DOCK8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOCK8_MOUSE
• UniProt AC: Q8C147
• Protein Name: Dedicator of cytokinesis protein 8
• Gene Name: Dock8
• Organism: Mus musculus (Mouse).
• Sequence Length: 2100
• Subcellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side . Enriched and co-localizes with GTPase CDC42 at the immunological synapse formed du
• Protein Description: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. [PubMed: 28028151]
• Protein Sequence: MATLPSAERRAFALKINRYSSSEIRKQFTLPPNLGQYHRHSISTSGFPSLQLPQLYEPVEPVDFEGLVMTHLNSLDAELAQELGDLTDDDLHVAFTPKECRTLQHSLPEEGVELDPHVRDCVQTYIREWLIVNRKNQGSSEFCSFKKTGSRRDFQKTLQKQTFESETLECSEPDTQTGPRHPLNVLCDVSGKGPLTSCDFDLRSLQPDERLENLLQLVSAEDFEKEKEEARKTNRPAELFALYPPVDEEDAVEIRPVPECPKEHLGNRILVKVLTLKFEIEIEPLFASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSIDPSSQARSAVFSVTYPSSDIYLVVKIEKVLQQGEIADCAEPYMIIKESDGGKSKEKVEKLKLQAESFCQRLGKYRMPFAWAPISLASFFNISTLERESTDVEPGVGRNSVGEKRSLSQSRRPSERTLSLEENGVGSNFKATTLATNIFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGSLRLEISPAPDVMNCCLTPEMLPVKPFPENRTRPHKEILEFPIREVYVPHTVYRNLLYVYPQRLNFASKLASARNITIKIQFMCGEDPSNAMPVIFGKSSGPEFLQEVYTAITYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASGESLLGYSWLPILLNERLQTGSYCLPVALEKLPPNYSIHSAEKVPLQNPPIKWAEGHKGVFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVSFPIRVLDQKITESTLEHELKLSIICLNSSRLEPLVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLRKDQHGRNCLLASYVHYVFRLPELHRDTSKSGGPTTVVPDPRYHTYGRTSAAAVSSKLMQARVMSSSNPDLTGSHCAADEEVKNIMSSKIADRNCSRMSYYCSGNSDAPGSTAAPRPVSKKHFHEELALQMVVSTGVVRETVFKYAWFFFELLVKSMAQYVHNLDKRDSFRRTRFSDRFKDDITTIVNVVTSEIAALLVKPQKESEQAEKINISLAFFLYDLLSIMDRGFVFNLIKHYCSQLSAKLNILPTLISMRLEFLRILCSHEHYLNLNLLFMNTDTAPASPCPSISSQNSSSCSSFQDQKIASMFDLTPEYRQQHFLTGLLFTELAVALDAEGDGISRVQRKAVSAIHSLLCSHDLDPRCRKPEVKVKIAALYLPLVGIILDALPQLYDFTDARSGRSRASGSYEEQDVANGINQNVALAIAGNHFNLKTSGAMLSSLPYKQYNMLNADTTRHLMICFLWIMKNADQSLIRKWIADLPSMQLNRILDLLFICVSCFEYKGKQSSDKVSNQVLQKSRDVKAKLEEALLRGEGARGEMMRRRIPGTDRFPGINENLRWRKEQTQWRQANEKLDKTKAELDQEALISGNLATEANLIILDMQENIIQASSALDCKDSLLGGVLRVLVNSLSCDQSTTYLTHCFATLRALIAKFGDLLFEEEMEQCADLCQRVLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFARVKMQVTMALASLVGKAPDFNEEHLRRSLRTILAYSEEDTAMQTTPFPMQVEELLCNLNSILYDTVKMREFQEDPEMLMDLMYRIAKSYQASPDLRLTWLQNMAEKHTKKKCFTEAAMCLVHAAALVAEYLSMLEDHSYLPVGSVSFQNISSNVLEESAVSDDTLSPDEDGVCSGRYFTESGLVGLLEQAAELFSTGGLYETVNEVYKLVIPILEAHRDFRKLTSTHDKLQKAFDNIINKDHKRMFGTYFRVGFYGSRFGDLDEQEFVYKEPAITKLPEISHRLEGFYGQCFGAEFVEVIKDSTPVDKTKLDPNKAYIQITFVEPYFDEYEMKDRVTYFEKNFNLRRFMYTTPFTLEGRPRGELHEQHRRNTVLTTMHAFPYIKTRIRVSQKEEFVLTPIEVAIEDMKKKTLQLAVATHQEPPDAKMLQMVLQGSVGATVNQGPLEVAQVFLAEIPADPKLYRHHNKLRLCFKEFIMRCGEAVEKNRRLITAEQREYQQELKKNYNKLRDSLRPMIERKIPELYKPIFRVDSQKRDSFHRSSFRKCETQLSQGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATLPSAERR -----CCCCCHHHHH	51.57	26745281
6	Phosphorylation	--MATLPSAERRAFA --CCCCCHHHHHHHH	45.96	28576409
20	Phosphorylation	ALKINRYSSSEIRKQ HHHHHCCCCHHHHHH	24.93	26824392
21	Phosphorylation	LKINRYSSSEIRKQF HHHHCCCCHHHHHHC	24.05	29176673
22	Phosphorylation	KINRYSSSEIRKQFT HHHCCCCHHHHHHCC	30.97	26824392
29	Phosphorylation	SEIRKQFTLPPNLGQ HHHHHHCCCCCCCCC	35.54	26745281
139	Phosphorylation	VNRKNQGSSEFCSFK HCCCCCCCCCCCCCC	19.55	-
140	Phosphorylation	NRKNQGSSEFCSFKK CCCCCCCCCCCCCCC	41.33	25266776
144	Phosphorylation	QGSSEFCSFKKTGSR CCCCCCCCCCCCCCH	45.48	27600695
157	Phosphorylation	SRRDFQKTLQKQTFE CHHHHHHHHHHHHCC	24.52	29176673
196	Phosphorylation	VSGKGPLTSCDFDLR CCCCCCCCCCCCCHH	30.37	29472430
197	Phosphorylation	SGKGPLTSCDFDLRS CCCCCCCCCCCCHHH	21.26	22817900
390	Phosphorylation	KLKLQAESFCQRLGK HHHHHHHHHHHHHCC	34.05	29899451
408	Phosphorylation	PFAWAPISLASFFNI CCCCCCHHHHHHCCH	19.47	26643407
411	Phosphorylation	WAPISLASFFNISTL CCCHHHHHHCCHHHC	35.35	24719451
416	Phosphorylation	LASFFNISTLEREST HHHHCCHHHCCCCCC	28.22	26643407
417	Phosphorylation	ASFFNISTLERESTD HHHCCHHHCCCCCCC	28.92	26643407
422	Phosphorylation	ISTLERESTDVEPGV HHHCCCCCCCCCCCC	35.81	26643407
423	Phosphorylation	STLERESTDVEPGVG HHCCCCCCCCCCCCC	39.03	26643407
433	Phosphorylation	EPGVGRNSVGEKRSL CCCCCCCCHHCCCCC	30.09	27566939
443	Phosphorylation	EKRSLSQSRRPSERT CCCCCCCCCCCCCCC	27.21	-
447	Phosphorylation	LSQSRRPSERTLSLE CCCCCCCCCCCCCHH	37.59	-
450	Phosphorylation	SRRPSERTLSLEENG CCCCCCCCCCHHHHC	19.35	25159016
452	Phosphorylation	RPSERTLSLEENGVG CCCCCCCCHHHHCCC	32.87	24723360
492	Phosphorylation	LFKFLADYKRSSSLQ HHHHHHHHHCCHHHH	11.60	-
495	Phosphorylation	FLADYKRSSSLQRRV HHHHHHCCHHHHHHH	21.81	22802335
497	Phosphorylation	ADYKRSSSLQRRVKS HHHHCCHHHHHHHHH	29.75	22802335
508	Phosphorylation	RVKSIPGSLRLEISP HHHHCCCCEEEEECC	12.64	21183079
625	Phosphorylation	AITYHNKSPDFYEEV HHHCCCCCCCHHHHC	34.71	23140645
629	Phosphorylation	HNKSPDFYEEVKIKL CCCCCCHHHHCEEEC	20.68	23140645
881	Phosphorylation	TVVPDPRYHTYGRTS EECCCCCCCCCCCCH	12.14	26745281
883	Phosphorylation	VPDPRYHTYGRTSAA CCCCCCCCCCCCHHH	20.80	26745281
