dbPTM

MY18A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MY18A_MOUSE
UniProt AC	Q9JMH9
Protein Name	Unconventional myosin-XVIIIa
Gene Name	Myo18a
Organism	Mus musculus (Mouse).
Sequence Length	2050
Subcellular Localization	Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasm, cytoskeleton. Colocalizes with actin. Isoform 2: Cytoplasm. Lacks the PDZ domain. Diffusely localized in the cytoplasm. Golgi apparatus. Golgi apparatus, trans-Golgi n
Protein Description	May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. [PubMed: 19837035 Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (By similarity May be involved in the maintenance of the stromal cell architectures required for cell to cell contact]
Protein Sequence	MFNLMKKDKDKDGGRKEKKEKKEKKERMSAAELRSLEEMSMRRGFFNLNRSSKRESKTRLEISNPIPIKVASGSDLHLTDIDSDSNRGSIILDSGHLSTASSSDDLKGEEGSFRGSVLQRAAKFGSLAKQNSQMIVKRFSFSQRSRDESASETSTPSEHSAAPSPQVEVRTLEGQLMQHPGLGIPRPGPRSRVPELVTKRFPADLRLPALVPPPPPALRELELQRRPTGDFGFSLRRTTMLDRAPEGQAYRRVVHFAEPGAGTKDLALGLVPGDRLVEINGQNVENKSRDEIVEMIRQSGDSVRLKVQPIPELSELSRSWLRTGEGHRREPADAKTEEQIAAEEAWYETEKVWLVHRDGFSLASQLKSEELSLPEGKARVKLDHDGAILDVDEDDIEKANAPSCDRLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLSTRGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIVLLGSSGSGKTTSFQHLVQYLATIAGTSGTKVFSVEKWQALSTLLEAFGNSPTIMNGSATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRPASEATFNVFYYLLACGDATLRTELHLNHLAENNVFGIVPLSKPEEKQKAAQQFSKLQAAMKVLAISPEEQKTCWLILASIYHLGAAGATKEAAEAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQLKGGTLQRSTSFRQGPEESGLGEGTKLSALECLEGMASGLYSELFTLLISLVNRALKSSQHSLCSMMIVDTPGFQNPEWGGSARGASFEELCHNYAQDRLQRLFHERTFLQELERYKEDNIELAFDDLEPVADDSVAAVDQASHLVRSLAHADEARGLLWLLEEEALVPGATEDALLDRLFSYYGPQEGDKKGQSPLLRSSKPRHFLLGHSHGTNWVEYNVAGWLNYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQIKLQVDALIDTIKRSKMHFVHCFLPVAEGWPGEPRSASSRRVSSSSELDLPPGDPCEAGLLQLDVSLLRAQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDEKRAVEELLESLDLEKSSCCLGLSRVFFRAGTLARLEEQRDEQTSRHLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIQVQLSEEQIRNKDEEIQQLRSKLEKVEKERNELRLSSDRLETRISELTSELTDERNTGESASQLLDAETAERLRTEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQELEDKMEVEQQSRRQLERRLGDLQADSDESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEETQREKLQREKLQREKDMLLAEAFSLKQQMEEKDLDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGSIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKALREKRELESKLSTLSDQVNQRDFESEKRLRKDLKRTKALLADAQIMLDHLKNNAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEMEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDMAQMNDLQAQIEESNKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFEKTQVKRLENLASRLKETMEKLTEERDQRAAAENREKEQNKRLQRQLRDTKEEMSELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKKKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAPSDDGSLKSSSPTSHWKPLAPDPSDDEHDPVDSISRPRFSHSYLSDSDTEAKLTETSA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	KEKKERMSAAELRSL HHHHHHHCHHHHHHH	30.46	22324799
35	Phosphorylation	MSAAELRSLEEMSMR HCHHHHHHHHHHHHH	53.40	21743459
40	Phosphorylation	LRSLEEMSMRRGFFN HHHHHHHHHHHCCCC	16.65	29514104
