FRM4B_MOUSE - dbPTM
FRM4B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FRM4B_MOUSE
UniProt AC Q920B0
Protein Name FERM domain-containing protein 4B
Gene Name Frmd4b
Organism Mus musculus (Mouse).
Sequence Length 1035
Subcellular Localization Cytoplasm, cytoskeleton . Cell junction, tight junction . Cell junction, adherens junction . Colocalized with PARD3 at adherens junction and tight junction (PubMed:20080746).
Protein Description Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. [PubMed: 20080746 Plays a redundant role with FRMD4A in epithelial polarization]
Protein Sequence MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLRTWCGLRDVYQMTEGRHCQVHLLDDRRLELLVQPKLLSRELLDLVASHFNLKEKEYFGITFIDDTGQENWLQLDHRVLEHDLPKKPGPTLLHFAVRFYIESISFLKDKNTVELFFLNAKACVHKGQIEVDSETIFKLAALVLQESKGDYTSDENARKDLKTLPVFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDLQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSKAKIPSARSLDDIAMDLTETGTQRGSKLVTLEAKSQFIMASNGSLISSGSQDSEGMEEQKREKILELKKKEKLLQEKLLQKVEELKKICLREAELTGRMPKEYPLNIGEKPPQVRRRVGTTFKLDDNLLPTEEDPALQELESNFLIQQKLVEAAKKLASEPDLCKTVKKKRKQDYTDAVKRLQEIENSINEYRIRCGKKPSQKAAVVPPEDIIPSESSSLSDTTTYDDPNDSFTLAGQRPSSVPHSPRILPPKSLGIERIHFRKSSINEQFMDTRHSREMLSTHSSPYKTLERRPQGGRSMPTTPVLTRNAYSSSHLEPDSSSQHCRQRSGSLESQSHLLSEMDSDKPFFTLSKSQRSSSTEILDDGSSYTSQSSSEYYCVTPAASPYYTTQTLDTRARGRRRSKKHSVSTSNSGSMPNLAQKDPLRNGVYSKGQDPPPSGYYIAGYPPYAECDLYYSGGYVYENDTEGQYSVNPSYRSSAHYGYDRQRDYSRSFHEDEVDRVPHNPYATLRLPRKAAVKSEHITKNIHKALVAEHLRGWYQRASGQKDQGHSPQTSFDSDRGSQRCLGFAGLQVPCSPSSRASSYSSVSSTNASGNWRTQLTIGLSEYENPVHSPYTSYYGSIYNPLSSPSRQYAETTPLDGTDGSQLEDNLEGSEQRLFWHEDSKPGTLV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
78UbiquitinationLELLVQPKLLSRELL
HHHHHCHHHHCHHHH		44.9922790023
95UbiquitinationVASHFNLKEKEYFGI
HHHHCCCCCHHEEEE		68.7722790023
275PhosphorylationLPWWLGISYKGIGQY
CCEEEEECCCCCCCC		20.9926643407
276PhosphorylationPWWLGISYKGIGQYD
CEEEEECCCCCCCCC		16.0026643407
282PhosphorylationSYKGIGQYDLQDKVK
CCCCCCCCCCCCCCC		17.2626060331
320PhosphorylationVHDPRRISVSRRTFG
ECCCCCEEEEEECCC		16.5430387612
363PhosphorylationFYLDRKQSKAKIPSA
HHHCHHHHHCCCCCC		37.30-
369PhosphorylationQSKAKIPSARSLDDI
HHHCCCCCCCCHHHH		39.5223984901
372PhosphorylationAKIPSARSLDDIAMD
CCCCCCCCHHHHCHH		35.5521082442
378OxidationRSLDDIAMDLTETGT
CCHHHHCHHHHHCCC		4.4217242355
383PhosphorylationIAMDLTETGTQRGSK
HCHHHHHCCCCCCCE		40.0521183079
411PhosphorylationSNGSLISSGSQDSEG
ECCCEECCCCCCCCC		35.1521183079
413PhosphorylationGSLISSGSQDSEGME
CCEECCCCCCCCCCH		32.5321183079
440UbiquitinationKEKLLQEKLLQKVEE
HHHHHHHHHHHHHHH		41.3522790023
483PhosphorylationQVRRRVGTTFKLDDN
CCCCCCCCEEECCCC		26.6323140645
544DimethylationDYTDAVKRLQEIENS
CHHHHHHHHHHHHHH		34.70-
605PhosphorylationLAGQRPSSVPHSPRI
ECCCCCCCCCCCCCC		42.2128066266
609PhosphorylationRPSSVPHSPRILPPK
CCCCCCCCCCCCCCH		15.1428066266
621PhosphorylationPPKSLGIERIHFRKS
CCHHHCCEEEEEECC		43.7317242355
628PhosphorylationERIHFRKSSINEQFM
