RIMS3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIMS3_MOUSE
• UniProt AC: Q80U57
• Protein Name: Regulating synaptic membrane exocytosis protein 3
• Gene Name: Rims3
• Organism: Mus musculus (Mouse).
• Sequence Length: 307
• Subcellular Localization: Cell junction, synapse.
• Protein Description: Regulates synaptic membrane exocytosis..
• Protein Sequence: MFNGEPGPASAGASRNVVRSSSISGEICGSQQAGGGAGTTTAKKRRSSLGAKMVAIVGLTQWSKSTLQLPQPEGATKKLRSNIRRSTETGIAVEMRSRVTRQGSRESTDGSTNSNSSEGTFIFPTRLGAESQFSDFLDGLGPAQIVGRQTLATPPMGDVHIAIMDRSGQLEVEVIEARGLTPKPGSKSLPATYIKAYLLENGACVAKKKTKVAKKTCDPLYQQALLFDEGPQGKVLQVIVWGDYGRMDHKCFMGMAQIMLDELDLSAAVTGWYKLFPTSSVADSTLGSLTRRLSQSSLESATSPSCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	ASRNVVRSSSISGEI CCCCEECCCCCCCEE	19.48	28066266
21	Phosphorylation	SRNVVRSSSISGEIC CCCEECCCCCCCEEC	22.56	28066266
22	Phosphorylation	RNVVRSSSISGEICG CCEECCCCCCCEECC	23.24	28066266
24	Phosphorylation	VVRSSSISGEICGSQ EECCCCCCCEECCCC	32.11	28066266
47	Phosphorylation	TTAKKRRSSLGAKMV HHHHHHHHHHCCCEE	33.67	29899451
48	Phosphorylation	TAKKRRSSLGAKMVA HHHHHHHHHCCCEEE	29.07	29899451
65	Phosphorylation	GLTQWSKSTLQLPQP ECCCCCHHCCCCCCC	28.91	29899451
66	Phosphorylation	LTQWSKSTLQLPQPE CCCCCHHCCCCCCCC	23.43	29899451
86	Phosphorylation	LRSNIRRSTETGIAV HHHHHHHHCCCCEEE	22.27	29899451
87	Phosphorylation	RSNIRRSTETGIAVE HHHHHHHCCCCEEEE	35.44	25521595
100	Phosphorylation	VEMRSRVTRQGSRES EEECCCCCCCCCCCC	19.03	29899451
104	Phosphorylation	SRVTRQGSRESTDGS CCCCCCCCCCCCCCC	25.24	25521595
107	Phosphorylation	TRQGSRESTDGSTNS CCCCCCCCCCCCCCC	30.59	25293948
108	Phosphorylation	RQGSRESTDGSTNSN CCCCCCCCCCCCCCC	39.36	25521595
111	Phosphorylation	SRESTDGSTNSNSSE CCCCCCCCCCCCCCC	27.50	25293948
112	Phosphorylation	RESTDGSTNSNSSEG CCCCCCCCCCCCCCC	48.47	25293948
114	Phosphorylation	STDGSTNSNSSEGTF CCCCCCCCCCCCCEE	37.87	25293948
116	Phosphorylation	DGSTNSNSSEGTFIF CCCCCCCCCCCEEEE	29.59	25293948
117	Phosphorylation	GSTNSNSSEGTFIFP CCCCCCCCCCEEEEE	44.27	25293948
120	Phosphorylation	NSNSSEGTFIFPTRL CCCCCCCEEEEECCC	14.98	25293948
279	Phosphorylation	WYKLFPTSSVADSTL HHHHCCCCHHHHHHH	24.05	21183079
288	Phosphorylation	VADSTLGSLTRRLSQ HHHHHHHHHHHHHHH	29.67	22817900
290	Phosphorylation	DSTLGSLTRRLSQSS HHHHHHHHHHHHHHH	18.55	21183079
294	Phosphorylation	GSLTRRLSQSSLESA HHHHHHHHHHHHHHC	26.63	25521595
296	Phosphorylation	LTRRLSQSSLESATS HHHHHHHHHHHHCCC	33.25	25521595
297	Phosphorylation	TRRLSQSSLESATSP HHHHHHHHHHHCCCC	28.63	25521595
300	Phosphorylation	LSQSSLESATSPSCS HHHHHHHHCCCCCCC	41.98	24925903
302	Phosphorylation	QSSLESATSPSCS-- HHHHHHCCCCCCC--	50.91	24925903
303	Phosphorylation	SSLESATSPSCS--- HHHHHCCCCCCC---	17.96	24925903
307	Phosphorylation	SATSPSCS------- HCCCCCCC-------	47.82	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIMS3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIMS3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIMS3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RIMS3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-296, AND MASSSPECTROMETRY.
PubMed: 17114649