51	Phosphorylation	GFFNLNRSSKRESKT CCCCCCCCCCCCCCC	38.85	21743459
52	Phosphorylation	FFNLNRSSKRESKTR CCCCCCCCCCCCCCC	32.28	27087446
72	Phosphorylation	PIPIKVASGSDLHLT CEEEEECCCCCCEEE	41.64	27087446
74	Phosphorylation	PIKVASGSDLHLTDI EEEECCCCCCEEEEC	34.21	27087446
79	Phosphorylation	SGSDLHLTDIDSDSN CCCCCEEEECCCCCC	21.84	27087446
83	Phosphorylation	LHLTDIDSDSNRGSI CEEEECCCCCCCCCE	43.18	27087446
85	Phosphorylation	LTDIDSDSNRGSIIL EEECCCCCCCCCEEE	32.17	27742792
89	Phosphorylation	DSDSNRGSIILDSGH CCCCCCCCEEEECCC	11.83	26239621
94	Phosphorylation	RGSIILDSGHLSTAS CCCEEEECCCCCCCC	25.35	26239621
98	Phosphorylation	ILDSGHLSTASSSDD EEECCCCCCCCCCCC	19.09	27087446
99	Phosphorylation	LDSGHLSTASSSDDL EECCCCCCCCCCCCC	36.60	27087446
101	Phosphorylation	SGHLSTASSSDDLKG CCCCCCCCCCCCCCC	30.39	25521595
102	Phosphorylation	GHLSTASSSDDLKGE CCCCCCCCCCCCCCC	35.01	27087446
103	Phosphorylation	HLSTASSSDDLKGEE CCCCCCCCCCCCCCC	32.42	21082442
112	Phosphorylation	DLKGEEGSFRGSVLQ CCCCCCCCCHHHHHH	18.30	30352176
116	Phosphorylation	EEGSFRGSVLQRAAK CCCCCHHHHHHHHHH	18.52	29514104
126	Phosphorylation	QRAAKFGSLAKQNSQ HHHHHHHHHHHHHHH	28.43	29899451
132	Phosphorylation	GSLAKQNSQMIVKRF HHHHHHHHHHHHHHC	20.73	22324799
132 (in isoform 6)	Phosphorylation	-	20.73	16452087
140	Phosphorylation	QMIVKRFSFSQRSRD HHHHHHCCCCHHCCC	28.20	27087446
142	Phosphorylation	IVKRFSFSQRSRDES HHHHCCCCHHCCCCC	24.40	22324799
145	Phosphorylation	RFSFSQRSRDESASE HCCCCHHCCCCCCCC	36.12	27087446
149	Phosphorylation	SQRSRDESASETSTP CHHCCCCCCCCCCCC	41.19	25619855
151	Phosphorylation	RSRDESASETSTPSE HCCCCCCCCCCCCCC	51.16	25619855
153	Phosphorylation	RDESASETSTPSEHS CCCCCCCCCCCCCCC	35.09	25619855
154	Phosphorylation	DESASETSTPSEHSA CCCCCCCCCCCCCCC	33.98	25619855
155	Phosphorylation	ESASETSTPSEHSAA CCCCCCCCCCCCCCC	37.95	25619855
157	Phosphorylation	ASETSTPSEHSAAPS CCCCCCCCCCCCCCC	48.29	27087446
160	Phosphorylation	TSTPSEHSAAPSPQV CCCCCCCCCCCCCCE	23.29	27087446
164	Phosphorylation	SEHSAAPSPQVEVRT CCCCCCCCCCEEEEE	24.20	27087446
228	Phosphorylation	LELQRRPTGDFGFSL HHHCCCCCCCCCCCC	47.79	-
234	Phosphorylation	PTGDFGFSLRRTTML CCCCCCCCCEEECCH	22.73	21183079
340 (in isoform 6)	Phosphorylation	-	4.42	25521595
372	Phosphorylation	QLKSEELSLPEGKAR HHCCCCCCCCCCCCC	45.20	29472430
429	Phosphorylation	LHTLRQRYGASLLHT HHHHHHHHCCCHHCC	14.54	25266776
432	Phosphorylation	LRQRYGASLLHTYAG HHHHHCCCHHCCCCC	27.40	25266776
436	Phosphorylation	YGASLLHTYAGPSLL HCCCHHCCCCCCCEE	18.29	25266776
437	Phosphorylation	GASLLHTYAGPSLLV CCCHHCCCCCCCEEE	9.98	25266776
446	Phosphorylation	GPSLLVLSTRGAPAV CCCEEEEECCCCCCC	14.47	25266776
447	Phosphorylation	PSLLVLSTRGAPAVY CCEEEEECCCCCCCC	29.03	25266776
457	Ubiquitination	APAVYSEKVMHMFKG CCCCCCHHHHHHHCC	38.63	-
493	Phosphorylation	LMSRQDQSIVLLGSS HHCCCCCEEEEECCC	23.97	22802335
499	Phosphorylation	QSIVLLGSSGSGKTT CEEEEECCCCCCCCC	31.34	22802335
500	Phosphorylation	SIVLLGSSGSGKTTS EEEEECCCCCCCCCC	34.87	22802335
502	Phosphorylation	VLLGSSGSGKTTSFQ EEECCCCCCCCCCHH	38.78	22802335
514	Phosphorylation	SFQHLVQYLATIAGT CHHHHHHHHHHHHCC	7.27	22802335
