| UniProt ID | MYOME_MOUSE | |
|---|---|---|
| UniProt AC | Q80YT7 | |
| Protein Name | Myomegalin | |
| Gene Name | Pde4dip | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 2224 | |
| Subcellular Localization | Isoform 2: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton . Golgi apparatus . Associated with the microtubule network at the growing distal tip of microtubules. Targeting to the Golgi apparatus requires A | |
| Protein Description | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity).; Isoform 2: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression.. | |
| Protein Sequence | MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEVSREDVYKRNIELKVEVESLKRELQDRKQHLDKTWADAEDLNSQNEAELRRQVEERQQETEHVYELLGNKIQLLQEEPRLAKNEATEMETLVEAEKRCNLELSERWTNAAKNREDAAGDQEKPDQYSEALAQRDRRIEELRQSLAAQEGLVEQLSQEKRQLLHLLEEPASMEVQPVPKGLPTQQKPDLHETPTTQPPVSESHLAELQDKIQQTEATNKILQEKLNDLSCELKSAQESSQKQDTTIQSLKEMLKSRESETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGIAPAQQQVALLDLQSALFCSQLEIQRLQRLVRQKERQLADGKRCVQLVEAAAQEREHQKEAAWKHNQELRKALQHLQGELHSKSQQLHVLEAEKYNEIRTQGQNIQHLSHSLSHKEQLIQELQELLQYRDNADKTLDTNEVFLEKLRQRIQDRAVALERVIDEKFSALEEKDKELRQLRLAVRDRDHDLERLRCVLSANEATMQSMESLLRARGLEVEQLTATCQNLQWLKEELETKFGHWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEVAEELCQRLQRKERMLQDLLSDRNKQAVEHEMEIQGLLQSMGTREQERQAAAEKMVQAFMERNSELQALRQYLGGKELMTSSQTFISNQPAGVTSIGPHHGEQTDQGSMQMPSRDDSTSLTAREEASIPRSTLGDSDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAMQEEELQVQAADLESLTRNVQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVEPQGQEVSGNKRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAQPENSERDGTLQVELEGAQVLRTRLEEVLGRSLERLSRLESLAAIGGGELESVQAQEMLHLRAEIHQHLEEKRKAEVELKELKAQIEEAGFSSVSHISRNTMLSLCLENAELKEQMGEAMSDGWEVEEDKEKGEVMLETVVAKGCLNENSLQAEFRKVQGKLKSAYNIINLLKEQLLLRSSEGNSKEMPELLVRLAREVDRMNTGLPSLGKHQHQEQENTTTARPGSRPQSLPLGAALSVDGYQLENKSQAQDSGHQPEFSLPGSTKHLRSQLAQCRQRYQDLQEKLLISEATVFAQANQLEKYRAVFSESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNNLRPVVLMEGLCSEQGYLDPVLVSPPAKKPLENKPGKQEEFRAHGTPDDSSLLRKDIRDLKAQLQNANKVIQNLRSRVRSLSATSDYSSSLERPRKLRAVATLEGASPHSVTDEDEGWLSDGTGAFYPPGLQAKKDLESLIQRVSQLEAQLPKTGLEGKLAEELRCASWPGKYDSLIQDQARELSYLRQKIREGRGICYLLTQHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGGQLTERLTSKLSTKDHKSEKEEAGLEPLALRLSRELQEKEKVIEVLQAKLDTRSLSPPSSHAVSDSHRSASTTSFLSDDIEACSDMDVASEYTHYDEKKPSPSHSAASASQGLKGESSSSPISLPTPQNPPKEASQAHPGFHFHSIPKPASLSQTPMHSALPSFVPFSPSGPPLLGCCETPMVSLAEAQQELQMLQKQLGESVSIAPPASTSTLLSNQTEASSPHYINPAQPHTPTRSTIELGRILEPGYLGSSGQWDMMRPQKGSVSGELSSGSSMYQLNSKPTGADLLEEHLGEIRNLRQRLEESICVNDRLREQLQHRLSSTARENGSTSHFYSQGLESMPQLYNENRALREENQSLQTRLSHASRGHSQEVDHLREALLSSRSQLQELEKELEQQKAERQQLSLQSELQIYESLCENPKKALKAFSLDSCHQVPGELSCLVAEIRALRGQLEQSIEVNNRLRLQLEQQMDRGAGKASLGPIAVGQSFPDKAEPANLHQGSAASPPVRDVGLNSPAMVLPNSSCSAPGSDHAIVTRTNNELSSDDSAAMKNPPKLEVDATDGPFANKHGRHVIGHVDDYDALQQQIGEGKLLIQKILSLMRSARSIPGQEAQDTEAPGNISAHELRSSAKALNHALEESTSLLNMFWRAALPNTHGPVLVGKEGQLMEKELLDLRAQVSQQEQILQNTAARLKRANQRKKSMEQFIVSHLTRTHDVLKKARTNLEMKSFRALTCTPAL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 37 | Phosphorylation | EERMQQKYEVSREDV HHHHHHHCCCCHHHH | 19.75 | - | |
