HOME3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOME3_MOUSE
• UniProt AC: Q99JP6
• Protein Name: Homer protein homolog 3 {ECO:0000305}
• Gene Name: Homer3 {ECO:0000312|MGI:MGI:1347359}
• Organism: Mus musculus (Mouse).
• Sequence Length: 356
• Subcellular Localization: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Postsynaptic density of neuronal cells..
• Protein Description: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity). Negatively regulates T cell activation through negative regulation of IL2 expression by inhibiting calcineurin-NFAT pathway activation through interaction with NFATC2 leading to reduction of interaction between NFATC2 and PPP3CA (By similarity)..
• Protein Sequence: MSTAREQPIFSTRAHVFQIDPTTKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQQLTQFAEKFQEVKEAARLAREKSQDGGEFTSTGLALASHQVPPSPLVSTNGPGEEKLFRSQSADTPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNQRLAGALREANAAATQWRQQLEVQRAEAELLRQRVAELEAQVAVEPVRAGEKEATSQSVEQLEARVQTKDQTLKNQSTGTREAPDTAEREETQQQVQDLETRNAELEQQLRSMECNLEEARAERERARAEVGRAAQLLDVRLFELSELREGLARLAEAAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	RNVYRIISIGGAKAI CCEEEEEEECCCEEE	16.89	30352176
65	Phosphorylation	AIINSTVTPNMTFTK EEEECCCCCCCEEEE	14.72	-
69	Phosphorylation	STVTPNMTFTKTSQK CCCCCCCEEEECCHH	34.49	29899451
120	Phosphorylation	ARLAREKSQDGGEFT HHHHHHHCCCCCCCC	28.84	25521595
127	Phosphorylation	SQDGGEFTSTGLALA CCCCCCCCCHHHHHH	22.52	25521595
128	Phosphorylation	QDGGEFTSTGLALAS CCCCCCCCHHHHHHC	26.29	26643407
129	Phosphorylation	DGGEFTSTGLALASH CCCCCCCHHHHHHCC	32.91	26643407
135	Phosphorylation	STGLALASHQVPPSP CHHHHHHCCCCCCCC	18.46	29899451
141	Phosphorylation	ASHQVPPSPLVSTNG HCCCCCCCCCCCCCC	25.46	24925903
157	Phosphorylation	GEEKLFRSQSADTPG CHHHHCCCCCCCCCC	22.58	25521595
159	Phosphorylation	EKLFRSQSADTPGPT HHHCCCCCCCCCCCC	29.38	25521595
162	Phosphorylation	FRSQSADTPGPTERE CCCCCCCCCCCCHHH	29.84	25521595
166	Phosphorylation	SADTPGPTERERLKK CCCCCCCCHHHHHHH	54.30	20415495
176	Phosphorylation	ERLKKMLSEGSVGEV HHHHHHHHCCCCCEE	36.09	29899451
179	Phosphorylation	KKMLSEGSVGEVQWE HHHHHCCCCCEEEEE	23.93	29899451
195	Phosphorylation	EFFALQDSNQRLAGA EEEEEECCCHHHHHH	23.15	-
252	Phosphorylation	AGEKEATSQSVEQLE CCCCCCCHHCHHHHH	27.75	29899451
254	Phosphorylation	EKEATSQSVEQLEAR CCCCCHHCHHHHHHH	27.65	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HOME3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOME3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOME3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRM1_MOUSE	Grm1	physical	22486777

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-159, AND MASSSPECTROMETRY.
PubMed: 16452087