517	Phosphorylation	HLVQYLATIAGTSGT HHHHHHHHHHCCCCC	14.57	22802335
521	Phosphorylation	YLATIAGTSGTKVFS HHHHHHCCCCCEEEE	18.24	22802335
522	Phosphorylation	LATIAGTSGTKVFSV HHHHHCCCCCEEEEH	43.47	22802335
524	Phosphorylation	TIAGTSGTKVFSVEK HHHCCCCCEEEEHHH	24.65	22802335
722	Phosphorylation	KHQLKGGTLQRSTSF HHHHCCCCCCCCCCC	28.52	26643407
726	Phosphorylation	KGGTLQRSTSFRQGP CCCCCCCCCCCCCCC	18.55	25521595
727	Phosphorylation	GGTLQRSTSFRQGPE CCCCCCCCCCCCCCC	33.79	25521595
728	Phosphorylation	GTLQRSTSFRQGPEE CCCCCCCCCCCCCCC	21.48	25521595
736	Phosphorylation	FRQGPEESGLGEGTK CCCCCCCCCCCCCCC	37.34	26643407
742	Phosphorylation	ESGLGEGTKLSALEC CCCCCCCCCHHHHHH	25.22	20469934
865	Phosphorylation	QASHLVRSLAHADEA HHHHHHHHHHCHHHH	23.56	25521595
912	Phosphorylation	EGDKKGQSPLLRSSK CCCCCCCCCCCCCCC	26.61	29472430
951	Phosphorylation	YTKQNPATQNAPRLL CCCCCCHHCCCCHHC	24.50	22802335
964	Ubiquitination	LLQDSQKKIISNLFL HCHHHHHHHHHHHHC	37.32	-
976	Phosphorylation	LFLGRAGSATVLSGS HHCCCCCCEEEECCC	21.56	27180971
978	Phosphorylation	LGRAGSATVLSGSIA CCCCCCEEEECCCCC	24.55	26239621
981	Phosphorylation	AGSATVLSGSIAGLE CCCEEEECCCCCCCC	26.59	27087446
983	Phosphorylation	SATVLSGSIAGLEGG CEEEECCCCCCCCCH	13.09	25521595
991	Phosphorylation	IAGLEGGSQLALRRA CCCCCCHHHHHHHHH	32.64	23140645
1000	Phosphorylation	LALRRATSMRKTFTT HHHHHHHHCCCCCCC	18.66	23140645
1004	Phosphorylation	RATSMRKTFTTGMAA HHHHCCCCCCCCCHH	18.82	29899451
1031	Phosphorylation	QVDALIDTIKRSKMH HHHHHHHHHHHHHCE	22.77	22871156
1033	Acetylation	DALIDTIKRSKMHFV HHHHHHHHHHHCEEE	53.35	23576753
1063	Phosphorylation	SASSRRVSSSSELDL CCCCCCCCCCCCCCC	23.77	26239621
1064	Phosphorylation	ASSRRVSSSSELDLP CCCCCCCCCCCCCCC	34.72	26239621
1065	Phosphorylation	SSRRVSSSSELDLPP CCCCCCCCCCCCCCC	21.96	26239621
1066	Phosphorylation	SRRVSSSSELDLPPG CCCCCCCCCCCCCCC	44.09	26239621
1136	Phosphorylation	TKKHGRNYIVVDEKR HCCCCCCEEEECHHH	8.17	29514104
1279	Phosphorylation	ERNELRLSSDRLETR HHHHHHCCHHHHHHH	24.61	25338131
1514	Phosphorylation	GFTQKVVSLEAELQD HHHHHHHHHHHHHHH	24.39	29899451
1524	Phosphorylation	AELQDISSQESKDEA HHHHHCCCCCCCCHH	38.00	29514104
1560 (in isoform 4)	Phosphorylation	-	16.80	-
1607 (in isoform 5)	Phosphorylation	-	5.35	20531401
1616 (in isoform 5)	Phosphorylation	-	63.11	25195567
1619 (in isoform 7)	Phosphorylation	-	48.88	20531401
1620 (in isoform 5)	Phosphorylation	-	55.94	25195567
1624 (in isoform 5)	Phosphorylation	-	58.26	20531401
1628 (in isoform 7)	Phosphorylation	-	11.91	25195567
1632 (in isoform 7)	Phosphorylation	-	7.05	25195567
1633	Phosphorylation	RELESKLSTLSDQVN HHHHHHHHHHHHHHH	30.91	29472430
1634	Phosphorylation	ELESKLSTLSDQVNQ HHHHHHHHHHHHHHH	40.49	29472430
1636	Phosphorylation	ESKLSTLSDQVNQRD HHHHHHHHHHHHHHH	26.53	29472430
1636 (in isoform 7)	Phosphorylation	-	26.53	20531401
1646	Phosphorylation	VNQRDFESEKRLRKD HHHHHHHHHHHHHHH	48.70	28285833
1691	Phosphorylation	LKNQLEESEFTCAAA HHHHHHHCCCHHHHH	28.74	22807455
1694	Phosphorylation	QLEESEFTCAAAVKA HHHHCCCHHHHHHHH	9.36	22807455
1703	Acetylation	AAAVKARKAMEVEME HHHHHHHHHCEEEHH	57.87	7385631
1831	Acetylation	ETRLEFEKTQVKRLE HHHHHHHHHHHHHHH	49.97	23236377
