PLEC_MOUSE - dbPTM
PLEC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLEC_MOUSE
UniProt AC Q9QXS1
Protein Name Plectin
Gene Name Plec
Organism Mus musculus (Mouse).
Sequence Length 4691
Subcellular Localization Cytoplasm, cytoskeleton. Cell junction, hemidesmosome.
Protein Description Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics..
Protein Sequence MVAGMLMPLDRLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLKARGLVRETFAWCHFYWYLTNEGIDHLRQYLHLPPEIVPASLQRVRRPVAMVIPARRRSPHVQTMQGPLGCPPKRGPLPAEDPAREERQVYRRKEREEGAPETPVVSATTVGTLARPGPEPAPATDERDRVQKKTFTKWVNKHLIKHWRAEAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPGAQDGVRANELQLRWQEYRELVLLLLQWIRHHTAAFEERKFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKVIYQSLEGAVQAGQLKIPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVSKLQMEAGLCEEQLNQADALLQSDIRLLASGKVAQRAGEVERDLDKADGMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVGAPVTQVTLQSTQRRPELEDSTLRYLQDLLAWVEENQRRIDSAEWGVDLPSVEAQLGSHRGMHQSIEEFRAKIERARNDESQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESYSALMRELEMKEKKIKEIQNTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLQKLQETLRRKYSCDRTITVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAIVQLKPRNPAHPVRGHVPLIAVCDYKQVEVTVHKGDQCQLVGPAQPSHWKVLSGSSSEAAVPSVCFLVPPPNQEAQEAVARLEAQHQALVTLWHQLHVDMKSLLAWQSLSRDIQLIRSWSLVTFRTLKPEEQRQALRNLELHYQAFLRDSQDAGGFGPEDRLVAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKDPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKTHEEQLKEAQAVPATLQELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAVPIANCQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSEIATTQAASTKALPNGRDAPDGPSVEAEPEYTFEGLRQKVPAQQLQEAGILSQEELQRLAQGHTTVAELTQREDVYRYLKGRSSIAGLLLKPTNEKLSVYTALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVRDHGVRLLEAQIATGGIIDPVHSHRVPVDVAYKRGYFDEEMNRILSDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDKAAKGGELVYTDTEARDVFEKATVSAPFGKFQGRTVTIWEIINSEYFTAEQRRDLLQQFRTGHITVEKIIKIVITVVEEHERKGQLCFEGLRALVPAAELLDSGVISHELYQQLQRGERSVREVAEADSVRQALRGTNVIAGVWLEEAGQKLSIYEALKKDLLQPEVAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYRDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAYARGYLDKETNRALTSPRDDARVYHDPSTQEPVTYSQLQQRCRSDQLTGLSLLPLSEKAVRARQEEVYSELQARETLEQAKVEVPVGSFKGRAMTVWELISSEYFTEEQRQELLRQFRTGKVTVEKVIKIVITIVEEVETRRQERLSFSGLRAPVPASELLDAKILSRAQFDQLKDGKTSVKELSEVGSVRTLLQGSGCLAGIYLEDSKEKVTIYEAMRRGLLRPSTATLLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGNTISLFQAMKKGLVLRDHAIRLLEAQVATGGIIDPVHSHRLPVDVAYQRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLKGAEKTEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSSMSLWEVMQSNMIPEDQRARLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQNLASYDYVRRRLTAEDLYEARIISLETYNLFREGTKNLREVLEMESAWRYLYGTGAVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLKRCRRDDPSGQMLLLLSDARKLTFRGLRKQITVEELVRSQVMDEATALQLQEGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAITKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISSAGPRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVSLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSSKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPSASLGGPESAVA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2 (in isoform 3)Phosphorylation-10.5529514104
