ARHGI_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARHGI_MOUSE
• UniProt AC: Q6P9R4
• Protein Name: Rho guanine nucleotide exchange factor 18
• Gene Name: Arhgef18
• Organism: Mus musculus (Mouse).
• Sequence Length: 1021
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Apical cell membrane .
• Protein Description: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells..
• Protein Sequence: MTISQKGGLQPTPSPAGSGVRLGPIAGDMDEADSVFLKLKQTADDSLSLTSSNAESVFIEDPYIASLRCEIESDAHEFEAESWSLSVDLAYAKKQKKEVVKRQDVLYELMQTEAHHVRTLKIMLKVYSRALQEELQFSGQAVSRLFPCADDLLDMHSHFLARLKERRQEFLEEGSDRNYVIQKIGDVLVQQFSGETGERMKEKYAVFCSGHNDAVGQYKLLLQQSKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYKDLSQALSLIKDIISQVDAKVSEYEKDQRLKEIAAKTDQKSSGKLKNGLTFRKEDMLQQRQLHLEGALCWKSTSGRLKDVLAVLLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASMQGPEMYEMYTSSKEDRNIWMAHIRRAVESCPDEEEDVFSEAEEKKIAEARTMKLQEFQERLSLKDQLIAQSLLEKQQIYLEMAQLSGLEESAQNRGLFRGGGDPSETLRGEQILRSAMSEIEGIQSLICQRHLGSTSSQVEEGSVSAGLPRRAETFGGYDSVGSPSKGGSFKRKVSNSDLRPQDWQGPASSPDSRPCDNSAPSGCCEESPQAVEMPSTESLPTVLELELVHRVQTLSQLLLSLQAVIAQQDSYVEMQRTAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAGVEKLQSQLRQEQQRWERERARQQQELELAGARLQEREGEARQMRQRLDQERTELERQRQAYQHDLERLREAQRAVDRERERLELLRRFKKQNTVPGALPPEVLAEAQPASHPPSFNGDGLEGHSAPAKAPGTQGSAMLHGTGPDNVERPEVARWDSAPPESRPAKSDVPIQLLSATNQIQRQTAVQQQIPTKLAASTKGGKEKGSKSRGSQRWESSASFDLKQQLLLSKFIGKDESASRNRRSLSPVLPAAHGSAPASDPCFPAPSPAPAATPPEAFKFGGTSLPPVSPASSLPTTPLATTDEVSKEDVIFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	PTPSPAGSGVRLGPI CCCCCCCCCCEECCC	35.90	-
204	Phosphorylation	GERMKEKYAVFCSGH CHHHHHHEEEEECCC	14.75	21183079
271	Phosphorylation	VERIIQNTEAGTEDY HHHHHHCCCCCCCCH	15.73	28285833
275	Phosphorylation	IQNTEAGTEDYKDLS HHCCCCCCCCHHHHH	32.50	28285833
322	Acetylation	TDQKSSGKLKNGLTF CCCCCCCCCCCCCCC	59.23	7627779
324	Acetylation	QKSSGKLKNGLTFRK CCCCCCCCCCCCCCH	53.08	7627789
331	Acetylation	KNGLTFRKEDMLQQR CCCCCCCHHHHHHHH	54.60	7627799
548	Phosphorylation	ICQRHLGSTSSQVEE HHHHHCCCCCCCCCC	31.32	28066266
549	Phosphorylation	CQRHLGSTSSQVEEG HHHHCCCCCCCCCCC	30.51	28066266
550	Phosphorylation	QRHLGSTSSQVEEGS HHHCCCCCCCCCCCC	22.07	29899451
551	Phosphorylation	RHLGSTSSQVEEGSV HHCCCCCCCCCCCCC	38.03	25338131
559	Phosphorylation	QVEEGSVSAGLPRRA CCCCCCCCCCCCCCC	20.51	29514104
568	Phosphorylation	GLPRRAETFGGYDSV CCCCCCHHCCCCCCC	26.96	27087446
572	Phosphorylation	RAETFGGYDSVGSPS CCHHCCCCCCCCCCC	12.86	28833060
574	Phosphorylation	ETFGGYDSVGSPSKG HHCCCCCCCCCCCCC	21.64	28833060
577	Phosphorylation	GGYDSVGSPSKGGSF CCCCCCCCCCCCCCC	24.68	25521595
579	Phosphorylation	YDSVGSPSKGGSFKR CCCCCCCCCCCCCEE	45.70	23684622
583	Phosphorylation	GSPSKGGSFKRKVSN CCCCCCCCCEECCCC	35.94	29895711
589	Phosphorylation	GSFKRKVSNSDLRPQ CCCEECCCCCCCCCC	33.38	29472430
591	Phosphorylation	FKRKVSNSDLRPQDW CEECCCCCCCCCCCC	30.43	28066266
630	Phosphorylation	PQAVEMPSTESLPTV CCCCCCCCCCCCCCH	43.42	23649490
715	Phosphorylation	AGVEKLQSQLRQEQQ HHHHHHHHHHHHHHH	41.43	24719451
892	Phosphorylation	TNQIQRQTAVQQQIP CCHHHHHHHHHHHCC	30.87	21454597
905	Phosphorylation	IPTKLAASTKGGKEK CCCHHHHCCCCCCCC	25.66	21454597
924	Phosphorylation	RGSQRWESSASFDLK CCCHHHCCCCCCCHH	25.01	28066266
925	Phosphorylation	GSQRWESSASFDLKQ CCHHHCCCCCCCHHH	19.20	26239621
927	Phosphorylation	QRWESSASFDLKQQL HHHCCCCCCCHHHHH	22.65	26239621
952	Phosphorylation	SASRNRRSLSPVLPA HHHCCCCCCCCCCCC	29.93	26824392
954	Phosphorylation	SRNRRSLSPVLPAAH HCCCCCCCCCCCCCC	17.76	26824392
961	Phosphorylation	SPVLPAAHGSAPASD CCCCCCCCCCCCCCC	32.61	21183079
963	Phosphorylation	VLPAAHGSAPASDPC CCCCCCCCCCCCCCC	22.63	25619855
967	Phosphorylation	AHGSAPASDPCFPAP CCCCCCCCCCCCCCC	40.81	25619855
975	Phosphorylation	DPCFPAPSPAPAATP CCCCCCCCCCCCCCC	35.48	25619855
981	Phosphorylation	PSPAPAATPPEAFKF CCCCCCCCCCHHHCC	41.29	25619855
997	Phosphorylation	GTSLPPVSPASSLPT CCCCCCCCCHHHCCC	22.11	26643407
1000	Phosphorylation	LPPVSPASSLPTTPL CCCCCCHHHCCCCCC	35.47	26643407
1001	Phosphorylation	PPVSPASSLPTTPLA CCCCCHHHCCCCCCC	40.24	26643407
1004	Phosphorylation	SPASSLPTTPLATTD CCHHHCCCCCCCCCC	46.46	25338131
1005	Phosphorylation	PASSLPTTPLATTDE CHHHCCCCCCCCCCC	17.86	26060331
1336	Phosphorylation	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21183079
1338	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARHGI_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARHGI_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARHGI_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ARHGI_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.