PDE4D_MOUSE - dbPTM
PDE4D_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDE4D_MOUSE
UniProt AC Q01063
Protein Name cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Gene Name Pde4d
Organism Mus musculus (Mouse).
Sequence Length 747
Subcellular Localization Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Apical cell membrane. Colocalized with SHANK2 to the apical membrane of colonic crypt cells (By similarity). Found in the soluble fracti
Protein Description Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes..
Protein Sequence MERDTCDVLSRSKSASEETLHSCNEEEDPFRGMEPYLVRRLSSRSIQLPPLAFRQLEQADLRSESENIPRPTSLPLKILPLIAVTSADSSGFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDQEEGRQGQTEKFQFELTLEEDCESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVAEEESQPETCVPDDCCPDT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6 (in isoform 3)Phosphorylation-3.89-
11 (in isoform 2)Phosphorylation-43.9024899341
14 (in isoform 2)Phosphorylation-37.9729899451
14PhosphorylationDVLSRSKSASEETLH
HHHHHCCCCCHHHHH		37.9727742792
16PhosphorylationLSRSKSASEETLHSC
HHHCCCCCHHHHHCC		42.9527742792
19PhosphorylationSKSASEETLHSCNEE
CCCCCHHHHHCCCCC		26.2227742792
42PhosphorylationPYLVRRLSSRSIQLP
HHHHHHHHHCCCCCC		23.1523140645
43PhosphorylationYLVRRLSSRSIQLPP
HHHHHHHHCCCCCCH		34.3423140645
103PhosphorylationNGTSAGRSPLDPMTS
CCCCCCCCCCCCCCC		28.9725168779
109PhosphorylationRSPLDPMTSPGSGLI
CCCCCCCCCCCCEEE		36.8429899451
110PhosphorylationSPLDPMTSPGSGLIL
CCCCCCCCCCCEEEE		22.4726824392
113PhosphorylationDPMTSPGSGLILQAN
CCCCCCCCEEEEEEE		33.5325168779
129PhosphorylationVHSQRRESFLYRSDS
CCCCCCHHHCCCCCC		20.8124925903
132PhosphorylationQRRESFLYRSDSDYD
CCCHHHCCCCCCCCC		13.1729899451
134PhosphorylationRESFLYRSDSDYDLS
CHHHCCCCCCCCCCC		28.1025619855
136PhosphorylationSFLYRSDSDYDLSPK
HHCCCCCCCCCCCHH		39.0425521595
138PhosphorylationLYRSDSDYDLSPKSM
CCCCCCCCCCCHHHH		23.8025619855
141PhosphorylationSDSDYDLSPKSMSRN
CCCCCCCCHHHHCCC		27.6425521595
149PhosphorylationPKSMSRNSSIASDIH
HHHHCCCCCCCCCCC		23.2429899451
150PhosphorylationKSMSRNSSIASDIHG
HHHCCCCCCCCCCCC		26.2325177544
153PhosphorylationSRNSSIASDIHGDDL
CCCCCCCCCCCCCCE		35.1129899451
191PhosphorylationNLQDRAPSKRSPMCN
CCCCCCCCCCCCCCC		39.4529899451
194PhosphorylationDRAPSKRSPMCNQPS
CCCCCCCCCCCCCCC		22.2628066266
201PhosphorylationSPMCNQPSINKATIT
CCCCCCCCCCCCCCC		29.0922324799
238PhosphorylationETLQTRHSVSEMASN
HHHHHHHHHHHHHHH		24.85-
240PhosphorylationLQTRHSVSEMASNKF
HHHHHHHHHHHHHHH		25.3519854140
244PhosphorylationHSVSEMASNKFKRML
HHHHHHHHHHHHHHH		38.9619854140
256PhosphorylationRMLNRELTHLSEMSR
HHHHHHHHHHHHHHC		18.9325162660
264PhosphorylationHLSEMSRSGNQVSEY
HHHHHHCCCCHHHHH		34.4922817900
269PhosphorylationSRSGNQVSEYISNTF
HCCCCHHHHHHHHHH		18.2129899451
271PhosphorylationSGNQVSEYISNTFLD
CCCHHHHHHHHHHCC		11.3520415495
273PhosphorylationNQVSEYISNTFLDKQ
CHHHHHHHHHHCCCC		28.9920415495
275PhosphorylationVSEYISNTFLDKQHE
HHHHHHHHHCCCCCC		20.8420415495
287PhosphorylationQHEVEIPSPTQKEKE
CCCCCCCCCCHHHHH		46.3625521595
289PhosphorylationEVEIPSPTQKEKEKK
CCCCCCCCHHHHHHH		57.5225521595
301PhosphorylationEKKKRPMSQISGVKK
HHHCCCHHHHHHHHH		27.35-
304PhosphorylationKRPMSQISGVKKLMH
CCCHHHHHHHHHHHC		29.8729899451
312PhosphorylationGVKKLMHSSSLTNSC
HHHHHHCCCCCCCCC		13.9924925903
313PhosphorylationVKKLMHSSSLTNSCI
HHHHHCCCCCCCCCC		18.0622324799
314PhosphorylationKKLMHSSSLTNSCIP
HHHHCCCCCCCCCCC		42.0824925903
316PhosphorylationLMHSSSLTNSCIPRF
HHCCCCCCCCCCCCC		27.3422324799
318PhosphorylationHSSSLTNSCIPRFGV
CCCCCCCCCCCCCCC		14.2622324799
534PhosphorylationMVETKKVTSSGVLLL
HHHCCCCCCCCEEEE		26.5125521595
535PhosphorylationVETKKVTSSGVLLLD
HHCCCCCCCCEEEEC		28.2525521595
536PhosphorylationETKKVTSSGVLLLDN
HCCCCCCCCEEEECC		24.4525521595
544PhosphorylationGVLLLDNYSDRIQVL
CEEEECCHHHHHHHH		16.1820415495
545PhosphorylationVLLLDNYSDRIQVLQ
EEEECCHHHHHHHHH		27.0220415495
596PhosphorylationRERGMEISPMCDKHN
HHHCCCCCCCCCCCC		8.0225521595
647PhosphorylationLEDNREWYQSTIPQS
HHHHHHHHHCCCCCC		6.4528066266
649PhosphorylationDNREWYQSTIPQSPS
HHHHHHHCCCCCCCC		16.7728066266
650PhosphorylationNREWYQSTIPQSPSP
HHHHHHCCCCCCCCC		22.5828066266
654PhosphorylationYQSTIPQSPSPAPDD
HHCCCCCCCCCCCCC		23.2221149613
656PhosphorylationSTIPQSPSPAPDDQE
CCCCCCCCCCCCCHH		38.6528066266
691PhosphorylationESDTEKDSGSQVEED
CCCCCCCCCCCCCCC		51.9525521595
693PhosphorylationDTEKDSGSQVEEDTS
CCCCCCCCCCCCCCC		34.7025521595
700PhosphorylationSQVEEDTSCSDSKTL
CCCCCCCCCCCCCEE		24.7625521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
136SPhosphorylationKinaseSIKQ60670
PSP
141SPhosphorylationKinaseSIKQ60670
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDE4D_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDE4D_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PDE4D_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDE4D_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory