dbPTM

1433E_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	1433E_MOUSE
UniProt AC	P62259
Protein Name	14-3-3 protein epsilon
Gene Name	Ywhae
Organism	Mus musculus (Mouse).
Sequence Length	255
Subcellular Localization	Nucleus . Cytoplasm . Melanosome .
Protein Description	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm..
Protein Sequence	MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDDREDLV -------CCHHHHHH	12.49	-
9	Phosphorylation	DDREDLVYQAKLAEQ CHHHHHHHHHHHHHH	15.28	22817900
9	Nitration	DDREDLVYQAKLAEQ CHHHHHHHHHHHHHH	15.28	-
12	Acetylation	EDLVYQAKLAEQAER HHHHHHHHHHHHHHH	32.48	23236377
12	Ubiquitination	EDLVYQAKLAEQAER HHHHHHHHHHHHHHH	32.48	22790023
20	Phosphorylation	LAEQAERYDEMVESM HHHHHHHHHHHHHHH	14.04	25521595
26	Phosphorylation	RYDEMVESMKKVAGM HHHHHHHHHHHHCCC	25.21	25521595
28	Acetylation	DEMVESMKKVAGMDV HHHHHHHHHHCCCCE	54.07	155535
29	Ubiquitination	EMVESMKKVAGMDVE HHHHHHHHHCCCCEE	28.77	22790023
46	Phosphorylation	VEERNLLSVAYKNVI HHHHHHHHHHHHHHH	14.10	26824392
49	Phosphorylation	RNLLSVAYKNVIGAR HHHHHHHHHHHHHHH	10.84	22817900
49	Nitration	RNLLSVAYKNVIGAR HHHHHHHHHHHHHHH	10.84	-
50	Ubiquitination	NLLSVAYKNVIGARR HHHHHHHHHHHHHHH	34.69	22790023
50	Acetylation	NLLSVAYKNVIGARR HHHHHHHHHHHHHHH	34.69	23236377
64	Phosphorylation	RASWRIISSIEQKEE HHHHHHHHHHHHHHH	23.92	22324799
65	Phosphorylation	ASWRIISSIEQKEEN HHHHHHHHHHHHHHC	21.53	25521595
69	Acetylation	IISSIEQKEENKGGE HHHHHHHHHHCCCCH	54.96	23864654
69	Ubiquitination	IISSIEQKEENKGGE HHHHHHHHHHCCCCH	54.96	-
69	Malonylation	IISSIEQKEENKGGE HHHHHHHHHHCCCCH	54.96	26320211
73	Ubiquitination	IEQKEENKGGEDKLK HHHHHHCCCCHHHHH	72.13	22790023
78	Acetylation	ENKGGEDKLKMIREY HCCCCHHHHHHHHHH	45.78	23201123
78	Ubiquitination	ENKGGEDKLKMIREY HCCCCHHHHHHHHHH	45.78	22790023
80	Ubiquitination	KGGEDKLKMIREYRQ CCCHHHHHHHHHHHH	37.71	-
85	Nitration	KLKMIREYRQMVETE HHHHHHHHHHHHHHH	9.04	-
97	S-palmitoylation	ETELKLICCDILDVL HHHHHHHHHHHHHHH	2.18	28526873
97	Glutathionylation	ETELKLICCDILDVL HHHHHHHHHHHHHHH	2.18	24333276
98	S-palmitoylation	TELKLICCDILDVLD HHHHHHHHHHHHHHH	2.64	28526873
98	S-nitrosylation	TELKLICCDILDVLD HHHHHHHHHHHHHHH	2.64	20925432
98	S-nitrosocysteine	TELKLICCDILDVLD HHHHHHHHHHHHHHH	2.64	-
106	Ubiquitination	DILDVLDKHLIPAAN HHHHHHHHHCCCCCC	35.83	22790023
106	Acetylation	DILDVLDKHLIPAAN HHHHHHHHHCCCCCC	35.83	22733758