EEEEEECCHHHHHHH		31.9925266776
629PhosphorylationRIHFRKSSINEQFMD
EEEEECCHHHHHHHC		32.2525266776
637PhosphorylationINEQFMDTRHSREML
HHHHHHCCHHHHHHH		20.6329472430
640PhosphorylationQFMDTRHSREMLSTH
HHHCCHHHHHHHHHC		27.0130387612
641PhosphorylationFMDTRHSREMLSTHS
HHCCHHHHHHHHHCC		27.5024719451
644PhosphorylationTRHSREMLSTHSSPY
CHHHHHHHHHCCCCC		4.5917242355
648PhosphorylationREMLSTHSSPYKTLE
HHHHHHCCCCCCCCC		32.85-
663PhosphorylationRRPQGGRSMPTTPVL
CCCCCCCCCCCCCCC		32.1827180971
666PhosphorylationQGGRSMPTTPVLTRN
CCCCCCCCCCCCCCC		34.7823984901
667PhosphorylationGGRSMPTTPVLTRNA
CCCCCCCCCCCCCCC		12.9127180971
671PhosphorylationMPTTPVLTRNAYSSS
CCCCCCCCCCCCCCC		23.3121743459
675PhosphorylationPVLTRNAYSSSHLEP
CCCCCCCCCCCCCCC		16.7917242355
676PhosphorylationVLTRNAYSSSHLEPD
CCCCCCCCCCCCCCC		23.9727742792
677PhosphorylationLTRNAYSSSHLEPDS
CCCCCCCCCCCCCCC		14.7629472430
678PhosphorylationTRNAYSSSHLEPDSS
CCCCCCCCCCCCCCC		26.5929899451
684PhosphorylationSSHLEPDSSSQHCRQ
CCCCCCCCCCHHHHH		42.4725367039
693PhosphorylationSQHCRQRSGSLESQS
CHHHHHHHCCHHHHH		25.1330352176
695PhosphorylationHCRQRSGSLESQSHL
HHHHHHCCHHHHHHH		30.1522942356
698PhosphorylationQRSGSLESQSHLLSE
HHHCCHHHHHHHHHH		42.1321082442
700PhosphorylationSGSLESQSHLLSEMD
HCCHHHHHHHHHHCC		25.9425159016
704PhosphorylationESQSHLLSEMDSDKP
HHHHHHHHHCCCCCC		36.9225159016
708PhosphorylationHLLSEMDSDKPFFTL
HHHHHCCCCCCCEEE		46.3423984901
771PhosphorylationRRRSKKHSVSTSNSG
CCCCCCCCCCCCCCC		27.0025367039
773PhosphorylationRSKKHSVSTSNSGSM
CCCCCCCCCCCCCCC		29.1825367039
774PhosphorylationSKKHSVSTSNSGSMP
CCCCCCCCCCCCCCC		29.7628066266
775PhosphorylationKKHSVSTSNSGSMPN
CCCCCCCCCCCCCCC		22.8428066266
777PhosphorylationHSVSTSNSGSMPNLA
CCCCCCCCCCCCCHH		31.8229472430
779PhosphorylationVSTSNSGSMPNLAQK
CCCCCCCCCCCHHHC		30.7828507225
857PhosphorylationRQRDYSRSFHEDEVD
CCCCCCCCCCHHHCC		25.6425367039
871PhosphorylationDRVPHNPYATLRLPR
CCCCCCCCCCEECCC		19.9626026062
873PhosphorylationVPHNPYATLRLPRKA
CCCCCCCCEECCCHH		13.4325367039
916PhosphorylationGQKDQGHSPQTSFDS
CCCCCCCCCCCCCCC		26.0629472430
919PhosphorylationDQGHSPQTSFDSDRG
CCCCCCCCCCCCCCC		34.4428066266
920PhosphorylationQGHSPQTSFDSDRGS
CCCCCCCCCCCCCCC		23.0828066266
923PhosphorylationSPQTSFDSDRGSQRC
CCCCCCCCCCCCCCC		27.4828066266
927PhosphorylationSFDSDRGSQRCLGFA
CCCCCCCCCCCCEEE		18.4929472430
941PhosphorylationAGLQVPCSPSSRASS
ECEEEECCCCCCCCC		23.0325266776
944PhosphorylationQVPCSPSSRASSYSS
EEECCCCCCCCCCCC		34.9422942356
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FRM4B_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FRM4B_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FRM4B_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CYH3_MOUSECyth3physical
11445584
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FRM4B_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-675 AND SER-698, ANDMASS SPECTROMETRY.

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