MAP6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAP6_MOUSE
• UniProt AC: Q7TSJ2
• Protein Name: Microtubule-associated protein 6
• Gene Name: Map6
• Organism: Mus musculus (Mouse).
• Sequence Length: 906
• Subcellular Localization: Cytoplasm, cytoskeleton . Golgi apparatus . Cell projection, axon . Cell projection, dendrite . Cytoplasmic vesicle, secretory vesicle membrane ; Lipid-anchor ; Cytoplasmic side . Isoform 1 and isoform 2 associate with axonal microtubules in neurons
• Protein Description: Involved in microtubule stabilization in many cell types, including neuronal cells. [PubMed: 9600916 Specifically has microtubule cold stabilizing activity]
• Protein Sequence: MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPAPLQPALAPPSRAVAIETQPAQGESDAVARATGPAPGPSVDRETVAAPGRSGLGLGAASASTSGSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQIPATSQPSQPVLGVPKRRPQSQERGPMQLSADARDPEGAGGAGVLAAGKASGVDQRDTRRKAGPAWMVTRNEGHEEKPLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPAWMVTRSEGHEEKPLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPAWMVTRTEGHEETPLPPAQSQTQEGGPAAGKASGADERDTRRKAGPAWMVRRSEGHEQTPAAHAQGTGPEGGKGRAVADALNRQIREEVASTVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEANKPSAADNKAMDRRRIRSLYSEPFKECPKVEKPSVQSSKPKKTSTSHKPPRKAKDKQVVSGQAAKKKTTEGPSATKPDDKEQSKEMNNKLAEAKESRVKPTSDASKNRGPVTKEPHKDQGSVAPGLPKGQEPLKDQGPVVPGLPKDQVPVVPGSLKGQSPTAPGPTKDQGAVLLGPVKDLGPVAPAPIKVQDHIASELLKNKDSVPLAPAKAQSPLLPEPLKNQSPVVPASTKDQSFPTPAPRKDPGPVIPEPEKDRAPTVPERRKDQHVSIMASLKNEAPMVPESVKNQGLAGPELVKDTGTDTTAPRYLKGHDSVFVAPVKNQGPVIPEPVKSQDPIIPALAKDQGPMLPEPPKNQSPVVLGPIKNQDPIIPVPLKGQDPLVPAPTKDQGPTAPDPLKTQGPKGTQLPTVSPSPPVMIPTVPHTEYIEGSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	S-palmitoylation	---MAWPCITRACCI ---CCCHHHHHHHHH	3.28	-
10	S-palmitoylation	WPCITRACCIARFWN CHHHHHHHHHHHHHH	1.23	-
11	S-palmitoylation	PCITRACCIARFWNQ HHHHHHHHHHHHHHH	2.38	-
14	Dimethylation	TRACCIARFWNQLDK HHHHHHHHHHHHHCC	19.73	-
14	Methylation	TRACCIARFWNQLDK HHHHHHHHHHHHHCC	19.73	54540749
21	Ubiquitination	RFWNQLDKADIAVPL HHHHHHCCCCCEEEE	57.46	22790023
23	Ubiquitination	WNQLDKADIAVPLVF HHHHCCCCCEEEEEE	34.81	27667366
32	Ubiquitination	AVPLVFTKYSEATEH EEEEEEEECHHHCCC	35.00	22790023
35	Ubiquitination	LVFTKYSEATEHPGA EEEEECHHHCCCCCC	57.42	27667366
72	Phosphorylation	TQPAQGESDAVARAT ECCCCCCCCHHHHHH	37.38	25521595
79	Phosphorylation	SDAVARATGPAPGPS CCHHHHHHCCCCCCC	37.84	29899451
81	Ubiquitination	AVARATGPAPGPSVD HHHHHHCCCCCCCCC	30.81	27667366
86	Phosphorylation	TGPAPGPSVDRETVA HCCCCCCCCCHHHCC	42.43	25521595
91	Phosphorylation	GPSVDRETVAAPGRS CCCCCHHHCCCCCCC	19.15	22324799
98	Phosphorylation	TVAAPGRSGLGLGAA HCCCCCCCCCCCCCC	44.26	22817900
106	Phosphorylation	GLGLGAASASTSGSG CCCCCCCCCCCCCCC	23.40	29899451
108	Phosphorylation	GLGAASASTSGSGPA CCCCCCCCCCCCCCC	22.17	25521595
