dbPTM

1433Z_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	1433Z_MOUSE
UniProt AC	P63101
Protein Name	14-3-3 protein zeta/delta
Gene Name	Ywhaz
Organism	Mus musculus (Mouse).
Sequence Length	245
Subcellular Localization	Cytoplasm. Melanosome. Located to stage I to stage IV melanosomes..
Protein Description	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner..
Protein Sequence	MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQPESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDKNELVQ -------CCHHHHHH	17.45	-
3	Acetylation	-----MDKNELVQKA -----CCHHHHHHHH	51.53	22733758
3	Malonylation	-----MDKNELVQKA -----CCHHHHHHHH	51.53	26320211
9	Ubiquitination	DKNELVQKAKLAEQA CHHHHHHHHHHHHHH	39.75	22790023
9	Acetylation	DKNELVQKAKLAEQA CHHHHHHHHHHHHHH	39.75	22826441
11	Ubiquitination	NELVQKAKLAEQAER HHHHHHHHHHHHHHH	56.09	22790023
11	Malonylation	NELVQKAKLAEQAER HHHHHHHHHHHHHHH	56.09	26320211
25	S-nitrosocysteine	RYDDMAACMKSVTEQ HHHHHHHHHHHHHHH	2.27	-
25	Glutathionylation	RYDDMAACMKSVTEQ HHHHHHHHHHHHHHH	2.27	24333276
25	S-nitrosylation	RYDDMAACMKSVTEQ HHHHHHHHHHHHHHH	2.27	24926564
28	Phosphorylation	DMAACMKSVTEQGAE HHHHHHHHHHHHHHH	13.85	25521595
37	Phosphorylation	TEQGAELSNEERNLL HHHHHHCCHHHHHHH	33.43	26525534
45	Phosphorylation	NEERNLLSVAYKNVV HHHHHHHHHHHHHHH	14.10	26824392
47	Ubiquitination	ERNLLSVAYKNVVGA HHHHHHHHHHHHHCC	13.25	27667366
48	Phosphorylation	RNLLSVAYKNVVGAR HHHHHHHHHHHHCCC	10.84	24865951
49	Ubiquitination	NLLSVAYKNVVGARR HHHHHHHHHHHCCCC	33.26	22790023
49	Acetylation	NLLSVAYKNVVGARR HHHHHHHHHHHCCCC	33.26	129705
53	Ubiquitination	VAYKNVVGARRSSWR HHHHHHHCCCCCCHH	14.75	27667366
57	Phosphorylation	NVVGARRSSWRVVSS HHHCCCCCCHHHHHH	28.79	29514104
58	Phosphorylation	VVGARRSSWRVVSSI HHCCCCCCHHHHHHH	19.65	22817900
63	Phosphorylation	RSSWRVVSSIEQKTE CCCHHHHHHHHHHCC	23.81	28066266
64	Ubiquitination	SSWRVVSSIEQKTEG CCHHHHHHHHHHCCH	20.66	27667366
64	Phosphorylation	SSWRVVSSIEQKTEG CCHHHHHHHHHHCCH	20.66	25521595
68	Ubiquitination	VVSSIEQKTEGAEKK HHHHHHHHCCHHHHH	35.44	27667366
68	Acetylation	VVSSIEQKTEGAEKK HHHHHHHHCCHHHHH	35.44	22826441
68	Malonylation	VVSSIEQKTEGAEKK HHHHHHHHCCHHHHH	35.44	26320211
69	Phosphorylation	VSSIEQKTEGAEKKQ HHHHHHHCCHHHHHH	39.07	29899451
74	Ubiquitination	QKTEGAEKKQQMARE HHCCHHHHHHHHHHH	56.18	22790023
85	Ubiquitination	MAREYREKIETELRD HHHHHHHHHHHHHHH	36.52	22790023
94	Glutathionylation	ETELRDICNDVLSLL HHHHHHHHHHHHHHH	4.10	24333276
94	Ubiquitination	ETELRDICNDVLSLL HHHHHHHHHHHHHHH	4.10	27667366
94	S-nitrosylation	ETELRDICNDVLSLL HHHHHHHHHHHHHHH	4.10	22588120
94	S-palmitoylation	ETELRDICNDVLSLL HHHHHHHHHHHHHHH	4.10	28526873
94	S-nitrosocysteine	ETELRDICNDVLSLL HHHHHHHHHHHHHHH	4.10	-
99	Phosphorylation	DICNDVLSLLEKFLI HHHHHHHHHHHHHCC	30.65	9421531
99	Ubiquitination	DICNDVLSLLEKFLI HHHHHHHHHHHHHCC	30.65	27667366
101	Ubiquitination	CNDVLSLLEKFLIPN HHHHHHHHHHHCCCC	6.38	27667366
