CLIP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLIP1_MOUSE
• UniProt AC: Q922J3
• Protein Name: CAP-Gly domain-containing linker protein 1
• Gene Name: Clip1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1391
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasmic vesicle membrane ; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle . Localizes to microtubule plus ends. Localizes preferentially to the ends of tyrosinated microtubules (PubMed
• Protein Description: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking..
• Protein Sequence: MSMLKPSGLKAPTKILKPGSTALKTPAAAAAPVEKTIPSEKASGPPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQAAPGRTASPLSTAAATMVSSSPATPSNIPHKPSQSTAKEPSATPQISNLTKTASESISNLSEAGSVKKGERELKVGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKAAAVRRVMAATPASLKRSPSASSLSSMSSVASSVSSKPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRAQEVAELRRRLESSKPPGDVDMSLSLLQEISALQEKLEAIHTDHQGEMTSLKEHFGAREEAFQKEIKALHTATEKLSKENESLRSKLDHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGIGTDSAEFAELKTQIERLRLDYQHEIESLQSKQDSERSAHAKEMETMQAKLMKIIKEKEDSLEAVKARLDSAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKYTEQSEVIGNFTSQLSAVKEKLLDLDALRKANSEGKLELETLRQQLEGAEKQIKNLETERNAESSKANSITKELQEKELVLTGLQDSLNQVNQVKETLEKELQTLKEKFASTSEEAVSAQTRMQDTVNKLHQKEEQFNVLSSELEKLRENLTDMEAKFKEKDDREDQLVKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERSVEELQLKLTKANENASFLQKSIGEVTLKAEQSQQQAARKHEEEKKELEEKLLELEKKMETSYNQCQDLKAKYEKASSETKTKHEEILQNLQKMLADTEDKLKAAQEANRDLMQDMEELKTQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNARLQNELDTLKENNLKTVEELNKSKELLSVENQKMEEFKKEIETLKQAAAQKSQQLSALQEENVKLAEELGRTRDEVTSHQKLEEERSVLNNQLLEMKKRESEFRKDADEEKASLQKSISLTSALLTEKDAELEKLRNEVTVLRGENATAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDAQAEEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGEDLNSYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRSEERPYCEICEMFGHWATNCNDDETF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSMLKPSGL ------CCCCCCCCC	44.09	29176673
20	Phosphorylation	TKILKPGSTALKTPA CCCCCCCCCCCCCCH	21.02	29176673
21	Phosphorylation	KILKPGSTALKTPAA CCCCCCCCCCCCCHH	41.76	29176673
43	Phosphorylation	TIPSEKASGPPSSET CCCCHHCCCCCCCCC	64.00	30635358
47	Phosphorylation	EKASGPPSSETQEEF HHCCCCCCCCCHHHH	43.89	25521595
48	Phosphorylation	KASGPPSSETQEEFV HCCCCCCCCCHHHHH	50.89	30635358
50	Phosphorylation	SGPPSSETQEEFVDD CCCCCCCCHHHHHHH	43.14	22942356
144	Phosphorylation	LQAAPGRTASPLSTA CCCCCCCCCCCHHHH	37.08	27742792
146	Phosphorylation	AAPGRTASPLSTAAA CCCCCCCCCHHHHHH	26.26	27742792
149	Phosphorylation	GRTASPLSTAAATMV CCCCCCHHHHHHHHH	21.27	25159016
150	O-linked_Glycosylation	RTASPLSTAAATMVS CCCCCHHHHHHHHHC	28.18	22517741
150	Phosphorylation	RTASPLSTAAATMVS CCCCCHHHHHHHHHC	28.18	25159016
154	Phosphorylation	PLSTAAATMVSSSPA CHHHHHHHHHCCCCC	17.24	25159016
157	Phosphorylation	TAAATMVSSSPATPS HHHHHHHCCCCCCCC	17.80	25777480
158	Phosphorylation	AAATMVSSSPATPSN HHHHHHCCCCCCCCC	29.00	25777480