12 (in isoform 14)Phosphorylation-4.3022802335
16 (in isoform 3)Phosphorylation-10.0529514104
17 (in isoform 6)Phosphorylation-26.9925168779
17 (in isoform 7)Phosphorylation-26.9925168779
17 (in isoform 8)Phosphorylation-26.9925168779
18 (in isoform 6)Phosphorylation-3.2525168779
18 (in isoform 7)Phosphorylation-3.2525168779
18 (in isoform 8)Phosphorylation-3.2525168779
19 (in isoform 3)Phosphorylation-1.9325521595
20 (in isoform 3)Phosphorylation-8.9127742792
21 (in isoform 3)Phosphorylation-35.2825521595
21 (in isoform 6)Phosphorylation-35.2825168779
21 (in isoform 7)Phosphorylation-35.2825168779
21 (in isoform 8)Phosphorylation-35.2825168779
22 (in isoform 6)Phosphorylation-49.1325168779
22 (in isoform 7)Phosphorylation-49.1325168779
22 (in isoform 8)Phosphorylation-49.1325168779
24 (in isoform 6)Phosphorylation-2.0925338131
24 (in isoform 7)Phosphorylation-2.0925338131
24 (in isoform 8)Phosphorylation-2.0925338131
26 (in isoform 3)Phosphorylation-7.0225159016
26 (in isoform 6)Phosphorylation-7.0225168779
26 (in isoform 7)Phosphorylation-7.0225168779
26 (in isoform 8)Phosphorylation-7.0225168779
28AcetylationREGVMVAKKDRRPRS
HCCCEEEECCCCCCC
43.74-
28AcetylationREGVMVAKKDRRPRS
HCCCEEEECCCCCCC
43.7423864654
30 (in isoform 6)Phosphorylation-51.6325168779
30 (in isoform 7)Phosphorylation-51.6325168779
30 (in isoform 8)Phosphorylation-51.6325168779
44 (in isoform 6)Phosphorylation-35.8130635358
44 (in isoform 7)Phosphorylation-35.8130635358
44 (in isoform 8)Phosphorylation-35.8130635358
48 (in isoform 6)Phosphorylation-2.9426824392
48 (in isoform 7)Phosphorylation-2.9426824392
48 (in isoform 8)Phosphorylation-2.9426824392
54PhosphorylationQVMRAMASLKARGLV
HHHHHHHHHHHCHHH
19.81-
114PhosphorylationVIPARRRSPHVQTMQ
EEECCCCCCCCCCCC
19.9726824392
119PhosphorylationRRSPHVQTMQGPLGC
CCCCCCCCCCCCCCC
15.4625619855
131 (in isoform 8)Phosphorylation-33.9329899451
158PhosphorylationREEGAPETPVVSATT
HHCCCCCCCCEEEEE
21.9626824392
162PhosphorylationAPETPVVSATTVGTL
CCCCCCEEEEECCCC
21.8225619855
164PhosphorylationETPVVSATTVGTLAR
CCCCEEEEECCCCCC
17.9525619855
165PhosphorylationTPVVSATTVGTLARP
CCCEEEEECCCCCCC
19.3625619855
193MalonylationVQKKTFTKWVNKHLI
HHHHHHHHHHHHHHH
44.9826320211
212PhosphorylationAEAQRHISDLYEDLR
HHHHHHHHHHHHHHC
18.5522817900
235PhosphorylationLEVLSGDSLPREKGR
HHHHHCCCCCCHHCC
43.7422210690
264MalonylationYLRHRQVKLVNIRND
HHHHCCEEEEEECCC
38.0826320211
362PhosphorylationMNKVYRQTNLENLDQ
HHHHHHHHCCCCHHH
32.5428464351
372PhosphorylationENLDQAFSVAERDLG
CCHHHHHHHHHHHHC
24.3528464351
405PhosphorylationSIITYVSSLYDAMPR
HHHHHHHHHHHHCCC
22.39-
407PhosphorylationITYVSSLYDAMPRVP
HHHHHHHHHHCCCCC
12.0122817900
491PhosphorylationKNRSKVIYQSLEGAV
