dbPTM

PP2AB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PP2AB_MOUSE
UniProt AC	P62715
Protein Name	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Gene Name	Ppp2cb
Organism	Mus musculus (Mouse).
Sequence Length	309
Subcellular Localization	Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles (By similarity)..
Protein Description	PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase..
Protein Sequence	MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MDDKAFTKELDQWVE CCHHHHHHHHHHHHH	50.23	22790023
21	Ubiquitination	VEQLNECKQLNENQV HHHHHHHHHCCHHHH	52.20	22790023
41	Acetylation	KAKEILTKESNVQEV HHHHHHHCCCCCCEE	56.55	23236377
41	Ubiquitination	KAKEILTKESNVQEV HHHHHHHCCCCCCEE	56.55	22790023
74	Ubiquitination	ELFRIGGKSPDTNYL HHHHCCCCCCCCCEE	54.31	-
127	Phosphorylation	SRQITQVYGFYDECL HHHHHEEEEHHHHHH	7.53	22817900
136	Ubiquitination	FYDECLRKYGNANVW HHHHHHHHHCCCCHH	44.56	-
212	Phosphorylation	DRGGWGISPRGAGYT CCCCCCCCCCCCCCC	12.47	22006019
283	Ubiquitination	MELDDTLKYSFLQFD EECCCCCEEEEEECC	40.72	-
284	Phosphorylation	ELDDTLKYSFLQFDP ECCCCCEEEEEECCC	14.04	22817900
285	Phosphorylation	LDDTLKYSFLQFDPA CCCCCEEEEEECCCC	20.21	28464351
304	Phosphorylation	EPHVTRRTPDYFL-- CCCCCCCCCCCCC--	19.74	27180971
307	Phosphorylation	VTRRTPDYFL----- CCCCCCCCCC-----	14.16	7510677
309	Methylation	RRTPDYFL------- CCCCCCCC-------	5.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PP2AB_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PP2AB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PP2AB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_MOUSE	Vcp	physical	20100830
2AAA_MOUSE	Ppp2r1a	physical	20100830
PP2AB_MOUSE	Ppp2cb	physical	20100830
2AAA_MOUSE	Ppp2r1a	physical	24390425
2ABA_MOUSE	Ppp2r2a	physical	24390425

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PP2AB_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Tyrosine phosphorylation of protein phosphatase 2A in response togrowth stimulation and v-src transformation of fibroblasts."; Chen J., Parsons S., Brautigan D.L.; J. Biol. Chem. 269:7957-7962(1994). Cited for: PHOSPHORYLATION AT TYR-307.	7510677 [Abstract]