dbPTM

KCAB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KCAB2_MOUSE
UniProt AC	P62482
Protein Name	Voltage-gated potassium channel subunit beta-2
Gene Name	Kcnab2
Organism	Mus musculus (Mouse).
Sequence Length	367
Subcellular Localization	Cytoplasm . Membrane Peripheral membrane protein Cytoplasmic side . Cell membrane Peripheral membrane protein Cytoplasmic side . Cell projection, axon . Cell junction, synapse, synaptosome . Cytoplasm, cytoskeleton . Recruited to the cytoplas
Protein Description	Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. [PubMed: 8576199 Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability]
Protein Sequence	MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPYSKKDYRS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MYPESTTGS ------CCCCCCCCC	18.73	28833060
5	Phosphorylation	---MYPESTTGSPAR ---CCCCCCCCCCCE	27.11	28833060
6	Phosphorylation	--MYPESTTGSPARL --CCCCCCCCCCCEE	33.25	25521595
7	Phosphorylation	-MYPESTTGSPARLS -CCCCCCCCCCCEEE	44.96	22942356
9	Phosphorylation	YPESTTGSPARLSLR CCCCCCCCCCEEEEE	17.19	25521595
14	Phosphorylation	TGSPARLSLRQTGSP CCCCCEEEEECCCCC	18.89	25521595
18	Phosphorylation	ARLSLRQTGSPGMIY CEEEEECCCCCCCEE	32.94	25521595
20	Phosphorylation	LSLRQTGSPGMIYST EEEECCCCCCCEEEC	22.97	25521595
25	Phosphorylation	TGSPGMIYSTRYGSP CCCCCCEEECCCCCH	8.63	24925903
26	Phosphorylation	GSPGMIYSTRYGSPK CCCCCEEECCCCCHH	8.76	25367039
27	Phosphorylation	SPGMIYSTRYGSPKR CCCCEEECCCCCHHH	15.78	24925903
28	Methylation	PGMIYSTRYGSPKRQ CCCEEECCCCCHHHH	28.07	24129315
28	Asymmetric dimethylarginine	PGMIYSTRYGSPKRQ CCCEEECCCCCHHHH	28.07	-
31	Phosphorylation	IYSTRYGSPKRQLQF EEECCCCCHHHHHHH	20.50	28382018
56	Phosphorylation	VSCLGLGTWVTFGGQ EEEEECCCEEEECCE	23.08	-
59	Phosphorylation	LGLGTWVTFGGQITD EECCCEEEECCEECH	14.23	-
104	Ubiquitination	VVLGNIIKKKGWRRS EEECHHHHHCCCCCC	44.64	22790023
111	Phosphorylation	KKKGWRRSSLVITTK HHCCCCCCCEEEEEE	21.32	28833060
112	Phosphorylation	KKGWRRSSLVITTKI HCCCCCCCEEEEEEE	25.50	25521595
124	Acetylation	TKIFWGGKAETERGL EEEECCCCHHCCCCC	38.83	-
124	Ubiquitination	TKIFWGGKAETERGL EEEECCCCHHCCCCC	38.83	22790023
141	Ubiquitination	KHIIEGLKASLERLQ HHHHHHHHHHHHHHC	46.95	22790023
248	S-palmitoylation	MTWSPLACGIVSGKY CCCCCCCCCCCCCCC	5.14	28680068
268	Ubiquitination	PYSRASLKGYQWLKD CCCHHHHCCHHHHHH	53.75	22790023
274	Ubiquitination	LKGYQWLKDKILSEE HCCHHHHHHHHCCHH	54.75	22790023
276	Ubiquitination	GYQWLKDKILSEEGR CHHHHHHHHCCHHHH	43.91	22790023
290	Ubiquitination	RRQQAKLKELQAIAE HHHHHHHHHHHHHHH	56.52	22790023
344	Phosphorylation	IQVLPKLSSSIVHEI HHHHHHCCHHHHHHH	28.32	21082442
345	Phosphorylation	QVLPKLSSSIVHEID HHHHHCCHHHHHHHH	34.22	25367039
358	Ubiquitination	IDSILGNKPYSKKDY HHHHHCCCCCCCCCC	43.46	22790023
360	Phosphorylation	SILGNKPYSKKDYRS HHHCCCCCCCCCCCC	34.43	22817900
361	Phosphorylation	ILGNKPYSKKDYRS- HHCCCCCCCCCCCC-	41.58	25367039
362	Ubiquitination	LGNKPYSKKDYRS-- HCCCCCCCCCCCC--	43.77	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KCAB2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KCAB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KCAB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
KCNA2_MOUSE	Kcna2	physical	21106837

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KCAB2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND MASSSPECTROMETRY.	17114649 [Abstract]
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; TYR-25 AND TYR-360,AND MASS SPECTROMETRY.	18034455 [Abstract]