CCCCHHHHHHHHHHH
8.6022817900
592AcetylationEVERDLDKADGMIRL
HHHCCHHHCCCHHHH
56.5323806337
608AcetylationFNDVQTLKDGRHPQG
HHCHHHHCCCCCCHH
62.6222826441
649O-linked_GlycosylationAGVGAPVTQVTLQST
CCCCCCEEEEEEEEC
19.1067054293
652PhosphorylationGAPVTQVTLQSTQRR
CCCEEEEEEEECCCC
14.8429514104
725PhosphorylationERARNDESQLSPATR
HHHHCCCCCCCHHHH
39.0125619855
728PhosphorylationRNDESQLSPATRGAY
HCCCCCCCHHHHHHH
12.5925521595
731PhosphorylationESQLSPATRGAYRDC
CCCCCHHHHHHHHHH
32.7827742792
762PhosphorylationARLRSLESLHGFVAA
HHHHHHHHHHHHHHH
30.8428464351
818MalonylationEMKEKKIKEIQNTGD
HHHHHHHHHHHHHHH
58.6126320211
823PhosphorylationKIKEIQNTGDRLLRE
HHHHHHHHHHHHHHC
24.8817208939
889PhosphorylationQLQKLQETLRRKYSC
HHHHHHHHHHHHCCC
16.7724719451
894PhosphorylationQETLRRKYSCDRTIT
HHHHHHHCCCCCEEE
16.8430635358
895PhosphorylationETLRRKYSCDRTITV
HHHHHHCCCCCEEEE
16.7523608596
899PhosphorylationRKYSCDRTITVTRLE
HHCCCCCEEEEEHHH
14.0324719451
901PhosphorylationYSCDRTITVTRLEDL
CCCCCEEEEEHHHHH
18.4023608596
916AcetylationLQDAQDEKEQLNEYK
HHHHHHHHHHHHHHH
60.0823806337
922PhosphorylationEKEQLNEYKGHLSGL
HHHHHHHHHHHHHHH
22.6124719451
923AcetylationKEQLNEYKGHLSGLA
HHHHHHHHHHHHHHH
33.4019859319
927PhosphorylationNEYKGHLSGLAKRAK
HHHHHHHHHHHHHHH
26.5318779572
931MalonylationGHLSGLAKRAKAIVQ
HHHHHHHHHHHHHEE
58.9126320211
940AcetylationAKAIVQLKPRNPAHP
HHHHEECCCCCCCCC
25.4923806337
958GlutathionylationHVPLIAVCDYKQVEV
CCCEEEEECCEEEEE
3.3224333276
1053PhosphorylationRDIQLIRSWSLVTFR
HHHHHHHHHEEEEEE
17.6429472430
1055PhosphorylationIQLIRSWSLVTFRTL
HHHHHHHEEEEEECC
17.7625521595
1058PhosphorylationIRSWSLVTFRTLKPE
HHHHEEEEEECCCHH
16.8229472430
1103PhosphorylationRLVAEREYGSCSRHY
HHHHHHHHHHHHHHH
22.14-
1105PhosphorylationVAEREYGSCSRHYQQ
HHHHHHHHHHHHHHH
14.1729514104
1132PhosphorylationSRCQRCISELKDIRL
HHHHHHHHHHHHHHH
40.27-
1144GlutathionylationIRLQLEACETRTVHR
HHHHHHHHCCCCCCE
3.9124333276
1146PhosphorylationLQLEACETRTVHRLR
HHHHHHCCCCCCEEC
31.3725619855
1148PhosphorylationLEACETRTVHRLRLP
HHHHCCCCCCEECCC
28.2525619855
1173UbiquitinationQRIAEQQKAQAEVEG
HHHHHHHHHHHHHCC
42.0122790023
1173AcetylationQRIAEQQKAQAEVEG
HHHHHHHHHHHHHCC
42.0123806337
1173SuccinylationQRIAEQQKAQAEVEG
HHHHHHHHHHHHHCC
42.0123806337
1173UbiquitinationQRIAEQQKAQAEVEG
HHHHHHHHHHHHHCC
42.01-
1183UbiquitinationAEVEGLGKGVARLSA
HHHCCCCHHHHHHCH
56.0822790023
1183MalonylationAEVEGLGKGVARLSA
HHHCCCCHHHHHHCH
56.0826320211
1183UbiquitinationAEVEGLGKGVARLSA
HHHCCCCHHHHHHCH
56.08-
1194UbiquitinationRLSAEAEKVLALPEP
HHCHHHHHHHCCCCC
49.9822790023
1194AcetylationRLSAEAEKVLALPEP
HHCHHHHHHHCCCCC
49.9823236377
1194UbiquitinationRLSAEAEKVLALPEP
HHCHHHHHHHCCCCC
49.98-
1218UbiquitinationELELTLGKLEQVRSL
HHHHHHHHHHHHHHH
52.5422790023
1218UbiquitinationELELTLGKLEQVRSL
HHHHHHHHHHHHHHH
52.54-
1232AcetylationLSAIYLEKLKTISLV
HHHHHHHHCCCEEEE
53.3322826441
1242PhosphorylationTISLVIRSTQGAEEV
CEEEEEECCCCHHHH
17.6018779572
1243PhosphorylationISLVIRSTQGAEEVL
EEEEEECCCCHHHHH
22.6018779572
1307 (in isoform 8)Acetylation-31.69-
