CNKR3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNKR3_MOUSE
• UniProt AC: Q8BMA3
• Protein Name: Connector enhancer of kinase suppressor of ras 3
• Gene Name: Cnksr3
• Organism: Mus musculus (Mouse).
• Sequence Length: 555
• Subcellular Localization: Cytoplasm . Apical cell membrane ; Peripheral membrane protein .
• Protein Description: Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC)..
• Protein Sequence: MEPVTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDTMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDLSVTKNKIIQLCLDLTTAVQKDCLIAEMEDKVLNVVKVLNGICDKTMRSTTDPVMSQCACLEEVHLPNVRPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVRKLRENPTGVVLLLKKRPTGSFSFTPAPLKNLRWKPPLVQTSPPPTTTQSPESTMDASLKKEKPAILDLYIPPPPAVPYSPRDENVSFGYRGHSKSKQPLPVRKGSESPNSFLDQESQRRRFTIADSDQLPGYSVETNVLPTKMRGKTPSYGKPRPLSMPADGNWMGIVDPFAKPRGNGRKGEDALCRYFSNERITPITEESASPMYRFSRPLTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGSKKKSASSSAKASSGEPSLLVSWLTRLKLLTH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MEPVTKWSPKQVVDW CCCCCCCCHHHHHHC	24.63	22817900
34	Ubiquitination	VHKFEREKIDGEQLL HHHHHHHCCCHHHHE	52.93	22790023
150	Phosphorylation	FTGITDLSVTKNKII CCCCCCCCCCHHHHH	30.47	20139300
240	Phosphorylation	GLHVITGTTENSPAD CEEEEEECCCCCCCC	23.45	20415495
241	Phosphorylation	LHVITGTTENSPADR EEEEEECCCCCCCCH	34.22	29899451
244	Phosphorylation	ITGTTENSPADRSQK EEECCCCCCCCHHHC	18.42	22817900
362	Phosphorylation	SPRDENVSFGYRGHS CCCCCCCCCCCCCCC	25.24	27742792
381	Phosphorylation	PLPVRKGSESPNSFL CCCCCCCCCCCCCCC	37.63	26824392
383	Phosphorylation	PVRKGSESPNSFLDQ CCCCCCCCCCCCCCH	30.95	26824392
386	Phosphorylation	KGSESPNSFLDQESQ CCCCCCCCCCCHHHH	30.48	25619855
392	Phosphorylation	NSFLDQESQRRRFTI CCCCCHHHHHCCEEE	24.29	28059163
398	Phosphorylation	ESQRRRFTIADSDQL HHHHCCEEECCCCCC	17.28	24719451
418	Ubiquitination	ETNVLPTKMRGKTPS ECCCCCCCCCCCCCC	25.35	22790023
425	Phosphorylation	KMRGKTPSYGKPRPL CCCCCCCCCCCCCCC	52.31	24719451
433	Phosphorylation	YGKPRPLSMPADGNW CCCCCCCCCCCCCCC	25.96	21082442
464	Phosphorylation	GEDALCRYFSNERIT CHHHHHHHHCCCCCC	15.46	23984901
466	Phosphorylation	DALCRYFSNERITPI HHHHHHHCCCCCCCC	28.93	23737553
471	Phosphorylation	YFSNERITPITEESA HHCCCCCCCCCCCCC	18.17	23984901
479	Phosphorylation	PITEESASPMYRFSR CCCCCCCCCCCCCCC	21.34	29514104
489	Phosphorylation	YRFSRPLTERHLVRG CCCCCCCCHHHHHCC	33.39	24719451
499	Phosphorylation	HLVRGADYIRGSRCY HHHCCCCEECCCCEE	7.62	24719451
503	Phosphorylation	GADYIRGSRCYINSD CCCEECCCCEEECCC	14.88	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNKR3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNKR3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNKR3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CNKR3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381, AND MASSSPECTROMETRY.
PubMed: 17242355