LRCH2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRCH2_MOUSE
• UniProt AC: Q3UMG5
• Protein Name: Leucine-rich repeat and calponin homology domain-containing protein 2
• Gene Name: Lrch2
• Organism: Mus musculus (Mouse).
• Sequence Length: 773
• Protein Sequence: MAASQGGGGNSGGGGCSGGGSGGGGGAAGGGGGGGGGGGGGAGAGGGGGCGGTVAVPIPVPTLFGQPFPNGPQWHPGSLQPQHTVRSLDRALEEAGNSGILSLSGRKLREFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDVSCNEIQVLPQQMGKLHSLKELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLNKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDDTISLHSQVSESNREQTSRNDSHITGSKPDSQKDQEVYDFIDPNTEDVAVPEEGDTHIGSFVSFLKGKEKSSEKSQKNEEPPNEKKVDKEQLLPEEEDDDLKEVTDLRKIAAQLLKQEQKNRILNHSTSVMRNKLKQTVECEKSVPADEGNSPLSPLAWQPLENQKDQIVDQQWPESQPIIWQNEERRRSKQIRKEYFKYKSTRKNSSGNENEEQESDNAHMSAQSPVSSEEYDRSDGFSHGPFGLKPRSAFSRASRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTKASQLSMA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
323	Phosphorylation	RMDKKPDSLDLPSLN CCCCCCCCCCCCCCC	32.10	22817900
328	Phosphorylation	PDSLDLPSLNKRMPS CCCCCCCCCCCCCCC	52.45	22942356
335	Phosphorylation	SLNKRMPSQPLTDSM CCCCCCCCCCCCCCH	34.78	28066266
339	Phosphorylation	RMPSQPLTDSMEDFY CCCCCCCCCCHHHHC	32.48	28066266
341	Phosphorylation	PSQPLTDSMEDFYPN CCCCCCCCHHHHCCC	20.88	24899341
346	Phosphorylation	TDSMEDFYPNKNHGP CCCHHHHCCCCCCCC	20.44	28066266
355	Phosphorylation	NKNHGPDSGIGSDNG CCCCCCCCCCCCCCC	35.13	29550500
359	Phosphorylation	GPDSGIGSDNGEKRL CCCCCCCCCCCCEEE	26.44	26824392
367	Phosphorylation	DNGEKRLSTTEPSDD CCCCEEECCCCCCCC	37.00	25619855
368	Phosphorylation	NGEKRLSTTEPSDDD CCCEEECCCCCCCCC	39.51	25619855
369	Phosphorylation	GEKRLSTTEPSDDDT CCEEECCCCCCCCCC	42.39	25619855
372	Phosphorylation	RLSTTEPSDDDTISL EECCCCCCCCCCEEH	47.65	25619855
376	Phosphorylation	TEPSDDDTISLHSQV CCCCCCCCEEHHHHC	21.33	25619855
386	Phosphorylation	LHSQVSESNREQTSR HHHHCCCCCCHHCCC	33.41	23649490
392	Phosphorylation	ESNREQTSRNDSHIT CCCCHHCCCCCCCCC	28.87	23649490
445	Phosphorylation	FLKGKEKSSEKSQKN HHCCCHHCCHHHHCC	44.83	29514104
446	Phosphorylation	LKGKEKSSEKSQKNE HCCCHHCCHHHHCCC	61.17	29514104
504 (in isoform 2)	Phosphorylation	-	4.18	25338131
507 (in isoform 2)	Phosphorylation	-	35.60	29514104
526	Phosphorylation	VPADEGNSPLSPLAW CCCCCCCCCCCCCCC	37.77	25619855
529	Phosphorylation	DEGNSPLSPLAWQPL CCCCCCCCCCCCCCC	22.66	25619855
571	Phosphorylation	SKQIRKEYFKYKSTR HHHHHHHHHHHHCCC	14.38	29514104
581 (in isoform 3)	Phosphorylation	-	42.53	29899451
581	Phosphorylation	YKSTRKNSSGNENEE HHCCCCCCCCCCCCH	42.53	25777480
582 (in isoform 3)	Phosphorylation	-	55.84	22807455
582	Phosphorylation	KSTRKNSSGNENEEQ HCCCCCCCCCCCCHH	55.84	25777480
591	Phosphorylation	NENEEQESDNAHMSA CCCCHHHHHCCCCCC	35.54	25777480
597	Phosphorylation	ESDNAHMSAQSPVSS HHHCCCCCCCCCCCH	17.18	25777480
600	Phosphorylation	NAHMSAQSPVSSEEY CCCCCCCCCCCHHHH	27.30	25777480
603	Phosphorylation	MSAQSPVSSEEYDRS CCCCCCCCHHHHCCC	35.10	25777480
604	Phosphorylation	SAQSPVSSEEYDRSD CCCCCCCHHHHCCCC	34.38	25777480
607	Phosphorylation	SPVSSEEYDRSDGFS CCCCHHHHCCCCCCC	16.77	25777480
610	Phosphorylation	SSEEYDRSDGFSHGP CHHHHCCCCCCCCCC	38.91	-
630	Phosphorylation	RSAFSRASRQEYGAA HHHHHHHHHHHHCCC	33.13	29514104
634	Phosphorylation	SRASRQEYGAADPGF HHHHHHHHCCCCCCH	12.06	29514104
642	Phosphorylation	GAADPGFTMRRKMEH CCCCCCHHHHHHHHH	18.71	26824392
733	Phosphorylation	ACKKLGVSQERLCLP HHHHHCCCHHHHCCC	25.24	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRCH2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRCH2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRCH2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LRCH2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.