dbPTM

TANC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TANC2_MOUSE
UniProt AC	A2A690
Protein Name	Protein TANC2
Gene Name	Tanc2
Organism	Mus musculus (Mouse).
Sequence Length	1994
Subcellular Localization
Protein Description
Protein Sequence	MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDVEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPSDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPVSTNAAAKDCSYGAVTSPTSTLESRDSGIIATLTNYSENMERTKYVGEGSKELGSGGNLKPWQSQKSSMDSCLYRVDENMAASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSLSGARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQAPSAHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGNFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLDVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLKEAIKLCPNNREIQRLLMRVEEECRQMQQQQQQQPPPPPQQPPQELPEEETEPEPQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPSQGLPVIQSPPSSPAHRDSAYISSSPLGSHQVFDFRSNSSVGSPTRQGYQSTSPALSPTHQNSHYRPSPPHTSPAHQGASYRFSPPPVGGQSKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETNVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGLRLQPAKAQIVRSNQPSSAVHSSTVIPTGAYGQVAHSMASKYQSSQGDMGVSQSRLVYQGSIGGIVGDGRPVQHVQASLSAGAICQHGGLTKEDLPQRPSSAYRGGMRYSQTPQIGRSQSASYYPVCHSKLDLERSSSQLGSPDVSHLIRRPISVNPNEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSTSNLTPTFRPSSSIQQMEIPLKPAYDRSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPHLHQQNRTWAVSSVDTVLSPTSPGNLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYYSPHGMLANGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQLSRDSRQGQTSPIKPKRPFVESNV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MFRNSLKMLLTG ---CCHHHHHHHHHC	25.72	29514104
11	Phosphorylation	NSLKMLLTGGKSSRK HHHHHHHHCCCCCCC	39.67	-
15	Phosphorylation	MLLTGGKSSRKNRSS HHHHCCCCCCCCCCC	38.35	-
21	Phosphorylation	KSSRKNRSSDGGSEE CCCCCCCCCCCCCCC	42.02	25521595
22	Phosphorylation	SSRKNRSSDGGSEEP CCCCCCCCCCCCCCC	36.72	19367708
26	Phosphorylation	NRSSDGGSEEPPDRR CCCCCCCCCCCCCCC	44.29	29550500
35	Phosphorylation	EPPDRRQSSVDSRQS CCCCCCCCCCCCCCC	30.44	29899451
129	Phosphorylation	SAITQRISPCSTLTS HHHCEEECCCCCCCC	23.26	25293948
132	Phosphorylation	TQRISPCSTLTSSTA CEEECCCCCCCCCCC	29.81	25293948
133	Phosphorylation	QRISPCSTLTSSTAS EEECCCCCCCCCCCC	40.55	25293948
135	Phosphorylation	ISPCSTLTSSTASPP ECCCCCCCCCCCCCC	22.25	19060867
136	Phosphorylation	SPCSTLTSSTASPPA CCCCCCCCCCCCCCC	28.89	25293948
137	Phosphorylation	PCSTLTSSTASPPAS CCCCCCCCCCCCCCC	23.82	25293948
138	Phosphorylation	CSTLTSSTASPPASS CCCCCCCCCCCCCCC	30.81	25293948
140	Phosphorylation	TLTSSTASPPASSPC CCCCCCCCCCCCCCC	31.35	25293948
144	Phosphorylation	STASPPASSPCSTLP CCCCCCCCCCCCCCC	40.35	29899451
164	Phosphorylation	AAAKDCSYGAVTSPT CCCCCCCCCCCCCCC	18.55	25619855
168	Phosphorylation	DCSYGAVTSPTSTLE CCCCCCCCCCCCCHH	28.58	25619855
169	Phosphorylation	CSYGAVTSPTSTLES CCCCCCCCCCCCHHC	21.41	25521595
