| UniProt ID | 2ABA_MOUSE | |
|---|---|---|
| UniProt AC | Q6P1F6 | |
| Protein Name | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | |
| Gene Name | Ppp2r2a | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 447 | |
| Subcellular Localization | ||
| Protein Description | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.. | |
| Protein Sequence | MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAGAGGGND ------CCCCCCCCC | 19.28 | - | |
| 62 | Ubiquitination | FQQEQENKIQSHSRG EECCCCCCCCCCCCC | 41.17 | - | |
| 105 | Ubiquitination | KIRWLPQKNAAQFLL HCCCCCCCCHHHHHH | 46.76 | - | |
| 113 | Phosphorylation | NAAQFLLSTNDKTIK CHHHHHHCCCCCEEE | 27.58 | 21454597 | |
| 129 | Ubiquitination | WKISERDKRPEGYNL EEEECCCCCCCCCCC | 75.87 | - | |
| 167 | Phosphorylation | MDLMVEASPRRIFAN HHEEEECCCCEEEEC | 12.87 | 19060867 | |
| 254 | Glutathionylation | SKGTIRLCDMRASAL CCCEEEECHHHHHHH | 2.51 | 24333276 | |
| 262 | Glutathionylation | DMRASALCDRHSKLF HHHHHHHHHHHHHHH | 4.29 | 24333276 | |
| 266 | Phosphorylation | SALCDRHSKLFEEPE HHHHHHHHHHHCCCC | 31.76 | 29899451 | |
| 267 | Ubiquitination | ALCDRHSKLFEEPED HHHHHHHHHHCCCCC | 51.58 | - | |
| 292 | Acetylation | ISSISDVKFSHSGRY HHHHHCCEECCCCCE | 46.25 | 22826441 | |
| 335 | Phosphorylation | YLRSKLCSLYENDCI HHHHHHHHHHCCCCC | 44.41 | 25521595 | |
| 378 | Phosphorylation | RNTKRDITLEASREN CCCCCCEEEHHHHHC | 23.88 | 20139300 | |
| 402 | Acetylation | RKVCASGKRKKDEIS CEECCCCCCCCCCEE | 59.56 | 15605977 | |
| 409 | Phosphorylation | KRKKDEISVDSLDFN CCCCCCEEECCCCCC | 20.16 | 22210690 | |
| 412 | Phosphorylation | KDEISVDSLDFNKKI CCCEEECCCCCCHHH | 27.90 | 22210690 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of 2ABA_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of 2ABA_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of 2ABA_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FXL16_MOUSE | Fbxl16 | physical | 24390425 | |
| 2AAA_HUMAN | PPP2R1A | physical | 26496610 | |
| F122A_HUMAN | FAM122A | physical | 26496610 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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