110	Phosphorylation	KFLIPNASQPESKVF HHCCCCCCCCCCEEE	53.56	25521595
114	Phosphorylation	PNASQPESKVFYLKM CCCCCCCCEEEEEEE	40.58	25521595
115	Acetylation	NASQPESKVFYLKMK CCCCCCCEEEEEEEC	34.40	23236377
115	Ubiquitination	NASQPESKVFYLKMK CCCCCCCEEEEEEEC	34.40	22790023
117	Ubiquitination	SQPESKVFYLKMKGD CCCCCEEEEEEECCH	7.31	27667366
118	Ubiquitination	QPESKVFYLKMKGDY CCCCEEEEEEECCHH	14.38	27667366
120	Acetylation	ESKVFYLKMKGDYYR CCEEEEEEECCHHHH	27.47	7298941
120	Ubiquitination	ESKVFYLKMKGDYYR CCEEEEEEECCHHHH	27.47	22790023
122	Ubiquitination	KVFYLKMKGDYYRYL EEEEEEECCHHHHHH	47.22	22790023
126	Phosphorylation	LKMKGDYYRYLAEVA EEECCHHHHHHHHHH	9.49	2021635
128	Phosphorylation	MKGDYYRYLAEVAAG ECCHHHHHHHHHHCC	8.31	25521595
136	Ubiquitination	LAEVAAGDDKKGIVD HHHHHCCCCCCCCCC	60.88	27667366
137	Ubiquitination	AEVAAGDDKKGIVDQ HHHHCCCCCCCCCCH	54.36	27667366
138	Acetylation	EVAAGDDKKGIVDQS HHHCCCCCCCCCCHH	58.60	23954790
138	Ubiquitination	EVAAGDDKKGIVDQS HHHCCCCCCCCCCHH	58.60	22790023
139	Ubiquitination	VAAGDDKKGIVDQSQ HHCCCCCCCCCCHHH	61.95	22790023
157	Acetylation	QEAFEISKKEMQPTH HHHHHHHHHHCCCCC	59.42	23236377
157	Malonylation	QEAFEISKKEMQPTH HHHHHHHHHHCCCCC	59.42	26320211
157	Ubiquitination	QEAFEISKKEMQPTH HHHHHHHHHHCCCCC	59.42	27667366
158	Malonylation	EAFEISKKEMQPTHP HHHHHHHHHCCCCCC	52.18	26320211
158	Ubiquitination	EAFEISKKEMQPTHP HHHHHHHHHCCCCCC	52.18	27667366
179	Phosphorylation	LNFSVFYYEILNSPE EEEHHHHHHHHCCHH	5.75	19218246
184	Phosphorylation	FYYEILNSPEKACSL HHHHHHCCHHHHHHH	30.87	21082442
190	Phosphorylation	NSPEKACSLAKTAFD CCHHHHHHHHHHHHH	35.90	29899451
193	Ubiquitination	EKACSLAKTAFDEAI HHHHHHHHHHHHHHH	45.75	-
194	Phosphorylation	KACSLAKTAFDEAIA HHHHHHHHHHHHHHH	27.27	25619855
205	Phosphorylation	EAIAELDTLSEESYK HHHHHHHCCCHHHCC	44.82	26239621
207	Phosphorylation	IAELDTLSEESYKDS HHHHHCCCHHHCCCH	41.22	24925903
210	Phosphorylation	LDTLSEESYKDSTLI HHCCCHHHCCCHHHH	33.17	24925903
211	Phosphorylation	DTLSEESYKDSTLIM HCCCHHHCCCHHHHH	23.30	25619855
214	Phosphorylation	SEESYKDSTLIMQLL CHHHCCCHHHHHHHH	22.44	26239621
215	Phosphorylation	EESYKDSTLIMQLLR HHHCCCHHHHHHHHH	30.36	26239621
226	Phosphorylation	QLLRDNLTLWTSDTQ HHHHHCCEEEECCCC	26.89	23737553
229	Phosphorylation	RDNLTLWTSDTQGDE HHCCEEEECCCCCCC	21.60	23737553
230	Phosphorylation	DNLTLWTSDTQGDEA HCCEEEECCCCCCCC	27.38	27087446
232	Phosphorylation	LTLWTSDTQGDEAEA CEEEECCCCCCCCCC	33.93	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
58	S	Phosphorylation	Kinase	PKCD	P28867	PSP
58	S	Phosphorylation	Kinase	PRKCD	P09215	GPS
58	S	Phosphorylation	Kinase	PKA	-	Uniprot
179	Y	Phosphorylation	Kinase	SRC	P12931	PSP
232	T	Phosphorylation	Kinase	CK1	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
58	S	Phosphorylation	9705322
Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
58	S	Phosphorylation	9705322
Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53.