1901 (in isoform 4)	Phosphorylation	-	27.89	20531401
1910 (in isoform 4)	Phosphorylation	-	12.76	25195567
1914 (in isoform 4)	Phosphorylation	-	3.33	25195567
1918 (in isoform 4)	Phosphorylation	-	5.70	20531401
1919	Acetylation	QSLQADLKLAFKRIG HHHHHHHHHHHHHHH	38.01	7970537
1938	Phosphorylation	AIEDEMESDENEDLI HHHHHHCCCCCHHHH	49.25	27087446
1938 (in isoform 1)	Phosphorylation	-	49.25	20531401
1947	Phosphorylation	ENEDLINSLQDMVTK CCHHHHHHHHHHHHH	22.03	26239621
1947 (in isoform 1)	Phosphorylation	-	22.03	25195567
1951 (in isoform 1)	Phosphorylation	-	2.38	25195567
1955 (in isoform 1)	Phosphorylation	-	19.05	20531401
1966	Phosphorylation	KNKLEGDSDVDSELE HHCCCCCCCCCHHHH	50.84	27087446
1970	Phosphorylation	EGDSDVDSELEDRVD CCCCCCCHHHHHHHH	43.88	25521595
1987	Ubiquitination	KSWLSKNKGPSKAPS HHHHHCCCCCCCCCC	75.76	-
1990	Phosphorylation	LSKNKGPSKAPSDDG HHCCCCCCCCCCCCC	50.55	25777480
1994	Phosphorylation	KGPSKAPSDDGSLKS CCCCCCCCCCCCCCC	53.87	25521595
1998	Phosphorylation	KAPSDDGSLKSSSPT CCCCCCCCCCCCCCC	39.35	25521595
2001	Phosphorylation	SDDGSLKSSSPTSHW CCCCCCCCCCCCCCC	41.14	23375375
2002	Phosphorylation	DDGSLKSSSPTSHWK CCCCCCCCCCCCCCC	38.46	23375375
2003	Phosphorylation	DGSLKSSSPTSHWKP CCCCCCCCCCCCCCC	39.01	23684622
2005	Phosphorylation	SLKSSSPTSHWKPLA CCCCCCCCCCCCCCC	34.86	23684622
2006	Phosphorylation	LKSSSPTSHWKPLAP CCCCCCCCCCCCCCC	30.63	21082442
2016	Phosphorylation	KPLAPDPSDDEHDPV CCCCCCCCCCCCCCC	66.14	26824392
2025	Phosphorylation	DEHDPVDSISRPRFS CCCCCCCCCCCCCCC	23.77	27742792
2027	Phosphorylation	HDPVDSISRPRFSHS CCCCCCCCCCCCCCC	39.94	27742792
2032	Phosphorylation	SISRPRFSHSYLSDS CCCCCCCCCCCCCCC	16.89	25521595
2034	Phosphorylation	SRPRFSHSYLSDSDT CCCCCCCCCCCCCHH	26.94	24925903
2035	Phosphorylation	RPRFSHSYLSDSDTE CCCCCCCCCCCCHHC	12.56	24925903
2037	Phosphorylation	RFSHSYLSDSDTEAK CCCCCCCCCCHHCCH	27.17	27087446
2039	Phosphorylation	SHSYLSDSDTEAKLT CCCCCCCCHHCCHHC	42.95	27087446
2041	Phosphorylation	SYLSDSDTEAKLTET CCCCCCHHCCHHCCC	41.62	25521595
2046	Phosphorylation	SDTEAKLTETSA--- CHHCCHHCCCCC---	36.19	22345495
2048	Phosphorylation	TEAKLTETSA----- HCCHHCCCCC-----	25.39	22345495
2049	Phosphorylation	EAKLTETSA------ CCHHCCCCC------	26.25	22345495

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MY18A_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
340	S	Phosphorylation		16452087
Isoform 6 is phosphorylated on Ser-340.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MY18A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MY18A_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MY18A_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1966 AND SER-1970, ANDMASS SPECTROMETRY.	19131326 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-1966; SER-1970;SER-2016; SER-2037 AND SER-2039, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72; SER-74; SER-83;SER-102; SER-164; SER-1966; SER-2032; SER-2037 AND SER-2039, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1966 AND SER-1970, ANDMASS SPECTROMETRY.	17203969 [Abstract]

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