PDE1A_MOUSE - dbPTM
PDE1A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDE1A_MOUSE
UniProt AC Q61481
Protein Name Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Gene Name Pde1a
Organism Mus musculus (Mouse).
Sequence Length 565
Subcellular Localization
Protein Description Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP (By similarity)..
Protein Sequence MCDSSPSSSHVWIAPVRNIIMGSTDTDIEELENATYKYLIGEQTEKMWQRLKGILRCLVKQLEKGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMMKKKPEEKPKFRSIVHAVQAGIFVERMYRKNYHMVGLTYPAAVIVTLKEVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKSQSSNYGASSSSTMIGFHVADSLRRSNTKGSVCDGSYAPDYSLSAVDLKSFKNNLVDIIQQNKERWKELAAQGELDLHKNSEELGNTEEKHADTRP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationVRNIIMGSTDTDIEE
CCEEECCCCCCCHHH		13.0120415495
24PhosphorylationRNIIMGSTDTDIEEL
CEEECCCCCCCHHHH		36.8720415495
26PhosphorylationIIMGSTDTDIEELEN
EECCCCCCCHHHHHH		38.6820415495
46UbiquitinationLIGEQTEKMWQRLKG
HHCHHHHHHHHHHHH		49.1522790023
120PhosphorylationVRDWLASTFTRKMGM
HHHHHHHHHHHHHCC		24.3428576409
122PhosphorylationDWLASTFTRKMGMMK
HHHHHHHHHHHCCCC		29.4828576409
365PhosphorylationQIKNIRNSLQQPEGI
HHHHHHHHCCCCCCC		20.0829899451
423PhosphorylationAELGLPFSPLCDRKS
CCCCCCCCCCCCCCC		18.2820415495
481PhosphorylationNYGASSSSTMIGFHV
CCCCCCCCCCHHHHH		24.76-
482PhosphorylationYGASSSSTMIGFHVA
CCCCCCCCCHHHHHH		18.11-
491PhosphorylationIGFHVADSLRRSNTK
HHHHHHHHHHCCCCC		17.6529899451
495PhosphorylationVADSLRRSNTKGSVC
HHHHHHCCCCCCCCC		42.2829899451
497PhosphorylationDSLRRSNTKGSVCDG
HHHHCCCCCCCCCCC		37.7229899451
500PhosphorylationRRSNTKGSVCDGSYA
HCCCCCCCCCCCCCC		22.5629899451
505PhosphorylationKGSVCDGSYAPDYSL
CCCCCCCCCCCCCCC		12.6029899451
506PhosphorylationGSVCDGSYAPDYSLS
CCCCCCCCCCCCCCC		27.9029899451
510PhosphorylationDGSYAPDYSLSAVDL
CCCCCCCCCCCCEEH		15.51-
511PhosphorylationGSYAPDYSLSAVDLK
CCCCCCCCCCCEEHH		24.19-
518UbiquitinationSLSAVDLKSFKNNLV
CCCCEEHHHHHHCHH		49.7522790023
532UbiquitinationVDIIQQNKERWKELA
HHHHHHCHHHHHHHH		44.3022790023
550PhosphorylationELDLHKNSEELGNTE
CCCCCCCHHHHCCCC		36.9329899451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDE1A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDE1A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDE1A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PDE1A_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDE1A_MOUSE

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Related Literatures of Post-Translational Modification

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