159	Phosphorylation	AATMVSSSPATPSNI HHHHHCCCCCCCCCC	15.85	25777480
162	Phosphorylation	MVSSSPATPSNIPHK HHCCCCCCCCCCCCC	30.54	25777480
164	Phosphorylation	SSSPATPSNIPHKPS CCCCCCCCCCCCCCC	42.93	25777480
171	Phosphorylation	SNIPHKPSQSTAKEP CCCCCCCCCCCCCCC	41.38	25777480
173	Phosphorylation	IPHKPSQSTAKEPSA CCCCCCCCCCCCCCC	34.37	25777480
174	Phosphorylation	PHKPSQSTAKEPSAT CCCCCCCCCCCCCCC	33.83	25777480
179	Phosphorylation	QSTAKEPSATPQISN CCCCCCCCCCCCHHH	45.96	28066266
181	Phosphorylation	TAKEPSATPQISNLT CCCCCCCCCCHHHHC	21.77	28066266
185	Phosphorylation	PSATPQISNLTKTAS CCCCCCHHHHCHHHH	22.12	28066266
190	Phosphorylation	QISNLTKTASESISN CHHHHCHHHHHHHHC	30.13	27087446
192	Phosphorylation	SNLTKTASESISNLS HHHCHHHHHHHHCHH	36.79	27742792
194	Phosphorylation	LTKTASESISNLSEA HCHHHHHHHHCHHHC	28.90	27087446
196	Phosphorylation	KTASESISNLSEAGS HHHHHHHHCHHHCCC	40.78	27087446
199	Phosphorylation	SESISNLSEAGSVKK HHHHHCHHHCCCCCC	29.65	27087446
203	Phosphorylation	SNLSEAGSVKKGERE HCHHHCCCCCCCCCE	37.50	27087446
284	Phosphorylation	VTKIGFPSTTPAKAK EEECCCCCCCHHHHH	42.52	26745281
285	Phosphorylation	TKIGFPSTTPAKAKA EECCCCCCCHHHHHH	36.72	26643407
286	Phosphorylation	KIGFPSTTPAKAKAA ECCCCCCCHHHHHHH	26.11	26745281
302	Phosphorylation	VRRVMAATPASLKRS HHHHHHCCHHHHCCC	15.17	28066266
305	Phosphorylation	VMAATPASLKRSPSA HHHCCHHHHCCCCCC	35.31	26824392
309	Phosphorylation	TPASLKRSPSASSLS CHHHHCCCCCCHHHH	22.94	28725479
311	Phosphorylation	ASLKRSPSASSLSSM HHHCCCCCCHHHHHH	41.87	27742792
313	Phosphorylation	LKRSPSASSLSSMSS HCCCCCCHHHHHHHH	35.83	27742792
314	Phosphorylation	KRSPSASSLSSMSSV CCCCCCHHHHHHHHH	31.80	27742792
316	Phosphorylation	SPSASSLSSMSSVAS CCCCHHHHHHHHHHH	26.41	25619855
317	Phosphorylation	PSASSLSSMSSVASS CCCHHHHHHHHHHHH	28.16	25619855
318	Oxidation	SASSLSSMSSVASSV CCHHHHHHHHHHHHC	2.88	17242355
319	Phosphorylation	ASSLSSMSSVASSVS CHHHHHHHHHHHHCC	24.49	25619855
320	Phosphorylation	SSLSSMSSVASSVSS HHHHHHHHHHHHCCC	17.04	25619855
323	Phosphorylation	SSMSSVASSVSSKPS HHHHHHHHHCCCCCC	29.17	25619855
324	Phosphorylation	SMSSVASSVSSKPSR HHHHHHHHCCCCCCC	19.11	25619855
326	Phosphorylation	SSVASSVSSKPSRTG HHHHHHCCCCCCCCC	34.29	26643407
327	Phosphorylation	SVASSVSSKPSRTGL HHHHHCCCCCCCCCC	46.56	26643407
330	Phosphorylation	SSVSSKPSRTGLLTE HHCCCCCCCCCCCCH	46.33	25619855
338	Phosphorylation	RTGLLTETSSRYARK CCCCCCHHHHHHHHH	27.11	29176673
339	Phosphorylation	TGLLTETSSRYARKI CCCCCHHHHHHHHHH	13.44	29176673
340	Phosphorylation	GLLTETSSRYARKIS CCCCHHHHHHHHHHH	36.41	29176673
347	Phosphorylation	SRYARKISGTTALQE HHHHHHHHCHHHHHH	32.87	26824392
349	Phosphorylation	YARKISGTTALQEAL HHHHHHCHHHHHHHH	11.34	26824392
350	Phosphorylation	ARKISGTTALQEALK HHHHHCHHHHHHHHH	28.97	27742792
414	Phosphorylation	AKMDQLRTMVEAADR HHHHHHHHHHHHHHH	33.87	21183079
460	Phosphorylation	DLEVATVSEKSRIME CEEEEECCCHHHHHH	34.65	26026062
463	Phosphorylation	VATVSEKSRIMELEK EEECCCHHHHHHHHH	24.00	22942356
552	Phosphorylation	HTATEKLSKENESLR HHHHHHHHHHCHHHH	49.33	23737553
