SYLC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYLC_MOUSE
• UniProt AC: Q8BMJ2
• Protein Name: Leucine--tRNA ligase, cytoplasmic
• Gene Name: Lars
• Organism: Mus musculus (Mouse).
• Sequence Length: 1178
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MAGRKGTAKVDFLKEIEKEAQQKWEAEKVFEVSASRLEKQKQSSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPEEEEEEEESSAKPGDIVVRDKAKGKKSKAAAKAGSSKYQWDIMKSLGLSDDDIVKFSEAEHWLDYFPPLAVQDLKTIGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLVKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETANGDIFICTQRAARNMSYQGFTKHNGVVPVVKELMGEEILGASLSAPLTCYKVVYVLPMLTIKEDKGTGVVTSVPSDSPDDLAALRDLKKKQALRTKFGIRDDMVLPFEPVPVLEIPGIGNLPAVTVCDELKIQSQNDREKLAEAKEKLYLRGFYDGVMLVDGFKGQKIQHVKKTIQKNMIDAGDALIYMEPEKQVMSRSADECVVALCDQWYLDYGDENWKKQTFQCLKNMETFCEESRKNFEASLDWLQEHACSRTYGLGTRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDLNGQAESPLGIRPQQMTKDVWDYVFFKDAPFPKTQIPKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEQSDKWPVSVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMLASCSSLRSGPADSFNDRVFASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELATEGMHRELVFRFIEVQTILLTPFCPHLCEHIWTLLGKPDSIMHASWPVAGPVDESLIRSSQYLMEVAHDLRLRLKNYMMPAKGKKTDKQPAQRPSHCTIYVAKNYPVWQHITLTTLRSHFEANNGKLPDNKVIASELGSLPELKKYMKKVMPFVAMIKENMEKKGPRVLDLELEFDEQAVLMENIVYLTNSLELEHIEVKFASEAEDKVREECCPGKPLNVFRTEPGVPVSLVNPQPSSGHFSTKIDIRQGDSCESIIRRLMKTDRGIKDLSKVKLMRFDDPLLGPRRVPVLGREHSEKTLISENAVFHVDLVSKKVHLTENGLRTDIGDTMVYLVH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	AEKVFEVSASRLEKQ HHHHHHHCHHHHHHH	17.21	28066266
35	Phosphorylation	KVFEVSASRLEKQKQ HHHHHCHHHHHHHHH	29.86	28066266
68	Phosphorylation	LHLGHTFSLSKCEFA EEECCEEEHHCCEEE	32.65	29514104
72	Glutathionylation	HTFSLSKCEFAVGYQ CEEEHHCCEEEECCH	4.70	24333276
155	Phosphorylation	KAAAKAGSSKYQWDI HHHHHHCCCHHHHHH	28.63	21659604
156	Phosphorylation	AAAKAGSSKYQWDIM HHHHHCCCHHHHHHH	34.17	21659604
158	Phosphorylation	AKAGSSKYQWDIMKS HHHCCCHHHHHHHHH	19.45	21659604
165	Phosphorylation	YQWDIMKSLGLSDDD HHHHHHHHCCCCHHH	15.41	29472430
169	Phosphorylation	IMKSLGLSDDDIVKF HHHHCCCCHHHCEEH	36.88	29472430
195	Ubiquitination	PLAVQDLKTIGLKVD CCCHHHHHHCCCEEE	46.52	-
239	Phosphorylation	KIKFGKRYTIYSPKD CCCCCCCEEEECCCC	10.85	28576409
243	Phosphorylation	GKRYTIYSPKDGQPC CCCEEEECCCCCCCC	22.94	22006019
250	Glutathionylation	SPKDGQPCMDHDRQT CCCCCCCCCCCCCCC	3.73	24333276
257	Phosphorylation	CMDHDRQTGEGVGPQ CCCCCCCCCCCCCCC	37.79	21183079
272	Acetylation	EYTLVKLKVLEPYPS EEEEEEEEEECCCCH	38.77	22826441
