dbPTM

DLGP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DLGP3_MOUSE
UniProt AC	Q6PFD5
Protein Name	Disks large-associated protein 3
Gene Name	Dlgap3
Organism	Mus musculus (Mouse).
Sequence Length	977
Subcellular Localization	Cell membrane Peripheral membrane protein . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell junction, synapse . Postsynaptic density of neuronal cells.
Protein Description	May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane..
Protein Sequence	MRGYHGDRGSHPRPARFADQQHMDVGPAARAPYLLGSREAFSTEPRFCAPRAGLGHLSPEGPLSLSEGPSSVGPEGGPGGVGAGGGSSTFPRMYPGQGPFDTCEDCVGHPQGKGATRLPPTLLDQFEKQLPVQQDGFHTLPYQRGPAGPGPGPGSGAAPEARSESPSRIRHLVHSVQKLFAKSHSLEAPGKRDYNGPKADGRGSSGGDSYSGPGSGGTPTSHHHHHHHHHHHHQSRHGKRSKSKDRKGDGRHQTKATGWWSSDDNLDSDSGFLGGRPPGEPGGPFCLDAPDGSYRDLSFKGRSGGSEGRCLACTGMSMSLDGQSVKRSAWHTMMVSQGRDGYPGAGPGKGLLGPETKAKARTYHYLQVPQDDWGGYPTGGKDGEIPCRRMRSGSYIKAMGDEESGDSDGSPKTSPKALARRFASRRSSSVDTARINCCVPPRIHPRSSIPGYSRSLTTGQLSEEFNQQLEAVCGSVFGELESQAVDALDLPGCFRMRSHSYLRAIQAGCSQDDDCLPLLAAPASVSGRPGSSFNFRKAPPPIPPGSQAPPRISITAQSSTDSAHESFTAAEGPARRCSSADGLDGPTMGARTLELAPVPPRASPKPPTLIIKTIPGREELRSLARQRKWRPSIGVQVETISDSDTENRSRREFHSIGVQVEEDKRRARFKRSNSVTAGVQADLELEGLAGLATVATEDKALQFGRSFQRHASEPQPGPRAPTYSVFRTVHTQGQWAYREGYPLPYEPPATDGSPGPTPVPAPGPGSGRRDSWMERGSRSLPDSGRTSPCPRDGEWFIKMLRAEVEKLEHWCQQMEREAEDYELPEEILEKIRSAVGSTQLLLSQKVQQFFRLCQQSLDPTAFPVPTFQDLAGFWDLLQLSIEDVTLKFLELQQLKANSWKLLEPKEEKKVPPPIPKKPSRGRGVPVKERSLDSVDRQRQEARKRLLAAKRAASFRHSSATESADSIEIYIPEAQTRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Methylation	EAFSTEPRFCAPRAG CHHCCCCCCCCCCCC	32.80	58859361
58	Phosphorylation	RAGLGHLSPEGPLSL CCCCCCCCCCCCCCC	18.41	29899451
64	Phosphorylation	LSPEGPLSLSEGPSS CCCCCCCCCCCCCCC	32.74	20415495
66	Phosphorylation	PEGPLSLSEGPSSVG CCCCCCCCCCCCCCC	36.81	20415495
70	Phosphorylation	LSLSEGPSSVGPEGG CCCCCCCCCCCCCCC	48.81	29899451
71	Phosphorylation	SLSEGPSSVGPEGGP CCCCCCCCCCCCCCC	33.94	20415495
139	Phosphorylation	VQQDGFHTLPYQRGP CCCCCCCCCCCCCCC	27.45	29899451
155	Phosphorylation	GPGPGPGSGAAPEAR CCCCCCCCCCCCHHH	28.52	29899451
163	Phosphorylation	GAAPEARSESPSRIR CCCCHHHCCCHHHHH	49.85	29899451
165	Phosphorylation	APEARSESPSRIRHL CCHHHCCCHHHHHHH	29.44	22817900
183	Phosphorylation	VQKLFAKSHSLEAPG HHHHHHHHCCCCCCC	18.19	23335269
185	Phosphorylation	KLFAKSHSLEAPGKR HHHHHHCCCCCCCCC	34.69	25521595
247	Ubiquitination	RSKSKDRKGDGRHQT CCCCCCCCCCCCCCC	72.06	-
255	Ubiquitination	GDGRHQTKATGWWSS CCCCCCCCCCCCCCC	37.06	-
261	Phosphorylation	TKATGWWSSDDNLDS CCCCCCCCCCCCCCC	19.85	22807455
262	Phosphorylation	KATGWWSSDDNLDSD CCCCCCCCCCCCCCC	34.95	29899451
268	Phosphorylation	SSDDNLDSDSGFLGG CCCCCCCCCCCCCCC	36.52	21082442