| 112 (in isoform 2) | Phosphorylation | - | 3.27 | 26643407 | |
| 114 (in isoform 2) | Phosphorylation | - | 70.68 | 26643407 | |
| 118 (in isoform 2) | Phosphorylation | - | 13.40 | 21183079 | |
| 178 (in isoform 2) | Phosphorylation | - | 3.81 | - | |
| 180 (in isoform 2) | Phosphorylation | - | 56.26 | 25367039 | |
| 193 (in isoform 2) | Phosphorylation | - | 35.67 | 29514104 | |
| 195 (in isoform 2) | Phosphorylation | - | 46.99 | 29514104 | |
| 214 (in isoform 2) | Phosphorylation | - | 4.23 | - | |
| 275 (in isoform 2) | Phosphorylation | - | 26.45 | - | |
| 287 (in isoform 2) | Acetylation | - | 46.45 | - | |
| 296 (in isoform 2) | Acetylation | - | 56.33 | - | |
| 305 (in isoform 2) | Phosphorylation | - | 56.73 | 28066266 | |
| 586 | Phosphorylation | IIQQLQTSLHDRNKE HHHHHHHHHHHCCHH | 15.67 | 24759943 | |
| 639 (in isoform 2) | Ubiquitination | - | 7.75 | - | |
| 705 | Phosphorylation | SNQPAGVTSIGPHHG HCCCCCCCEECCCCC | 17.44 | - | |
| 728 | Phosphorylation | QMPSRDDSTSLTARE CCCCCCCCCCCCHHH | 24.96 | 28066266 | |
| 729 | Phosphorylation | MPSRDDSTSLTAREE CCCCCCCCCCCHHHH | 34.45 | 28066266 | |
| 730 | Phosphorylation | PSRDDSTSLTAREEA CCCCCCCCCCHHHHH | 27.89 | 28066266 | |
| 732 | Phosphorylation | RDDSTSLTAREEASI CCCCCCCCHHHHHCC | 24.36 | 28066266 | |
| 738 | Phosphorylation | LTAREEASIPRSTLG CCHHHHHCCCHHHCC | 36.08 | 25338131 | |
| 742 | Phosphorylation | EEASIPRSTLGDSDT HHHCCCHHHCCCHHH | 23.72 | 29233185 | |
| 743 | Phosphorylation | EASIPRSTLGDSDTV HHCCCHHHCCCHHHH | 35.72 | 25338131 | |
| 926 | Phosphorylation | LEEVLGRSLERLSRL HHHHHHHHHHHHHHH | 32.55 | 19854140 | |
| 1005 (in isoform 2) | Ubiquitination | - | 72.46 | - | |
| 1020 (in isoform 2) | Ubiquitination | - | 8.66 | - | |
| 1074 | Phosphorylation | KEQLLLRSSEGNSKE HHHHHHCCCCCCCCH | 32.48 | 20139300 | |
| 1075 | Phosphorylation | EQLLLRSSEGNSKEM HHHHHCCCCCCCCHH | 42.99 | 20139300 | |
| 1114 | Phosphorylation | QHQEQENTTTARPGS HCCCCCCCCCCCCCC | 25.44 | - | |
| 1161 | Ubiquitination | FSLPGSTKHLRSQLA CCCCCCHHHHHHHHH | 42.19 | - | |
| 1197 | Ubiquitination | AQANQLEKYRAVFSE HHHHHHHHHHHHHCH | 48.94 | - | |
| 1293 | Phosphorylation | EEFRAHGTPDDSSLL HHHHHCCCCCCHHHH | 17.43 | 28464351 | |
| 1316 | Ubiquitination | AQLQNANKVIQNLRS HHHHHHHHHHHHHHH | 38.00 | - | |
| 1336 | Ubiquitination | SATSDYSSSLERPRK CCCCCCCCCCCCCCH | 32.48 | - | |
