SPAS2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPAS2_MOUSE
• UniProt AC: Q8K1N4
• Protein Name: Spermatogenesis-associated serine-rich protein 2
• Gene Name: Spats2
• Organism: Mus musculus (Mouse).
• Sequence Length: 545
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MSRKQSQKDSSGFIFDLQSNTVLAQGGTFENMKEKINAVRAIVPNKSNNEIILVLQHFDNCVDKTVQAFMEGSASEVLKEWIVTGKKKNKKKKSKPKPASEASGSAPDSSKSAPIQEEQPASSEKGSINGYHVNGAINDAESVDSLSEGLETLSIDARELEDPEFAAAETLDRTGSVLENGVSDFEPKSLTAHSISNVQQSRNAAKSLSRTTPGAQVSNLGMENVPLSSTNKKLGSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELQSCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTDVAVRMSEEQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKQSIDSFGQVSHPKNSYSTRSRCSLVAPVSLSGPSDGSAASSSPDASVPSLPGANKRNCAPREASAAMTNSSDRPCQAHREVFPGNRRGGQGYRAQSQKTADPSNPGRHDSVGRYRNSSWYSSGPRYQGVPPQAPGNAGERSRPYSAGTNGTGAISEPSPPKPSFKKGLPQRKPRASQAEAANS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
94	Phosphorylation	KKNKKKKSKPKPASE CCCCCCCCCCCCHHH	64.17	25338131
100	Phosphorylation	KSKPKPASEASGSAP CCCCCCHHHCCCCCC	42.07	25338131
122	Phosphorylation	IQEEQPASSEKGSIN CCCCCCCCCCCCCCC	45.79	25619855
123	Phosphorylation	QEEQPASSEKGSING CCCCCCCCCCCCCCC	45.49	25619855
127	Phosphorylation	PASSEKGSINGYHVN CCCCCCCCCCCEEEC	24.77	25293948
131	Phosphorylation	EKGSINGYHVNGAIN CCCCCCCEEECCCCC	9.71	25293948
142	Phosphorylation	GAINDAESVDSLSEG CCCCCHHHHHHHHHC	32.70	27087446
145	Phosphorylation	NDAESVDSLSEGLET CCHHHHHHHHHCCEE	31.47	21659605
147	Phosphorylation	AESVDSLSEGLETLS HHHHHHHHHCCEEEE	33.30	22817900
174	Phosphorylation	AAETLDRTGSVLENG HHHHHCHHCCHHHCC	33.21	26643407
176	Phosphorylation	ETLDRTGSVLENGVS HHHCHHCCHHHCCCC	23.94	26643407
189	Phosphorylation	VSDFEPKSLTAHSIS CCCCCCCCCCHHHHH	41.49	22817900
191	Phosphorylation	DFEPKSLTAHSISNV CCCCCCCCHHHHHHH	29.43	22817900
194	Phosphorylation	PKSLTAHSISNVQQS CCCCCHHHHHHHHHH	25.83	26643407
196	Phosphorylation	SLTAHSISNVQQSRN CCCHHHHHHHHHHHH	33.68	23984901
207	Phosphorylation	QSRNAAKSLSRTTPG HHHHHHHHHHCCCCC	27.18	26643407
209	Phosphorylation	RNAAKSLSRTTPGAQ HHHHHHHHCCCCCCC	34.37	26643407
211	Phosphorylation	AAKSLSRTTPGAQVS HHHHHHCCCCCCCCC	33.69	26643407
212	Phosphorylation	AKSLSRTTPGAQVSN HHHHHCCCCCCCCCC	20.72	26643407
218	Phosphorylation	TTPGAQVSNLGMENV CCCCCCCCCCCCCCC	17.79	26643407
336	Acetylation	VELRADIKHFVSERK HHHHHHHHHHHHHCC	31.38	7627985
346 (in isoform 2)	Phosphorylation	-	52.63	22871156
361 (in isoform 2)	Phosphorylation	-	2.77	22871156
382	Phosphorylation	KNSYSTRSRCSLVAP CCCCCCCCCEEEEEE	37.41	25619855
385	Phosphorylation	YSTRSRCSLVAPVSL CCCCCCEEEEEEEEC	25.43	25619855
391	Phosphorylation	CSLVAPVSLSGPSDG EEEEEEEECCCCCCC	18.76	25619855
393	Phosphorylation	LVAPVSLSGPSDGSA EEEEEECCCCCCCCC	40.94	26643407
396	Phosphorylation	PVSLSGPSDGSAASS EEECCCCCCCCCCCC	59.12	25777480
399	Phosphorylation	LSGPSDGSAASSSPD CCCCCCCCCCCCCCC	26.17	25777480
402	Phosphorylation	PSDGSAASSSPDASV CCCCCCCCCCCCCCC	30.94	25777480
403	Phosphorylation	SDGSAASSSPDASVP CCCCCCCCCCCCCCC	40.96	26643407
404	Phosphorylation	DGSAASSSPDASVPS CCCCCCCCCCCCCCC	25.05	26643407
408	Phosphorylation	ASSSPDASVPSLPGA CCCCCCCCCCCCCCC	41.77	25777480
411	Phosphorylation	SPDASVPSLPGANKR CCCCCCCCCCCCCCC	45.07	25777480
426	Phosphorylation	NCAPREASAAMTNSS CCCCHHHHHHHCCCC	16.29	26824392
430	Phosphorylation	REASAAMTNSSDRPC HHHHHHHCCCCCCCC	27.50	28066266
458	Phosphorylation	GQGYRAQSQKTADPS CCCCCCCCCCCCCCC	32.43	27149854
460	Ubiquitination	GYRAQSQKTADPSNP CCCCCCCCCCCCCCC	51.43	-
465	Phosphorylation	SQKTADPSNPGRHDS CCCCCCCCCCCCCCC	57.09	25619855
472	Phosphorylation	SNPGRHDSVGRYRNS CCCCCCCCCCCCCCC	21.98	26824392
479	Phosphorylation	SVGRYRNSSWYSSGP CCCCCCCCCCHHCCC	17.16	26745281
480	Phosphorylation	VGRYRNSSWYSSGPR CCCCCCCCCHHCCCC	33.32	23684622
482	Phosphorylation	RYRNSSWYSSGPRYQ CCCCCCCHHCCCCCC	8.56	26643407
483	Phosphorylation	YRNSSWYSSGPRYQG CCCCCCHHCCCCCCC	23.66	26745281
484	Phosphorylation	RNSSWYSSGPRYQGV CCCCCHHCCCCCCCC	36.80	21743459
520	Phosphorylation	TGAISEPSPPKPSFK CCCCCCCCCCCCCCC	50.19	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPAS2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPAS2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPAS2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SPAS2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176, AND MASSSPECTROMETRY.
PubMed: 17242355