VAT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VAT1_MOUSE
• UniProt AC: Q62465
• Protein Name: Synaptic vesicle membrane protein VAT-1 homolog
• Gene Name: Vat1
• Organism: Mus musculus (Mouse).
• Sequence Length: 406
• Subcellular Localization: Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. The majority is localized in the cytoplasm a small amount is associated with mitochondria..
• Protein Description: Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity)..
• Protein Sequence: MSAEREAAEAATVAAATEAGAETGTGAGEGAPSQPPTVEVASDPQPPPAPEASASASAPPLRCLVLTGFGGYDKVKLQSRPAVPPAPGPGQLTLRVRACGLNFADLMGRQGLYDRLPPLPVTPGMEGAGVVVAVGEGVGDRKAGDRVMVLNRSGMWQEEVTVPSAQTFLMPEAMTFEEAAALLVNYITAYMVLFDFGNLRPGHSVLVHMAAGGVGMAALQLCRTVENVTVFGTASASKHEVLKENGVTHPIDYHTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYHLLKPMGKVVTYGMANLLTGPKRNLMAMARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELVNSVVTRLVALYNQGHIKPRIDSVWPFEKVADAMKQMQEKKNIGKVLLVPGPEKET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAEREAAE ------CCHHHHHHH	38.55	29514104
2	Acetylation	------MSAEREAAE ------CCHHHHHHH	38.55	-
33	Phosphorylation	GAGEGAPSQPPTVEV CCCCCCCCCCCEEEE	55.58	-
42	Phosphorylation	PPTVEVASDPQPPPA CCEEEECCCCCCCCC	55.81	-
53	Phosphorylation	PPPAPEASASASAPP CCCCCCCCCCCCCCC	22.54	25338131
63	S-nitrosocysteine	ASAPPLRCLVLTGFG CCCCCEEEEEEECCC	3.98	-
63	S-nitrosylation	ASAPPLRCLVLTGFG CCCCCEEEEEEECCC	3.98	24926564
63	Glutathionylation	ASAPPLRCLVLTGFG CCCCCEEEEEEECCC	3.98	24333276
72	Phosphorylation	VLTGFGGYDKVKLQS EEECCCCCCCEEEEC	16.99	29514104
76	Ubiquitination	FGGYDKVKLQSRPAV CCCCCCEEEECCCCC	46.69	-
99	S-palmitoylation	LTLRVRACGLNFADL EEEEEEECCCCHHHH	4.45	28526873
99	S-nitrosylation	LTLRVRACGLNFADL EEEEEEECCCCHHHH	4.45	20925432
99	Glutathionylation	LTLRVRACGLNFADL EEEEEEECCCCHHHH	4.45	24333276
99	S-nitrosocysteine	LTLRVRACGLNFADL EEEEEEECCCCHHHH	4.45	-
122	Phosphorylation	RLPPLPVTPGMEGAG CCCCCCCCCCCCCCC	16.52	26824392
253	Phosphorylation	GVTHPIDYHTTDYVD CCCCCCCCCCCCCHH	11.20	-
263	Ubiquitination	TDYVDEIKKISPKGV CCCHHHHHHHCCCCC	41.84	-
268	Ubiquitination	EIKKISPKGVDIVMD HHHHHCCCCCCEEEE	65.85	-
282	Phosphorylation	DPLGGSDTAKGYHLL ECCCCCCCHHCCCCC	31.78	25338131
308	Ubiquitination	ANLLTGPKRNLMAMA HHHHHCCHHHHHHHH	56.09	-
368	Ubiquitination	LYNQGHIKPRIDSVW HHHCCCCCCCCCCCC	23.67	-
379	Acetylation	DSVWPFEKVADAMKQ CCCCCHHHHHHHHHH	43.00	22826441
385	Ubiquitination	EKVADAMKQMQEKKN HHHHHHHHHHHHHCC	44.32	-
406	Phosphorylation	VPGPEKET------- ECCCCCCC-------	55.78	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VAT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VAT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VAT1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VAT1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.