314	Phosphorylation	EGRCLACTGMSMSLD CCCEEEECCCCEEEC	30.25	22324799
317	Phosphorylation	CLACTGMSMSLDGQS EEEECCCCEEECCCC	13.43	22324799
319	Phosphorylation	ACTGMSMSLDGQSVK EECCCCEEECCCCHH	18.92	22324799
324	Phosphorylation	SMSLDGQSVKRSAWH CEEECCCCHHHHHHE	34.83	22324799
363	Phosphorylation	TKAKARTYHYLQVPQ HHHCCEEEEEEECCC	5.28	-
392	Phosphorylation	IPCRRMRSGSYIKAM CCCCCCCCCCCEEEC	23.81	23737553
394	Phosphorylation	CRRMRSGSYIKAMGD CCCCCCCCCEEECCC	25.57	29899451
395	Phosphorylation	RRMRSGSYIKAMGDE CCCCCCCCEEECCCC	15.23	29899451
404	Phosphorylation	KAMGDEESGDSDGSP EECCCCCCCCCCCCC	45.94	25521595
407	Phosphorylation	GDEESGDSDGSPKTS CCCCCCCCCCCCCCC	47.61	25521595
410	O-linked_Glycosylation	ESGDSDGSPKTSPKA CCCCCCCCCCCCHHH	28.37	48011
410	Phosphorylation	ESGDSDGSPKTSPKA CCCCCCCCCCCCHHH	28.37	25521595
413	Phosphorylation	DSDGSPKTSPKALAR CCCCCCCCCHHHHHH	54.36	25521595
414	Phosphorylation	SDGSPKTSPKALARR CCCCCCCCHHHHHHH	30.45	22324799
427	Phosphorylation	RRFASRRSSSVDTAR HHHHHHCCCCCCEEE	26.34	23335269
428	Phosphorylation	RFASRRSSSVDTARI HHHHHCCCCCCEEEE	32.35	22324799
429	Phosphorylation	FASRRSSSVDTARIN HHHHCCCCCCEEEEE	25.84	25521595
432	Phosphorylation	RRSSSVDTARINCCV HCCCCCCEEEEEEEC	18.71	22324799
448	Phosphorylation	PRIHPRSSIPGYSRS CCCCCCCCCCCCCCC	33.80	22807455
498	Phosphorylation	PGCFRMRSHSYLRAI CCCCHHCCHHHHHHH	13.87	22817900
500	Phosphorylation	CFRMRSHSYLRAIQA CCHHCCHHHHHHHHH	27.40	29899451
510	Phosphorylation	RAIQAGCSQDDDCLP HHHHHCCCCCCCCHH	35.41	22817900
531	Phosphorylation	SVSGRPGSSFNFRKA CCCCCCCCCCCCCCC	34.14	21082442
553	Phosphorylation	SQAPPRISITAQSST CCCCCEEEEEEECCC	18.37	22807455
555	Phosphorylation	APPRISITAQSSTDS CCCEEEEEEECCCCC	16.32	22807455
558	Phosphorylation	RISITAQSSTDSAHE EEEEEEECCCCCHHH	32.51	19060867
559	Phosphorylation	ISITAQSSTDSAHES EEEEEECCCCCHHHH	24.93	19060867
560	Phosphorylation	SITAQSSTDSAHESF EEEEECCCCCHHHHH	38.94	19060867
562	Phosphorylation	TAQSSTDSAHESFTA EEECCCCCHHHHHCC	31.45	22817900
566	Phosphorylation	STDSAHESFTAAEGP CCCCHHHHHCCCCCC	20.31	22817900
568	Phosphorylation	DSAHESFTAAEGPAR CCHHHHHCCCCCCCC	33.95	22807455
578	Phosphorylation	EGPARRCSSADGLDG CCCCCCCCCCCCCCC	27.09	25521595
579	Phosphorylation	GPARRCSSADGLDGP CCCCCCCCCCCCCCC	33.72	22324799
587	Phosphorylation	ADGLDGPTMGARTLE CCCCCCCCCCCCEEE	33.49	29899451
632	Phosphorylation	RQRKWRPSIGVQVET HHHCCCCCCCEEEEE	24.33	26804993
639	Phosphorylation	SIGVQVETISDSDTE CCCEEEEECCCCCCC	27.24	22817900
641	Phosphorylation	GVQVETISDSDTENR CEEEEECCCCCCCCC	38.18	22817900
643	Phosphorylation	QVETISDSDTENRSR EEEECCCCCCCCCCH	39.37	22817900
645	Phosphorylation	ETISDSDTENRSRRE EECCCCCCCCCCHHH	38.83	19060867
655	Phosphorylation	RSRREFHSIGVQVEE CCHHHHHHCCCCHHH	26.76	29899451
