CENPJ_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CENPJ_MOUSE
• UniProt AC: Q569L8
• Protein Name: Centromere protein J
• Gene Name: Cenpj
• Organism: Mus musculus (Mouse).
• Sequence Length: 1344
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localized within the center of microtubule asters. During centriole biogenesis, it is concentrated wi
• Protein Description: Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (By similarity)..
• Protein Sequence: MFLMPTSSELNSGQNFLTQWMTSPSRAGVILNRGFPILEADDKQAATNVSTSFPAKATHFSNSFSISSEEDSFHEEQKLEAGGPYKPWSENPEAPPVFPSVRKEPIASRQDAPGCQEDNNNDLTPHLESEFKEVANKNPLFKKLEQLKEIQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSAQHAFPGTLLPDDQSQKHRSPGDLTLPPHSYSNPTQENSCASNVLPDEQSNFCRATQDSVLTSKNASDLFYESQYQEAHVKRNDLKEESPAHPSGEGALPRWEKKMGRSQEGKDVNLQKCGDSSEVVNIDERPIKAAVREKQQTFEDYLEEQIQLEERELRQKQLQEAEGPLLAKTKPKQPFLKRGEGLARFTNAKSKFQKGKESKLASTQSPSEDQPGSKVDRQHLQRKTALINKDLCAETPTVKKDSKARPKAGFASLRQKPKVTKTNMRESLSPPGLKVQTGKKRDGQFRHQVKGERNAHASNKENVPACIKPWDAGCKMWSKTQGRERLPLSTGPVGCVVSRSPIRETDRETESSLDFSLQKKLEIWEREKEKENLELDEFLFLERAADEISFSSNSSFVLRILERDQQICDGHRLSSTPVKAVQQREAQQADPRGQSNCSEIPRYGVAHENESECEAMLLSWGSGSPDGLRELSCKRSMKAFQTSTSEIQSQWDARDDGVANSDSSTESEEQHDITIKPSTEVGDRVFSNREDSPQVCDAKGPIRDTGAQEDKWRDADLDLSDKECSSDESVIVESLNNKVLEPLRLPSSQAGSKIDFDDERSWTDLEENPYEHGVIHREEAIYGTPQTQCHSKSEGCVLDKTIKRKIAPVKKGEDFKCDRRISPPPPSDLMVKFFPSLKPKPKLDSHLENESKLNLSQDQPPEFMVCFIGDSVRSQVLREKVTELESEIEKFKAENTSLAKLRIERESALEKLRKEIADFEQQKARELARIEEYRKEETRKLQKERKVFEKYTAAARTFPDKKEREEIQALKQQIADLQEDLKRKETKWSSTQSRLRSQIEMLVKENTDLREEIKVMERFRLDAWKRAEAMENSPKACQYMMATKKDESMNSSFQFQKSHVSSGVQVEKYKKKYLPAQGNLSRRIKSAPPRDLGSSDKGQAALPREPLQQVNFPDLEYKNKEEKEEEIQGEISHPDGKVEKIYKNGRRVVLFPNGTRKEVSADGKSVTVTFFNGDVKQVMPDERVVYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHFPDGRKEITFPDQTIKTLFADGQEESIFPDGTIVRVQRDGNKIIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYTSGRVRVKDKDGNVLMDTEM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
240	Phosphorylation	FCRATQDSVLTSKNA CCHHCCCHHHCCCCH	14.81	28833060
248	Phosphorylation	VLTSKNASDLFYESQ HHCCCCHHHHHHHHH	44.21	-
290	Phosphorylation	WEKKMGRSQEGKDVN HHHHCCCCCCCCCCC	27.18	28059163
304	Phosphorylation	NLQKCGDSSEVVNID CCHHCCCCCCCEECC	17.43	-
391	Phosphorylation	KESKLASTQSPSEDQ CHHHCCCCCCCCCCC	27.71	28066266
393	Phosphorylation	SKLASTQSPSEDQPG HHCCCCCCCCCCCCC	30.40	28066266
395	Phosphorylation	LASTQSPSEDQPGSK CCCCCCCCCCCCCCH	60.08	28066266
440	Phosphorylation	RPKAGFASLRQKPKV CCCCCCHHHCCCCCC	23.09	27149854
455	Phosphorylation	TKTNMRESLSPPGLK CCCCHHHHCCCCCEE	24.63	28066266
457	Phosphorylation	TNMRESLSPPGLKVQ CCHHHHCCCCCEEEE	38.02	26824392
526	Phosphorylation	GPVGCVVSRSPIRET CCEEEEEECCCCCCC	13.47	25159016
528	Phosphorylation	VGCVVSRSPIRETDR EEEEEECCCCCCCCC	19.71	25159016
577	Phosphorylation	ERAADEISFSSNSSF HHHCCCCCCCCCCCH	19.61	-
583	Phosphorylation	ISFSSNSSFVLRILE CCCCCCCCHHHHHHH	24.51	-
604	Phosphorylation	DGHRLSSTPVKAVQQ CCCCCCCCCCHHHHH	28.82	27149854
650	Phosphorylation	AMLLSWGSGSPDGLR EEEHHCCCCCCCHHH	29.82	25293948
652	Phosphorylation	LLSWGSGSPDGLREL EHHCCCCCCCHHHHH	22.86	25293948
715	Phosphorylation	EVGDRVFSNREDSPQ CCCCCCCCCCCCCCC	31.92	30482847
720	Phosphorylation	VFSNREDSPQVCDAK CCCCCCCCCCCCCCC	16.69	27149854
748	Phosphorylation	RDADLDLSDKECSSD CCCCCCCCCCCCCCC	46.43	25293948
753	Phosphorylation	DLSDKECSSDESVIV CCCCCCCCCCCCEEE	41.75	25293948
754	Phosphorylation	LSDKECSSDESVIVE CCCCCCCCCCCEEEH	57.99	25293948
757	Phosphorylation	KECSSDESVIVESLN CCCCCCCCEEEHHHC	23.33	25293948
762	Phosphorylation	DESVIVESLNNKVLE CCCEEEHHHCCCCCC	26.04	25293948
775	Phosphorylation	LEPLRLPSSQAGSKI CCCCCCCCCCCCCCC	39.41	28285833
850	Phosphorylation	FKCDRRISPPPPSDL CCCCCCCCCCCCHHH	29.55	25266776
855	Phosphorylation	RISPPPPSDLMVKFF CCCCCCCHHHHHHCC	49.50	19854140
1061	Phosphorylation	RAEAMENSPKACQYM HHHHHHHCHHHHHHH	17.93	21659604
1342	Phosphorylation	DGNVLMDTEM----- CCCEEEECCC-----	21.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
577	S	Phosphorylation	Kinase	PLK2	P53351	Uniprot
583	S	Phosphorylation	Kinase	PLK2	P53351	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
577	S	Phosphorylation	Phosphorylation at Ser-577 and Ser-583 by PLK2 is required for procentriole formation and centriole elongation.	-
583	S	Phosphorylation	Phosphorylation at Ser-577 and Ser-583 by PLK2 is required for procentriole formation and centriole elongation.	-
583	S	Phosphorylation	Phosphorylation at Ser-583 is also mediated by PLK4 but is not a critical step in PLK4 function in procentriole assembly.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CENPJ_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CENPJ_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.