RGRF2_MOUSE - dbPTM
RGRF2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGRF2_MOUSE
UniProt AC P70392
Protein Name Ras-specific guanine nucleotide-releasing factor 2
Gene Name Rasgrf2
Organism Mus musculus (Mouse).
Sequence Length 1189
Subcellular Localization Cytoplasm. Cell membrane
Peripheral membrane protein. Endoplasmic reticulum membrane
Peripheral membrane protein. Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity)..
Protein Description Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation..
Protein Sequence MQKSVRYNEGHALYLAMLARKEGTKRGFLSKKAAEASRWHEKWFALYQNVLFYFEGEQSGRPAGMYLLEGCSCERTPAPPRTNAGPAGARDALDKQYYFTVLFGHDGQKPLELRCEEEQAGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIATNQLRHQLEDQDTEIERLKSEIVALNKTKERMRPYHVHQEEEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAETEYVHQLYILVNGFLRPLRMAASSKKPPINHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIQCTLIEEPDGSDDDPKGSGHMFGHLDFKIVVEPPDAASFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTATVVLAKLSDIYKRPFTSIPVRSLELFFATSQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSSLNSRIGALDLTNSSSSSSPTTTTHSPAASPPPHTAVLESAPADKAGDSADMSPCRSPTTPRHLRYRQPGGQVADSAHCSVSPASAFAIATAAAGHGSPPGFNNERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMELAEQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTAYRIDQQPKVIQYLLDKALVIDEDSLYELSLKIEPRLPA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
410UbiquitinationPHEHVERKSLEFAKS
CCHHHHHHHHHHHHH		45.9827667366
416UbiquitinationRKSLEFAKSKLEELS
HHHHHHHHHHHHHHH		54.1427667366
484PhosphorylationLSKVRLGSLSLKKEG
CCCEEECCCCCCCCC		21.2729899451
486PhosphorylationKVRLGSLSLKKEGER
CEEECCCCCCCCCCC		39.5822324799
543PhosphorylationSDDDPKGSGHMFGHL
CCCCCCCCCCCCCEE		31.4825777480
563PhosphorylationVEPPDAASFTVVLLA
ECCCCHHCEEEEEEC		24.1425777480
565PhosphorylationPPDAASFTVVLLAPS
CCCHHCEEEEEECCC		13.7525777480
572PhosphorylationTVVLLAPSRQEKAAW
EEEEECCCHHHHHHH		40.7725777480
630PhosphorylationTDICFSKTLNSCKVP
CCCCCCCCCCCCCCC		29.9423984901
633PhosphorylationCFSKTLNSCKVPQIR
CCCCCCCCCCCCCCC		20.5918056256
705PhosphorylationLELFFATSQNNREHL
EEEEEEECCCCHHHC		27.7329899451
717PhosphorylationEHLVDGKSPRLCRKF
HHCCCCCCHHHHHHC		22.3022324799
725PhosphorylationPRLCRKFSSPPPLAV
HHHHHHCCCCCCEEE		44.9921082442
726PhosphorylationRLCRKFSSPPPLAVS
HHHHHCCCCCCEEEC		44.5525521595
733PhosphorylationSPPPLAVSRTSSPVR
CCCCEEECCCCCCCH		25.0024759943
736PhosphorylationPLAVSRTSSPVRARK
CEEECCCCCCCHHCH		31.38-
737PhosphorylationLAVSRTSSPVRARKL
EEECCCCCCCHHCHH		27.1415128856
745PhosphorylationPVRARKLSLTSSLNS
CCHHCHHHHCHHHHH		32.4127742792
747PhosphorylationRARKLSLTSSLNSRI
HHCHHHHCHHHHHCC		16.9422324799
748PhosphorylationARKLSLTSSLNSRIG
HCHHHHCHHHHHCCC		37.8122324799
749PhosphorylationRKLSLTSSLNSRIGA
CHHHHCHHHHHCCCC		26.7427180971
752PhosphorylationSLTSSLNSRIGALDL
HHCHHHHHCCCCEEC		30.4822324799
760PhosphorylationRIGALDLTNSSSSSS
CCCCEECCCCCCCCC		32.4925777480
762PhosphorylationGALDLTNSSSSSSPT
CCEECCCCCCCCCCC		26.7625777480
763PhosphorylationALDLTNSSSSSSPTT
CEECCCCCCCCCCCC		35.9925777480
763O-linked_GlycosylationALDLTNSSSSSSPTT
CEECCCCCCCCCCCC		35.9922517741
764PhosphorylationLDLTNSSSSSSPTTT
EECCCCCCCCCCCCC		33.7825777480
765PhosphorylationDLTNSSSSSSPTTTT
ECCCCCCCCCCCCCC		36.4625777480
766PhosphorylationLTNSSSSSSPTTTTH
CCCCCCCCCCCCCCC		42.1425777480
767PhosphorylationTNSSSSSSPTTTTHS
CCCCCCCCCCCCCCC		28.3725777480
769PhosphorylationSSSSSSPTTTTHSPA
CCCCCCCCCCCCCCC		38.4319060867
770PhosphorylationSSSSSPTTTTHSPAA
CCCCCCCCCCCCCCC		32.8319060867
771PhosphorylationSSSSPTTTTHSPAAS
CCCCCCCCCCCCCCC		25.6225777480
772PhosphorylationSSSPTTTTHSPAASP
CCCCCCCCCCCCCCC		20.4725777480
774PhosphorylationSPTTTTHSPAASPPP
CCCCCCCCCCCCCCC		17.7225777480
778PhosphorylationTTHSPAASPPPHTAV
CCCCCCCCCCCCEEE		39.7925777480
783PhosphorylationAASPPPHTAVLESAP
CCCCCCCEEEECCCC		25.0025777480
788PhosphorylationPHTAVLESAPADKAG
CCEEEECCCCCCCCC		35.0825777480
797PhosphorylationPADKAGDSADMSPCR
CCCCCCCCCCCCCCC		25.8329899451
801PhosphorylationAGDSADMSPCRSPTT
CCCCCCCCCCCCCCC		22.7722324799
805PhosphorylationADMSPCRSPTTPRHL
CCCCCCCCCCCCCCC		33.0625521595
807PhosphorylationMSPCRSPTTPRHLRY
CCCCCCCCCCCCCCC		51.1622324799
808PhosphorylationSPCRSPTTPRHLRYR
CCCCCCCCCCCCCCC		23.0122324799
846PhosphorylationTAAAGHGSPPGFNNE
HHHCCCCCCCCCCCC		23.4229899451
924PhosphorylationANILRALSQDDQDDI
HHHHHHHCCCCCCCH		30.4925521595
1066AcetylationRLKKTWAKVSKQTKA
HHHHHHHHHHHHHHH		38.3115230873
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
736SPhosphorylationKinaseCDK5P49615
Uniprot
737SPhosphorylationKinaseCDK5Q00535
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGRF2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGRF2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RGRF2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGRF2_MOUSE

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Related Literatures of Post-Translational Modification

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