184	S	Phosphorylation	9705322
Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria.
232	T	Phosphorylation	9705322
Phosphorylation on Thr-232; inhibits binding of RAF1 (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of 1433Z_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIN1_MOUSE	Rin1	physical	9144171
FOXO_CAEEL	daf-16	physical	11124266
LRRK2_MOUSE	Lrrk2	physical	21390248
KS6A5_MOUSE	Rps6ka5	physical	20129940
CAMKV_MOUSE	Camkv	physical	16959763
AT2B1_MOUSE	Atp2b1	physical	16959763
TANC2_MOUSE	Tanc2	physical	16959763
CAMP2_MOUSE	Camsap2	physical	16959763
GRM1B_MOUSE	Gramd1b	physical	16959763
ACTS_MOUSE	Acta1	physical	16959763
ACTG_MOUSE	Actg1	physical	16959763
KAD5_MOUSE	Ak5	physical	16959763
AP2B1_MOUSE	Ap2b1	physical	16959763
ARHGI_MOUSE	Arhgef18	physical	16959763
ARHG2_MOUSE	Arhgef2	physical	16959763
ARHG7_MOUSE	Arhgef7	physical	16959763
ARI1A_MOUSE	Arid1a	physical	16959763
ATAD3_MOUSE	Atad3a	physical	16959763
AT2B2_MOUSE	Atp2b2	physical	16959763
SIK3_MOUSE	Sik3	physical	16959763
BCR_MOUSE	Bcr	physical	16959763
BRAF_MOUSE	Braf	physical	16959763
C1QA_MOUSE	C1qa	physical	16959763
KCC2A_MOUSE	Camk2a	physical	16959763
KCC2B_MOUSE	Camk2b	physical	16959763
KCC2D_MOUSE	Camk2d	physical	16959763
KCC2G_MOUSE	Camk2g	physical	16959763
CAZA2_MOUSE	Capza2	physical	16959763
CAPZB_MOUSE	Capzb	physical	16959763
CLH1_MOUSE	Cltc	physical	16959763
CN37_MOUSE	Cnp	physical	16959763
COR2A_MOUSE	Coro2a	physical	16959763
CLIP2_MOUSE	Clip2	physical	16959763
ODP2_MOUSE	Dlat	physical	16959763
GRDN_MOUSE	Ccdc88a	physical	16959763
PSD3_MOUSE	Psd3	physical	16959763
DYHC1_MOUSE	Dync1h1	physical	16959763
RHEB_MOUSE	Rheb	physical	16959763
EF1A1_MOUSE	Eef1a1	physical	16959763
EF1B_MOUSE	Eef1b2	physical	16959763
EF1G_MOUSE	Eef1g	physical	16959763
ENAH_MOUSE	Enah	physical	16959763
ENOA_MOUSE	Eno1	physical	16959763
DEMA_MOUSE	Dmtn	physical	16959763
EVL_MOUSE	Evl	physical	16959763
GFAP_MOUSE	Gfap	physical	16959763
GIT1_MOUSE	Git1	physical	16959763
GOGA3_MOUSE	Golga3	physical	16959763
GELS_MOUSE	Gsn	physical	16959763
HOME3_MOUSE	Homer3	physical	16959763
HSP72_MOUSE	Hspa2	physical	16959763
GRP78_MOUSE	Hspa5	physical	16959763
GRP75_MOUSE	Hspa9	physical	16959763
AINX_MOUSE	Ina	physical	16959763
INP5E_MOUSE	Inpp5e	physical	16959763
ITPR1_MOUSE	Itpr1	physical	16959763
IP3KA_MOUSE	Itpka	physical	16959763
KCAB2_MOUSE	Kcnab2	physical	16959763
KCD16_MOUSE	Kctd16	physical	16959763
KINH_MOUSE	Kif5b	physical	16959763
KIF5C_MOUSE	Kif5c	physical	16959763
KIF2A_MOUSE	Kif2a	physical	16959763
LDB1_MOUSE	Ldb1	physical	16959763
MADD_MOUSE	Madd	physical	16959763
