dbPTM

GRDN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GRDN_MOUSE
UniProt AC	Q5SNZ0
Protein Name	Girdin
Gene Name	Ccdc88a
Organism	Mus musculus (Mouse).
Sequence Length	1873
Subcellular Localization	Membrane . Cell membrane . Cytoplasm, cytosol . Cytoplasmic vesicle . Cell projection, lamellipodium . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localizes to the cell
Protein Description	Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. [PubMed: 19778506 Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself]
Protein Sequence	MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKSESQRVNKKVNNDASLRIHNLSILVKQIKFYYQETLQQLIMMPLPDILIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIEKIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMVSHLRRLIDERDEHSETIVELSEERDGVHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQIEVELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESELSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELAEAPQKSLGHEVNELTSSKLLKLEMENQSLTKTVEELRSTADSAAGSTSKILKVEKENQRLNKKVEILENEIIQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETCGKLSKIEFEKRQMKKELELYKEKGERAEELENELNHLGKENELLQKKITNLKITCEKLETLEQENSELERENRKFKKTLDSFKNLTFQLESLEKENSQLDEENLELRRSVESLKCASMRMAQLQLENKELESEKEQLRKGLELMRASFKKTERLEVSYQGLDTENQRLQKALENSNKKIQQLESELQDLEMENQTLQKSLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLFKEINVYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRHELKTVKKNYEALKQRQDEERMVQSSIPVSGEDDKWGRESQEATRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESIMKEREDLKSLYDALIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHKDLEDRYNQLLKQKGQLEDLEKMIKTEQEKMLLESKNHEVVASEYKKLCGENDRLNYTYSQLLKETEILQMDHKNLKSVLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLAGGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAAFRSKQLVNNKDTTSFEDISPQGISDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNIQSRPQSHSSGDFSLLHDHETWSSSGSSPIQYLKRQTRSSPMLQHKISETIESRAHHKMKAGSPGSEVVTLQQFLEESNKLTSIQLKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCTLARSVSGKTPGDFYDRRTTKPEFLRTGPQKTEDAYTISSAGKPTPSTQGKIKLVKETSVSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLSKDSRLPVSVDSSPPTAGSSSTTASNVNKVQESRNSKSRSREQQSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Acetylation	ESQRVNKKVNNDASL HHHHHHHHCCCCHHH	45.02	6568759
228	Phosphorylation	VHFLPHASSSAQSPC CEECCCCCCCCCCCC	23.07	25619855
229	Phosphorylation	HFLPHASSSAQSPCG EECCCCCCCCCCCCC	30.40	25619855
230	Phosphorylation	FLPHASSSAQSPCGS ECCCCCCCCCCCCCC	28.03	25619855
233	Phosphorylation	HASSSAQSPCGSPGM CCCCCCCCCCCCCCC	23.13	27087446
237	Phosphorylation	SAQSPCGSPGMKRTE CCCCCCCCCCCCCCC	25.62	27087446
243	Phosphorylation	GSPGMKRTESRQHLS CCCCCCCCCCCCHHH	32.56	26643407
245	Phosphorylation	PGMKRTESRQHLSVE CCCCCCCCCCHHHHH	36.31	26643407
250	Phosphorylation	TESRQHLSVELADAK CCCCCHHHHHHHHHH	16.06	29899451
440	Phosphorylation	LEQISRTSELAEAPQ HHHHHCHHHHHHHHH	29.51	22942356