557	Phosphorylation	KLSKENESLRSKLDH HHHHHCHHHHHHHHH	40.44	23737553
586	Phosphorylation	KLETAIASHQQAMEE HHHHHHHHHHHHHHH	18.73	25338131
662	Phosphorylation	IIKEKEDSLEAVKAR HHHHHHHHHHHHHHH	29.24	29899451
672	Phosphorylation	AVKARLDSAEDQHLV HHHHHHHCHHHHHHH	37.84	25521595
684	Phosphorylation	HLVEMEDTLNKLQEA HHHHHHHHHHHHHHH	20.94	21183079
723	Ubiquitination	TSQLSAVKEKLLDLD HHHHHHHHHHHCCHH	49.17	-
817	Phosphorylation	KEKFASTSEEAVSAQ HHHHCCCCHHHHHHH	30.83	21454597
822	Phosphorylation	STSEEAVSAQTRMQD CCCHHHHHHHHHHHH	23.00	21454597
825	Phosphorylation	EEAVSAQTRMQDTVN HHHHHHHHHHHHHHH	28.02	21454597
874	Acetylation	DREDQLVKAKEKLEN CHHHHHHHHHHHHHH	63.43	19852181
890	Phosphorylation	IAEIMKMSGDNSSQL HHHHHHHHCCCHHHH	37.16	19131326
910	Phosphorylation	ELRLKERSVEELQLK HHHHHHHCHHHHHHH	34.67	21183079
919	Phosphorylation	EELQLKLTKANENAS HHHHHHHHHHHCCHH	26.90	28059163
931	Phosphorylation	NASFLQKSIGEVTLK CHHHHHHHHHHHHHH	23.90	21743459
1029	Acetylation	MQDMEELKTQADKAK HHHHHHHHHHHHHHH	41.70	6566133
1052	Phosphorylation	MQIMEQMTKEKTETL HHHHHHHHHHHHHHH	35.43	26026062
1058	Phosphorylation	MTKEKTETLASLEDT HHHHHHHHHHCHHHH	32.62	29899451
1061	Phosphorylation	EKTETLASLEDTKQT HHHHHHHCHHHHHHH	35.09	29899451
1078	Phosphorylation	RLQNELDTLKENNLK HHHHHHHHHHHCCCH	52.97	19854140
1171	Phosphorylation	LEMKKRESEFRKDAD HHHHHHHHHHHCCCH	46.17	21454597
1183	Phosphorylation	DADEEKASLQKSISL CCHHHHHHHHHHHHH	42.26	20415495
1187	Phosphorylation	EKASLQKSISLTSAL HHHHHHHHHHHHHHH	12.40	22324799
1189	Phosphorylation	ASLQKSISLTSALLT HHHHHHHHHHHHHHC	32.46	22324799
1191	Phosphorylation	LQKSISLTSALLTEK HHHHHHHHHHHHCCC	12.74	29899451
1192	Phosphorylation	QKSISLTSALLTEKD HHHHHHHHHHHCCCH	23.39	22324799
1196	Phosphorylation	SLTSALLTEKDAELE HHHHHHHCCCHHHHH	41.67	20415495
1255	Phosphorylation	KENKRQLSSSSGNTD HHHHHHHHCCCCCCC	21.60	25521595
1256	Phosphorylation	ENKRQLSSSSGNTDA HHHHHHHCCCCCCCH	36.80	30635358
1257	Phosphorylation	NKRQLSSSSGNTDAQ HHHHHHCCCCCCCHH	38.60	30635358
1258	Phosphorylation	KRQLSSSSGNTDAQA HHHHHCCCCCCCHHH	37.70	30635358
1261	Phosphorylation	LSSSSGNTDAQAEED HHCCCCCCCHHHHHH	35.92	30635358
1314	Phosphorylation	GNGEDLNSYDSDDQE CCCCCCCCCCCCHHH	37.30	27087446
1315	Phosphorylation	NGEDLNSYDSDDQEK CCCCCCCCCCCHHHH	20.56	29899451
1317	Phosphorylation	EDLNSYDSDDQEKQS CCCCCCCCCHHHHHH	34.55	27087446
1324	Phosphorylation	SDDQEKQSKKKPRLF CCHHHHHHHCCCCCE	58.47	27742792
1383	Phosphorylation	EMFGHWATNCNDDET HHHCCHHCCCCCCCC	34.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
311	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLIP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLIP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CLIP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-890, AND MASSSPECTROMETRY.
PubMed: 19131326

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194; SER-199 ANDSER-203, AND MASS SPECTROMETRY.
PubMed: 17242355

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, AND MASSSPECTROMETRY.
PubMed: 15345747