300
2131	O-linked_Glycosylation	TKQEEFESIEEALPD CCHHHHHHHHHHCCC		55411475

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
456	T	Phosphorylation	Kinase	MAPK1	P63085	Uniprot
1406	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1406	S	Phosphorylation	Phosphorylation at Ser-1406 reduces sensitivity to feedback inhibition by UTP (By similarity).	-
1859	S	Phosphorylation	Phosphorylation at Ser-1859 by RPS6KB1 downstream of MTOR promotes oligomerization and stimulates dihydroorotase activity.	21183079

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PYR1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PYR1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.