171	Phosphorylation	YGAVTSPTSTLESRD CCCCCCCCCCHHCCC	33.83	25619855
172	Phosphorylation	GAVTSPTSTLESRDS CCCCCCCCCHHCCCC	34.09	25619855
173	Phosphorylation	AVTSPTSTLESRDSG CCCCCCCCHHCCCCC	36.70	25619855
176	Phosphorylation	SPTSTLESRDSGIIA CCCCCHHCCCCCEEE	44.49	25619855
179	Phosphorylation	STLESRDSGIIATLT CCHHCCCCCEEEEEE	30.68	29899451
219	Phosphorylation	KPWQSQKSSMDSCLY CCCHHCCCCHHHHEE	24.21	22807455
220	Phosphorylation	PWQSQKSSMDSCLYR CCHHCCCCHHHHEEE	33.37	29899451
235	Phosphorylation	VDENMAASTYSLNKI CCCHHCCCCCCCCCC	20.52	29472430
236	Phosphorylation	DENMAASTYSLNKIP CCHHCCCCCCCCCCC	16.65	28066266
237	Phosphorylation	ENMAASTYSLNKIPE CHHCCCCCCCCCCCC	14.52	29899451
238	Phosphorylation	NMAASTYSLNKIPER HHCCCCCCCCCCCCC	26.09	25521595
268	Phosphorylation	YLMPRPNSVAATSSA EECCCCCCEECCCCC	18.80	22817900
272	Phosphorylation	RPNSVAATSSAHLED CCCCEECCCCCHHHH	17.30	28066266
273	Phosphorylation	PNSVAATSSAHLEDL CCCEECCCCCHHHHH	22.32	28066266
274	Phosphorylation	NSVAATSSAHLEDLA CCEECCCCCHHHHHH	18.49	28066266
289	Phosphorylation	YLDEQRHTPLRTSLR HCCCCCCCCCHHHCC	26.63	25521595
294	Phosphorylation	RHTPLRTSLRMPRQS CCCCCHHHCCCCCCH	13.93	27149854
301	Phosphorylation	SLRMPRQSLSGARTQ HCCCCCCHHCCCCCC	26.28	29899451
307	Phosphorylation	QSLSGARTQQDLRVR CHHCCCCCCCCHHHE	30.01	29514104
398	Phosphorylation	TRMRQIASDSPHASP HHHHHHHCCCCCCCC	40.00	22324799
400	Phosphorylation	MRQIASDSPHASPKH HHHHHCCCCCCCCCC	18.98	25521595
404	Phosphorylation	ASDSPHASPKHVDAN HCCCCCCCCCCCCCC	31.29	25521595
417	Phosphorylation	ANRELPLTQAPSAHS CCCCCCCCCCCCCCC	22.27	25619855
421	Phosphorylation	LPLTQAPSAHSSITS CCCCCCCCCCCCCCC	41.45	25619855
424	Phosphorylation	TQAPSAHSSITSGSC CCCCCCCCCCCCCCC	24.13	25619855
425	Phosphorylation	QAPSAHSSITSGSCP CCCCCCCCCCCCCCC	21.73	25619855
427	Phosphorylation	PSAHSSITSGSCPGT CCCCCCCCCCCCCCC	29.05	25619855
428	Phosphorylation	SAHSSITSGSCPGTP CCCCCCCCCCCCCCH	27.34	25619855
430	Phosphorylation	HSSITSGSCPGTPEM CCCCCCCCCCCCHHH	19.53	25619855
434	Phosphorylation	TSGSCPGTPEMRRRQ CCCCCCCCHHHHHHH	10.96	21082442
643	Phosphorylation	NTTFGKLSSHLKTLS CCCHHHHHHHHHHHC	21.14	25293948
644	Phosphorylation	TTFGKLSSHLKTLSQ CCHHHHHHHHHHHCC	43.19	25293948
648	Phosphorylation	KLSSHLKTLSQGSYL HHHHHHHHHCCCCEE	37.69	25293948
650	Phosphorylation	SSHLKTLSQGSYLYL HHHHHHHCCCCEEEE	37.41	25293948
653	Phosphorylation	LKTLSQGSYLYLKLT HHHHCCCCEEEEEEH	12.34	25293948
654	Phosphorylation	KTLSQGSYLYLKLTF HHHCCCCEEEEEEHH	13.24	25293948
656	Phosphorylation	LSQGSYLYLKLTFDL HCCCCEEEEEEHHHH	8.11	25293948
1245	Phosphorylation	DIMIILLSKLMEEGD CHHHHHHHHHHHHCC	21.94	22006019
1298	Phosphorylation	VSLLLNLSRCRRKMN HHHHHHHHHHHHHHC	28.41	22006019
1303	Acetylation	NLSRCRRKMNDFGMA HHHHHHHHHCCCCCH	23.78	7713811
1438	Phosphorylation	LQTEARPSQGLPVIQ ECCCCCCCCCCCCCC	31.18	27742792
