ACTH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACTH_MOUSE
• UniProt AC: P63268
• Protein Name: Actin, gamma-enteric smooth muscle
• Gene Name: Actg2
• Organism: Mus musculus (Mouse).
• Sequence Length: 376
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells..
• Protein Sequence: MCEEETTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKPEYDEAGPSIVHRKCF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MCEEETTAL ------CCCCCCEEE	10.16	-
3	Acetylation	-----MCEEETTALV -----CCCCCCEEEE	58.53	-
34	Phosphorylation	APRAVFPSIVGRPRH CCCCCCHHHCCCCCC	20.59	27180971
45	Oxidation	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	23911929
48	Oxidation	HQGVMVGMGQKDSYV CCCEEEECCCCCCCC	3.32	23911929
51	Acetylation	VMVGMGQKDSYVGDE EEEECCCCCCCCCCH	42.80	9696925
51	Ubiquitination	VMVGMGQKDSYVGDE EEEECCCCCCCCCCH	42.80	-
53	Phosphorylation	VGMGQKDSYVGDEAQ EECCCCCCCCCCHHH	28.84	25521595
54	Phosphorylation	GMGQKDSYVGDEAQS ECCCCCCCCCCHHHC	20.70	26824392
61	Phosphorylation	YVGDEAQSKRGILTL CCCCHHHCCCCEEEE	31.22	27087446
62	Ubiquitination	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	-
62	Acetylation	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	9696933
67	Phosphorylation	QSKRGILTLKYPIEH HCCCCEEEEECEECC	21.20	27600695
69	Ubiquitination	KRGILTLKYPIEHGI CCCEEEEECEECCCC	43.69	-
69	Acetylation	KRGILTLKYPIEHGI CCCEEEEECEECCCC	43.69	9696953
70	Phosphorylation	RGILTLKYPIEHGII CCEEEEECEECCCCC	16.74	26239621
74	Methylation	TLKYPIEHGIITNWD EEECEECCCCCCCHH	33.21	-
78	Phosphorylation	PIEHGIITNWDDMEK EECCCCCCCHHHHHH	28.47	36012721
85	Acetylation	TNWDDMEKIWHHSFY CCHHHHHHHHHHHHH	44.45	9696927
92	Nitration	KIWHHSFYNELRVAP HHHHHHHHHCCCCCC	15.67	-
104	Phosphorylation	VAPEEHPTLLTEAPL CCCCCCCCCCCCCCC	35.99	28542873
107	Phosphorylation	EEHPTLLTEAPLNPK CCCCCCCCCCCCCCC	32.96	22210690
114	Ubiquitination	TEAPLNPKANREKMT CCCCCCCCCCHHHHH	58.16	-
142	Phosphorylation	VAIQAVLSLYASGRT HHHHHHHHHHHCCCC	16.85	19060867
144	Phosphorylation	IQAVLSLYASGRTTG HHHHHHHHHCCCCEE	8.71	36642107
146	Phosphorylation	AVLSLYASGRTTGIV HHHHHHHCCCCEEEE	18.43	-
149	Phosphorylation	SLYASGRTTGIVLDS HHHHCCCCEEEEEEC	32.66	22210690
150	Phosphorylation	LYASGRTTGIVLDSG HHHCCCCEEEEEECC	24.45	22210690
156	Phosphorylation	TTGIVLDSGDGVTHN CEEEEEECCCCCCCC	34.32	28542873
167	Phosphorylation	VTHNVPIYEGYALPH CCCCCCEECCCCHHH	9.38	28464351
170	Phosphorylation	NVPIYEGYALPHAIM CCCEECCCCHHHHHH	7.94	36642093
187	Phosphorylation	DLAGRDLTDYLMKIL HCCCCCHHHHHHHHH	27.21	24899341
189	Phosphorylation	AGRDLTDYLMKILTE CCCCHHHHHHHHHHH	11.94	2001175
192	Ubiquitination	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	-
192	Acetylation	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	22646711
195	Phosphorylation	DYLMKILTERGYSFV HHHHHHHHHCCCCCE	27.40	46158553
199	Phosphorylation	KILTERGYSFVTTAE HHHHHCCCCCEEHHC	12.73	36642141
199	Nitration	KILTERGYSFVTTAE HHHHHCCCCCEEHHC	12.73	-