449	Phosphorylation	LAEAPQKSLGHEVNE HHHHHHHHHCHHHHH	34.04	26824392
481	Phosphorylation	KTVEELRSTADSAAG HHHHHHHHHCHHCCC	40.34	-
482	Phosphorylation	TVEELRSTADSAAGS HHHHHHHHCHHCCCC	28.22	-
491	Phosphorylation	DSAAGSTSKILKVEK HHCCCCHHHHHHHHH	21.28	-
799	Phosphorylation	ENQTLQKSLEELKIS HHHHHHHHHHHHHHC	28.22	27149854
884	Ubiquitination	KESCVRLKELEKENK HHHHHHHHHHHHHCH	50.08	-
954	Phosphorylation	QSTDDSRYKLLESKL CCCCHHHHHHHHHHH	15.22	29514104
1019	Phosphorylation	DEERMVQSSIPVSGE HHHHHHHHCCCCCCC	20.87	24759943
1020	Phosphorylation	EERMVQSSIPVSGED HHHHHHHCCCCCCCC	17.51	24759943
1172	Phosphorylation	LLHERQASEYESLIS HHHHHHHHHHHHHHH	32.16	25338131
1359	Phosphorylation	FHVEQRQYIDKLNEL CHHHHHHHHHHHHHH	17.18	29514104
1384	Phosphorylation	IMDQYKFYDPSPPRR HHHHHCCCCCCCCCC	23.85	29514104
1387	Phosphorylation	QYKFYDPSPPRRRGN HHCCCCCCCCCCCCC	44.64	24925903
1415 (in isoform 3)	Phosphorylation	-	34.63	26643407
1417	Phosphorylation	INRERQKSLTLTPTR HCHHHHHCCEECCCC	20.46	25521595
1419	Phosphorylation	RERQKSLTLTPTRSD HHHHHCCEECCCCCC	35.36	28418008
1421	Phosphorylation	RQKSLTLTPTRSDSS HHHCCEECCCCCCCC	19.85	28066266
1423	Phosphorylation	KSLTLTPTRSDSSEG HCCEECCCCCCCCCC	37.25	28066266
1424 (in isoform 3)	Phosphorylation	-	39.40	26643407
1425	Phosphorylation	LTLTPTRSDSSEGFL CEECCCCCCCCCCCC	44.30	25293948
1426 (in isoform 3)	Phosphorylation	-	53.55	26643407
1427	Phosphorylation	LTPTRSDSSEGFLQL ECCCCCCCCCCCCCC	31.38	25293948
1427 (in isoform 3)	Phosphorylation	-	31.38	26643407
1428	Phosphorylation	TPTRSDSSEGFLQLP CCCCCCCCCCCCCCC	46.89	30372032
1439	Phosphorylation	LQLPHQDSQDSSSVG CCCCCCCCCCCCCCC	29.35	25293948
1442	Phosphorylation	PHQDSQDSSSVGSNS CCCCCCCCCCCCCCC	19.51	25293948
1443	Phosphorylation	HQDSQDSSSVGSNSL CCCCCCCCCCCCCCC	37.01	25293948
1444	Phosphorylation	QDSQDSSSVGSNSLE CCCCCCCCCCCCCCC	34.15	25293948
1447	Phosphorylation	QDSSSVGSNSLEDGQ CCCCCCCCCCCCCCC	22.53	25293948
1449	Phosphorylation	SSSVGSNSLEDGQTL CCCCCCCCCCCCCCC	34.53	25293948
1455	Phosphorylation	NSLEDGQTLGTKKSS CCCCCCCCCCCCHHH	32.46	25293948
1462	Phosphorylation	TLGTKKSSMVALKRL CCCCCHHHHHHHHCC	26.59	29899451
1470 (in isoform 2)	Phosphorylation	-	30.20	26643407
1479 (in isoform 2)	Phosphorylation	-	66.43	26643407
1481 (in isoform 2)	Phosphorylation	-	48.30	26643407
1482 (in isoform 2)	Phosphorylation	-	4.82	26643407
1489	Phosphorylation	MKACYRRSMSMNDLV HHHHHHHCCCHHHHH	13.25	29899451
1498	Phosphorylation	SMNDLVQSMVLAGGQ CHHHHHHHHHHCCCC	11.90	29899451
1509	Phosphorylation	AGGQWTGSTENLEVP CCCCCCCCCCCCCCC	25.77	29899451
1560	Phosphorylation	QLVNNKDTTSFEDIS CCCCCCCCCCHHHCC	26.42	15345747
1561	Phosphorylation	LVNNKDTTSFEDISP CCCCCCCCCHHHCCC	41.36	26824392
1562	Phosphorylation	VNNKDTTSFEDISPQ CCCCCCCCHHHCCCC	28.82	25521595
1567	Phosphorylation	TTSFEDISPQGISDD CCCHHHCCCCCCCCC	24.40	25619855
1572	Phosphorylation	DISPQGISDDSSTGS HCCCCCCCCCCCCCC	42.04	25777480