114	Phosphorylation	HLIPAANTGESKVFY HCCCCCCCCCCEEEE	37.28	28464351
117	Phosphorylation	PAANTGESKVFYYKM CCCCCCCCEEEEEEE	35.15	28542873
118	Acetylation	AANTGESKVFYYKMK CCCCCCCEEEEEEEC	31.87	23236377
118	Ubiquitination	AANTGESKVFYYKMK CCCCCCCEEEEEEEC	31.87	-
118	Succinylation	AANTGESKVFYYKMK CCCCCCCEEEEEEEC	31.87	23954790
123	Ubiquitination	ESKVFYYKMKGDYHR CCEEEEEEECCCHHH	23.82	22790023
123	Acetylation	ESKVFYYKMKGDYHR CCEEEEEEECCCHHH	23.82	23236377
125	Ubiquitination	KVFYYKMKGDYHRYL EEEEEEECCCHHHHH	44.47	22790023
125	Acetylation	KVFYYKMKGDYHRYL EEEEEEECCCHHHHH	44.47	7618923
131	Phosphorylation	MKGDYHRYLAEFATG ECCCHHHHHHHHHCC	9.28	25521595
131	Nitration	MKGDYHRYLAEFATG ECCCHHHHHHHHHCC	9.28	-
137	Phosphorylation	RYLAEFATGNDRKEA HHHHHHHCCCCHHHH	41.67	31437443
142	Ubiquitination	FATGNDRKEAAENSL HHCCCCHHHHHHHHH	55.35	-
142	Malonylation	FATGNDRKEAAENSL HHCCCCHHHHHHHHH	55.35	26320211
142	Acetylation	FATGNDRKEAAENSL HHCCCCHHHHHHHHH	55.35	23236377
148	Phosphorylation	RKEAAENSLVAYKAA HHHHHHHHHHHHHHH	18.74	29895711
153	Acetylation	ENSLVAYKAASDIAM HHHHHHHHHHCHHCC	27.95	23954790
182	Phosphorylation	LNFSVFYYEILNSPD EEEEHHHHHHHCCHH	5.75	22817900
187	Phosphorylation	FYYEILNSPDRACRL HHHHHHCCHHHHHHH	25.40	21082442
196	Ubiquitination	DRACRLAKAAFDDAI HHHHHHHHHHHHHHH	44.85	22790023
196	Acetylation	DRACRLAKAAFDDAI HHHHHHHHHHHHHHH	44.85	23954790
208	Phosphorylation	DAIAELDTLSEESYK HHHHHHHCCCHHHCC	44.82	25619855
210	Phosphorylation	IAELDTLSEESYKDS HHHHHCCCHHHCCCH	41.22	24925903
213	Phosphorylation	LDTLSEESYKDSTLI HHCCCHHHCCCHHHH	33.17	24925903
214	Phosphorylation	DTLSEESYKDSTLIM HCCCHHHCCCHHHHH	23.30	24925903
217	Phosphorylation	SEESYKDSTLIMQLL CHHHCCCHHHHHHHH	22.44	26239621
218	Phosphorylation	EESYKDSTLIMQLLR HHHCCCHHHHHHHHH	30.36	28066266
229	Phosphorylation	QLLRDNLTLWTSDMQ HHHHCCCEEEECCCC	26.89	29472430
232	Phosphorylation	RDNLTLWTSDMQGDG HCCCEEEECCCCCCC	20.26	21149613
233	Phosphorylation	DNLTLWTSDMQGDGE CCCEEEECCCCCCCH	21.36	21149613
244	Ubiquitination	GDGEEQNKEALQDVE CCCHHHHHHHHHHCH	44.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of 1433E_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of 1433E_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of 1433E_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIN1_MOUSE	Rin1	physical	9144171
UBP8_HUMAN	USP8	physical	17720156
UBP8_MOUSE	Usp8	physical	16944949
NDEL1_MOUSE	Ndel1	physical	16944949