672	Phosphorylation	RRARFKRSNSVTAGV HHHHHHHCCCCCCCC	33.76	29899451
674	Phosphorylation	ARFKRSNSVTAGVQA HHHHHCCCCCCCCCC	23.30	29899451
676	Phosphorylation	FKRSNSVTAGVQADL HHHCCCCCCCCCCCE	19.95	22807455
706	Phosphorylation	KALQFGRSFQRHASE HHHHHHHHHHHHCCC	26.55	22324799
712	Phosphorylation	RSFQRHASEPQPGPR HHHHHHCCCCCCCCC	43.62	25521595
722	Phosphorylation	QPGPRAPTYSVFRTV CCCCCCCCCCEEEEE	27.69	22324799
723	Phosphorylation	PGPRAPTYSVFRTVH CCCCCCCCCEEEEEE	11.19	22324799
724	Phosphorylation	GPRAPTYSVFRTVHT CCCCCCCCEEEEEEC	19.77	22324799
745	Phosphorylation	REGYPLPYEPPATDG ECCCCCCCCCCCCCC	49.07	29899451
750	Phosphorylation	LPYEPPATDGSPGPT CCCCCCCCCCCCCCC	46.82	22817900
753	Phosphorylation	EPPATDGSPGPTPVP CCCCCCCCCCCCCCC	29.50	29899451
757	Phosphorylation	TDGSPGPTPVPAPGP CCCCCCCCCCCCCCC	42.72	29899451
771	Phosphorylation	PGSGRRDSWMERGSR CCCCCCCCHHHCCCC	26.89	22324799
777	Phosphorylation	DSWMERGSRSLPDSG CCHHHCCCCCCCCCC	25.56	22324799
779	Phosphorylation	WMERGSRSLPDSGRT HHHCCCCCCCCCCCC	46.05	25521595
783	Phosphorylation	GSRSLPDSGRTSPCP CCCCCCCCCCCCCCC	28.38	25521595
786	Phosphorylation	SLPDSGRTSPCPRDG CCCCCCCCCCCCCCH	40.31	25521595
787	Phosphorylation	LPDSGRTSPCPRDGE CCCCCCCCCCCCCHH	24.12	25521595
830	Ubiquitination	LPEEILEKIRSAVGS CCHHHHHHHHHHHHH	39.72	-
837	Phosphorylation	KIRSAVGSTQLLLSQ HHHHHHHHHHHHHHH	13.33	29899451
895	Ubiquitination	FLELQQLKANSWKLL HHHHHHHHHCCCCCC	40.98	-
930	Phosphorylation	GVPVKERSLDSVDRQ CCCCCCCCCCHHHHH	37.31	25521595
933	Phosphorylation	VKERSLDSVDRQRQE CCCCCCCHHHHHHHH	31.07	22817900
957	Phosphorylation	RAASFRHSSATESAD HHHHHCCCCCCCCCC	19.88	22324799
958	Phosphorylation	AASFRHSSATESADS HHHHCCCCCCCCCCC	32.84	22324799
960	Phosphorylation	SFRHSSATESADSIE HHCCCCCCCCCCCEE	32.21	29899451
962	Phosphorylation	RHSSATESADSIEIY CCCCCCCCCCCEEEE	32.78	22324799
965	Phosphorylation	SATESADSIEIYIPE CCCCCCCCEEEECCH	23.10	21082442
969	Phosphorylation	SADSIEIYIPEAQTR CCCCEEEECCHHHHC	9.53	20415495

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DLGP3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DLGP3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DLGP3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DLGP3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DLGP3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; SER-500; SER-930 ANDSER-965, AND MASS SPECTROMETRY.	16452087 [Abstract]
"Proteomic analysis of in vivo phosphorylated synaptic proteins."; Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I.,Blackstock W.P., Choudhary J.S., Grant S.G.; J. Biol. Chem. 280:5972-5982(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; SER-394; SER-404;SER-407; SER-410 AND SER-414, AND MASS SPECTROMETRY.	15572359 [Abstract]