dbPTM

SRGP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRGP3_MOUSE
UniProt AC	Q812A2
Protein Name	SLIT-ROBO Rho GTPase-activating protein 3
Gene Name	Srgap3
Organism	Mus musculus (Mouse).
Sequence Length	1099
Subcellular Localization
Protein Description	GTPase-activating protein for RAC1 and perhaps CDC42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons (By similarity)..
Protein Sequence	MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGELSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCSQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESIKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVAESCIRFINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPADRVHPIQQILITLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHVNEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPHSEPGTIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYVGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTEHISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLSRGRIESPEKRRMATFGSAGSINYPDKKALTEGLSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPISSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMFPNSSSDKSGTM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Ubiquitination	LQEFFRRKAEIELEY HHHHHHHHHHHHHHH	46.22	-
64	Phosphorylation	AEIELEYSRSLEKLA HHHHHHHHHHHHHHH	13.15	23737553
66	Phosphorylation	IELEYSRSLEKLAER HHHHHHHHHHHHHHH	34.63	23737553
190	Acetylation	EAEKQEEKQFNKSGE HHHHHHHHHHCHHCC	60.48	7610851
214	Phosphorylation	DRPQRRSSVKKIEKM CCHHHHHHHHHHHHH	35.82	-
392	Phosphorylation	QTLQDMLTVEDFDVS HHHHHHCCCCCCCHH	18.40	26643407
399	Phosphorylation	TVEDFDVSDAFQHSR CCCCCCHHHHHHCCC	25.68	26643407
405	Phosphorylation	VSDAFQHSRSTESIK HHHHHHCCCCHHHHH	19.69	26643407
407	Phosphorylation	DAFQHSRSTESIKSA HHHHCCCCHHHHHHH	39.27	29899451
408	Phosphorylation	AFQHSRSTESIKSAA HHHCCCCHHHHHHHH	32.42	26160508
410	Phosphorylation	QHSRSTESIKSAASE HCCCCHHHHHHHHHH	35.09	29899451
413	Phosphorylation	RSTESIKSAASETYM CCHHHHHHHHHHHHH	27.65	19060867
416	Phosphorylation	ESIKSAASETYMSKI HHHHHHHHHHHHHHH	30.13	25338131
418	Phosphorylation	IKSAASETYMSKINI HHHHHHHHHHHHHHH	23.25	29899451
419	Phosphorylation	KSAASETYMSKINIA HHHHHHHHHHHHHHH	8.71	29899451
497	Phosphorylation	MRRPRPLSVYSHKLF CCCCCCCEEHHHHCC	22.99	29514104
556	Phosphorylation	EVNDIKNSFERGEDP EHHHHHCHHHCCCCC	24.39	-
759	Phosphorylation	KFDYVGRSPRELSFK CCCCCCCCHHHCCCC	23.52	23737553
808	Phosphorylation	QDMDDAFSDSLSQKA ECCCHHHHHHHHHHC	28.19	29899451
817	Phosphorylation	SLSQKADSEASSGPL HHHHHCCCCCCCCCC	39.66	25521595
820	Phosphorylation	QKADSEASSGPLLDD HHCCCCCCCCCCCCC	31.60	25521595
821	Phosphorylation	KADSEASSGPLLDDK HCCCCCCCCCCCCCH	52.02	25521595
830	Phosphorylation	PLLDDKASSKNDLQS CCCCCHHCCCCCCCC	47.81	21183079
831	Phosphorylation	LLDDKASSKNDLQSP CCCCHHCCCCCCCCC	40.10	22807455
837	Phosphorylation	SSKNDLQSPTEHISD CCCCCCCCCCHHHHH	40.88	24925903
839	Phosphorylation	KNDLQSPTEHISDYG CCCCCCCCHHHHHHC	45.50	25521595
843	Phosphorylation	QSPTEHISDYGFGGV CCCCHHHHHHCCCCC	27.04	24925903
845	Phosphorylation	PTEHISDYGFGGVMG CCHHHHHHCCCCCCC	13.94	24925903