NF1_MOUSE	Nf1	physical	16944949
SRCN1_MOUSE	Srcin1	physical	16944949
ATAT_MOUSE	Atat1	physical	16944949
RS3_MOUSE	Rps3	physical	16944949
CP131_MOUSE	Cep131	physical	16944949
RLA0_MOUSE	Rplp0	physical	16944949
INP5E_MOUSE	Inpp5e	physical	16944949
EDC3_MOUSE	Edc3	physical	16944949
ADT2_MOUSE	Slc25a5	physical	16944949
ACTZ_MOUSE	Actr1a	physical	16944949
GIT1_MOUSE	Git1	physical	16944949
ATPA_MOUSE	Atp5a1	physical	16944949
ATPB_MOUSE	Atp5b	physical	16944949
ACLY_MOUSE	Acly	physical	16944949
CAPZB_MOUSE	Capzb	physical	16944949
SYLC_MOUSE	Lars	physical	16944949
SRGP2_MOUSE	Srgap2	physical	16944949
KLC4_MOUSE	Klc4	physical	16944949
HOME1_MOUSE	Homer1	physical	16944949
LANC2_MOUSE	Lancl2	physical	16944949
EXOC4_MOUSE	Exoc4	physical	16944949
HOME3_MOUSE	Homer3	physical	16944949
IF2B1_MOUSE	Igf2bp1	physical	16944949
R3HD2_MOUSE	R3hdm2	physical	16944949
FUS_MOUSE	Fus	physical	16944949
NUAK1_MOUSE	Nuak1	physical	16944949
AINX_MOUSE	Ina	physical	16944949
PSA1_MOUSE	Psma1	physical	16944949
DYR1A_MOUSE	Dyrk1a	physical	16944949
TIF1B_MOUSE	Trim28	physical	16944949
LRCH2_MOUSE	Lrch2	physical	16944949
CE170_MOUSE	Cep170	physical	16944949
VP9D1_MOUSE	Vps9d1	physical	16944949
HS90B_MOUSE	Hsp90ab1	physical	16944949
P85B_MOUSE	Pik3r2	physical	16944949
WDR37_MOUSE	Wdr37	physical	16944949
BORC5_MOUSE	Loh12cr1	physical	16944949
DCLK1_MOUSE	Dclk1	physical	16944949
GIT2_MOUSE	Git2	physical	16944949
SFPQ_MOUSE	Sfpq	physical	16944949
1433G_MOUSE	Ywhag	physical	16944949
CTND1_MOUSE	Ctnnd1	physical	16944949
SRBS2_MOUSE	Sorbs2	physical	16944949
OGT1_MOUSE	Ogt	physical	16944949
MINY4_MOUSE	Fam188b	physical	16944949
EF1B_MOUSE	Eef1b2	physical	16944949
RB6I2_MOUSE	Erc1	physical	16944949
RIMS2_MOUSE	Rims2	physical	16944949
DMWD_MOUSE	Dmwd	physical	16944949
EWS_MOUSE	Ewsr1	physical	16944949
KIF5A_MOUSE	Kif5a	physical	16944949
MARK1_MOUSE	Mark1	physical	16944949
KSR1_MOUSE	Ksr1	physical	16944949
CBL_MOUSE	Cbl	physical	16944949
IRS1_MOUSE	Irs1	physical	16944949
MARK4_MOUSE	Mark4	physical	16944949
G3P_MOUSE	Gapdh	physical	16944949
CBR1_MOUSE	Cbr1	physical	16944949
PGAM5_MOUSE	Pgam5	physical	16944949
MSD4_MOUSE	Msantd4	physical	16944949
DOCK8_MOUSE	Dock8	physical	16944949
DBNL_MOUSE	Dbnl	physical	16944949
FLNA_MOUSE	Flna	physical	16944949
NUCL_MOUSE	Ncl	physical	16944949
CRTC1_MOUSE	Crtc1	physical	16944949
YBOX1_MOUSE	Ybx1	physical	16944949