| 1359 | Phosphorylation | GASPHSVTDEDEGWL CCCCCCCCCCCCCCC | 36.36 | 21183079 | |
| 1370 | Phosphorylation | EGWLSDGTGAFYPPG CCCCCCCCCCCCCCC | 30.26 | 21183079 | |
| 1372 | Ubiquitination | WLSDGTGAFYPPGLQ CCCCCCCCCCCCCHH | 10.71 | - | |
| 1382 | Ubiquitination | PPGLQAKKDLESLIQ CCCHHHHHHHHHHHH | 71.24 | - | |
| 1457 | Ubiquitination | QHAKDTVKSFEDLLR HHHHHHHHHHHHHHH | 52.07 | - | |
| 1491 | Ubiquitination | GQLTERLTSKLSTKD CHHHHHHHHHHCCCC | 30.00 | - | |
| 1532 | Ubiquitination | VIEVLQAKLDTRSLS HHHHHHHHHCCCCCC | 33.66 | - | |
| 1557 | Ubiquitination | HRSASTTSFLSDDIE CCCCCCCCHHHCCHH | 25.03 | - | |
| 1600 | Phosphorylation | SQGLKGESSSSPISL HCCCCCCCCCCCCCC | 44.16 | 29472430 | |
| 1601 | Phosphorylation | QGLKGESSSSPISLP CCCCCCCCCCCCCCC | 30.45 | 29472430 | |
| 1602 | Phosphorylation | GLKGESSSSPISLPT CCCCCCCCCCCCCCC | 49.79 | 25521595 | |
| 1603 | Phosphorylation | LKGESSSSPISLPTP CCCCCCCCCCCCCCC | 28.35 | 29472430 | |
| 1606 | Phosphorylation | ESSSSPISLPTPQNP CCCCCCCCCCCCCCC | 31.51 | 23140645 | |
| 1609 | Phosphorylation | SSPISLPTPQNPPKE CCCCCCCCCCCCCHH | 42.68 | 23140645 | |
| 1632 | Ubiquitination | HFHSIPKPASLSQTP CCCCCCCCCCCCCCC | 23.02 | - | |
| 1707 | Ubiquitination | NQTEASSPHYINPAQ CCCCCCCCCCCCCCC | 23.08 | - | |
| 1778 | Phosphorylation | DLLEEHLGEIRNLRQ HHHHHHHHHHHHHHH | 30.14 | - | |
| 1890 | Phosphorylation | KAERQQLSLQSELQI HHHHHHHHHHHHHHH | 21.74 | 26026062 | |
| 1893 | Phosphorylation | RQQLSLQSELQIYES HHHHHHHHHHHHHHH | 45.63 | - | |
| 1898 | Phosphorylation | LQSELQIYESLCENP HHHHHHHHHHHHCCH | 6.11 | - | |
| 1900 | Phosphorylation | SELQIYESLCENPKK HHHHHHHHHHCCHHH | 22.73 | 26026062 | |
| 1987 | Phosphorylation | PANLHQGSAASPPVR CCCCCCCCCCCCCCC | 17.68 | 30352176 | |
| 1990 | Phosphorylation | LHQGSAASPPVRDVG CCCCCCCCCCCCCCC | 29.47 | 29472430 | |
| 2091 | Phosphorylation | SLMRSARSIPGQEAQ HHHHHHCCCCCCCCC | 32.62 | 21183079 | |
| 2107 | Phosphorylation | TEAPGNISAHELRSS CCCCCCCCHHHHHHH | 27.80 | 25367039 | |
| 2110 | Phosphorylation | PGNISAHELRSSAKA CCCCCHHHHHHHHHH | 45.66 | - | |
| 2112 | Phosphorylation | NISAHELRSSAKALN CCCHHHHHHHHHHHH | 26.11 | - | |
| 2115 | Phosphorylation | AHELRSSAKALNHAL HHHHHHHHHHHHHHH | 11.46 | - | |
| 2120 | Phosphorylation | SSAKALNHALEESTS HHHHHHHHHHHHHHH | 32.32 | - | |
| 2155 | Acetylation | KEGQLMEKELLDLRA CCCCCCHHHHHHHHH | 39.43 | - | |
| 2187 | Phosphorylation | RANQRKKSMEQFIVS HHHHHHHHHHHHHHH | 30.50 | 29472430 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MYOME_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MYOME_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MYOME_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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