1575	Phosphorylation	PQGISDDSSTGSRVH CCCCCCCCCCCCCEE	34.49	25777480
1576	Phosphorylation	QGISDDSSTGSRVHA CCCCCCCCCCCCEEE	43.72	25777480
1577	Phosphorylation	GISDDSSTGSRVHAS CCCCCCCCCCCEEEC	43.03	25777480
1579	Phosphorylation	SDDSSTGSRVHASRP CCCCCCCCCEEECCC	31.08	25777480
1584	Phosphorylation	TGSRVHASRPASLDS CCCCEEECCCCCCCC	24.74	26824392
1588	Phosphorylation	VHASRPASLDSGRTS EEECCCCCCCCCCCC	35.08	26824392
1591	Phosphorylation	SRPASLDSGRTSTSN CCCCCCCCCCCCCCC	35.15	25619855
1594	Phosphorylation	ASLDSGRTSTSNSNN CCCCCCCCCCCCCCC	39.62	25338131
1595	Phosphorylation	SLDSGRTSTSNSNNN CCCCCCCCCCCCCCC	28.60	25338131
1596	Phosphorylation	LDSGRTSTSNSNNNA CCCCCCCCCCCCCCC	31.17	25338131
1597	Phosphorylation	DSGRTSTSNSNNNAS CCCCCCCCCCCCCCC	37.72	25338131
1599	Phosphorylation	GRTSTSNSNNNASLH CCCCCCCCCCCCCCC	40.48	25338131
1604	Phosphorylation	SNSNNNASLHEVKAG CCCCCCCCCCEEEEC	32.17	27841257
1617	Phosphorylation	AGAVNIQSRPQSHSS ECCEECCCCCCCCCC	41.97	26643407
1621	Phosphorylation	NIQSRPQSHSSGDFS ECCCCCCCCCCCCCC	28.19	26643407
1623	Phosphorylation	QSRPQSHSSGDFSLL CCCCCCCCCCCCCEE	41.06	26643407
1624	Phosphorylation	SRPQSHSSGDFSLLH CCCCCCCCCCCCEEE	36.64	26643407
1625	Phosphorylation	RPQSHSSGDFSLLHD CCCCCCCCCCCEEEC	42.89	24719451
1628	Phosphorylation	SHSSGDFSLLHDHET CCCCCCCCEEECCCC	34.46	26643407
1646	Phosphorylation	SGSSPIQYLKRQTRS CCCCHHHHHHHHCCC	18.21	29514104
1649	Phosphorylation	SPIQYLKRQTRSSPM CHHHHHHHHCCCCHH	40.27	24719451
1651	Phosphorylation	IQYLKRQTRSSPMLQ HHHHHHHCCCCHHHH	36.23	25338131
1653	Phosphorylation	YLKRQTRSSPMLQHK HHHHHCCCCHHHHHH	42.03	24453211
1654	Phosphorylation	LKRQTRSSPMLQHKI HHHHCCCCHHHHHHH	15.84	24453211
1662	Phosphorylation	PMLQHKISETIESRA HHHHHHHHHHHHHHH	33.23	22817900
1667	Phosphorylation	KISETIESRAHHKMK HHHHHHHHHHHHHHC	30.80	29895711
1677	Phosphorylation	HHKMKAGSPGSEVVT HHHHCCCCCCHHHHH	30.83	24925903
1680	Phosphorylation	MKAGSPGSEVVTLQQ HCCCCCCHHHHHHHH	30.51	24925903
1684	Phosphorylation	SPGSEVVTLQQFLEE CCCHHHHHHHHHHHH	24.83	25619855
1692	Phosphorylation	LQQFLEESNKLTSIQ HHHHHHHCCCCCCEE	29.86	25619855
1702	Phosphorylation	LTSIQLKSSSQENLL CCCEEECCCCCCHHH	43.76	24925903
1703	Phosphorylation	TSIQLKSSSQENLLD CCEEECCCCCCHHHH	34.16	24925903
1704	Phosphorylation	SIQLKSSSQENLLDE CEEECCCCCCHHHHH	48.91	25521595
1715	Phosphorylation	LLDEVMKSLSVSSDF HHHHHHHHCCCCHHH	14.05	25777480
1717	Phosphorylation	DEVMKSLSVSSDFLG HHHHHHCCCCHHHCC	27.35	24453211
1719	Phosphorylation	VMKSLSVSSDFLGKD HHHHCCCCHHHCCCC	22.33	25521595
1720	Phosphorylation	MKSLSVSSDFLGKDK HHHCCCCHHHCCCCC	30.17	26745281
1736	Phosphorylation	VSCTLARSVSGKTPG CEEEEECCCCCCCCC	18.28	25777480
1738	Phosphorylation	CTLARSVSGKTPGDF EEEECCCCCCCCCCC	35.50	26239621
1741	Phosphorylation	ARSVSGKTPGDFYDR ECCCCCCCCCCCCCC	35.71	25777480
1767	Phosphorylation	PQKTEDAYTISSAGK CCCCCCCEEECCCCC	19.54	18563927
1768	Phosphorylation	QKTEDAYTISSAGKP CCCCCCEEECCCCCC	18.99	25338131