1386GlutathionylationQAVPIANCQAAREQL
HHHHCCCHHHHHHHH
1.8424333276
1397AcetylationREQLRQEKALLEEIE
HHHHHHHHHHHHHHH
35.6823954790
1409AcetylationEIERHGEKVEECQKF
HHHHHCHHHHHHHHH
60.5823864654
1415AcetylationEKVEECQKFAKQYIN
HHHHHHHHHHHHHHH
59.9723806337
1415MalonylationEKVEECQKFAKQYIN
HHHHHHHHHHHHHHH
59.9726320211
1418AcetylationEECQKFAKQYINAIK
HHHHHHHHHHHHHHH
46.9322826441
1443PhosphorylationAQLEPVASPAKKPKV
ECCCCCCCCCCCCCC
26.1424925903
1452PhosphorylationAKKPKVQSGSESVIQ
CCCCCCCCCCHHHHH
47.4725338131
1456PhosphorylationKVQSGSESVIQEYVD
CCCCCCHHHHHHHHH
26.6429514104
1473PhosphorylationTRYSELTTLTSQYIK
HHHHHHHHHHHHHHH
40.4321183079
1478PhosphorylationLTTLTSQYIKFISET
HHHHHHHHHHHHHHH
13.0721183079
1516UbiquitinationEVEAALEKQRQLAEA
HHHHHHHHHHHHHHH
52.1922790023
1516UbiquitinationEVEAALEKQRQLAEA
HHHHHHHHHHHHHHH
52.19-
1562PhosphorylationDAQQQKRSIQEELQH
HHHHHHHHHHHHHHH
35.3430635358
1573PhosphorylationELQHLRQSSEAEIQA
HHHHHHHCCHHHHHH
24.5830635358
1574PhosphorylationLQHLRQSSEAEIQAK
HHHHHHCCHHHHHHH
32.2725521595
1581UbiquitinationSEAEIQAKAQQVEAA
CHHHHHHHHHHHHHH
30.2822790023
1581UbiquitinationSEAEIQAKAQQVEAA
CHHHHHHHHHHHHHH
30.28-
1718PhosphorylationALETAQRSAEVELQS
HHHHHHHHHHHHHHH
19.3930635358
1725PhosphorylationSAEVELQSKRASFAE
HHHHHHHHHHHHHHH
36.4126824392
1726UbiquitinationAEVELQSKRASFAEK
HHHHHHHHHHHHHHH
38.7422790023
1726UbiquitinationAEVELQSKRASFAEK
HHHHHHHHHHHHHHH
38.74-
1729PhosphorylationELQSKRASFAEKTAQ
HHHHHHHHHHHHHHH
29.0823684622
1733AcetylationKRASFAEKTAQLERT
HHHHHHHHHHHHHHH
45.8123806337
1740PhosphorylationKTAQLERTLQEEHVT
HHHHHHHHHHHHCCH
24.3427180971
1801PhosphorylationEEVAQQKSLAQADAE
HHHHHHHHHHHHHHH
25.3029514104
2033AcetylationEEQAALHKADIEERL
HHHHHHHHCCHHHHH
48.9123236377
2047PhosphorylationLAQLRKASESELERQ
HHHHHHHCHHHHHHH
44.6924899341
2049PhosphorylationQLRKASESELERQKG
HHHHHCHHHHHHHHC
45.0122210690
2303AcetylationQAEQAALKQKQAADA
HHHHHHHHHHHHHHH
51.2023806337
2303MalonylationQAEQAALKQKQAADA
HHHHHHHHHHHHHHH
51.2026320211
2303SuccinylationQAEQAALKQKQAADA
HHHHHHHHHHHHHHH
51.2023806337
2369PhosphorylationTEAARQRSQVEEELF
HHHHHHHHHHHHHHH
30.1820531401
2460MalonylationAEKMLKEKMQAVQEA
HHHHHHHHHHHHHHH
34.4226320211
2586PhosphorylationLEIQRQQSDHDAERL
HHHHHHCCHHHHHHH
28.6823737553
2639PhosphorylationETQALQKSFLSEKDS
HHHHHHHHHCCHHHH
20.61-
2644UbiquitinationQKSFLSEKDSLLQRE
HHHHCCHHHHHHHHH
49.6022790023
2644AcetylationQKSFLSEKDSLLQRE
HHHHCCHHHHHHHHH
49.6023806337
2644UbiquitinationQKSFLSEKDSLLQRE
HHHHCCHHHHHHHHH
49.60-
2646PhosphorylationSFLSEKDSLLQRERF
HHCCHHHHHHHHHHH
41.8929514104
2660AcetylationFIEQEKAKLEQLFQD
HHHHHHHHHHHHHHH
64.7223806337
2660SuccinylationFIEQEKAKLEQLFQD
HHHHHHHHHHHHHHH
64.7223806337
2757PhosphorylationHRAALAHSEIATTQA
HHHHHHHCHHHHHHH
25.7029514104
2762O-linked_GlycosylationAHSEIATTQAASTKA
HHCHHHHHHHCCCCC
13.7422517741
2766PhosphorylationIATTQAASTKALPNG
HHHHHHCCCCCCCCC
33.1929514104
2781PhosphorylationRDAPDGPSVEAEPEY
CCCCCCCCCCCCCCC
37.8120531401
2788PhosphorylationSVEAEPEYTFEGLRQ