1446	Phosphorylation	QGLPVIQSPPSSPAH CCCCCCCCCCCCCCC	27.88	27742792
1449	Phosphorylation	PVIQSPPSSPAHRDS CCCCCCCCCCCCCCC	52.95	25263469
1450	Phosphorylation	VIQSPPSSPAHRDSA CCCCCCCCCCCCCCC	31.70	27742792
1456	Phosphorylation	SSPAHRDSAYISSSP CCCCCCCCCEECCCC	23.95	25777480
1458	Phosphorylation	PAHRDSAYISSSPLG CCCCCCCEECCCCCC	12.80	25777480
1460	Phosphorylation	HRDSAYISSSPLGSH CCCCCEECCCCCCCC	16.46	25338131
1461	Phosphorylation	RDSAYISSSPLGSHQ CCCCEECCCCCCCCC	26.81	21082442
1462	Phosphorylation	DSAYISSSPLGSHQV CCCEECCCCCCCCCE	19.84	26824392
1466	Phosphorylation	ISSSPLGSHQVFDFR ECCCCCCCCCEEECC	20.59	21183079
1474	Phosphorylation	HQVFDFRSNSSVGSP CCEEECCCCCCCCCC	40.85	22817900
1476	Phosphorylation	VFDFRSNSSVGSPTR EEECCCCCCCCCCCC	27.87	22817900
1477	Phosphorylation	FDFRSNSSVGSPTRQ EECCCCCCCCCCCCC	34.45	22817900
1480	Phosphorylation	RSNSSVGSPTRQGYQ CCCCCCCCCCCCCCC	22.42	25521595
1482	Phosphorylation	NSSVGSPTRQGYQST CCCCCCCCCCCCCCC	37.00	21454597
1521	Phosphorylation	QGASYRFSPPPVGGQ CCCCCCCCCCCCCCC	27.74	25521595
1532	Phosphorylation	VGGQSKEYPSPPPSP CCCCCCCCCCCCCCC	16.85	25619855
1534	Phosphorylation	GQSKEYPSPPPSPLR CCCCCCCCCCCCCCC	49.49	25521595
1538	Phosphorylation	EYPSPPPSPLRRGPQ CCCCCCCCCCCCCCC	42.19	27742792
1546	Phosphorylation	PLRRGPQYRASPPAE CCCCCCCCCCCCCHH	15.98	29899451
1549	Phosphorylation	RGPQYRASPPAESMS CCCCCCCCCCHHHCC	23.55	23527152
1556	Phosphorylation	SPPAESMSVYRSQSG CCCHHHCCEEECCCC	25.85	21183079
1560	Phosphorylation	ESMSVYRSQSGSPVR HHCCEEECCCCCCCE	15.83	29899451
1562	Phosphorylation	MSVYRSQSGSPVRYQ CCEEECCCCCCCEEE	42.35	21183079
1564	Phosphorylation	VYRSQSGSPVRYQQE EEECCCCCCCEEEEE	26.01	19060867
1567	Asymmetric dimethylarginine	SQSGSPVRYQQETNV CCCCCCCEEEEECCH	27.25	-
1567	Methylation	SQSGSPVRYQQETNV CCCCCCCEEEEECCH	27.25	24129315
1568	Phosphorylation	QSGSPVRYQQETNVS CCCCCCEEEEECCHH	18.12	25619855
1572	Phosphorylation	PVRYQQETNVSQLPG CCEEEEECCHHHCCC	36.26	25619855
1575	Phosphorylation	YQQETNVSQLPGRPK EEEECCHHHCCCCCC	28.24	25619855
1580	Asymmetric dimethylarginine	NVSQLPGRPKSPLSK CHHHCCCCCCCCHHH	33.27	-
1580	Methylation	NVSQLPGRPKSPLSK CHHHCCCCCCCCHHH	33.27	24129315
1583	Phosphorylation	QLPGRPKSPLSKMAQ HCCCCCCCCHHHHCC	33.48	26824392
1586	Phosphorylation	GRPKSPLSKMAQRPY CCCCCCHHHHCCCCC	24.62	25619855
1593	Phosphorylation	SKMAQRPYQMPQLPV HHHCCCCCCCCCCCC	21.45	29514104
1608	Methylation	AVPQQGLRLQPAKAQ CCCCCCCCCCCCCHH	37.79	58860007
1637	Phosphorylation	TVIPTGAYGQVAHSM CEECCCCCHHHHHHH	14.94	20116462
1643	O-linked_Glycosylation	AYGQVAHSMASKYQS CCHHHHHHHHHHHHC	13.30	55414201
1643	Phosphorylation	AYGQVAHSMASKYQS CCHHHHHHHHHHHHC	13.30	-
1650	Phosphorylation	SMASKYQSSQGDMGV HHHHHHHCCCCCCCC	22.87	29899451
1651	Phosphorylation	MASKYQSSQGDMGVS HHHHHHCCCCCCCCC	23.74	29899451
1658	Phosphorylation	SQGDMGVSQSRLVYQ CCCCCCCCHHHEEEE	19.40	-
1660	Phosphorylation	GDMGVSQSRLVYQGS CCCCCCHHHEEEECC	21.78	-
