DMWD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DMWD_MOUSE
• UniProt AC: Q08274
• Protein Name: Dystrophia myotonica WD repeat-containing protein
• Gene Name: Dmwd
• Organism: Mus musculus (Mouse).
• Sequence Length: 665
• Subcellular Localization: Perikaryon . Cell projection, dendrite . Nucleus . In neurons, shows punctate expression throughout the cell body, nucleus and dendrites. Not detected in axons.
• Protein Sequence: MAAGGAEGGPGPSAAMGDCAEIKSQFRTREGFYKLLPGDATRRSGPTSAQTPAPPQPTQPPPGPAAASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGDPDGAGEPPSTPSGLGAGGDRVCFNLGRELYFYPGCCRSGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETISLLVGFSAGQVQYLDLIKKDTSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCTSTPPQYSLLKQGEGFAVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYTTRAEEAASASADGDPSGEEEEPEVTSSDTGAPVSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLSPHPSLARTRTLPGTPGATPPASGSSRAGETGAGPLPRSLSRSNSLPHPAGGGKAGGPSASMEPGIPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGNSSNDKLSGPAPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFLEDCIITACQEGLICTWARPGKAFTDEETEAQAGQASWPRSPSKSVVEGISSQPGSSPSGTVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAGGAEGG ------CCCCCCCCC	18.14	-
111	Phosphorylation	DGAGEPPSTPSGLGA CCCCCCCCCCCCCCC	64.76	29899451
112	Phosphorylation	GAGEPPSTPSGLGAG CCCCCCCCCCCCCCC	27.52	25521595
114	Phosphorylation	GEPPSTPSGLGAGGD CCCCCCCCCCCCCCC	46.90	20415495
145	Phosphorylation	CRSGSQRSIDLNKPI CCCCCCCCCCCCCCC	16.90	22817900
385	Phosphorylation	TRAEEAASASADGDP CCHHHHHHHCCCCCC	29.79	27180971
387	Phosphorylation	AEEAASASADGDPSG HHHHHHHCCCCCCCC	25.13	21183079
393	Phosphorylation	ASADGDPSGEEEEPE HCCCCCCCCCCCCCC	64.67	25521595
402	Phosphorylation	EEEEPEVTSSDTGAP CCCCCCCCCCCCCCC	22.35	20415495
403	Phosphorylation	EEEPEVTSSDTGAPV CCCCCCCCCCCCCCC	31.24	20415495
404	Phosphorylation	EEPEVTSSDTGAPVS CCCCCCCCCCCCCCC	29.80	20415495
406	Phosphorylation	PEVTSSDTGAPVSPL CCCCCCCCCCCCCCC	36.87	20415495
411	Phosphorylation	SDTGAPVSPLPKAGS CCCCCCCCCCCCCCE	21.47	25338131
451	Phosphorylation	PHPSLARTRTLPGTP CCHHHCCCCCCCCCC	23.54	26643407
453	Phosphorylation	PSLARTRTLPGTPGA HHHCCCCCCCCCCCC	36.37	25266776
457	Phosphorylation	RTRTLPGTPGATPPA CCCCCCCCCCCCCCC	19.33	26643407
461	Phosphorylation	LPGTPGATPPASGSS CCCCCCCCCCCCCCC	35.40	26643407
465	Phosphorylation	PGATPPASGSSRAGE CCCCCCCCCCCCCCC	45.01	25293948
467	Phosphorylation	ATPPASGSSRAGETG CCCCCCCCCCCCCCC	17.73	25293948
468	Phosphorylation	TPPASGSSRAGETGA CCCCCCCCCCCCCCC	29.67	22817900
481	Phosphorylation	GAGPLPRSLSRSNSL CCCCCCCCCCCCCCC	28.85	22324799
483	Phosphorylation	GPLPRSLSRSNSLPH CCCCCCCCCCCCCCC	34.60	29899451
485	Phosphorylation	LPRSLSRSNSLPHPA CCCCCCCCCCCCCCC	27.65	22942356
487	Phosphorylation	RSLSRSNSLPHPAGG CCCCCCCCCCCCCCC	44.52	25521595
501	Phosphorylation	GGKAGGPSASMEPGI CCCCCCCCCCCCCCC	35.93	21454597
503	Phosphorylation	KAGGPSASMEPGIPF CCCCCCCCCCCCCCC	28.19	24719451
517	Phosphorylation	FSIGRFATLTLQERR CEECEEEEEEHHHHH	19.98	26824392
519	Phosphorylation	IGRFATLTLQERRDR ECEEEEEEHHHHHHH	23.26	24719451
535	Phosphorylation	AEKEHKRYHSLGNIS CHHHHHHHHCCCCCC	10.68	23984901
537	Phosphorylation	KEHKRYHSLGNISRG HHHHHHHCCCCCCCC	29.10	26824392
542	Phosphorylation	YHSLGNISRGGSGGN HHCCCCCCCCCCCCC	28.95	29899451
543	Methylation	HSLGNISRGGSGGNS HCCCCCCCCCCCCCC	50.09	24129315
550	Phosphorylation	RGGSGGNSSNDKLSG CCCCCCCCCCCCCCC	33.52	24719451
562	Phosphorylation	LSGPAPRSRLDPAKV CCCCCCHHHCCHHHH	35.82	22942356
643	Phosphorylation	GQASWPRSPSKSVVE CCCCCCCCCCCCCEE	29.46	25521595
645	Phosphorylation	ASWPRSPSKSVVEGI CCCCCCCCCCCEECC	38.52	29899451
647	Phosphorylation	WPRSPSKSVVEGISS CCCCCCCCCEECCCC	35.41	20415495
653	Phosphorylation	KSVVEGISSQPGSSP CCCEECCCCCCCCCC	33.50	20415495
654	Phosphorylation	SVVEGISSQPGSSPS CCEECCCCCCCCCCC	38.17	20415495
658	Phosphorylation	GISSQPGSSPSGTVV CCCCCCCCCCCCCCC	45.84	25293948
659	Phosphorylation	ISSQPGSSPSGTVV- CCCCCCCCCCCCCC-	29.06	25521595
661	Phosphorylation	SQPGSSPSGTVV--- CCCCCCCCCCCC---	49.39	26643407
663	Phosphorylation	PGSSPSGTVV----- CCCCCCCCCC-----	23.56	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DMWD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DMWD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DMWD_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DMWD_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.