CCCCCCCCCCHHHHC
27.6926026062
2809PhosphorylationLQEAGILSQEELQRL
HHHCCCCCHHHHHHH
33.3629514104
2827PhosphorylationHTTVAELTQREDVYR
CCCHHHHHCHHHHHH
19.6529514104
2833PhosphorylationLTQREDVYRYLKGRS
HHCHHHHHHHHCCCC
13.0825367039
2848AcetylationSIAGLLLKPTNEKLS
CCHHHHCCCCCCCHH
50.1723806337
2857PhosphorylationTNEKLSVYTALQRQL
CCCCHHHHHHHHHHC
5.2826643407
2858PhosphorylationNEKLSVYTALQRQLL
CCCHHHHHHHHHHCC
20.8026643407
2866PhosphorylationALQRQLLSPGTALIL
HHHHHCCCCCCEEHE
29.8526824392
2893PhosphorylationPVRNRRLTVNEAVKE
CCCCCCCCHHHHHHH
21.3424899341
2910AcetylationVGPELHHKLLSAERA
CCHHHHHHHHHHHHH
40.1423236377
2913PhosphorylationELHHKLLSAERAVTG
HHHHHHHHHHHHHCC
38.2227149854
2974PhosphorylationRVPVDVAYKRGYFDE
CCCCCHHHHCCCCCH
10.8927180971
2988PhosphorylationEEMNRILSDPSDDTK
HHHHHHHCCCCCCCC
45.1420531401
3031AcetylationRLLPLTDKAAKGGEL
EEEECCCCCCCCCCE
45.0423236377
3040PhosphorylationAKGGELVYTDTEARD
CCCCCEEECCCCHHH
16.1217947660
3041PhosphorylationKGGELVYTDTEARDV
CCCCEEECCCCHHHH
29.0326525534
3060UbiquitinationTVSAPFGKFQGRTVT
EEECCCCCCCCEEEE
34.5922790023
3060AcetylationTVSAPFGKFQGRTVT
EEECCCCCCCCEEEE
34.5923806337
3060UbiquitinationTVSAPFGKFQGRTVT
EEECCCCCCCCEEEE
34.59-
3098AcetylationTGHITVEKIIKIVIT
CCCCCHHHHHHHEEH
45.45-
3117GlutathionylationHERKGQLCFEGLRAL
HHHCCCCCHHHHHHH
1.9324333276
3141PhosphorylationGVISHELYQQLQRGE
CCCCHHHHHHHHHCC
7.3925367039
3185PhosphorylationAGQKLSIYEALKKDL
HHHHCCHHHHHHHCC
7.5629514104
3238AcetylationVGPELHEKLLSAEKA
CCHHHHHHHHCHHHH
43.9423236377
3244UbiquitinationEKLLSAEKAVTGYRD
HHHHCHHHHHCCCCC
48.1222790023
3244AcetylationEKLLSAEKAVTGYRD
HHHHCHHHHHCCCCC
48.1223806337
3244SuccinylationEKLLSAEKAVTGYRD
HHHHCHHHHHCCCCC
48.1223806337
3244UbiquitinationEKLLSAEKAVTGYRD
HHHHCHHHHHCCCCC
48.12-
3253PhosphorylationVTGYRDPYSGQSVSL
HCCCCCCCCCCCHHH
29.7122817900
3283PhosphorylationRLLDAQLSTGGIVDP
HHHHHHCCCCCCCCC
16.9629514104
3291PhosphorylationTGGIVDPSKSHRVPL
CCCCCCCCCCCCCCC
42.1828464351
3309UbiquitinationYARGYLDKETNRALT
HHCCCCCHHHCCCCC
64.9422790023
3309AcetylationYARGYLDKETNRALT
HHCCCCCHHHCCCCC
64.9423806337
3309MalonylationYARGYLDKETNRALT
HHCCCCCHHHCCCCC
64.9426320211
3309UbiquitinationYARGYLDKETNRALT
HHCCCCCHHHCCCCC
64.94-
3316PhosphorylationKETNRALTSPRDDAR
HHHCCCCCCCCCCCC
35.3823737553
3317PhosphorylationETNRALTSPRDDARV
HHCCCCCCCCCCCCC
20.8424899341
3359UbiquitinationSLLPLSEKAVRARQE
CHHCCCHHHHHHHHH
49.1322790023
3359UbiquitinationSLLPLSEKAVRARQE
CHHCCCHHHHHHHHH
49.13-
3369PhosphorylationRARQEEVYSELQARE
HHHHHHHHHHHHHHH
10.3322817900
3370PhosphorylationARQEEVYSELQARET
HHHHHHHHHHHHHHH
36.6925367039
3382UbiquitinationRETLEQAKVEVPVGS
HHHHHHCCCCCCCCC
38.3322790023
3382UbiquitinationRETLEQAKVEVPVGS
HHHHHHCCCCCCCCC
38.33-
3389PhosphorylationKVEVPVGSFKGRAMT
CCCCCCCCCCCHHCH
24.8229176673
3391UbiquitinationEVPVGSFKGRAMTVW
CCCCCCCCCHHCHHH
49.5422790023
3391AcetylationEVPVGSFKGRAMTVW
CCCCCCCCCHHCHHH
49.5423806337
3391MalonylationEVPVGSFKGRAMTVW
CCCCCCCCCHHCHHH
49.5426320211
3391SuccinylationEVPVGSFKGRAMTVW