858	Phosphorylation	MGRVRLRSDGAAIPR CCCEEECCCCCCCCC	45.01	25521595
868	Phosphorylation	AAIPRRRSGGDTHSP CCCCCCCCCCCCCCC	45.37	24925903
872	Phosphorylation	RRRSGGDTHSPPRGL CCCCCCCCCCCCCCC	27.77	24925903
874	Phosphorylation	RSGGDTHSPPRGLGP CCCCCCCCCCCCCCC	38.40	25521595
882	Phosphorylation	PPRGLGPSIDTPPRA CCCCCCCCCCCCCCC	31.16	24925903
885	Phosphorylation	GLGPSIDTPPRAAAC CCCCCCCCCCCCCCC	33.26	28066266
894	Phosphorylation	PRAAACPSSPHKIPL CCCCCCCCCCCCCCC	57.28	25266776
895	Phosphorylation	RAAACPSSPHKIPLS CCCCCCCCCCCCCCC	19.03	25266776
908	Phosphorylation	LSRGRIESPEKRRMA CCCCCCCCHHHHHCC	35.67	29899451
916	Phosphorylation	PEKRRMATFGSAGSI HHHHHCCCCCCCCCC	21.13	26239621
919	Phosphorylation	RRMATFGSAGSINYP HHCCCCCCCCCCCCC	25.84	25521595
922	Phosphorylation	ATFGSAGSINYPDKK CCCCCCCCCCCCCHH	13.84	26239621
925	Phosphorylation	GSAGSINYPDKKALT CCCCCCCCCCHHHHC	15.90	28066266
936	Phosphorylation	KALTEGLSMRSTCGS HHHCCCCCCCCCCCC	24.01	29514104
947	Phosphorylation	TCGSTRHSSLGDHKS CCCCCCCCCCCCCCH	24.78	29899451
948	Phosphorylation	CGSTRHSSLGDHKSL CCCCCCCCCCCCCHH	30.19	26824392
954	Phosphorylation	SSLGDHKSLEAEALA CCCCCCCHHHHHHHH	28.20	25521595
1006	Phosphorylation	KNPPGPISSEPASPL CCCCCCCCCCCCCCC	31.61	28066266
1007	Phosphorylation	NPPGPISSEPASPLH CCCCCCCCCCCCCCE	48.60	28066266
1011	Phosphorylation	PISSEPASPLHTIVI CCCCCCCCCCEEEEE	38.42	28066266
1015	Phosphorylation	EPASPLHTIVIRDPD CCCCCCEEEEECCCC	25.31	28066266
1028	Phosphorylation	PDAAMRRSSSSSTEM CCHHHHHCCCCCCHH	24.98	29899451
1029	Phosphorylation	DAAMRRSSSSSTEMM CHHHHHCCCCCCHHH	32.21	29899451
1030	Phosphorylation	AAMRRSSSSSTEMMT HHHHHCCCCCCHHHH	29.56	29899451
1031	Phosphorylation	AMRRSSSSSTEMMTT HHHHCCCCCCHHHHH	43.13	29899451
1032	Phosphorylation	MRRSSSSSTEMMTTF HHHCCCCCCHHHHHC	30.27	25338131
1037	Phosphorylation	SSSTEMMTTFKPALS CCCCHHHHHCHHHHH	27.98	28576409
1068	Phosphorylation	RPVVQHRSSSSSSSG CCCEECCCCCCCCCC	32.23	24925903
1069	Phosphorylation	PVVQHRSSSSSSSGV CCEECCCCCCCCCCC	33.91	25521595
1070	Phosphorylation	VVQHRSSSSSSSGVG CEECCCCCCCCCCCC	35.17	24925903
1071	Phosphorylation	VQHRSSSSSSSGVGS EECCCCCCCCCCCCC	35.87	25521595
1072	Phosphorylation	QHRSSSSSSSGVGSP ECCCCCCCCCCCCCC	30.39	24925903
1073	Phosphorylation	HRSSSSSSSGVGSPA CCCCCCCCCCCCCCC	32.81	24925903
1074	Phosphorylation	RSSSSSSSGVGSPAV CCCCCCCCCCCCCCC	39.17	29899451
1078	Phosphorylation	SSSSGVGSPAVTPTE CCCCCCCCCCCCCCH	13.79	24925903
1082	Phosphorylation	GVGSPAVTPTEKMFP CCCCCCCCCCHHCCC	26.97	24925903
1084	Phosphorylation	GSPAVTPTEKMFPNS CCCCCCCCHHCCCCC	38.58	29899451
1098	Phosphorylation	SSSDKSGTM------ CCCCCCCCC------	27.14	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
858	S	Phosphorylation	Kinase	PRKACA	P05132	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRGP3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRGP3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SRGP3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRGP3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1070, AND MASSSPECTROMETRY.	17114649 [Abstract]