109	Phosphorylation	LGAASASTSGSGPAD CCCCCCCCCCCCCCH	36.50	25521595
110	Phosphorylation	GAASASTSGSGPADS CCCCCCCCCCCCCHH	28.59	25521595
112	Phosphorylation	ASASTSGSGPADSVM CCCCCCCCCCCHHHH	41.17	21183079
117	Phosphorylation	SGSGPADSVMRQDYR CCCCCCHHHHHHHHH	21.66	20415495
127	Ubiquitination	RQDYRAWKVQRPEPS HHHHHHHHCCCCCCC	27.75	27667366
139	Phosphorylation	EPSCRPRSEYQPSDA CCCCCCCCCCCCCCC	43.25	25521595
141	Phosphorylation	SCRPRSEYQPSDAPF CCCCCCCCCCCCCCC	27.28	18034455
156	Ubiquitination	ERETQYQKDFRAWPL CCCCHHHHHHHCCCC	54.63	22790023
161	Ubiquitination	YQKDFRAWPLPRRGD HHHHHHCCCCCCCCC	7.24	27667366
174	Ubiquitination	GDHPWIPKPVQIPAT CCCCCCCCCEECCCC	49.00	22790023
181	Phosphorylation	KPVQIPATSQPSQPV CCEECCCCCCCCCCC	23.65	-
182	O-linked_Glycosylation	PVQIPATSQPSQPVL CEECCCCCCCCCCCC	42.05	22517741
185	Phosphorylation	IPATSQPSQPVLGVP CCCCCCCCCCCCCCC	39.21	-
185	O-linked_Glycosylation	IPATSQPSQPVLGVP CCCCCCCCCCCCCCC	39.21	22517741
193	Ubiquitination	QPVLGVPKRRPQSQE CCCCCCCCCCCCCCC	59.64	22790023
198	Phosphorylation	VPKRRPQSQERGPMQ CCCCCCCCCCCCCCC	36.37	22324799
207	Phosphorylation	ERGPMQLSADARDPE CCCCCCCCCCCCCCC	13.76	25521595
226	Ubiquitination	AGVLAAGKASGVDQR HHHHHCCHHCCCCHH	34.35	22790023
235	Phosphorylation	SGVDQRDTRRKAGPA CCCCHHHHHHHCCCE	34.26	29899451
238	Ubiquitination	DQRDTRRKAGPAWMV CHHHHHHHCCCEEEE	55.17	22790023
254	Ubiquitination	RNEGHEEKPLPPAQS CCCCCCCCCCCCCHH	49.20	22790023
272	Ubiquitination	EGGPAAGKASGADQR CCCCCCCCCCCCCHH	34.35	22790023
279	Ubiquitination	KASGADQRDTRRKAG CCCCCCHHHHHHHCC	48.06	27667366
284	Ubiquitination	DQRDTRRKAGPAWMV CHHHHHHHCCCEEEE	55.17	27667366
288 (in isoform 3)	Phosphorylation	-	13.18	29514104
290 (in isoform 3)	Phosphorylation	-	2.10	29514104
292	Phosphorylation	AGPAWMVTRSEGHEE CCCEEEEECCCCCCC	16.63	29899451
294	O-linked_Glycosylation	PAWMVTRSEGHEEKP CEEEEECCCCCCCCC	38.27	55412603
294	Phosphorylation	PAWMVTRSEGHEEKP CEEEEECCCCCCCCC	38.27	29899451
300	Ubiquitination	RSEGHEEKPLPPAQS CCCCCCCCCCCCCHH	49.20	22790023
318	Ubiquitination	EGGPAAGKASGADQR CCCCCCCCCCCCCHH	34.35	-
330	Ubiquitination	DQRDTRRKAGPAWMV CHHHHHHHCCCEEEE	55.17	27667366
364	Ubiquitination	EGGPAAGKASGADER CCCCCCCCCCCCCHH	34.35	22790023
366	Phosphorylation	GPAAGKASGADERDT CCCCCCCCCCCHHHH	37.69	-
373	Phosphorylation	SGADERDTRRKAGPA CCCCHHHHHHHCCCE	38.30	29899451
376	Ubiquitination	DERDTRRKAGPAWMV CHHHHHHHCCCEEEE	55.17	22790023
386	Phosphorylation	PAWMVRRSEGHEQTP CEEEEECCCCCCCCC	37.05	25521595
386	O-linked_Glycosylation	PAWMVRRSEGHEQTP CEEEEECCCCCCCCC	37.05	31579269
392	Phosphorylation	RSEGHEQTPAAHAQG CCCCCCCCCCCCCCC	16.35	25521595
406	Ubiquitination	GTGPEGGKGRAVADA CCCCCCCHHHHHHHH	56.96	22790023
425	O-linked_Glycosylation	IREEVASTVSSSYRN HHHHHHHHHCHHHHH	18.05	22517741
441	Ubiquitination	FRAWTDIKPVKPIKA CEECCCCCCCCCCCC	46.71	22790023
