GGYF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GGYF1_MOUSE
• UniProt AC: Q99MR1
• Protein Name: GRB10-interacting GYF protein 1
• Gene Name: Gigyf1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1044
• Protein Description: May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1..
• Protein Sequence: MAAETLNFGPEWLRALSSGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEELQDKEFAAVLQEEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLPATSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRNPREIQRSQSWDDRGERRFEKPARRDGVRSGFEEGGAGPRKEHARSDSENWRSLREEQEDDGSWRLGAGPRRDGDRWRSTSPDGGPRSAGWREHGERRRKFDFDLRGERGGCGEEDGRVGGGNSHLRRCRGLDGFEDDKDGLPEWCLEDEDEEMGTFDASGAFLPLKKGPKEAIPEEQELDFRGLEEEEEEEEEPSEGVDEERPEAGGKEATPLPPPENSSSPSSLPALGPLWTTNEEGGEAVEKELPPAEGDELRGLSLSPRISSPPGPPGDLEDEEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSTAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQHFLQLVGSRQLPQCTTLREKAAMGDLTPPQQQQLTTFLQQLQALKTPRGGDQNLLPTMSRSLSVPDSGPLWDLHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQQQEEQKRRQEEEELFRRKQVRQQELLLKLLQQQQATNVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQMESERQLHKQAAPREPLRAQAPNHRVQLGGLGSAPLNQWVSEAGPLWGGPDKSGGSSGGNLGLWEDTLKSGGSLARSLGLKSSRSSPSLSDSYSHLSGRPVRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSTAGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQQQQQQQQQEAWLSSTSLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGPSGEIESVDDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	PEWLRALSSGGSVAS HHHHHHHHCCCCCCC		25619855
18	Phosphorylation	EWLRALSSGGSVASP HHHHHHHCCCCCCCC		25619855
21	Phosphorylation	RALSSGGSVASPPPS HHHHCCCCCCCCCCC		25619855
24	Phosphorylation	SSGGSVASPPPSPAM HCCCCCCCCCCCCCC		25521595
28	Phosphorylation	SVASPPPSPAMPKYK CCCCCCCCCCCCCCC		21082442
137	Phosphorylation	DSCFYQRSIEEGDGA CCCCEECCCCCCCCC		25521595
155	Phosphorylation	NPREIQRSQSWDDRG CHHHHHHHCCCCCHH		27087446
157	Phosphorylation	REIQRSQSWDDRGER HHHHHHCCCCCHHCH		25521595
177	Phosphorylation	ARRDGVRSGFEEGGA CCCCCCCCCCCCCCC		22817900
195	Phosphorylation	KEHARSDSENWRSLR HHHCCCCCHHHHHHH		29899451
226	Phosphorylation	RDGDRWRSTSPDGGP CCCCCCCCCCCCCCC		22324799
227	Phosphorylation	DGDRWRSTSPDGGPR CCCCCCCCCCCCCCC		25521595
228	Phosphorylation	GDRWRSTSPDGGPRS CCCCCCCCCCCCCCC		27087446
235	Phosphorylation	SPDGGPRSAGWREHG CCCCCCCCCCCHHCC		25266776
343	Phosphorylation	EEEEEEPSEGVDEER HHHCCCCCCCCCCCC		25619855
359	Phosphorylation	EAGGKEATPLPPPEN CCCCCCCCCCCCCCC		26643407
367	Phosphorylation	PLPPPENSSSPSSLP CCCCCCCCCCCCCCC		26643407
368	Phosphorylation	LPPPENSSSPSSLPA CCCCCCCCCCCCCCC		26643407
369	Phosphorylation	PPPENSSSPSSLPAL CCCCCCCCCCCCCCC		26643407
371	Phosphorylation	PENSSSPSSLPALGP CCCCCCCCCCCCCCC		26643407
372	Phosphorylation	ENSSSPSSLPALGPL CCCCCCCCCCCCCCC		26643407
381	Phosphorylation	PALGPLWTTNEEGGE CCCCCCEEECCCCCC		25168779
382	Phosphorylation	ALGPLWTTNEEGGEA CCCCCEEECCCCCCC		25168779
406	Phosphorylation	GDELRGLSLSPRISS CCCCCCCCCCCCCCC		22324799
408	Phosphorylation	ELRGLSLSPRISSPP CCCCCCCCCCCCCCC		26824392
412	Phosphorylation	LSLSPRISSPPGPPG CCCCCCCCCCCCCCC		25521595
413	Phosphorylation	SLSPRISSPPGPPGD CCCCCCCCCCCCCCC		25521595
440	Phosphorylation	EAEKLVASLQDSSLE HHHHHHHHHHCCCCC		26643407
444	Phosphorylation	LVASLQDSSLEEEQF HHHHHHCCCCCHHHH		26643407
445	Phosphorylation	VASLQDSSLEEEQFT HHHHHCCCCCHHHHH		26643407
452	Phosphorylation	SLEEEQFTAAMQTQG CCCHHHHHHHHHHCC		26643407
540	Phosphorylation	VPFAPGPSPPPLLGN CCCCCCCCCCCCCCC		26824392
598	Phosphorylation	KAAMGDLTPPQQQQL HHHCCCCCCHHHHHH		26643407
632	Phosphorylation	LLPTMSRSLSVPDSG CHHHCCCCCCCCCCC		-
634	Phosphorylation	PTMSRSLSVPDSGPL HHCCCCCCCCCCCCC		-
746	Phosphorylation	LLQQQQATNVPVPPA HHHHHHHHCCCCCCC		25777480
755	Phosphorylation	VPVPPAPSSPPPLWA CCCCCCCCCCCCCHH		26745281
756	Phosphorylation	PVPPAPSSPPPLWAG CCCCCCCCCCCCHHH		27087446
770	Phosphorylation	GLAKQGLSMKTLLEL HHHHCCCCHHHHHHH		21659604
860	Phosphorylation	ARSLGLKSSRSSPSL HHHCCCCCCCCCCCH		26643407
861	Phosphorylation	RSLGLKSSRSSPSLS HHCCCCCCCCCCCHH		26643407
863	Phosphorylation	LGLKSSRSSPSLSDS CCCCCCCCCCCHHHH		27742792
864	Phosphorylation	GLKSSRSSPSLSDSY CCCCCCCCCCHHHHH		30387612
866	Phosphorylation	KSSRSSPSLSDSYSH CCCCCCCCHHHHHHH		27742792
868	Phosphorylation	SRSSPSLSDSYSHLS CCCCCCHHHHHHHHC		25367039
870	Phosphorylation	SSPSLSDSYSHLSGR CCCCHHHHHHHHCCC		18846507
871	Phosphorylation	SPSLSDSYSHLSGRP CCCHHHHHHHHCCCC		24719451
872	Phosphorylation	PSLSDSYSHLSGRPV CCHHHHHHHHCCCCC		18846507
875	Phosphorylation	SDSYSHLSGRPVRKK HHHHHHHCCCCCCCC		18846507
1022	Phosphorylation	RRALMLHSDPSILGY HHHHHHCCCHHHHCC		25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GGYF1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GGYF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GGYF1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GGYF1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.