| UniProt ID | PP2BB_MOUSE | |
|---|---|---|
| UniProt AC | P48453 | |
| Protein Name | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | |
| Gene Name | Ppp3cb | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 525 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.. | |
| Protein Sequence | MAAPEPARAAPPPPPPPPPPLGADRVVKAVPFPPTHRLTSEEVFDMDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHTTENHGTGNHSAQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAAPEPARA ------CCCCCCCCC | 31.55 | - | |
| 116 | Phosphorylation | KLFEVGGSPANTRYL HHHCCCCCCCCCEEE | 18.21 | 22817900 | |
| 152 | Phosphorylation | LKILYPSTLFLLRGN HHHHCHHHHHHHCCC | 19.61 | 29899451 | |
| 172 | Acetylation | LTEYFTFKQECKIKY HHHEEEECCHHHCCC | 41.97 | 22826441 | |
| 237 | S-palmitoylation | PPAFGPMCDLLWSDP CCCCCCCCHHHCCCC | 3.62 | 28680068 | |
| 297 | Phosphorylation | HEAQDAGYRMYRKSQ HHHHHHCCCCHHHHC | 8.23 | 29899451 | |
| 332 | Ubiquitination | NNKAAVLKYENNVMN CCCEEEEEEECCEEC | 43.87 | - | |
| 332 | Acetylation | NNKAAVLKYENNVMN CCCEEEEEEECCEEC | 43.87 | 22826441 | |
| 421 | Phosphorylation | GKMARVFSVLREESE HHHHHHHHHHHHHCC | 19.86 | 23335269 | |
| 427 | Phosphorylation | FSVLREESESVLTLK HHHHHHHCCCEEEEC | 30.34 | 20415495 | |
| 429 | Phosphorylation | VLREESESVLTLKGL HHHHHCCCEEEECCC | 31.54 | 20415495 | |
| 432 | Phosphorylation | EESESVLTLKGLTPT HHCCCEEEECCCCCC | 25.03 | 20415495 | |
| 437 | Phosphorylation | VLTLKGLTPTGMLPS EEEECCCCCCCCCCC | 27.72 | - | |
| 453 | Phosphorylation | VLAGGRQTLQSATVE CCCCCHHHHHHHHHH | 25.96 | - | |
| 456 | Phosphorylation | GGRQTLQSATVEAIE CCHHHHHHHHHHHHH | 29.08 | - | |
| 458 | Phosphorylation | RQTLQSATVEAIEAE HHHHHHHHHHHHHHH | 24.91 | - | |
| 472 | Phosphorylation | EKAIRGFSPPHRICS HHHHCCCCCCCCCCC | 40.10 | 22324799 | |
| 479 | Phosphorylation | SPPHRICSFEEAKGL CCCCCCCCHHHHCCH | 33.06 | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PP2BB_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PP2BB_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PP2BB_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PP2BB_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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