IP3KA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IP3KA_MOUSE
• UniProt AC: Q8R071
• Protein Name: Inositol-trisphosphate 3-kinase A
• Gene Name: Itpka
• Organism: Mus musculus (Mouse).
• Sequence Length: 459
• Protein Sequence: MTLPGRPTGMARPRGAGPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAAPAPVIPQLTVTSEEDVTPASPGPPDQEGNWLPAAGSHLQQPRRLSTSSLSSTGSSSLLEDSEDDLLSDSESRSRGNVQLETSEDVGQKSHWQKIRTMVNLPVMSPFRKRYSWVQLAGHTGSFKAAGTSGLILKRSSEPEHYCLVRLMADVLRGCVPAFHGIVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVTRVFEEFMQGDAEVLRRYLNRLQQIRDTLEISDFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	PRGAGPCSPGLERAP CCCCCCCCCCCCCCC	25.74	29899451
35	Methylation	RRSVGELRLLFEARC CCCHHHHHHHHHHHH	25.66	24129315
41	Methylation	LRLLFEARCAAVAAA HHHHHHHHHHHHHHH	11.92	58858045
55	Methylation	AAAAGEPRARGAKRR HHHCCCCCHHCCHHC	32.39	24129315
62	Methylation	RARGAKRRGGQVPNG CHHCCHHCCCCCCCC	53.54	24129315
83	Phosphorylation	APVIPQLTVTSEEDV CCCCCEEEECCCCCC	19.25	26060331
85	Phosphorylation	VIPQLTVTSEEDVTP CCCEEEECCCCCCCC	25.78	26060331
94	Phosphorylation	EEDVTPASPGPPDQE CCCCCCCCCCCCCCC	31.43	29899451
119	Phosphorylation	LQQPRRLSTSSLSST CCCCCCCCCCCCCCC	25.16	24925903
120	Phosphorylation	QQPRRLSTSSLSSTG CCCCCCCCCCCCCCC	27.25	24925903
121	Phosphorylation	QPRRLSTSSLSSTGS CCCCCCCCCCCCCCC	26.38	25293948
122	Phosphorylation	PRRLSTSSLSSTGSS CCCCCCCCCCCCCCC	32.15	24925903
124	Phosphorylation	RLSTSSLSSTGSSSL CCCCCCCCCCCCCHH	28.00	25293948
125	Phosphorylation	LSTSSLSSTGSSSLL CCCCCCCCCCCCHHC	41.92	25293948
126	Phosphorylation	STSSLSSTGSSSLLE CCCCCCCCCCCHHCC	37.39	25293948
128	Phosphorylation	SSLSSTGSSSLLEDS CCCCCCCCCHHCCCC	19.49	25293948
129	Phosphorylation	SLSSTGSSSLLEDSE CCCCCCCCHHCCCCC	26.75	24925903
130	Phosphorylation	LSSTGSSSLLEDSED CCCCCCCHHCCCCCC	38.38	24925903
135	Phosphorylation	SSSLLEDSEDDLLSD CCHHCCCCCCCCCCC	33.28	24925903
141	Phosphorylation	DSEDDLLSDSESRSR CCCCCCCCCCHHHCC	46.52	24925903
143	Phosphorylation	EDDLLSDSESRSRGN CCCCCCCCHHHCCCC	33.81	29899451
145	Phosphorylation	DLLSDSESRSRGNVQ CCCCCCHHHCCCCCE	39.24	29899451
178	Phosphorylation	MVNLPVMSPFRKRYS HHCCCCCCCCHHCCE	22.56	-
184	Phosphorylation	MSPFRKRYSWVQLAG CCCCHHCCEEEECCC	15.21	29899451
185	Phosphorylation	SPFRKRYSWVQLAGH CCCHHCCEEEECCCC	25.46	25521595
195	Phosphorylation	QLAGHTGSFKAAGTS ECCCCCCCCCCCCCC	25.40	-
268	Phosphorylation	CKMGVRTYLEEELTK CCCHHHHHHHHHHHH	11.10	21183079
310	Acetylation	HAQRAVTKPRYMQWR HHHHHHHCHHHHHHH	22.39	19859229
310	Ubiquitination	HAQRAVTKPRYMQWR HHHHHHHCHHHHHHH	22.39	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
119	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IP3KA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IP3KA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IP3KA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.