441	Acetylation	FRAWTDIKPVKPIKA CEECCCCCCCCCCCC	46.71	23806337
444	Acetylation	WTDIKPVKPIKAKPQ CCCCCCCCCCCCCCC	49.94	23806337
444	Ubiquitination	WTDIKPVKPIKAKPQ CCCCCCCCCCCCCCC	49.94	22790023
452	Phosphorylation	PIKAKPQYKPPDDKM CCCCCCCCCCCCCCC	33.71	29514104
458	Ubiquitination	QYKPPDDKMVHETSY CCCCCCCCCCCCCCC	50.64	22790023
475	Ubiquitination	QFKGEANKPSAADNK EECCCCCCCCHHHCH	47.61	22790023
482	Ubiquitination	KPSAADNKAMDRRRI CCCHHHCHHHHHHHH	45.71	22790023
491	Phosphorylation	MDRRRIRSLYSEPFK HHHHHHHHHHCCCHH	29.32	25521595
493	Phosphorylation	RRRIRSLYSEPFKEC HHHHHHHHCCCHHHC	16.54	22807455
498	Ubiquitination	SLYSEPFKECPKVEK HHHCCCHHHCCCCCC	69.95	22790023
527	Malonylation	HKPPRKAKDKQVVSG CCCCCCCCCCCCCCC	69.37	26073543
529	Malonylation	PPRKAKDKQVVSGQA CCCCCCCCCCCCCHH	44.26	26073543
553	Ubiquitination	SATKPDDKEQSKEMN CCCCCCHHHHHHHHH	66.10	27667366
607	Ubiquitination	PKGQEPLKDQGPVVP CCCCCCCCCCCCCCC	59.74	27667366
627	Phosphorylation	QVPVVPGSLKGQSPT HCCCCCCCCCCCCCC	22.34	22324799
632	Phosphorylation	PGSLKGQSPTAPGPT CCCCCCCCCCCCCCC	32.65	25521595
634	Phosphorylation	SLKGQSPTAPGPTKD CCCCCCCCCCCCCCC	51.21	25521595
639	Phosphorylation	SPTAPGPTKDQGAVL CCCCCCCCCCCCEEE	53.84	24925903
669	Phosphorylation	KVQDHIASELLKNKD CCHHHHHHHHHCCCC	28.33	25521595
687	Phosphorylation	LAPAKAQSPLLPEPL CCCCCCCCCCCCCCC	23.52	25521595
698	Phosphorylation	PEPLKNQSPVVPAST CCCCCCCCCCCCCCC	29.11	25521595
704	Phosphorylation	QSPVVPASTKDQSFP CCCCCCCCCCCCCCC	29.89	29899451
704	O-linked_Glycosylation	QSPVVPASTKDQSFP CCCCCCCCCCCCCCC	29.89	22517741
705	Phosphorylation	SPVVPASTKDQSFPT CCCCCCCCCCCCCCC	40.52	-
705	O-linked_Glycosylation	SPVVPASTKDQSFPT CCCCCCCCCCCCCCC	40.52	22517741
709	Phosphorylation	PASTKDQSFPTPAPR CCCCCCCCCCCCCCC	43.24	-
785	Methylation	TTAPRYLKGHDSVFV CCCCHHHCCCCEEEE	45.31	-
789	Phosphorylation	RYLKGHDSVFVAPVK HHHCCCCEEEEECCC	16.27	25521595
832	Phosphorylation	PEPPKNQSPVVLGPI CCCCCCCCCCEEECC	29.11	25521595
886	Phosphorylation	GTQLPTVSPSPPVMI CCCCCCCCCCCCEEC	23.34	25619855
888	Phosphorylation	QLPTVSPSPPVMIPT CCCCCCCCCCEECCC	34.04	25619855
895	Phosphorylation	SPPVMIPTVPHTEYI CCCEECCCCCCCCCC	35.43	25619855
899	Phosphorylation	MIPTVPHTEYIEGSP ECCCCCCCCCCCCCC	25.14	25619855
901	Phosphorylation	PTVPHTEYIEGSP-- CCCCCCCCCCCCC--	12.86	25619855
905	Phosphorylation	HTEYIEGSP------ CCCCCCCCC------	18.04	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAP6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAP6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAP6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MAP6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108; SER-632; SER-687;SER-832 AND SER-905, AND MASS SPECTROMETRY.
PubMed: 17114649

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-141, AND MASSSPECTROMETRY.
PubMed: 18034455