CCCCCCCCCHHCHHH
49.5423806337
3391UbiquitinationEVPVGSFKGRAMTVW
CCCCCCCCCHHCHHH
49.54-
3427AcetylationTGKVTVEKVIKIVIT
CCCCCHHHHHHHHEE
44.94-
3427MalonylationTGKVTVEKVIKIVIT
CCCCCHHHHHHHHEE
44.9426320211
3434PhosphorylationKVIKIVITIVEEVET
HHHHHHEEHHHHHHH
14.2121183079
3448PhosphorylationTRRQERLSFSGLRAP
HHHHHCCCCCCCCCC
24.4827180971
3465UbiquitinationASELLDAKILSRAQF
HHHHHHHHHHHHHHH
43.7922790023
3465AcetylationASELLDAKILSRAQF
HHHHHHHHHHHHHHH
43.7922826441
3465UbiquitinationASELLDAKILSRAQF
HHHHHHHHHHHHHHH
43.79-
3490PhosphorylationKELSEVGSVRTLLQG
HHHHHHCCHHHHHCC
17.3829514104
3516PhosphorylationSKEKVTIYEAMRRGL
CCCEEEHHHHHHCCC
6.5625367039
3581AcetylationEKAVTGYKDPYSGNT
HHHHCCCCCCCCCCC
54.2823236377
3714PhosphorylationTRRAFEETQIDIPGG
HHHHHHHCCEECCCC
24.5125777480
3723PhosphorylationIDIPGGGSHGGSSMS
EECCCCCCCCCCCCC
23.4125777480
3727PhosphorylationGGGSHGGSSMSLWEV
CCCCCCCCCCCHHHH
27.7125777480
3728PhosphorylationGGSHGGSSMSLWEVM
CCCCCCCCCCHHHHH
18.7025777480
3730PhosphorylationSHGGSSMSLWEVMQS
CCCCCCCCHHHHHHH
32.0725777480
3737PhosphorylationSLWEVMQSNMIPEDQ
CHHHHHHHCCCCHHH
15.4025777480
3783PhosphorylationIRQQNLASYDYVRRR
HHHCCCCCHHHHHHC
23.0030635358
3784PhosphorylationRQQNLASYDYVRRRL
HHCCCCCHHHHHHCC
12.9920116462
3786PhosphorylationQNLASYDYVRRRLTA
CCCCCHHHHHHCCCH
6.3930635358
3792PhosphorylationDYVRRRLTAEDLYEA
HHHHHCCCHHHHHHC
26.6221183079
3797PhosphorylationRLTAEDLYEARIISL
CCCHHHHHHCCCCCH
21.6222817900
3860PhosphorylationALKKGLLSAEVARLL
HHHHCCCCHHHHHHH
27.6827149854
3907PhosphorylationELHDRLLSAERAVTG
HHHHHHHHHHHHHCC
32.4526824392
3913PhosphorylationLSAERAVTGYRDPYT
HHHHHHHCCCCCCCH
27.7528576409
3932AcetylationSLFQAMKKELIPAEE
HHHHHHHHHCCCHHH
44.6722826441
3975AcetylationYQRGYLNKDTHDQLS
HHCCCCCCCCCCCCC
62.5022826441
3982PhosphorylationKDTHDQLSEPSEVRS
CCCCCCCCCCHHHHH
41.6624899341
4037PhosphorylationRGLRKQITVEELVRS
HHHHCCCCHHHHHHH
21.2627087446
4061PhosphorylationQLQEGLTSIEEVTKN
HHHHCCCCHHHHHHH
32.8028464351
4126 (in isoform 3)Phosphorylation-28.85-
4127 (in isoform 3)Phosphorylation-3.31-
4150PhosphorylationEFKDKLLSAERAVTG
HHHHHHHCHHHHHCC
38.2227149854
4162PhosphorylationVTGYKDPYSGKLISL
HCCCCCCCCHHHHHH
39.9422499769
4163PhosphorylationTGYKDPYSGKLISLF
CCCCCCCCHHHHHHH
34.5422499769
4212AcetylationLPVEVAYKRGLFDEE
CCHHHHHHCCCCCHH
30.198264465
4212MalonylationLPVEVAYKRGLFDEE
CCHHHHHHCCCCCHH
30.1926320211
4245 (in isoform 3)Phosphorylation-8.8019144319
4248 (in isoform 3)Phosphorylation-3.3919144319
4261S-palmitoylationTDPQTGLCLLPLKEK
CCCCCCCEEEECCHH
3.7728526873
4274PhosphorylationEKKRERKTSSKSSVR
HHHCCCCCCCCCCCC
44.44-
4275PhosphorylationKKRERKTSSKSSVRK
HHCCCCCCCCCCCCC
38.5121454597
4276PhosphorylationKRERKTSSKSSVRKR
HCCCCCCCCCCCCCC
41.6122817900
4303DimethylationMSVYEAYRKGLIDHQ
CHHHHHHHCCCCCCH
33.35-
4303MethylationMSVYEAYRKGLIDHQ
CHHHHHHHCCCCCCH
33.3518964695
4343PhosphorylationSMIIDRRSGRQYDID
EEEEECCCCCCCCCC
38.9425367039
4347PhosphorylationDRRSGRQYDIDDAIT
ECCCCCCCCCCHHHH
17.3225367039