1771	Phosphorylation	EDAYTISSAGKPTPS CCCEEECCCCCCCCC	36.87	22871156
1778	Phosphorylation	SAGKPTPSTQGKIKL CCCCCCCCCCCCEEE	35.52	22871156
1779	Phosphorylation	AGKPTPSTQGKIKLV CCCCCCCCCCCEEEE	42.41	22871156
1789	Phosphorylation	KIKLVKETSVSRQSK CEEEEEEECCCCCCC	28.80	29514104
1790	Phosphorylation	IKLVKETSVSRQSKD EEEEEEECCCCCCCC	21.13	29514104
1792	Phosphorylation	LVKETSVSRQSKDSN EEEEECCCCCCCCCC	25.11	21189417
1794	Phosphorylation	KETSVSRQSKDSNPY EEECCCCCCCCCCCC	47.53	24719451
1795	Phosphorylation	ETSVSRQSKDSNPYA EECCCCCCCCCCCCC	37.00	25338131
1798	Phosphorylation	VSRQSKDSNPYATLP CCCCCCCCCCCCCCC	43.36	29514104
1801	Phosphorylation	QSKDSNPYATLPRAS CCCCCCCCCCCCCCH	19.23	25619855
1803	Phosphorylation	KDSNPYATLPRASSV CCCCCCCCCCCCHHH	31.30	25619855
1808	Phosphorylation	YATLPRASSVISTAE CCCCCCCHHHHHCCC	26.81	29176673
1809	Phosphorylation	ATLPRASSVISTAEG CCCCCCHHHHHCCCC	23.61	25521595
1812	Phosphorylation	PRASSVISTAEGTTR CCCHHHHHCCCCCCC	21.29	29176673
1813	Phosphorylation	RASSVISTAEGTTRR CCHHHHHCCCCCCCC	20.01	29176673
1821	Phosphorylation	AEGTTRRTSIHDFLS CCCCCCCCCHHHHHC	28.83	25521595
1822	Phosphorylation	EGTTRRTSIHDFLSK CCCCCCCCHHHHHCC	19.00	26824392
1828	Phosphorylation	TSIHDFLSKDSRLPV CCHHHHHCCCCCCCE	34.12	28725479
1831	Phosphorylation	HDFLSKDSRLPVSVD HHHHCCCCCCCEEEC	39.18	25619855
1836	Phosphorylation	KDSRLPVSVDSSPPT CCCCCCEEECCCCCC	20.47	25619855
1839	Phosphorylation	RLPVSVDSSPPTAGS CCCEEECCCCCCCCC	42.46	25619855
1840	Phosphorylation	LPVSVDSSPPTAGSS CCEEECCCCCCCCCC	30.36	15345747
1843	Phosphorylation	SVDSSPPTAGSSSTT EECCCCCCCCCCCCC	47.21	25619855
1846	Phosphorylation	SSPPTAGSSSTTASN CCCCCCCCCCCCHHH	20.74	25619855
1847	Phosphorylation	SPPTAGSSSTTASNV CCCCCCCCCCCHHHH	30.68	25619855
1848	Phosphorylation	PPTAGSSSTTASNVN CCCCCCCCCCHHHHH	31.32	25619855
1849	Phosphorylation	PTAGSSSTTASNVNK CCCCCCCCCHHHHHH	28.47	25619855
1850	Phosphorylation	TAGSSSTTASNVNKV CCCCCCCCHHHHHHH	30.00	25619855
1852	Phosphorylation	GSSSTTASNVNKVQE CCCCCCHHHHHHHHH	38.94	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1417	S	Phosphorylation	Kinase	AKT1	P31750	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
1417	S	Phosphorylation	-
Tyrosine phosphorylation is required for AKT1-dependent phosphorylation of Ser-1417 (By similarity).
1692	S	Phosphorylation	-
Phosphorylation at Ser-1692 by PRKCQ disrupts interaction with GNAI3 and inhibits guanine nucleotide exchange factor activity (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GRDN_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
AKT1_MOUSE	Akt1	physical	15753085
AKT2_MOUSE	Akt2	physical	15753085

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GRDN_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1560; THR-1561;SER-1562; SER-1677; SER-1704 AND SER-1840, AND MASS SPECTROMETRY.	15345747 [Abstract]

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