HOME1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOME1_MOUSE
• UniProt AC: Q9Z2Y3
• Protein Name: Homer protein homolog 1 {ECO:0000305}
• Gene Name: Homer1 {ECO:0000312|MGI:MGI:1347345}
• Organism: Mus musculus (Mouse).
• Sequence Length: 366
• Subcellular Localization: Cytoplasm . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell junction, synapse . Cell projection, dendritic spine . Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. T
• Protein Description: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 5 counteracts the effects by competing for binding sites. Isoform 3 regulates the trafficking and surface expression of GRM5. Isoform 5 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, isoform 2 and isoform 3 to regulate synaptic metabotropic glutamate function. Isoform 5, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity)..
• Protein Sequence: MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFPHSAGDRTQALSHASSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHSHKTELNQTVQELEETLKVKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRSNLKTLLEILDGKIFELTELRDNLAKLLECS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGEQPIFST ------CCCCCCEEC	42.10	-
22	Ubiquitination	QIDPNTKKNWVPTSK EECCCCCCCCCCCCC	54.74	-
59	Phosphorylation	GSKAIINSTITPNMT CCEEEECCCCCCCCE	15.69	29899451
60	Phosphorylation	SKAIINSTITPNMTF CEEEECCCCCCCCEE	25.12	25521595
117	Phosphorylation	ARLAKEKSQEKMELT HHHHHHHHHHHHCCC	44.67	-
128	Phosphorylation	MELTSTPSQESAGGD HCCCCCCCCCCCCCC	46.82	29899451
131	Phosphorylation	TSTPSQESAGGDLQS CCCCCCCCCCCCCCC	25.28	29899451
138	Phosphorylation	SAGGDLQSPLTPESI CCCCCCCCCCCHHHC	29.22	29899451
141	Phosphorylation	GDLQSPLTPESINGT CCCCCCCCHHHCCCC	28.52	29899451
144	Phosphorylation	QSPLTPESINGTDDE CCCCCHHHCCCCCCC	23.66	29899451
153	Phosphorylation	NGTDDERTPDVTQNS CCCCCCCCCCCCCCC	23.07	29899451
185	Phosphorylation	GDRTQALSHASSAIS CCHHHHHHHHHHHHH	21.74	19737024
185	O-linked_Glycosylation	GDRTQALSHASSAIS CCHHHHHHHHHHHHH	21.74	20547801
188	Phosphorylation	TQALSHASSAISKHW HHHHHHHHHHHHHHH	18.19	21454597
189	Phosphorylation	QALSHASSAISKHWE HHHHHHHHHHHHHHH	30.33	19737024
203	Methylation	EAELATLKGNNAKLT HHHHHHHHCCCHHHH	56.06	-
208	Ubiquitination	TLKGNNAKLTAALLE HHHCCCHHHHHHHHH	48.79	-
221	Ubiquitination	LESTANVKQWKQQLA HHHHHCHHHHHHHHH	50.69	-
224	Ubiquitination	TANVKQWKQQLAAYQ HHCHHHHHHHHHHHH	26.18	-
249	O-linked_Glycosylation	TELECVSSQANAVHS HHHHHHHHHHHHHHH	16.96	55412271
298	Phosphorylation	ELQEQRDSLTQKLQE HHHHHHHHHHHHHHH	35.19	29899451
311	Ubiquitination	QEVEIRNKDLEGQLS HHHHHHCCCCCHHHH	54.57	-
318	Phosphorylation	KDLEGQLSDLEQRLE CCCCHHHHHHHHHHH	32.06	25521595
326	Ubiquitination	DLEQRLEKSQNEQEA HHHHHHHHCHHHHHH	63.03	-
327	Phosphorylation	LEQRLEKSQNEQEAF HHHHHHHCHHHHHHH	28.94	-
339	Ubiquitination	EAFRSNLKTLLEILD HHHHHHHHHHHHHHC	41.18	-
361	Ubiquitination	ELRDNLAKLLECS-- HHHHHHHHHHHCC--	57.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
117	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOME1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOME1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRM1_MOUSE	Grm1	physical	15579147
ITPR1_MOUSE	Itpr1	physical	15579147
HOME1_MOUSE	Homer1	physical	15579147
GRID2_MOUSE	Grid2	physical	15579147
1433Z_MOUSE	Ywhaz	physical	16959763
GRM5_MOUSE	Grm5	physical	9808458
HOME1_RAT	Homer1	physical	9808458
HOME2_MOUSE	Homer2	physical	9808458
CTIP_HUMAN	RBBP8	physical	26496610
MPZL1_HUMAN	MPZL1	physical	26496610
KIF3B_HUMAN	KIF3B	physical	26496610
HOME3_HUMAN	HOMER3	physical	26496610
COBL1_HUMAN	COBLL1	physical	26496610
LMA2L_HUMAN	LMAN2L	physical	26496610
PSRC1_HUMAN	PSRC1	physical	26496610
FRYL_HUMAN	FRYL	physical	26496610
AGAP2_MOUSE	Agap2	physical	28671696
BIN1_MOUSE	Bin1	physical	28671696
KCC2A_MOUSE	Camk2a	physical	28671696
CNTN4_MOUSE	Cntn4	physical	28671696
CYH3_MOUSE	Cyth3	physical	28671696
DLGP1_MOUSE	Dlgap1	physical	28671696
DYN1_MOUSE	Dnm1	physical	28671696
GIPC1_MOUSE	Gipc1	physical	28671696
GRM1_MOUSE	Grm1	physical	28671696
GRM5_MOUSE	Grm5	physical	28671696
LZTS3_MOUSE	Lzts3	physical	28671696
M3K5_MOUSE	Map3k5	physical	28671696
MYH10_MOUSE	Myh10	physical	28671696
NCAM1_MOUSE	Ncam1	physical	28671696
NCDN_MOUSE	Ncdn	physical	28671696
PPIA_MOUSE	Ppia	physical	28671696
PP2BA_MOUSE	Ppp3ca	physical	28671696
KPCA_MOUSE	Prkca	physical	28671696
SHAN1_MOUSE	Shank1	physical	28671696
SHAN2_MOUSE	Shank2	physical	28671696
SHAN3_MOUSE	Shank3	physical	28671696
SHPS1_MOUSE	Sirpa	physical	28671696
SPTB2_MOUSE	Sptbn1	physical	28671696
TENR_MOUSE	Tnr	physical	28671696
WASF1_MOUSE	Wasf1	physical	28671696
1433B_MOUSE	Ywhab	physical	28671696
1433E_MOUSE	Ywhae	physical	28671696
1433F_MOUSE	Ywhah	physical	28671696
1433Z_MOUSE	Ywhaz	physical	28671696

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.