4370PhosphorylationLDQYRAGTLSITEFA
HHHHHCCCCCHHHHH
19.1525619855
4372PhosphorylationQYRAGTLSITEFADM
HHHCCCCCHHHHHHH
27.5725619855
4374PhosphorylationRAGTLSITEFADMLS
HCCCCCHHHHHHHHC
22.9825619855
4381PhosphorylationTEFADMLSGNAGGFR
HHHHHHHCCCCCCCC
24.3027087446
4389PhosphorylationGNAGGFRSRSSSVGS
CCCCCCCCCCCCCCC
33.9627087446
4391PhosphorylationAGGFRSRSSSVGSSS
CCCCCCCCCCCCCCC
28.3624925903
4392PhosphorylationGGFRSRSSSVGSSSS
CCCCCCCCCCCCCCC
28.1224925903
4393PhosphorylationGFRSRSSSVGSSSSY
CCCCCCCCCCCCCCC
31.5727087446
4396PhosphorylationSRSSSVGSSSSYPIS
CCCCCCCCCCCCCCC
25.5427087446
4397PhosphorylationRSSSVGSSSSYPISS
CCCCCCCCCCCCCCC
19.8525521595
4398PhosphorylationSSSVGSSSSYPISSA
CCCCCCCCCCCCCCC
35.2724925903
4399PhosphorylationSSVGSSSSYPISSAG
CCCCCCCCCCCCCCC
36.5624925903
4400PhosphorylationSVGSSSSYPISSAGP
CCCCCCCCCCCCCCC
13.4124925903
4403PhosphorylationSSSSYPISSAGPRTQ
CCCCCCCCCCCCCCE
15.0525619855
4404PhosphorylationSSSYPISSAGPRTQL
CCCCCCCCCCCCCEE
37.6525619855
4409PhosphorylationISSAGPRTQLASWSD
CCCCCCCCEECCCCC
30.9427087446
4413PhosphorylationGPRTQLASWSDPTEE
CCCCEECCCCCCCCC
35.3927087446
4415PhosphorylationRTQLASWSDPTEETG
CCEECCCCCCCCCCC
31.0827087446
4418PhosphorylationLASWSDPTEETGPVA
ECCCCCCCCCCCCCC
51.9825619855
4421PhosphorylationWSDPTEETGPVAGIL
CCCCCCCCCCCCCEE
40.3225619855
4487UbiquitinationVNKGLVDKIMVDRIN
HHCCCCCHHHHHHHH
25.8122790023
4487UbiquitinationVNKGLVDKIMVDRIN
HHCCCCCHHHHHHHH
25.81-
4498AcetylationDRINLAQKAFCGFED
HHHHHHHHHHCCCCC
37.5122826441
4546PhosphorylationGGLIEPDTPGRVSLD
CCCCCCCCCCCCCHH
38.06-
4573PhosphorylationAQKLRDVSAYSKYLT
HHHHHCHHHHHCCCC
26.2726824392
4575PhosphorylationKLRDVSAYSKYLTCP
HHHCHHHHHCCCCCC
9.7420531401
4576PhosphorylationLRDVSAYSKYLTCPK
HHCHHHHHCCCCCCC
17.9729514104
4614PhosphorylationLLEAAAQSSKGYYSP
HHHHHHHCCCCCCCC
29.3223737553
4615PhosphorylationLEAAAQSSKGYYSPY
HHHHHHCCCCCCCCC
20.3023737553
4616UbiquitinationEAAAQSSKGYYSPYS
HHHHHCCCCCCCCCE
57.0622790023
4616UbiquitinationEAAAQSSKGYYSPYS
HHHHHCCCCCCCCCE
57.06-
4618PhosphorylationAAQSSKGYYSPYSVS
HHHCCCCCCCCCEEC
12.4227742792
4619PhosphorylationAQSSKGYYSPYSVSG
HHCCCCCCCCCEECC
16.3127742792
4620PhosphorylationQSSKGYYSPYSVSGS
HCCCCCCCCCEECCC
14.6327087446
4622PhosphorylationSKGYYSPYSVSGSGS
CCCCCCCCEECCCCC
18.7627742792
4623PhosphorylationKGYYSPYSVSGSGST
CCCCCCCEECCCCCC
17.1227087446
4625PhosphorylationYYSPYSVSGSGSTAG
CCCCCEECCCCCCCC
22.6927087446
4627PhosphorylationSPYSVSGSGSTAGSR
CCCEECCCCCCCCCC
23.2825521595
4629PhosphorylationYSVSGSGSTAGSRTG
CEECCCCCCCCCCCC
19.4425521595
4630PhosphorylationSVSGSGSTAGSRTGS
EECCCCCCCCCCCCC
38.2725521595
4633PhosphorylationGSGSTAGSRTGSRTG
CCCCCCCCCCCCCCC
24.9727087446
4634MethylationSGSTAGSRTGSRTGS
CCCCCCCCCCCCCCC
42.0324129315
4635PhosphorylationGSTAGSRTGSRTGSR
CCCCCCCCCCCCCCC
41.0027087446
4637PhosphorylationTAGSRTGSRTGSRAG
CCCCCCCCCCCCCCC
26.5127087446
4639PhosphorylationGSRTGSRTGSRAGSR
CCCCCCCCCCCCCCC
41.0027087446
4641PhosphorylationRTGSRTGSRAGSRRG
CCCCCCCCCCCCCCC
20.5326160508