200	Phosphorylation	ILTERGYSFVTTAER HHHHCCCCCEEHHCH	18.96	35093905
203	Phosphorylation	ERGYSFVTTAEREIV HCCCCCEEHHCHHHH	20.48	24899341
204	Phosphorylation	RGYSFVTTAEREIVR CCCCCEEHHCHHHHH	22.63	24899341
214	Acetylation	REIVRDIKEKLCYVA HHHHHHHHHHHCEEE	53.75	11921239
216	Ubiquitination	IVRDIKEKLCYVALD HHHHHHHHHCEEEEE	38.56	-
219	Phosphorylation	DIKEKLCYVALDFEN HHHHHHCEEEEECCH	10.13	24351
230	Phosphorylation	DFENEMATAASSSSL ECCHHHHHHCCCCCC	22.80	23737553
233	Phosphorylation	NEMATAASSSSLEKS HHHHHHCCCCCCCHH	28.43	23737553
234	Phosphorylation	EMATAASSSSLEKSY HHHHHCCCCCCCHHE	21.15	23737553
235	Phosphorylation	MATAASSSSLEKSYE HHHHCCCCCCCHHEE	36.13	23737553
236	Phosphorylation	ATAASSSSLEKSYEL HHHCCCCCCCHHEEC	42.36	23737553
240	Phosphorylation	SSSSLEKSYELPDGQ CCCCCCHHEECCCCC	17.92	25521595
240	O-linked_Glycosylation	SSSSLEKSYELPDGQ CCCCCCHHEECCCCC	17.92	9696909
241	Nitration	SSSLEKSYELPDGQV CCCCCHHEECCCCCE	32.33	-
241	Phosphorylation	SSSLEKSYELPDGQV CCCCCHHEECCCCCE	32.33	24925903
250	Phosphorylation	LPDGQVITIGNERFR CCCCCEEEECCCEEC	24.79	46158343
261	Phosphorylation	ERFRCPETLFQPSFI CEECCCCHHCCCCCC	20.29	22817900
266	Phosphorylation	PETLFQPSFIGMESA CCHHCCCCCCCHHCC	20.79	46158271
280	Phosphorylation	AGIHETTYNSIMKCD CCCCCCCCHHHHCCC	17.84	15569657
292	Ubiquitination	KCDIDIRKDLYANNV CCCCEECHHHHHCCC	53.04	-
304	Phosphorylation	NNVLSGGTTMYPGIA CCCCCCCCCCCCCHH	16.35	21082442
307	Phosphorylation	LSGGTTMYPGIADRM CCCCCCCCCCHHHHH	9.01	-
316	Ubiquitination	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	-
316	Acetylation	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	9696923
319	Phosphorylation	DRMQKEITALAPSTM HHHHHHHHHHCCCCE	19.40	25521595
324	Phosphorylation	EITALAPSTMKIKII HHHHHCCCCEEEEEE	35.21	25521595
325	Phosphorylation	ITALAPSTMKIKIIA HHHHCCCCEEEEEEC	22.79	46158475
327	Acetylation	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	9696935
327	Ubiquitination	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	-
329	Acetylation	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	9696949
329	Ubiquitination	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	-
363	Phosphorylation	MWISKPEYDEAGPSI HHHCCCCCCCCCCCC	27.84	20469934
363	Nitration	MWISKPEYDEAGPSI HHHCCCCCCCCCCCC	27.84	-
369	Phosphorylation	EYDEAGPSIVHRKCF CCCCCCCCCCCCCCC	36.00	20469934

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACTH_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
45	M	Oxidation	Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization.	23911929
48	M	Oxidation	Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization.	23911929
74	H	Methylation	Methylated at His-74 by SETD3.	-
85	K	Methylation	Monomethylation at Lys-85 (K85me1) regulates actin-myosin interaction and actomyosin-dependent processes.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACTH_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ACTH_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.