GRM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM1_MOUSE
• UniProt AC: P97772
• Protein Name: Metabotropic glutamate receptor 1
• Gene Name: Grm1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1199
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity)..
• Protein Sequence: MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGYVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPITIRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSTHFSPPSSPSMVVHRRGPPVATTPPLPPHLSAEETPLFLADSVIPKGLPPPLPQQQQQPPPQPPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNGLRSLYPPPPPPQHLQMLPLQLSTFREEPISPPGEDDDDDSSERFKLLQEFVYEREGNTEEDDLEEEEDLPAASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	N-linked_Glycosylation	ADPVLLPNITLGSEI CCCCCCCCCCCCHHH	39.59	-
103	Phosphorylation	LPNITLGSEIRDSCW CCCCCCCHHHHHHCC	32.72	23737553
223	N-linked_Glycosylation	LDIVKRYNWTYVSAV HHHHHHCCCEEEEEE	28.75	-
258	Phosphorylation	EGLCIAHSDKIYSNA CCCEEEECCCCCCCC	31.42	25338131
397	N-linked_Glycosylation	FKKVCTGNESLEENY CCCCCCCCCCHHHHH	19.96	-
515	N-linked_Glycosylation	DDYKIQMNKSGMVRS HHCEEEECCCCCCEE	20.97	-
565	S-palmitoylation	DEFTCRACDLGWWPN CCEEEECCCCCCCCC	1.99	28680068
578	S-palmitoylation	PNAELTGCEPITIRY CCCEECCCEEEEEEE	4.78	28680068
677	Phosphorylation	MCYSALVTKTNRIAR HHHHHHHHHHHHHHH	32.76	28576409
679	Phosphorylation	YSALVTKTNRIARIL HHHHHHHHHHHHHHH	21.99	23608596
747	N-linked_Glycosylation	KEVYLICNTSNLGVV CEEEEEECCCCCCEE	39.28	-
841	Ubiquitination	KMYIIIAKPERNVRS CEEEEEECCCCCHHC	36.68	22790023
851	Phosphorylation	RNVRSAFTTSDVVRM CCHHCCCCCCCEEEE	25.71	29899451
852	Phosphorylation	NVRSAFTTSDVVRMH CHHCCCCCCCEEEEE	19.24	24925903
853	Phosphorylation	VRSAFTTSDVVRMHV HHCCCCCCCEEEEEE	25.92	24925903
869	Phosphorylation	DGKLPCRSNTFLNIF CCCCCCCCCCHHHEE	47.11	20415495
871	Phosphorylation	KLPCRSNTFLNIFRR CCCCCCCCHHHEECC	30.64	22817900
892	Phosphorylation	NANSNGKSVSWSEPG CCCCCCCCCCCCCCC	23.84	29899451
894 (in isoform 2)	Phosphorylation	-	31.79	22324799
894	Phosphorylation	NSNGKSVSWSEPGGR CCCCCCCCCCCCCCC	31.79	22817900
896 (in isoform 2)	Phosphorylation	-	26.80	22324799
897 (in isoform 2)	Phosphorylation	-	41.53	22324799
901 (in isoform 2)	Phosphorylation	-	35.09	22324799
914	Phosphorylation	QHVWQRLSVHVKTNE CCCEEEEEEEEECCC	16.62	29899451
943	Phosphorylation	SYQGSGKSLTFSDAS CCCCCCCCEECCCCC	35.85	29899451
945	Phosphorylation	QGSGKSLTFSDASTK CCCCCCEECCCCCCC	28.34	29899451
950	Phosphorylation	SLTFSDASTKTLYNV CEECCCCCCCEEEEE	35.11	29899451
953	Phosphorylation	FSDASTKTLYNVEEE CCCCCCCEEEEEECC	34.27	24925903
955	Phosphorylation	DASTKTLYNVEEEDN CCCCCEEEEEECCCC	23.53	24925903
963	Phosphorylation	NVEEEDNTPSTHFSP EEECCCCCCCCCCCC	30.82	24925903
965	Phosphorylation	EEEDNTPSTHFSPPS ECCCCCCCCCCCCCC	32.26	24925903
966	Phosphorylation	EEDNTPSTHFSPPSS CCCCCCCCCCCCCCC	28.30	24925903
969	Phosphorylation	NTPSTHFSPPSSPSM CCCCCCCCCCCCCCC	28.44	24925903
972	Phosphorylation	STHFSPPSSPSMVVH CCCCCCCCCCCCEEE	59.26	24925903
973	Phosphorylation	THFSPPSSPSMVVHR CCCCCCCCCCCEEEC	27.11	24925903
975	Phosphorylation	FSPPSSPSMVVHRRG CCCCCCCCCEEECCC	26.59	24925903
987	Phosphorylation	RRGPPVATTPPLPPH CCCCCCCCCCCCCCC	39.82	20415495
988	Phosphorylation	RGPPVATTPPLPPHL CCCCCCCCCCCCCCC	17.11	29899451
996	Phosphorylation	PPLPPHLSAEETPLF CCCCCCCCCCCCCCE	30.51	29899451
1000	Phosphorylation	PHLSAEETPLFLADS CCCCCCCCCCEECCC	19.45	20415495
1007	Phosphorylation	TPLFLADSVIPKGLP CCCEECCCCCCCCCC	19.15	20415495
1089	Phosphorylation	QMLPLQLSTFREEPI EECEEEHHHCCCCCC	16.73	29899451
1097	Phosphorylation	TFREEPISPPGEDDD HCCCCCCCCCCCCCC	35.44	25521595
1107	Phosphorylation	GEDDDDDSSERFKLL CCCCCCCCCHHHHHH	40.88	25521595
1108	Phosphorylation	EDDDDDSSERFKLLQ CCCCCCCCHHHHHHH	39.52	25521595
1143	Phosphorylation	LPAASKLTPEDSPAL CCCHHCCCCCCCCCC	28.50	19060867
1147	Phosphorylation	SKLTPEDSPALTPPS HCCCCCCCCCCCCCC	15.48	24925903
1151	Phosphorylation	PEDSPALTPPSPFRD CCCCCCCCCCCCCCC	34.95	24925903
1154	Phosphorylation	SPALTPPSPFRDSVA CCCCCCCCCCCCCCC	37.56	25521595
1164	Phosphorylation	RDSVASGSSVPSSPV CCCCCCCCCCCCCCC	26.18	22807455
1165	Phosphorylation	DSVASGSSVPSSPVS CCCCCCCCCCCCCCC	41.39	19060867
1168	Phosphorylation	ASGSSVPSSPVSESV CCCCCCCCCCCCCCE	45.15	22817900
1169	Phosphorylation	SGSSVPSSPVSESVL CCCCCCCCCCCCCEE	24.21	22817900
1178	Phosphorylation	VSESVLCTPPNVTYA CCCCEECCCCCCEEE	37.30	22817900
1197	Phosphorylation	RDYKQSSSTL----- EHHHHHCCCC-----	38.69	16452087
1198	Phosphorylation	DYKQSSSTL------ HHHHHCCCC------	38.13	16452087

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRM1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_HUMAN	UBC	physical	22486777

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.