MARK3_MOUSE	Mark3	physical	16959763
MATR3_MOUSE	Matr3	physical	16959763
MBP_MOUSE	Mbp	physical	16959763
ROGDI_MOUSE	Rogdi	physical	16959763
MTAP2_MOUSE	Map2	physical	16959763
MAP6_MOUSE	Map6	physical	16959763
MTMR1_MOUSE	Mtmr1	physical	16959763
MYH10_MOUSE	Myh10	physical	16959763
MYH9_MOUSE	Myh9	physical	16959763
MY18A_MOUSE	Myo18a	physical	16959763
MYO5A_MOUSE	Myo5a	physical	16959763
NDEL1_MOUSE	Ndel1	physical	16959763
NFM_MOUSE	Nefm	physical	16959763
NFL_MOUSE	Nefl	physical	16959763
NF1_MOUSE	Nf1	physical	16959763
NOS1_MOUSE	Nos1	physical	16959763
NSF_MOUSE	Nsf	physical	16959763
PACS1_MOUSE	Pacs1	physical	16959763
PDE1A_MOUSE	Pde1a	physical	16959763
PDE1B_MOUSE	Pde1b	physical	16959763
PDE4D_MOUSE	Pde4d	physical	16959763
ODPB_MOUSE	Pdhb	physical	16959763
PADI2_MOUSE	Padi2	physical	16959763
PFKAL_MOUSE	Pfkl	physical	16959763
PFKAM_MOUSE	Pfkm	physical	16959763
PFKAP_MOUSE	Pfkp	physical	16959763
PLEC_MOUSE	Plec	physical	16959763
PP1G_MOUSE	Ppp1cc	physical	16959763
LIPA2_MOUSE	Ppfia2	physical	16959763
LIPA3_MOUSE	Ppfia3	physical	16959763
NEB2_MOUSE	Ppp1r9b	physical	16959763
PP2AB_MOUSE	Ppp2cb	physical	16959763
2AAA_MOUSE	Ppp2r1a	physical	16959763
PP2BA_MOUSE	Ppp3ca	physical	16959763
PP2BB_MOUSE	Ppp3cb	physical	16959763
PP2BC_MOUSE	Ppp3cc	physical	16959763
KAPCB_MOUSE	Prkacb	physical	16959763
KAP3_MOUSE	Prkar2b	physical	16959763
RFIP5_MOUSE	Rab11fip5	physical	16959763
RB6I2_MOUSE	Erc1	physical	16959763
RPGF2_MOUSE	Rapgef2	physical	16959763
RGRF2_MOUSE	Rasgrf2	physical	16959763
RIMS3_MOUSE	Rims3	physical	16959763
MTMR5_MOUSE	Sbf1	physical	16959763
SFPQ_MOUSE	Sfpq	physical	16959763
EAA1_MOUSE	Slc1a3	physical	16959763
SNF5_MOUSE	Smarcb1	physical	16959763
SPTA1_MOUSE	Spta1	physical	16959763
SPTB2_MOUSE	Sptbn1	physical	16959763
STRN_MOUSE	Strn	physical	16959763
SYN1_MOUSE	Syn1	physical	16959763
SYN2_MOUSE	Syn2	physical	16959763
SYGP1_MOUSE	Syngap1	physical	16959763
TPIS_MOUSE	Tpi1	physical	16959763
TRIM3_MOUSE	Trim3	physical	16959763
TBA1A_MOUSE	Tuba1a	physical	16959763
TBB2A_MOUSE	Tubb2a	physical	16959763
EFTU_MOUSE	Tufm	physical	16959763
VAT1_MOUSE	Vat1	physical	16959763
WDR37_MOUSE	Wdr37	physical	16959763
WDR7_MOUSE	Wdr7	physical	16959763
1433B_MOUSE	Ywhab	physical	16959763
1433E_MOUSE	Ywhae	physical	16959763
1433G_MOUSE	Ywhag	physical	16959763
1433F_MOUSE	Ywhah	physical	16959763
HOME1_MOUSE	Homer1	physical	16959763
CTND1_MOUSE	Ctnnd1	physical	17993462
TAU_MOUSE	Mapt	physical	19014373

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of 1433Z_MOUSE

Related Literatures of Post-Translational Modification

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