884	Phosphorylation	PDPRYHTYGRTSAAA CCCCCCCCCCCHHHH	7.41	25367039
888	Phosphorylation	YHTYGRTSAAAVSSK CCCCCCCHHHHHHHH	17.98	-
903	Phosphorylation	LMQARVMSSSNPDLT HHHHHHHHCCCCCCC	27.97	21082442
904	Phosphorylation	MQARVMSSSNPDLTG HHHHHHHCCCCCCCC	18.95	25521595
905	Phosphorylation	QARVMSSSNPDLTGS HHHHHHCCCCCCCCC	45.11	25521595
910	Phosphorylation	SSSNPDLTGSHCAAD HCCCCCCCCCCCCCC	43.98	25619855
912	Phosphorylation	SNPDLTGSHCAADEE CCCCCCCCCCCCCHH	15.34	25619855
937	Phosphorylation	DRNCSRMSYYCSGNS CCCCCCCCEEECCCC	16.31	19060867
973	Phosphorylation	ALQMVVSTGVVRETV HHHHHHHCCCHHHHH	23.53	-
1007	Phosphorylation	HNLDKRDSFRRTRFS HCCCHHHCCHHHCCC	25.37	23737553
1146	Phosphorylation	FQDQKIASMFDLTPE HCHHHHHHHHCCCHH	24.37	22817900
1231	Phosphorylation	LDALPQLYDFTDARS HHHHHHHCCCCCCCC	12.08	-
1241	Phosphorylation	TDARSGRSRASGSYE CCCCCCCCCCCCCCC	35.41	25266776
1244	Phosphorylation	RSGRSRASGSYEEQD CCCCCCCCCCCCHHH	27.45	25521595
1246	Phosphorylation	GRSRASGSYEEQDVA CCCCCCCCCCHHHHH	27.20	26745281
1247	Phosphorylation	RSRASGSYEEQDVAN CCCCCCCCCHHHHHC	27.32	26745281
1273	Phosphorylation	GNHFNLKTSGAMLSS CCCCEECCCCHHHHC	35.24	21082442
1274	Phosphorylation	NHFNLKTSGAMLSSL CCCEECCCCHHHHCC	23.98	25266776
1346	Phosphorylation	FEYKGKQSSDKVSNQ HHHCCCCCCHHHHHH	43.95	27566939
1347	Phosphorylation	EYKGKQSSDKVSNQV HHCCCCCCHHHHHHH	38.67	27566939
1357	Ubiquitination	VSNQVLQKSRDVKAK HHHHHHHHHHHHHHH	43.21	-
1922	Phosphorylation	RRNTVLTTMHAFPYI HHCHHHHHHHHHHHH	11.64	29895711
1928	Phosphorylation	TTMHAFPYIKTRIRV HHHHHHHHHCEEEEC	14.48	29895711
2057	Phosphorylation	NYNKLRDSLRPMIER HHHHHHHHHHHHHHH	21.61	25777480
2070	Phosphorylation	ERKIPELYKPIFRVD HHHCHHHHCCEEECC	17.04	25367039
2078	Phosphorylation	KPIFRVDSQKRDSFH CCEEECCCCCCCCCC	34.44	25266776
2083	Phosphorylation	VDSQKRDSFHRSSFR CCCCCCCCCCHHHHH	27.30	25266776
2087	Phosphorylation	KRDSFHRSSFRKCET CCCCCCHHHHHHHHH	25.84	30482847
2088	Phosphorylation	RDSFHRSSFRKCETQ CCCCCHHHHHHHHHH	29.09	25266776
2094	Phosphorylation	SSFRKCETQLSQGS- HHHHHHHHHHHCCC-	44.26	23140645
2097	Phosphorylation	RKCETQLSQGS---- HHHHHHHHCCC----	23.76	25266776
2100	Phosphorylation	ETQLSQGS------- HHHHHCCC-------	29.43	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOCK8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOCK8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOCK8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DOCK8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.