TBCD7_MOUSE	Tbc1d7	physical	16944949
DDX6_MOUSE	Ddx6	physical	16944949
MARK2_MOUSE	Mark2	physical	16944949
LRCH3_MOUSE	Lrch3	physical	16944949
K22O_MOUSE	Krt76	physical	16944949
EF1G_MOUSE	Eef1g	physical	16944949
DCLK2_MOUSE	Dclk2	physical	16944949
CAZA1_MOUSE	Capza1	physical	16944949
KI21B_MOUSE	Kif21b	physical	16944949
RAB3I_MOUSE	Rab3ip	physical	16944949
TRI32_MOUSE	Trim32	physical	16944949
SPD2A_MOUSE	Sh3pxd2a	physical	16944949
NONO_MOUSE	Nono	physical	16944949
TANC2_MOUSE	Tanc2	physical	16944949
PURA_MOUSE	Pura	physical	16944949
ERC2_MOUSE	Erc2	physical	16944949
KINH_MOUSE	Kif5b	physical	16944949
CASP3_MOUSE	Casp3	physical	16944949
RHG33_MOUSE	Arhgap33	physical	16944949
CAPR1_MOUSE	Caprin1	physical	16944949
RIMS3_MOUSE	Rims3	physical	16944949
SYN2_MOUSE	Syn2	physical	16944949
1433F_MOUSE	Ywhah	physical	16944949
DCX_MOUSE	Dcx	physical	16944949
CBR3_MOUSE	Cbr3	physical	16944949
DREB_MOUSE	Dbn1	physical	16944949
NAV1_MOUSE	Nav1	physical	16944949
SYN1_MOUSE	Syn1	physical	16944949
MAP1B_MOUSE	Map1b	physical	16944949
CLH1_MOUSE	Cltc	physical	16944949
SRGP3_MOUSE	Srgap3	physical	16944949
WDR48_MOUSE	Wdr48	physical	16944949
TBCD4_MOUSE	Tbc1d4	physical	16944949
EF1A1_MOUSE	Eef1a1	physical	16944949
DLGP3_MOUSE	Dlgap3	physical	16944949
TSC1_MOUSE	Tsc1	physical	16944949
CACB1_MOUSE	Cacnb1	physical	16944949
PACS1_MOUSE	Pacs1	physical	16944949
RFIP2_MOUSE	Rab11fip2	physical	16944949
BRSK2_MOUSE	Brsk2	physical	16944949
GRDN_MOUSE	Ccdc88a	physical	16944949
ROAA_MOUSE	Hnrnpab	physical	16944949
MARK3_MOUSE	Mark3	physical	16944949
EF1A2_MOUSE	Eef1a2	physical	16944949
FRM4B_MOUSE	Frmd4b	physical	16944949
FRM4A_MOUSE	Frmd4a	physical	16944949
HSP7C_MOUSE	Hspa8	physical	16944949
CAZA2_MOUSE	Capza2	physical	16944949
PACS2_MOUSE	Pacs2	physical	16944949
SYN3_MOUSE	Syn3	physical	16944949
GGYF1_MOUSE	Gigyf1	physical	16944949
BRSK1_MOUSE	Brsk1	physical	16944949
MPRIP_MOUSE	Mprip	physical	16944949
BAIP2_MOUSE	Baiap2	physical	16944949
AHI1_MOUSE	Ahi1	physical	16944949
CYH2_MOUSE	Cyth2	physical	16944949
1433B_MOUSE	Ywhab	physical	18687683
LRRK2_MOUSE	Lrrk2	physical	21390248
CTND1_MOUSE	Ctnnd1	physical	17993462
TAU_MOUSE	Mapt	physical	19014373
MPIP2_MOUSE	Cdc25b	physical	25059436

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of 1433E_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210, AND MASSSPECTROMETRY.	17203969 [Abstract]