1724	O-linked_Glycosylation	QTPQIGRSQSASYYP CCCCCCCCCCCCCCC	24.23	30831185
1724	Phosphorylation	QTPQIGRSQSASYYP CCCCCCCCCCCCCCC	24.23	24759943
1726	Phosphorylation	PQIGRSQSASYYPVC CCCCCCCCCCCCCCC	22.04	24759943
1728	Phosphorylation	IGRSQSASYYPVCHS CCCCCCCCCCCCCCC	30.37	29899451
1729	Phosphorylation	GRSQSASYYPVCHSK CCCCCCCCCCCCCCH	16.11	29899451
1730	Phosphorylation	RSQSASYYPVCHSKL CCCCCCCCCCCCCHH	6.16	29899451
1742	Phosphorylation	SKLDLERSSSQLGSP CHHCHHHCHHCCCCC	25.60	25293948
1743	Phosphorylation	KLDLERSSSQLGSPD HHCHHHCHHCCCCCC	28.46	25293948
1744	Phosphorylation	LDLERSSSQLGSPDV HCHHHCHHCCCCCCH	30.58	25177544
1748	Phosphorylation	RSSSQLGSPDVSHLI HCHHCCCCCCHHHHH	26.90	25177544
1779	Phosphorylation	TPRPLLHSQSVGLRF CCCCCCCCCCCCEEE	24.91	29899451
1781	Phosphorylation	RPLLHSQSVGLRFSP CCCCCCCCCCEEECC	22.59	19060867
1823	Phosphorylation	LKPAYDRSCDELSPV CCCCCCCCCCCCCCC	24.03	25619855
1828	Phosphorylation	DRSCDELSPVSPTQG CCCCCCCCCCCCCCC	22.62	25521595
1831	Phosphorylation	CDELSPVSPTQGGYP CCCCCCCCCCCCCCC	26.13	25521595
1833	Phosphorylation	ELSPVSPTQGGYPSE CCCCCCCCCCCCCCC	32.13	25619855
1837	Phosphorylation	VSPTQGGYPSEPTRS CCCCCCCCCCCCCCC	15.48	25619855
1839	Phosphorylation	PTQGGYPSEPTRSRT CCCCCCCCCCCCCCC	47.96	25619855
1842	Phosphorylation	GGYPSEPTRSRTTPF CCCCCCCCCCCCCCC	36.91	25619855
1882	Phosphorylation	SSVDTVLSPTSPGNL EECCEEECCCCCCCC	23.07	29899451
1894	Phosphorylation	GNLPQPESFSPPSSI CCCCCCCCCCCCCCC	37.39	29899451
1896	Phosphorylation	LPQPESFSPPSSISN CCCCCCCCCCCCCEE	45.22	29899451
1899	Phosphorylation	PESFSPPSSISNIAF CCCCCCCCCCEEEEE	43.62	29899451
1923	Phosphorylation	GHLLEDDYYSPHGML CCCCCCCCCCCCCHH	20.40	22817900
1932	N-linked_Glycosylation	SPHGMLANGSRGDLL CCCCHHCCCCHHHHH	45.04	20571061
1947	Phosphorylation	ERVSQASSYPDVKVA HHHHHHHCCCCCCHH	43.64	25338131
1948	Phosphorylation	RVSQASSYPDVKVAR HHHHHHCCCCCCHHH	10.85	29514104
1956	O-linked_Glycosylation	PDVKVARTLPVAQAY CCCCHHHCCCHHHHH	26.19	55414217
1956	Phosphorylation	PDVKVARTLPVAQAY CCCCHHHCCCHHHHH	26.19	29514104
1963	Phosphorylation	TLPVAQAYQDNLYRQ CCCHHHHHHHHHHHH	12.34	29514104
1968	Phosphorylation	QAYQDNLYRQLSRDS HHHHHHHHHHHHCCC	11.54	29514104
1972	Phosphorylation	DNLYRQLSRDSRQGQ HHHHHHHHCCCCCCC	26.21	29514104
1980	Phosphorylation	RDSRQGQTSPIKPKR CCCCCCCCCCCCCCC	43.21	21454597
1981	Phosphorylation	DSRQGQTSPIKPKRP CCCCCCCCCCCCCCC	19.42	23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TANC2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TANC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TANC2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TANC2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TANC2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1534 AND SER-1549, ANDMASS SPECTROMETRY.	17114649 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1534, AND MASSSPECTROMETRY.	16452087 [Abstract]