dbPTM

RHEB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RHEB_MOUSE
UniProt AC	Q921J2
Protein Name	GTP-binding protein Rheb
Gene Name	Rheb
Organism	Mus musculus (Mouse).
Sequence Length	184
Subcellular Localization	Endomembrane system Lipid-anchor Cytoplasmic side . Golgi apparatus membrane Lipid-anchor Cytoplasmic side . Cytoplasm, cytosol . Endoplasmic reticulum membrane Lipid-anchor Cytoplasmic side .
Protein Description	Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity..
Protein Sequence	MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFKRIILEAEKIDGAASQGKSSCSVM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	IAILGYRSVGKSSLT EEEECEEECCCCEEE	27.09	24719451
92	Phosphorylation	YSVTSIKSFEVIKVI EEEEECCCCEEEEEE	25.60	22324799
120	Ubiquitination	PIMLVGNKKDLHMER EEEEECCCCCCCEEE	41.56	-
130	Phosphorylation	LHMERVISYEEGKAL CCEEEEEEHHHHHHH	24.51	21336308
161	Acetylation	QTAVDVFKRIILEAE HHHHHHHHHHHHHHH	42.40	23954790
161	Ubiquitination	QTAVDVFKRIILEAE HHHHHHHHHHHHHHH	42.40	-
161	Succinylation	QTAVDVFKRIILEAE HHHHHHHHHHHHHHH	42.40	23954790
169	Acetylation	RIILEAEKIDGAASQ HHHHHHHHHCCCHHC	53.82	6568351
175	Phosphorylation	EKIDGAASQGKSSCS HHHCCCHHCCCCCCC	38.64	25338131
180	Phosphorylation	AASQGKSSCSVM--- CHHCCCCCCCCC---	17.56	23608596
181	Methylation	ASQGKSSCSVM---- HHCCCCCCCCC----	4.60	-
181	Farnesylation	ASQGKSSCSVM---- HHCCCCCCCCC----	4.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
130	S	Phosphorylation	Kinase	MAPKAPK5	O54992	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RHEB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RHEB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
BNIP3_MOUSE	Bnip3	physical	17928295

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RHEB_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Inactivation of Rheb by PRAK-mediated phosphorylation is essentialfor energy-depletion-induced suppression of mTORC1."; Zheng M., Wang Y.H., Wu X.N., Wu S.Q., Lu B.J., Dong M.Q., Zhang H.,Sun P., Lin S.C., Guan K.L., Han J.; Nat. Cell Biol. 13:263-272(2011). Cited for: PHOSPHORYLATION AT SER-130, AND MUTAGENESIS OF SER-130.	21336308 [Abstract]