4645PhosphorylationRTGSRAGSRRGSFDA
CCCCCCCCCCCCCCC
20.1629514104
4647MethylationGSRAGSRRGSFDATG
CCCCCCCCCCCCCCC
46.9724129315
4649PhosphorylationRAGSRRGSFDATGSG
CCCCCCCCCCCCCCC
20.3827087446
4653PhosphorylationRRGSFDATGSGFSMT
CCCCCCCCCCCEEEE
33.4526239621
4655PhosphorylationGSFDATGSGFSMTFS
CCCCCCCCCEEEEEE
32.1025168779
4658PhosphorylationDATGSGFSMTFSSSS
CCCCCCEEEEEECCC
22.0426239621
4660PhosphorylationTGSGFSMTFSSSSYS
CCCCEEEEEECCCCC
21.1126239621
4662PhosphorylationSGFSMTFSSSSYSSS
CCEEEEEECCCCCCC
21.8326239621
4663PhosphorylationGFSMTFSSSSYSSSG
CEEEEEECCCCCCCC
21.0728833060
4664PhosphorylationFSMTFSSSSYSSSGY
EEEEEECCCCCCCCC
31.9028833060
4665PhosphorylationSMTFSSSSYSSSGYG
EEEEECCCCCCCCCC
30.8628833060
4666PhosphorylationMTFSSSSYSSSGYGR
EEEECCCCCCCCCCC
17.9628833060
4667PhosphorylationTFSSSSYSSSGYGRR
EEECCCCCCCCCCCC
21.7028833060
4668PhosphorylationFSSSSYSSSGYGRRY
EECCCCCCCCCCCCC
21.3928833060
4669PhosphorylationSSSSYSSSGYGRRYA
ECCCCCCCCCCCCCC
30.0528833060
4671PhosphorylationSSYSSSGYGRRYASG
CCCCCCCCCCCCCCC
14.9228833060
4675PhosphorylationSSGYGRRYASGPSAS
CCCCCCCCCCCCCCC
12.0830635358
4677PhosphorylationGYGRRYASGPSASLG
CCCCCCCCCCCCCCC
42.1526745281
4680PhosphorylationRRYASGPSASLGGPE
CCCCCCCCCCCCCCH
33.7326745281
4682PhosphorylationYASGPSASLGGPESA
CCCCCCCCCCCCHHC
31.7026745281
4688PhosphorylationASLGGPESAVA----
CCCCCCHHCCC----
31.0429514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
4546TPhosphorylationKinaseCDK1P11440
Uniprot

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
21SPhosphorylation

19144319

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLEC_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ACTH_MOUSEActg2physical
9808630

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PLEC_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4389 AND SER-4393, ANDMASS SPECTROMETRY.
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4396 AND SER-4399, ANDMASS SPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212; SER-1729; SER-4393AND SER-4633, AND MASS SPECTROMETRY.
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis.";
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
J. Proteome Res. 7:3957-3967(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4391 AND SER-4393, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4393; SER-4397; SER-4629AND SER-4633, AND MASS SPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-728; SER-1443 ANDSER-4393, AND MASS SPECTROMETRY.
"Mitochondrial phosphoproteome revealed by an improved IMAC method andMS/MS/MS.";
Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.;
Mol. Cell. Proteomics 6:669-676(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-823, AND MASSSPECTROMETRY.
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-2788; TYR-3040;TYR-3369; TYR-3797 AND TYR-4622, PHOSPHORYLATION [LARGE SCALEANALYSIS] AT TYR-26 (ISOFORM PLEC-1A), AND MASS SPECTROMETRY.

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