TRIM3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRIM3_MOUSE
• UniProt AC: Q9R1R2
• Protein Name: Tripartite motif-containing protein 3
• Gene Name: Trim3
• Organism: Mus musculus (Mouse).
• Sequence Length: 744
• Subcellular Localization: Cytoplasm. Early endosome . Golgi apparatus, trans-Golgi network . Cell projection, dendrite .
• Protein Description: Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B. [PubMed: 24086586]
• Protein Sequence: MAKREDSPGPEVQPMDKQFLVCSICLDRYRCPKVLPCLHTFCERCLQNYIPPQSLTLSCPVCRQTSILPEQGVSALQNNFFISSLMEAMQQAPEGAHDPEDPHPLSAVAGRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVVEQHKAALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAAFEDLEQALQQRKQALVSDLESICGAKQKVLQTQLDTLRQGQEHIGSSCSFAEQALRLGSAPEVLLVRKHMRERLAALAAQAFPERPHENAQLELVLEVDGLRRSVLNLGALLTTSATAHETVATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELCAEITGPDGVRLAVPVVDHKNGTYELVYTARTEGDLLLSVLLYGQPVRGSPFRVRALRPGDLPPSPDDVKRRVKSPGGPGSHVRQKAVRRPSSMYSTGGKRKDNPIEDELVFRVGSRGREKGEFTNLQGVSAASSGRIVVADSNNQCIQVFSNEGQFKFRFGVRGRSPGQLQRPTGVAVDTNGDIIVADYDNRWVSIFSPEGKFKTKIGAGRLMGPKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGRFGGRGATDRHFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSAEPLYGPQGLALTSDGHVVVADAGNHCFKAYRYLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAKREDSPG ------CCCCCCCCC	21.44	-
7	Phosphorylation	-MAKREDSPGPEVQP -CCCCCCCCCCCCCC	27.31	24925903
344	Phosphorylation	VGQPASLTVTTKDKD CCCCCEEEEEEECCC	17.20	25338131
346	Phosphorylation	QPASLTVTTKDKDGR CCCEEEEEEECCCCC	23.93	25338131
357	Phosphorylation	KDGRLVRTGSAELCA CCCCEEECCCCEEEE	28.19	23527152
359	Phosphorylation	GRLVRTGSAELCAEI CCEEECCCCEEEEEE	20.25	23527152
427	Phosphorylation	RPGDLPPSPDDVKRR CCCCCCCCHHHHHHH	38.73	25521595
437	Phosphorylation	DVKRRVKSPGGPGSH HHHHHCCCCCCCCHH	26.39	25521595
443	Phosphorylation	KSPGGPGSHVRQKAV CCCCCCCHHHHHHHH	23.18	25367039
454	Phosphorylation	QKAVRRPSSMYSTGG HHHHCCCHHHCCCCC	26.40	25521595
455	Phosphorylation	KAVRRPSSMYSTGGK HHHCCCHHHCCCCCC	25.15	27087446
457	Phosphorylation	VRRPSSMYSTGGKRK HCCCHHHCCCCCCCC	12.67	22817900
458	Phosphorylation	RRPSSMYSTGGKRKD CCCHHHCCCCCCCCC	16.37	27087446
459	Phosphorylation	RPSSMYSTGGKRKDN CCHHHCCCCCCCCCC	32.25	29472430
487	Phosphorylation	GREKGEFTNLQGVSA CCCCCCCCCCCCCCC	30.62	26643407
493	Phosphorylation	FTNLQGVSAASSGRI CCCCCCCCCCCCCCE	25.58	26643407
496	Phosphorylation	LQGVSAASSGRIVVA CCCCCCCCCCCEEEE	32.80	26643407
529	Phosphorylation	RFGVRGRSPGQLQRP EEECCCCCCCCCCCC	35.88	28418008
565	Ubiquitination	SIFSPEGKFKTKIGA EEECCCCCCCCEECC	41.86	22790023
568	Phosphorylation	SPEGKFKTKIGAGRL CCCCCCCCEECCCCC	30.90	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRIM3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRIM3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRIM3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LST2_HUMAN	ZFYVE28	physical	19460345
CDN1A_MOUSE	Cdkn1a	physical	23318451

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, AND MASSSPECTROMETRY.
PubMed: 19367708

"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, AND MASSSPECTROMETRY.
PubMed: 16452087