280	Acetylation	VLEPYPSKLSGLKGK EECCCCHHHCCCCCC	42.01	23236377
343	Acetylation	MSYQGFTKHNGVVPV CCCCCCHHCCCCHHH	32.58	23236377
352	Acetylation	NGVVPVVKELMGEEI CCCHHHHHHHCCCCC	45.42	7721303
370	Glutathionylation	SLSAPLTCYKVVYVL CCCCCCHHHEEEEEE	4.00	24333276
386	Acetylation	MLTIKEDKGTGVVTS EEEEEECCCCCEEEE	60.51	23236377
388	Phosphorylation	TIKEDKGTGVVTSVP EEEECCCCCEEEECC	32.32	25293948
392	Phosphorylation	DKGTGVVTSVPSDSP CCCCCEEEECCCCCH	22.92	25293948
393	Phosphorylation	KGTGVVTSVPSDSPD CCCCEEEECCCCCHH	22.03	28066266
396	Phosphorylation	GVVTSVPSDSPDDLA CEEEECCCCCHHHHH	48.87	28066266
398	Phosphorylation	VTSVPSDSPDDLAAL EEECCCCCHHHHHHH	34.27	19060867
575	S-palmitoylation	DWLQEHACSRTYGLG HHHHHHHHHCCCCCC	2.82	28526873
643	Ubiquitination	VWDYVFFKDAPFPKT HHHEEEECCCCCCCC	41.33	-
721	Ubiquitination	LNSEKMSKSTGNFLT ECCCCCCCCCCCCCH	48.84	-
722	Phosphorylation	NSEKMSKSTGNFLTL CCCCCCCCCCCCCHH	33.95	25521595
723	Phosphorylation	SEKMSKSTGNFLTLS CCCCCCCCCCCCHHH	39.62	23984901
735	Ubiquitination	TLSQAVDKFSADGMR HHHHHHHHCCCCCCC	34.32	-
735	Acetylation	TLSQAVDKFSADGMR HHHHHHHHCCCCCCC	34.32	22826441
751	Phosphorylation	ALADAGDTVEDANFV EECCCCCCHHCCCHH	25.52	-
783	S-palmitoylation	VKEMLASCSSLRSGP HHHHHHHCHHCCCCC	2.39	28526873
809	Ubiquitination	EMNAGIIKTDQNYEK HHCCCEEECCCCHHH	44.09	-
923	Acetylation	KNYMMPAKGKKTDKQ HHHCCCCCCCCCCCC	66.45	7615565
923	Malonylation	KNYMMPAKGKKTDKQ HHHCCCCCCCCCCCC	66.45	32601280
926	Acetylation	MMPAKGKKTDKQPAQ CCCCCCCCCCCCCCC	71.30	7615575
936	Phosphorylation	KQPAQRPSHCTIYVA CCCCCCCCCCEEEEE	33.12	25367039
939	Phosphorylation	AQRPSHCTIYVAKNY CCCCCCCEEEEECCC	15.21	25367039
941	Phosphorylation	RPSHCTIYVAKNYPV CCCCCEEEEECCCCC	4.00	25367039
972	Acetylation	NGKLPDNKVIASELG CCCCCCCHHHHHHHC	42.26	23806337
980	Phosphorylation	VIASELGSLPELKKY HHHHHHCCCHHHHHH	54.07	22817900
985	Acetylation	LGSLPELKKYMKKVM HCCCHHHHHHHHHHH	39.95	23236377
985	Ubiquitination	LGSLPELKKYMKKVM HCCCHHHHHHHHHHH	39.95	-
987	Phosphorylation	SLPELKKYMKKVMPF CCHHHHHHHHHHHHH	16.75	22817900
1049	Acetylation	FASEAEDKVREECCP ECHHHHHHHHHHHCC	34.40	23806337
1058	Acetylation	REECCPGKPLNVFRT HHHHCCCCCCCEEEC	31.32	22826441
1095	S-palmitoylation	DIRQGDSCESIIRRL ECCCCCCHHHHHHHH	5.90	28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYLC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYLC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYLC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SYLC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.